Sleep - cloudfront.net
... Psychological Dependence • Drug dependence based on psychological or emotional needs – Usually crave drug – Can be as powerful as physiological addiction ...
... Psychological Dependence • Drug dependence based on psychological or emotional needs – Usually crave drug – Can be as powerful as physiological addiction ...
Modeling and Simulation of Biochemical Processes
... To accurately model the reactions, the rate at which the individual reactions fire must be calculated. The rate at which chemical reactions occur is calculated using the stoichiometry defined by the type of reaction assuming temperature and pressure are constant. For example, the reaction V + X → Y + ...
... To accurately model the reactions, the rate at which the individual reactions fire must be calculated. The rate at which chemical reactions occur is calculated using the stoichiometry defined by the type of reaction assuming temperature and pressure are constant. For example, the reaction V + X → Y + ...
ENHANCEMENT OF DISSOLUTION OF NIFEDIPINE BY SURFACE SOLID DISPERSION TECHNIQUE Research Article
... INTRODUCTION Bioavailability of poorly water‐soluble hydrophobic drugs is limited by their solubility and dissolution rate. Several studies were carried out to increase the dissolution rate of drugs [1]. One such study was solid dispersion which has shown promising results in improving ...
... INTRODUCTION Bioavailability of poorly water‐soluble hydrophobic drugs is limited by their solubility and dissolution rate. Several studies were carried out to increase the dissolution rate of drugs [1]. One such study was solid dispersion which has shown promising results in improving ...
Highlights of PET studies on chiral radiotracers and drugs at
... can be done where a subject serves as his/her own control. Moreover, multiple tracers can be used so that different parameters can be assessed in the same subject. An important point is that PET can be used to assess the behavior of a drug at its site of action directly in human subjects. This is re ...
... can be done where a subject serves as his/her own control. Moreover, multiple tracers can be used so that different parameters can be assessed in the same subject. An important point is that PET can be used to assess the behavior of a drug at its site of action directly in human subjects. This is re ...
VICH GL36(R): Studies to evaluate the safety of residues of
... However, based on the understanding of microbial ecology, such effects cannot be excluded. Although the effect of antimicrobial residues in food on the human intestinal flora has been a concern for many years, a harmonized approach to determine the threshold dose that might adversely disturb the flo ...
... However, based on the understanding of microbial ecology, such effects cannot be excluded. Although the effect of antimicrobial residues in food on the human intestinal flora has been a concern for many years, a harmonized approach to determine the threshold dose that might adversely disturb the flo ...
3 Perinatal Pharmacology
... the maternal plasma half-life of these drugs is very short, and less drug will ultimately reach the fetus. Conversely, some drugs have long-lived metabolites which can reach the fetus. For example, normeperidine, a metabolite of meperidine, is twice as toxic as the parent compound but only half as a ...
... the maternal plasma half-life of these drugs is very short, and less drug will ultimately reach the fetus. Conversely, some drugs have long-lived metabolites which can reach the fetus. For example, normeperidine, a metabolite of meperidine, is twice as toxic as the parent compound but only half as a ...
1 Revised manuscript Published in Colloids and Surfaces A
... degradation of the polyester. The PEG-containing triblock copolymer (Pluronic) proved to be an efficient surface modifier which can be applied in a blend form since it is miscible with PLGA in a certain concentration range depending on their composition [11-13]. The adsorption of Pluronic is however ...
... degradation of the polyester. The PEG-containing triblock copolymer (Pluronic) proved to be an efficient surface modifier which can be applied in a blend form since it is miscible with PLGA in a certain concentration range depending on their composition [11-13]. The adsorption of Pluronic is however ...
Pharm Profil-PANNARELLA-Apr PV
... was resolved after both drugs were discontinued. Which drug might have caused the bone marrow aplasia was not determined. A similar drug combination was given to a healthy animal, but no anemia developed.20 DOSAGE AND ADMINISTRATION Dosing and administration guidelines for FBZ are presented in Table ...
... was resolved after both drugs were discontinued. Which drug might have caused the bone marrow aplasia was not determined. A similar drug combination was given to a healthy animal, but no anemia developed.20 DOSAGE AND ADMINISTRATION Dosing and administration guidelines for FBZ are presented in Table ...
Options for regulating new psychoactive drugs: a review of
... It is easy to think of the drug problem as defined by a few substances that have troubled societies for decades, if not centuries. Heroin, still regarded as the drug causing the greatest harm in aggregate, has been part of the consciousness of most Western societies for a century. For the United Kin ...
... It is easy to think of the drug problem as defined by a few substances that have troubled societies for decades, if not centuries. Heroin, still regarded as the drug causing the greatest harm in aggregate, has been part of the consciousness of most Western societies for a century. For the United Kin ...
New drugs and indications in 2011. France is better focused on
... G As in previous years, drug regulatory agencies continued to grant marketing authorisation prematurely or on the basis of inadequate evaluation. This was especially true for paediatric medicines, despite some limited progress. G In the wake of the Mediator° disaster, the French health authorities i ...
... G As in previous years, drug regulatory agencies continued to grant marketing authorisation prematurely or on the basis of inadequate evaluation. This was especially true for paediatric medicines, despite some limited progress. G In the wake of the Mediator° disaster, the French health authorities i ...
Structure, function and selective inhibition of bacterial acetyl
... pylori (Salama et al. 2004) and Pseudomonas aeruginosa (Jacobs et al. 2003) among others. Bacteria require regulated expression of the acc genes in order to maintain appropriate cellular concentrations of the enzyme's subunits. The importance of maintaining the correct stoichiometry in vivo has been ...
... pylori (Salama et al. 2004) and Pseudomonas aeruginosa (Jacobs et al. 2003) among others. Bacteria require regulated expression of the acc genes in order to maintain appropriate cellular concentrations of the enzyme's subunits. The importance of maintaining the correct stoichiometry in vivo has been ...
Chemogenetic Analysis of Human Protein
... the case that the enzymes of this class represent particularly attractive targets for drug discovery efforts, because of the disease association and druggability of these proteins. The enzymes of the PMT class can be subdivided into two major families: the protein lysine methyltransferases (PKMTs) a ...
... the case that the enzymes of this class represent particularly attractive targets for drug discovery efforts, because of the disease association and druggability of these proteins. The enzymes of the PMT class can be subdivided into two major families: the protein lysine methyltransferases (PKMTs) a ...
Interactions of herbs and food products with drugs
... highlight the risks associated with Foods are intended to be safe for The effects of drugs may be enhanced concurrent use of herbal remedies and by a mechanism dissimilar from that human consumption, but at the same prescription drugs. of the drug, for example, by time, few foods can produce an Ther ...
... highlight the risks associated with Foods are intended to be safe for The effects of drugs may be enhanced concurrent use of herbal remedies and by a mechanism dissimilar from that human consumption, but at the same prescription drugs. of the drug, for example, by time, few foods can produce an Ther ...
Barbiturates - Alabama Counter Drug
... into chunks. It is the companies hope that these actions will help prevent future sexual assaults. Advance Slideshow to slide 6 D. How is Rohypnol Consumed? 1. While Rohypnol can be crushed into a powder and snorted, it is almost always ingested orally either in its pill form or dissolved in a drin ...
... into chunks. It is the companies hope that these actions will help prevent future sexual assaults. Advance Slideshow to slide 6 D. How is Rohypnol Consumed? 1. While Rohypnol can be crushed into a powder and snorted, it is almost always ingested orally either in its pill form or dissolved in a drin ...
3040 - Zhang, Hongyu
... their side chains are then packed into three-dimensional structures referred to as the tertiary structures. Proteins are very important and interesting biomolecules to the scientists in and outside the field of life science not only because of their crucial functional roles in life but also because ...
... their side chains are then packed into three-dimensional structures referred to as the tertiary structures. Proteins are very important and interesting biomolecules to the scientists in and outside the field of life science not only because of their crucial functional roles in life but also because ...
Cocaine-Like Discriminative Stimulus Effects of
... Abstract Background. In recent years, commercial bath salts products containing synthetic cathinone analogues have emerged as illicit drugs of abuse. These cathinones are structurally similar to the psychostimulants 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH), and produce the ...
... Abstract Background. In recent years, commercial bath salts products containing synthetic cathinone analogues have emerged as illicit drugs of abuse. These cathinones are structurally similar to the psychostimulants 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH), and produce the ...
HIV Prevention among Injecting Drug Users: Responses in
... and the Newly Independent States). Such interventions include opioid substitution pharmacotherapy, needlesyringe exchange and distribution, condom and bleach distribution, outreach to IDUs, peer education programs, and social network interventions. In some communities, completely new models of inter ...
... and the Newly Independent States). Such interventions include opioid substitution pharmacotherapy, needlesyringe exchange and distribution, condom and bleach distribution, outreach to IDUs, peer education programs, and social network interventions. In some communities, completely new models of inter ...
Drugs: dilemmas, choices and the law (summary)
... sociability. Deaths have occurred at parties, ‘raves’ and clubs among users who keep dancing ...
... sociability. Deaths have occurred at parties, ‘raves’ and clubs among users who keep dancing ...
Physicians` Desk Reference
... The Physicians’ Desk Reference (PDR) has merged with the HCNN, the only service that provides electronic delivery of important FDA-required drug Alerts to physicians. ISMS has worked with the HCNN to help physicians enroll in this important network service. The 2010 PDR will ship soon and you will n ...
... The Physicians’ Desk Reference (PDR) has merged with the HCNN, the only service that provides electronic delivery of important FDA-required drug Alerts to physicians. ISMS has worked with the HCNN to help physicians enroll in this important network service. The 2010 PDR will ship soon and you will n ...
Severe hepatotoxicity by Indian Ayurvedic herbal products: A
... 8. Previous information on hepatotoxicity of the drug Reaction labelled in the product characteristics Reaction published but unlabelled Reaction unknown 9. Response to readministration Doubling of ALT with the drug alone Doubling of ALT with the drugs already given at the time of 1 st rea ...
... 8. Previous information on hepatotoxicity of the drug Reaction labelled in the product characteristics Reaction published but unlabelled Reaction unknown 9. Response to readministration Doubling of ALT with the drug alone Doubling of ALT with the drugs already given at the time of 1 st rea ...
The Emperor`s New Drugs: An Analysis of Antidepressant
... for an indication be reported. Calculating summary statistics only for medications for which means on all trials were reported circumvented the missing data problem. Of the two widely used methods of coping with attrition in clinical trials, LOCF analyses are considered the more stringent. The FDA d ...
... for an indication be reported. Calculating summary statistics only for medications for which means on all trials were reported circumvented the missing data problem. Of the two widely used methods of coping with attrition in clinical trials, LOCF analyses are considered the more stringent. The FDA d ...
Antibiotics court order based on what happened, and didn`t happen
... in animal feed, especially at doses lower than those necessary to prevent or treat disease, favors the development of antibiotic-resistant bacteria; (2) animals receiving antibiotics in their feed may serve as a reservoir of antibiotic pathogens, which can produce human infections; (3) the prevalenc ...
... in animal feed, especially at doses lower than those necessary to prevent or treat disease, favors the development of antibiotic-resistant bacteria; (2) animals receiving antibiotics in their feed may serve as a reservoir of antibiotic pathogens, which can produce human infections; (3) the prevalenc ...
iCup 10 Panel Drug Screening Kit Insert
... of any combination of the above listed drug analytes. This assay provides only a preliminary analytical test result. A more specific alternate chemical method must be used in order to obtain a confirmed analytical result. Gas chromatography/mass spectrometry (GC/MS) is the preferred confirmatory met ...
... of any combination of the above listed drug analytes. This assay provides only a preliminary analytical test result. A more specific alternate chemical method must be used in order to obtain a confirmed analytical result. Gas chromatography/mass spectrometry (GC/MS) is the preferred confirmatory met ...
Drug design
Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase ""drug design"" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.