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BOX 25.3 GIANT SYNAPTIC TERMINALS: ENDBULBS AND
BOX 25.3 GIANT SYNAPTIC TERMINALS: ENDBULBS AND

... The largest synaptic terminals in the brain are contained in the central auditory pathway. There are two types of these giant synaptic terminals: (1) endbulbs of Held, which are found in the ventral cochlear nucleus (Fig. 25.18A), and (2) calyceal endings, which are found in the medial nucleus of th ...
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CHAPTER 4 How do neurons transmit information?
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Chapter 7 - Faculty Web Sites
Chapter 7 - Faculty Web Sites

... Step 4: Neurotransmitter molecules bind to receptors on the postsynaptic neuron. Step 5: Sodium ion channels open. Step 6: Sodium ions enter the Postsynaptic neuron, causing Depolarization and possible action potential. Copyright © 2012 Pearson Education, Inc. ...
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... o The sodium–potassium exchange pump ejects 3 Na+ ions for every 2 K+ ions that it brings into the cell  It serves to stabilize the resting potential when the ratio of Na + entry to K+ loss through passive channels is 3:2 o At the normal resting potential, these passive and active mechanisms are in ...
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NVCC Bio 211 - gserianne.com
NVCC Bio 211 - gserianne.com

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... stored in vesicles in the axon terminals. Impulse reaches terminal  opens calcium channels  Calcium enters the terminal  vesicles move toward membrane for exocytosis neurotransmitters are released and diffuse through synaptic cleft neurotransmitters bind with receptors on postsynaptic membrane. ...
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NVCC Bio 211 - gserianne.com
NVCC Bio 211 - gserianne.com

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End-plate potential



End plate potentials (EPPs) are the depolarizations of skeletal muscle fibers caused by neurotransmitters binding to the postsynaptic membrane in the neuromuscular junction. They are called ""end plates"" because the postsynaptic terminals of muscle fibers have a large, saucer-like appearance. When an action potential reaches the axon terminal of a motor neuron, vesicles carrying neurotransmitters (mostly acetylcholine) are exocytosed and the contents are released into the neuromuscular junction. These neurotransmitters bind to receptors on the postsynaptic membrane and lead to its depolarization. In the absence of an action potential, acetylcholine vesicles spontaneously leak into the neuromuscular junction and cause very small depolarizations in the postsynaptic membrane. This small response (~0.5mV) is called a miniature end plate potential (MEPP) and is generated by one acetylcholine-containing vesicle. It represents the smallest possible depolarization which can be induced in a muscle.
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