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Somatic Sensory System
Somatic Sensory System

... • Varies 20 fold throughout body • Fingertips have highest resolution – Due to high density of mechanoreceptors – Receptor subtypes with small receptive fields – More cortical neurons dedicated to deciphering sensory information ...
Neurophysiology
Neurophysiology

... • The response to one tone can be reduced or eliminated by introducing a second tone near the neuron’s CF. • (Fig 6.16) • Second tone can be either one which normally would excite the neuron or not ...
AQA Biology: Energy transfers and changes in
AQA Biology: Energy transfers and changes in

... 11 The number/concentration of sodium ions that must enter/degree of depolarisation of the neurone necessary to set up an action potential. 12a If several action potentials arrive in a very short time at the synapse; their effects may ‘add up’ to cause an action potential in the postsynaptic neurone ...
2003-2005 - Parkinson Canada
2003-2005 - Parkinson Canada

... Lay Summary: Work in Dr. Miller’s laboratory has demonstrated the existence of stem cells within the adult rodent and human skin that are capable of becoming neurons, astrocytes, and oligodendrocytes (the three main cell types in the central nervous system). This suggests that cells from one’s own ...
Chapter 2: Introduction to Physiology of Perception
Chapter 2: Introduction to Physiology of Perception

... • Increase in stimulus intensity can increase the firing rate of neurons • Refractory period is 1 ms - upper firing rate is 500 to 800 impulses per second • Spontaneous activity of action potentials occurs without stimulation ...
Psychopharmacology
Psychopharmacology

... • Natural ligands for BDZ receptors? – The BDZ receptors occur in high concentrations in the amygdala and other portions of the limbic system that regulates the fear response – There are endogenous inverse agonists that bind to the BDZ receptor and produce opposite actions of the drugs we have discu ...
Receptors and Hormone Action
Receptors and Hormone Action

... z E.g. Protein kinase A activate cAMP-responsiveelement binding protein (CREB), or modify structural proteins in chromatin z Activated CREB binds to specific cAMP-responsive elements in the regulatory regions of certain genes to activate gene expression ...
Special Senses
Special Senses

... interpreted as coming from a source other than actual source ...
Human Physiology
Human Physiology

...  Some protein channel gates are opened by the binding of another molecule with the protein;  this causes a conformational change in the protein molecule that opens or closes the gate.  This is called chemical gating. ...
3 Medical Terminology - MedicalScienceTwoCCP
3 Medical Terminology - MedicalScienceTwoCCP

...  Most found between neurons (some are between a neuron and another cell)  Synaptic bulb ...
Signal Transduction
Signal Transduction

... activity of the receptor and autophosphorylation of tyrosine residues in its cytosolic domain. The activated receptor also can phosphorylate other protein substrates. Ras is an intracellular GTPase switch protein that acts downstream from most RTKs. RTKs are linked indirectly to Ras via two proteins ...
The NEURON
The NEURON

The NEURON
The NEURON

... •Branch near the cell body ...
Particle Size of Beta Amyloid Peptide Aggregates Using Dynamic
Particle Size of Beta Amyloid Peptide Aggregates Using Dynamic

... amyloid peptide 1-42 to embryonic chick ciliary ganglion (CG) neurons inhibits potassium-evoked ACh release. The A? aggregates (at a concentration of 10 um) have to be preincubated (aging) for at least 72 hours at 37 C after solubilizing lyophilized peptide monomers in water. This requirement may be ...
Anatomy Review - Interactive Physiology
Anatomy Review - Interactive Physiology

... c. neurotransmitter 28. (Page 7.) Chemical synapses transmit signals more slowly than __________ ________ but the signal may be either ________ or __________, and the signal can be modified as it passes from one neuron to the next. a. electrical synapses, excitatory, inhibitory b. chemical synapses, ...
Impact of Neuroscience in Human Development
Impact of Neuroscience in Human Development

... brought a critical reality to light, and has shown that psychiatric disorders and neurological diseases are amongst the most important contributors to the global burden of the diseases, and a great danger for the quality of life. For the younger generations, mental retardation, and numerous neuronal ...
Monitoring the activity of G protein-coupled receptors
Monitoring the activity of G protein-coupled receptors

... We also demonstrated the use of the cAMP-Glo™ Assay with Gαi-coupled receptors where an agonist response results in a decrease in adenylate cyclase activity. Both GPR41 and GPR43 receptors are activated by free fatty acids within physiological concentration range (16). GPR41 and GPR43 may be coupled ...
Protein Trafficking4
Protein Trafficking4

... • Agonist-dependent down-regulation of receptors has been observed for a wide variety of ligands: e.g., GABAA receptors treated with GABA, BDZs, barbs, and neurosteroids; antidepressants and β-adrenergic receptors. • Cell surface receptor number is a balance between 2 competing processes: delivery a ...
Unit 3 Biological Bases of Behavior 11_12
Unit 3 Biological Bases of Behavior 11_12

... insufficient GABA-producing neurons in parts of the brain involved in the coordination of movement. ...
Perception and Reality
Perception and Reality

... The dendrites (sometimes called a dendritic tree) get the chemical inputs from other neurons The axon is the output mechanism that sends messages to other neurons The cell body does all of the processing of the information received from the dendrite and determines what message should be sent out thr ...
Brain Plasticity-
Brain Plasticity-

... synapses. One theory of short-term memory states that memories may be caused by “reverberating” neuronal circuits -- that is, an incoming nerve impulse stimulates the first neuron which stimulates the second, and so on, with branches from the second neuron synapsing with the first. After a period of ...
PPT
PPT

... 106-107 Na+ ions per second are prevented from entering the cell for a period of ~1 second ...
Chapter 2
Chapter 2

... • Space between Axon and Dendrite of a receiving cell • The location where Neurotransmitters are released ...
Introduction to Psychology, 7th Edition, Rod
Introduction to Psychology, 7th Edition, Rod

... • Parkinson’s Disease – It is caused by destruction of neurons that produce dopamine – L-dopa is a medication that boosts the levels of dopamine in the brain – eventually the drug causes involuntary jerky movements – after prolonged use, L-dopa’s beneficial effect may be replaced by unwanted jerky m ...
Somatic and Special Senses
Somatic and Special Senses

...  Rapid turns of the head or body stimulate the hair cells of the crista ampularis.  The semicircular canals move with the head or body, but the fluid inside the membranous canals remains stationary. This action bends the capula in one or more of the canals in a direction opposite that of the head ...
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Molecular neuroscience



Molecular neuroscience is a branch of neuroscience that observes concepts in molecular biology applied to the nervous systems of animals. The scope of this subject primarily pertains to a reductionist view of neuroscience, considering topics such as molecular neuroanatomy, mechanisms of molecular signaling in the nervous system, the effects of genetics on neuronal development, and the molecular basis for neuroplasticity and neurodegenerative diseases. As with molecular biology, molecular neuroscience is a relatively new field that is considerably dynamic.
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