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Direct and Indirect Activation of Cortical Neurons by Electrical
Direct and Indirect Activation of Cortical Neurons by Electrical

... doi:10.1152/jn.00126.2006. Electrical microstimulation has been used to elucidate cortical function. This review discusses neuronal excitability and effective current spread estimated by using three different methods: 1) single-cell recording, 2) behavioral methods, and 3) functional magnetic resona ...
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... Two-photon (2P) excitation is a method that has revolutionized many areas of biological science as it enables three-dimensionally defined excitation of chromophores in biological tissue. We have developed 2P uncaging methods to reveal the microarchitecture of synaptic connections at a level of singl ...
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Slide 1 - Elsevier Store
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Single-unit recording

In neuroscience, single-unit recordings provide a method of measuring the electro-physiological responses of single neurons using a microelectrode system. When a neuron generates an action potential, the signal propagates down the neuron as a current which flows in and out of the cell through excitable membrane regions in the soma and axon. A microelectrode is inserted into the brain, where it can record the rate of change in voltage with respect to time. These microelectrodes must be fine-tipped, high-impedance conductors; they are primarily glass micro-pipettes or metal microelectrodes made of platinum or tungsten. Microelectrodes can be carefully placed within (or close to) the cell membrane, allowing the ability to record intracellularly or extracellularly.Single-unit recordings are widely used in cognitive science, where it permits the analysis of human cognition and cortical mapping. This information can then be applied to brain machine interface (BMI) technologies for brain control of external devices.
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