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Nerve Cells - Dr Magrann
Nerve Cells - Dr Magrann

... There are five types of glial cells that we will cover: Oligodendrocytes, Schwann cells, astrocytes, and microglia. 1. OLIGODENDROCYTES (“few branches”). They are found in the CNS, are very large and complex cells. Ogliodendrocytes form MYELIN SHEATHS. This sheath is a covering around an axon to spe ...
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... to 4) enabling cellular models of neuron type-specific disease, and to 5) attempts to functionally repair CNS circuitry. For example, data from our lab and others demonstrate that new neurons can be added to adult neocortical and other CNS circuitry via manipulation of transplanted or endogenous pro ...
LA4 INVESTIGATOR Name Thomas M. Jessell and Jane Dodd
LA4 INVESTIGATOR Name Thomas M. Jessell and Jane Dodd

... (alpha-fucose)-asialo-GM1 glycolipid expressed by subsets of rat dorsal ganglion neurons. J. Biol. Chem. 264, 3409-3415. Lee, C.J., Kong, H., Manzini, M.C., Albuquerque, C., Chao, M.V., and MacDermott, A.B. (2001). Kainate receptors expressed by a subpopulation of developing nociceptors rapidly swit ...
powerpoint
powerpoint

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The Nervous System
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In the Light

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Calcium-activated chloride channels: a new target to
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... characteristic of the ANO2 channels. This phenotype was also observed in the knockdown of ANO2 in CA1 hippocampal neurons, providing further evidence that Ca2+-activated Cl− conductance via ANO2 channels hyperpolarizes the membrane potential in these CNS neurons. The thalamus-specific ANO2 knockdown ...
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Controlling Robots with the Mind
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... There were caveats, however. Georgopoulos had recorded the activity of single neurons one at a time and from only one motor area. This approach left unproved the underlying hypothesis that some kind of coding scheme emerges from the simultaneous activity of many neurons distributed across multiple c ...
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Optogenetics



Optogenetics (from Greek optikós, meaning ""seen, visible"") is a biological technique which involves the use of light to control cells in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method employed in neuroscience that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue—even within freely-moving animals—and to precisely measure the effects of those manipulations in real-time. The key reagents used in optogenetics are light-sensitive proteins. Spatially-precise neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while temporally-precise recordings can be made with the help of optogenetic sensors for calcium (Aequorin, Cameleon, GCaMP), chloride (Clomeleon) or membrane voltage (Mermaid).The earliest approaches were developed and applied by Boris Zemelman and Gero Miesenböck, at the Sloan-Kettering Cancer Center in New York City, and Dirk Trauner, Richard Kramer and Ehud Isacoff at the University of California, Berkeley; these methods conferred light sensitivity but were never reported to be useful by other laboratories due to the multiple components these approaches required. A distinct single-component approach involving microbial opsin genes introduced in 2005 turned out to be widely applied, as described below. Optogenetics is known for the high spatial and temporal resolution that it provides in altering the activity of specific types of neurons to control a subject's behaviour.In 2010, optogenetics was chosen as the ""Method of the Year"" across all fields of science and engineering by the interdisciplinary research journal Nature Methods. At the same time, optogenetics was highlighted in the article on “Breakthroughs of the Decade” in the academic research journal Science. These journals also referenced recent public-access general-interest video Method of the year video and textual SciAm summaries of optogenetics.
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