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RESOURCE - Synthetic Neurobiology Group
RESOURCE - Synthetic Neurobiology Group

... Cell type–specific expression of optogenetic molecules allows temporally precise manipulation of targeted neuronal activity. Here we present a toolbox of four knock-in mouse lines engineered for strong, Cre-dependent expression of channelrhodopsins ChR2-tdTomato and ChR2-EYFP, halorhodopsin eNpHR3.0 ...
Chapter 2: The Brain and Behavior
Chapter 2: The Brain and Behavior

... scale is exaggerated here. Such measurements require ultra-small electrodes, as described later in this chapter.) The inside of an axon at rest is about -60 to -70 millivolts, compared with the outside. Electrochemical changes in a neuron generate an action potential. When positively charged sodium ...
Sensory Pathways (Ascending Tracts)
Sensory Pathways (Ascending Tracts)

... Second order neurons give axons that cross medline through anterior gray and white commissures within ...
Chapter 28: Nervous
Chapter 28: Nervous

... Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings ...
Dexterous Finger Movements in Primate Without Monosynaptic
Dexterous Finger Movements in Primate Without Monosynaptic

... vation of neurons with long descending axons. In contrast, on the lesioned side, the direct CS volley was completely abolished (solid line), while the synaptic volley (interrupted line) remained (mediated by descending axons in an intact funicle). Extracellular recordings of field potentials were ma ...
Chapter 11 ppt A
Chapter 11 ppt A

... The Axon: Functional Characteristics • Conducting region of neuron • Generates nerve impulses • Transmits them along axolemma (neuron cell membrane) to axon terminal – Secretory region – Neurotransmitters released into extracellular space • Either excite or inhibit neurons with which axons in close ...
Introduction to the Nervous System
Introduction to the Nervous System

... of the nerves are associated with the special senses of smell, vision, hearing, and equilibrium and have only sensory fibers. Five other nerves are primarily motor in function but do have some sensory fibers for proprioception. The remaining four nerves consist of significant amounts of both sensory ...
1. Materials and Methods
1. Materials and Methods

... head holder and a chamber for single neuron recordings. Single neurons were recorded using tungsten microelectrodes (impedance: 0.5-1.5 M measured at 1 kHz) inserted through the dura. Individual action potentials were isolated with a time-amplitude voltage discriminator (BAK Electronics, Germantown ...
Modelling the Grid-like Encoding of Visual Space
Modelling the Grid-like Encoding of Visual Space

... mechanisms that directly integrate information on the velocity and direction of an animal into a periodic representation of the animal’s location (Kerdels, 2016). As a consequence, the particular models do not generalize well, i.e., they can not be used to describe or investigate the behavior of neu ...
Document
Document

... characterize excitatory and inhibitory motor neurons in the human gastric sling and clasp fibers, their location, structure, responses, and how they affect that area of the body and potential complications that may arise there. Often times, there is a discrepancy with the cell signaling that takes p ...
The Elementary Nervous System Revisited1
The Elementary Nervous System Revisited1

... 1989). The a-type mating factor of yeast shows sequence similarities with the vertebrate reproductive hormone GnRH and mimics its effects, stimulating release of luteinizing hormone from pituitary cells (Loumaye et al., 1982). Both are produced by post-translational cleavage of a pro-protein. Whethe ...
Signaling in large-scale neural networks
Signaling in large-scale neural networks

... stimulus was applied. It is in this model that we have seen motoneurons and interneurons enter the high conductance state due to a parallel increase in excitatory and inhibitory synaptic activity during scratching (Alaburda et al. 2005; Berg et al. 2007). This was a surprising finding for two reason ...
35-2 The Nervous System
35-2 The Nervous System

... End Show Copyright Pearson Prentice Hall ...
What Are Different Brains Made Of?
What Are Different Brains Made Of?

... size are built of the same amounts of each kind of cell. It is also not true that a bigger brain is always made of more cells than a smaller brain. We can think about this with an example. Imagine that you receive two brains of the same weight but belonging to different species. This is what we see ...
Paper: Temporal Convergence of Dynamic Cell Assemblies in the
Paper: Temporal Convergence of Dynamic Cell Assemblies in the

... groups that were temporally differentiated and fired in serial episodes along the trial. In the GPe, the average sustained response was composed of two response groups that were primarily differentiated by their immediate change in firing rate direction. However, unlike MSNs, neurons in both GPe res ...
Propagation of Epileptiform Events across the Corpus Callosum in a
Propagation of Epileptiform Events across the Corpus Callosum in a

... of bicuculline in one hemisphere produced local epileptiform events (EEs); when we simultaneously recorded single pyramidal neurons in whole-cell voltage-clamp mode in contralateral cortex, we found large GABAergic IPSCs that correlated with the EEs (but not correlated EPSCs), demonstrating strong f ...
Pacemaker Potentials for the Periodic Burst Discharge in the Heart
Pacemaker Potentials for the Periodic Burst Discharge in the Heart

... ABSTRACT From somata of the pacemaker neurons in the Squilla heart ganglion, pacemaker potentials for the spontaneous periodic burst discharge are recorded with intracellular electrodes. The electrical activity is composed of slow potentials and superimposed spikes, and is divided into four types, w ...
PPT - Sheffield Department of Computer Science
PPT - Sheffield Department of Computer Science

... weights that will allow the model to get each output unit correct, provided such a set of weights exist. ...
doc Practice midterm
doc Practice midterm

... 7. Which of the following pairs of structures are analogous (perform similar functions) a. Nucleus gracilis and main sensory nucleus of V b. Intermediolateral cell column of spinal cord and dorsal motor nucleus of the vagus c. Hypoglossal nucleus and ventral horn spinal cord d. Clarke’s column and S ...
PPT - Michael J. Watts
PPT - Michael J. Watts

... • Adds an additional layer (or layers) of neurons to a perceptron • Additional layer called hidden (or intermediate) layer • Additional layer of adjustable connections ...
Phineas Gage Reading Guide Directions: After you read each
Phineas Gage Reading Guide Directions: After you read each

... found on the brains of stroke patients. 6. Who was Carl Wernicke? What is Wernicke's area? Carl Wernicke is a German who finds another similar spot on the left temporal lobe. This controls the ability to understand speech. 7. Would you say Broca and Wernicke are "whole-brainers" or "Localizers?" Exp ...
Nervous
Nervous

... What is the association between cutaneous sensation and spinal nerves? Spinal nerves innervate specific regions of the body and are mapped out on a Dermatomal map Predict the possible site of nerve damage for a patient who suffered whiplash and developed anesthesia in the left arm, forearm and ...
Effect of deep brain stimulation on substantia nigra neurons in a
Effect of deep brain stimulation on substantia nigra neurons in a

... electrophoresed to the SNc at electrophoresis currents of 5–100 nA and stagnation currents of 5–10 nA. Except for Glu, other neurotransmitter detection solutions were electrophoresed using a positive charge. Unit neuron discharge was displayed on an oscilloscope after it was mediated and filtered th ...
Cell type-specific pharmacology of NMDA receptors using masked
Cell type-specific pharmacology of NMDA receptors using masked

... regulated by receptors on the surface of brain cells called N-Methyl-D-aspartate receptors (or NMDA receptors for short). These receptors help to strengthen signals between brain cells, which allows a new concept or action to be learned. However, it has been difficult to pin down how the role of NMD ...
Brain Research - Dana Foundation
Brain Research - Dana Foundation

... conversation in a noisy room, for example. This information may engage memory, emotion and language centers as we interpret and respond to what we see, hear, taste, smell and feel. ...
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Single-unit recording

In neuroscience, single-unit recordings provide a method of measuring the electro-physiological responses of single neurons using a microelectrode system. When a neuron generates an action potential, the signal propagates down the neuron as a current which flows in and out of the cell through excitable membrane regions in the soma and axon. A microelectrode is inserted into the brain, where it can record the rate of change in voltage with respect to time. These microelectrodes must be fine-tipped, high-impedance conductors; they are primarily glass micro-pipettes or metal microelectrodes made of platinum or tungsten. Microelectrodes can be carefully placed within (or close to) the cell membrane, allowing the ability to record intracellularly or extracellularly.Single-unit recordings are widely used in cognitive science, where it permits the analysis of human cognition and cortical mapping. This information can then be applied to brain machine interface (BMI) technologies for brain control of external devices.
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