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Bischoff_Thesis_notes
Bischoff_Thesis_notes

...  Turner & Anderson (1997) – both segments discharges temporally related to arm movement as well as movement direction and amplitude  Nambu (1990) – discharge during delay period of go/no-go task + movement and visual-stimulu sensitive cells  Depletion of dopamine (or blockade of D2 receptors) rai ...
Loss of MECP2 leads to telomere dysfunction and
Loss of MECP2 leads to telomere dysfunction and

... bioRxiv preprint first posted online Apr. 24, 2017; doi: http://dx.doi.org/10.1101/130401. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license. ...
By ON THE ROLE OF THE SUPERIOR COLLICULUS IN THE CONTROL... VISUALLY-GUIDED SACCADES
By ON THE ROLE OF THE SUPERIOR COLLICULUS IN THE CONTROL... VISUALLY-GUIDED SACCADES

... of simulating saccadic sensory to motor transformations. This model was designed to predict how the spatial interactions between neural signals related to visual processing and saccadic preparation interact within the SC to influence saccadic reaction time. I concluded that saccade latency was stron ...
Eyeblink Conditioning During an Interstimulus Interval Switch in
Eyeblink Conditioning During an Interstimulus Interval Switch in

... (Coleman & Gormezano, 1971; Gormezano, Kehoe, & Marshall, 1983; Schneiderman, 1966; Schneiderman & Gormezano, 1964; Smith, 1968; Smith, Coleman, & Gormezano, 1969). It can thus be argued that an ISI of 200 –500 ms is optimal for rabbit eyeblink conditioning, and longer or shorter ISIs are nonoptimal ...
Severely dystrophic axons at amyloid plaques
Severely dystrophic axons at amyloid plaques

... Nuclear size was measured using Zeiss LSM Image Browser software. The number of amyloid plaques stained with Thioflavine S was determined in the same cortical regions where we based our axon studies, those where axon imaging is most clear. Six sagittal sections (3 sections/hemisphere) were made at 1. ...
Neurobiology of Economic Choice: A Good
Neurobiology of Economic Choice: A Good

... affect values in the form of action costs (the actions necessary to obtain different goods often bear different costs). The model proposed here assumes that the action cost (i.e., the physical effort) is computed, represented in a nonspatial way, and integrated with other determinants in the computa ...
Olfaction
Olfaction

... an odorant following exposure to another odorant q  Presumed to occur because the two odors share one or more olfactory receptors for their transduction, but the order of odorants also plays a role ...
Ionotropic Glutamate Receptors in Aplysia californica and Molecular
Ionotropic Glutamate Receptors in Aplysia californica and Molecular

... a multitude of molecular changes that may result in learned behaviors. Mammalian systems may be difficult to work use to understand learned behaviors due to highly complex nervous systems; the human brain consists of one trillion neurons and highly complicated neuronal networks, making it difficult ...
Dendritic Signal Integration
Dendritic Signal Integration

... modeling of neurons with dendritic trees. Such models are now being used to provide insight into how charge spreads in elaborately branching dendritic trees containing many different types of ion channels. Another way that dendrites influence EPSPs is via their effect on spatial summation. If two sy ...
From Thought to Action
From Thought to Action

... modulated via an intervening network of many neurons. Colloquially, the modulation of membrane potentials is referred to as "information processing" when examined within a neuron or network, and "communication" when described as occuring between neurons or networks. These word choices have inspired ...
The Role of the Terminal Nerve and GnRH in Olfactory System
The Role of the Terminal Nerve and GnRH in Olfactory System

... olfactory nerve or ventral olfactory bulb, with fibers that extend rostrally to the olfactory epithelium and caudally to the preoptic area, although collaterals can branch widely throughout the brain (Oka, 1997). The terminals of the rostral processes have proven difficult to locate precisely, but t ...
View: Chapter Text (PDF with new
View: Chapter Text (PDF with new

... Dorsally at the midline, fasciculus gracilis axons terminate in the nucleus gracilis. Further laterally, fasciculus cuneatus axons terminate in the medial cuneate nucleus (nucleus cuneatus medialis) (Fig. 18–8). The fasciculi are composed of cranial branches of primary afferent axons associated wit ...
Amygdala Modulation of Cerebellar Learning
Amygdala Modulation of Cerebellar Learning

... Figure 1A shows the onsets and offsets of the stimuli used in delay eyeblink conditioning (dEBC). The sampling window for each trial was 1000 ms, consisting of a 300 ms baseline period, 400 ms CS period, 25 ms US period, and 275 ms post-US period. The CS was an 85 dB, 2.0 kHz pure tone. The mean int ...
Pallidal Origin of GABA Release within the Substantia Nigra Pars
Pallidal Origin of GABA Release within the Substantia Nigra Pars

... High-frequency stimulation of the subthalamic nucleus (HFS-STN) is an effective treatment for alleviating the motor symptoms of parkinsonian patients. However, the neurochemical basis of its effects remains unknown. We showed previously that 1 h of HFS-STN in normal rats increases extracellular glut ...
Pain Take Home Messages
Pain Take Home Messages

... 6. Longer training produces persistent placebo and nocebo effects a. Long lasting experience of reduction of pain upon placebo light signal (green) reduces pain perception even when the actual intensity of the stimulus is not decreased i. True for tactile or painful stimuli ii. Persistent placebo ef ...
Background Paper 3 - Yale School of Medicine
Background Paper 3 - Yale School of Medicine

... determined by EM counts correlates with the capacity to learn delayed nonmatching-tosample (DNMS), the relationship is stronger when behavior is correlated with thin spine density17. Furthermore, the mean size of the spine head in thin spines correlates with the capacity to learn DNMS for a given mo ...
Chapter 02: Biopsychology, Neuroscience, and Human Nature
Chapter 02: Biopsychology, Neuroscience, and Human Nature

... Incorrect. Down syndrome is not an adaptive quality of human beings; rather, it is an illness that is caused by having one too many chromosomes. d. language Correct. The ability to use language as a means of communication is certainly adaptive to human beings. e. the ability to program a cell phone ...
Aerobic Glycolysis in the Frontal Cortex Correlates with Memory
Aerobic Glycolysis in the Frontal Cortex Correlates with Memory

... H magnetic resonance spectroscopy. Mice were anesthetized with 2% isoflurane and scanned using a 9.4 T small-animal MRI scanner equipped with a 30 mm millipede volume radiofrequency coil (Agilent). T2-weighted images were acquired and a voxel (2 ⫻ 4 ⫻ 3 mm 3) was localized to the frontal cortex for ...
Structure and dynamics of the corticothalamic driver pathway in the
Structure and dynamics of the corticothalamic driver pathway in the

... Each moment of life, our brains excel at the complex tasks of acquiring information about the environment, processing and analyzing those signals, store and retrieve memories, decide on appropriate behavior and finally coordinate the muscular contractions for an appropriate behavioral response. Acco ...
Neurotransmitter Transporters
Neurotransmitter Transporters

... glutamate or a slow shift in the membrane potential produced by noradrenaline (norepinephrine), the duration of this potential determines how it interacts with other synaptic responses occurring close in time (temporal summation), and how they ultimately alter the excitability of the postsynaptic ne ...
PDF
PDF

... A critical problem in daily decision making is how to choose actions now in order to bring about rewards later. Indeed, many of our actions have long-term consequences, and it is important to not be myopic in balancing the pros and cons of different options, but rather to take into account both imme ...
(2000). Cerebral hemisphere regulation of motivated behavior.
(2000). Cerebral hemisphere regulation of motivated behavior.

... intrinsic activity [327] that controls behavioral state — the sleep / wake cycle and levels of arousal within a particular state. Obviously, behavior is quite different when one is asleep or awake, and when awake there is a certain basic level of arousal or spontaneous activity that is independent o ...
Pharmacology 18a – Priciples of GABAergic Transmission
Pharmacology 18a – Priciples of GABAergic Transmission

... 1. Which are the principal inhibitory and excitatory amino acid neurotransmitters in the mammalian CNS? With which types of neurons are these transmitters associated? 2. Briefly describe the processes involved in GABAergic synaptic transmission. How may this knowledge be useful in the design of nove ...
Cerebral hemisphere regulation of motivated
Cerebral hemisphere regulation of motivated

... intrinsic activity [327] that controls behavioral state — the sleep / wake cycle and levels of arousal within a particular state. Obviously, behavior is quite different when one is asleep or awake, and when awake there is a certain basic level of arousal or spontaneous activity that is independent o ...
Spike-timing-dependent plasticity: common themes
Spike-timing-dependent plasticity: common themes

... From this perspective, STDP strengthens only the synapses of the most correlated inputs. At this stage of the development of a column, activity originates in the input layer, passes unto the correlated group of neurons, and then unto other neurons in the network layer. However, the firing of the inpu ...
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Feature detection (nervous system)

Feature detection is a process by which the nervous system sorts or filters complex natural stimuli in order to extract behaviorally relevant cues that have a high probability of being associated with important objects or organisms in their environment, as opposed to irrelevant background or noise. Feature detectors are individual neurons – or groups of neurons – in the brain which code for perceptually significant stimuli. Early in the sensory pathway feature detectors tend to have simple properties; later they become more and more complex as the features to which they respond become more and more specific. For example, simple cells in the visual cortex of the domestic cat (Felis catus), respond to edges – a feature which is more likely to occur in objects and organisms in the environment. By contrast, the background of a natural visual environment tends to be noisy – emphasizing high spatial frequencies but lacking in extended edges. Responding selectively to an extended edge – either a bright line on a dark background, or the reverse – highlights objects that are near or very large. Edge detectors are useful to a cat, because edges do not occur often in the background “noise” of the visual environment, which is of little consequence to the animal.
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