From, Dr. GEETHA SAWKAR, 1st MD Dept of Rasashastra, B.L.D.E.
... Brief resume of the intended work: 6.1 Need for the study of Reproduction is a fundamental feature of all known life each individual organism exists as the result of reproduction .It is the biological process by which new “offspring” individual organisms are produced from their parents1 A childless ...
... Brief resume of the intended work: 6.1 Need for the study of Reproduction is a fundamental feature of all known life each individual organism exists as the result of reproduction .It is the biological process by which new “offspring” individual organisms are produced from their parents1 A childless ...
Injectable Anesthetics - Dr. Roberta Dev Anand
... May keep in refrigerator up to 24 hours* more expensive than ketamine-diazepam or thiopental Now there is propofol-28 Lasts up to 28 days ...
... May keep in refrigerator up to 24 hours* more expensive than ketamine-diazepam or thiopental Now there is propofol-28 Lasts up to 28 days ...
FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF Research Article
... The regression coefficient (R2) value of Zero order, First order, Higuchi’s, and Peppas plots for formulation F5 were found to be 0.984, 0.870, 0.971, 0.974. The optimized formulation F5 (0.971) follows Higuchi’s plot since the regression coefficient (R2) is found to be linear, this confirms that th ...
... The regression coefficient (R2) value of Zero order, First order, Higuchi’s, and Peppas plots for formulation F5 were found to be 0.984, 0.870, 0.971, 0.974. The optimized formulation F5 (0.971) follows Higuchi’s plot since the regression coefficient (R2) is found to be linear, this confirms that th ...
The effect of food and gastrointestinal residence on drug
... tablet was not able to provide therapeutic blood levels when administered under the fed condition to subjects 007-RJM and 008-STE. The reason for this failure was obvious upon analysis of the scintigraphic images. Subject 007-RJM showed gastric emptying of the tablet at 16 min post dose. and when th ...
... tablet was not able to provide therapeutic blood levels when administered under the fed condition to subjects 007-RJM and 008-STE. The reason for this failure was obvious upon analysis of the scintigraphic images. Subject 007-RJM showed gastric emptying of the tablet at 16 min post dose. and when th ...
BETHANECHOL CHLORIDE TABLETS, USP 5 mg - Upsher
... Because of the selective action of bethanechol chloride, nicotinic symptoms of cholinergic stimulation are usually absent or minimal when orally or subcutaneously administered in therapeutic doses, while muscarinic effects are prominent. Muscarinic effects usually occur within 5 to 15 minutes after ...
... Because of the selective action of bethanechol chloride, nicotinic symptoms of cholinergic stimulation are usually absent or minimal when orally or subcutaneously administered in therapeutic doses, while muscarinic effects are prominent. Muscarinic effects usually occur within 5 to 15 minutes after ...
Print this article - Research in Pharmaceutical Sciences
... tellurium. Metalloid containing compounds have been used as antiprotozoal drugs. Boron-based drugs, the benzoxaboroles have been exploited as potential treatments for neglected tropical diseases. Arsenic has been used as a medicinal agent and arsphenamine was the main drug used to treat syphilis. Ar ...
... tellurium. Metalloid containing compounds have been used as antiprotozoal drugs. Boron-based drugs, the benzoxaboroles have been exploited as potential treatments for neglected tropical diseases. Arsenic has been used as a medicinal agent and arsphenamine was the main drug used to treat syphilis. Ar ...
![An evaluation of the brain distribution of [11C]GSK1034702, a](http://s1.studyres.com/store/data/000857129_1-46758d24dde6b1895e180ea5a7fc1ab1-300x300.png)
An evaluation of the brain distribution of [11C]GSK1034702, a
... concentrations. Brain time activity curves (TACs) were corrected for the contribution of blood activity assuming a 5% blood volume. A metabolite-corrected arterial input function and regional TACs were fitted to a compartmental model to derive regional VT estimates as well as a whole brain VT. ...
... concentrations. Brain time activity curves (TACs) were corrected for the contribution of blood activity assuming a 5% blood volume. A metabolite-corrected arterial input function and regional TACs were fitted to a compartmental model to derive regional VT estimates as well as a whole brain VT. ...
Development and Validation of HPTLC method
... stock standard solution with methanol to reach a concentration of 10µg/ml and 4µg/ml for SITA and SIMVA respectively. Twenty tablets were weighed accurately, finely powdered and powder equivalent to 100 mg of sitagliptin and 40 mg of simvastatin was weighed accurately. The powder was transferred to ...
... stock standard solution with methanol to reach a concentration of 10µg/ml and 4µg/ml for SITA and SIMVA respectively. Twenty tablets were weighed accurately, finely powdered and powder equivalent to 100 mg of sitagliptin and 40 mg of simvastatin was weighed accurately. The powder was transferred to ...
New Functional Ligands for the Preparation of Photoactive Nanoparticle‐Based Materials Laura Amorín Ferré
... Servei D'anàlisi Química (SAQ), al servei de Ressonància Magnètica Nuclear (RMN) i al Servei de Microscopia (SM) de la Universitat Autònoma de Barcelona pel suport tècnic i l'ajuda professional prestada quan l'he necessitada. ...
... Servei D'anàlisi Química (SAQ), al servei de Ressonància Magnètica Nuclear (RMN) i al Servei de Microscopia (SM) de la Universitat Autònoma de Barcelona pel suport tècnic i l'ajuda professional prestada quan l'he necessitada. ...
DrugSmart Cup® Product Instructions
... anxiety. Physical dependence is apparent in users and leads to depressed coordination, disrupted decision making, decreased respiration, hypothermia and coma. Heroin is quickly metabolized to morphine, morphine glucuronide and 6acetylmorphine. Thus, the presence of morphine (or the metabolite, morph ...
... anxiety. Physical dependence is apparent in users and leads to depressed coordination, disrupted decision making, decreased respiration, hypothermia and coma. Heroin is quickly metabolized to morphine, morphine glucuronide and 6acetylmorphine. Thus, the presence of morphine (or the metabolite, morph ...
Jennifer Olson 1 Psychotropic Medication: Magic Bullet to Treat
... During the 1930’s through the 1950’s, scientists were discovering what they called “magic bullet” medications, like antihistamines and insulin.20 During the flurry of drug testing at this time, some drugs were discovered to have side effects that researchers thought could be useful in psychology.21 ...
... During the 1930’s through the 1950’s, scientists were discovering what they called “magic bullet” medications, like antihistamines and insulin.20 During the flurry of drug testing at this time, some drugs were discovered to have side effects that researchers thought could be useful in psychology.21 ...
Whole-Animal Selection of Aptamers Targeting Murine Spinal Cord
... to the binding affinity of an antibody to an antigen, but there are many advantages of aptamers and aptabodiesTM over antibodies: they are inexpensive, easy to produce in large quantities, their high specificity can be extended to functional groups other than proteins, and they have been observed to ...
... to the binding affinity of an antibody to an antigen, but there are many advantages of aptamers and aptabodiesTM over antibodies: they are inexpensive, easy to produce in large quantities, their high specificity can be extended to functional groups other than proteins, and they have been observed to ...
Characterization of Drug Action
... Normally, an impulse travels along the nerve and produces an action potential. The action potential is triggered by the neurotransmitter released at the previous synapse. Ultimately, the nerve transmission binds to a receptor on a cell and enters the cell. Once inside the cell, the message is given ...
... Normally, an impulse travels along the nerve and produces an action potential. The action potential is triggered by the neurotransmitter released at the previous synapse. Ultimately, the nerve transmission binds to a receptor on a cell and enters the cell. Once inside the cell, the message is given ...
PHAR 7633 Chapter 16 Routes of Excretion
... of one compound by another. A common example of this phenomena is the inhibition of penicillin excretion by competition with probenecid. When penicillin was first used it was expensive and in short supply, thus probenecid was used to reduce the excretion of the penicillin and thereby prolong penicil ...
... of one compound by another. A common example of this phenomena is the inhibition of penicillin excretion by competition with probenecid. When penicillin was first used it was expensive and in short supply, thus probenecid was used to reduce the excretion of the penicillin and thereby prolong penicil ...
rajiv gandhi university of health sciences
... decrease the risk of stroke by 34%, of heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease7. There are many classes of antihypertensive, which lower blood pressure by different means; among the most important and most widely used are ...
... decrease the risk of stroke by 34%, of heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease7. There are many classes of antihypertensive, which lower blood pressure by different means; among the most important and most widely used are ...
Stimulants Drug Information
... Piperazines, such as benzylpiperazine and trifluoromethylpiperazine, possess stimulant and hallucinogenic activity. They became especially popular worldwide as party drugs in the recent years. ...
... Piperazines, such as benzylpiperazine and trifluoromethylpiperazine, possess stimulant and hallucinogenic activity. They became especially popular worldwide as party drugs in the recent years. ...
Dart Transmitters - Wildlife Materials
... tail section with flexible 25 cm antenna, and adapter that attaches the transmitter to the front drug section. The user must furnish the drug section of the dart, which includes a drug barrel, plunger, explosive charge and double-barbed needle. If requested, a 1 ½ double-barbed needle can be suppli ...
... tail section with flexible 25 cm antenna, and adapter that attaches the transmitter to the front drug section. The user must furnish the drug section of the dart, which includes a drug barrel, plunger, explosive charge and double-barbed needle. If requested, a 1 ½ double-barbed needle can be suppli ...
Quantitative Prediction of Transporter- and Enzyme
... we reported the utility of the in vitro data to simulate pharmacokinetics of several OATP substrates using physiologicallybased pharmacokinetic (PBPK) modeling (Varma et al., 2012, 2013a,b). Our studies suggested that, for quantitative DDI predictions, the multiple components of transporter- and met ...
... we reported the utility of the in vitro data to simulate pharmacokinetics of several OATP substrates using physiologicallybased pharmacokinetic (PBPK) modeling (Varma et al., 2012, 2013a,b). Our studies suggested that, for quantitative DDI predictions, the multiple components of transporter- and met ...
hallucinogens and dissociative drugs
... hallucinogens, DMT does not appear to induce tolerance (Winstock, 2013). As with some other hallucinogens, there is little information to suggest that ayahuasca use creates lasting physiological or neurological deficits, ...
... hallucinogens, DMT does not appear to induce tolerance (Winstock, 2013). As with some other hallucinogens, there is little information to suggest that ayahuasca use creates lasting physiological or neurological deficits, ...
Molecular profiling approaches for identifying novel biomarkers
... become drug development candidates is to build up a reference database of expression profiles from known toxicants. The success of such a database relies on the principle that shared mechanisms of toxicity induced by structurally related or unrelated compounds have similar transcriptional responses ...
... become drug development candidates is to build up a reference database of expression profiles from known toxicants. The success of such a database relies on the principle that shared mechanisms of toxicity induced by structurally related or unrelated compounds have similar transcriptional responses ...
Anti-cytomegalovirus applications of the intrinsically active drug
... Human cytomegalovirus (HCMV) infections are a complicating factor in immunocompromised hosts such as AIDS-patients, transplant recipients or premature neonates. Primary infections or reactivations in immunocompromised subjects cause severe morbidity or even mortality. Currently, antiviral therapy i ...
... Human cytomegalovirus (HCMV) infections are a complicating factor in immunocompromised hosts such as AIDS-patients, transplant recipients or premature neonates. Primary infections or reactivations in immunocompromised subjects cause severe morbidity or even mortality. Currently, antiviral therapy i ...
Some drugs can cause taste disturbances
... Some drugs can cause taste disturbances ...leading to loss of appetite and noncompliance. Some of the most common culprits are surprising. Lunesta causes a metallic aftertaste in up to one-third of patients...especially at higher doses. If patients complain, lower the dose or switch to another sleep ...
... Some drugs can cause taste disturbances ...leading to loss of appetite and noncompliance. Some of the most common culprits are surprising. Lunesta causes a metallic aftertaste in up to one-third of patients...especially at higher doses. If patients complain, lower the dose or switch to another sleep ...
Benzodiazepines
... Used to eliminate acidic drug that mainly excreted by the kidney eg salicylates Serious fluid and electrolytes disturbance may occur Need expert monitoring ...
... Used to eliminate acidic drug that mainly excreted by the kidney eg salicylates Serious fluid and electrolytes disturbance may occur Need expert monitoring ...
Hallucinogens: LSD, Peyote, Psilocybin, and PCP - ncadd-sfv
... Psilocybin, and PCP Hallucinogenic compounds in the form of, or extracted from, plants and mushrooms have been used for centuries, mostly in religious rituals. Almost all hallucinogens contain nitrogen and are classified as alkaloids. Many hallucinogens have chemical structures similar to those of n ...
... Psilocybin, and PCP Hallucinogenic compounds in the form of, or extracted from, plants and mushrooms have been used for centuries, mostly in religious rituals. Almost all hallucinogens contain nitrogen and are classified as alkaloids. Many hallucinogens have chemical structures similar to those of n ...
Drug design
Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase ""drug design"" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.