msb20105-sup-0002 - Molecular Systems Biology
... and H2AX foci (green) after 8 days doxycycline removal. White indicates significant overlap according to a pixel-by-pixel Pearson correlation analysis. C) Representative sen--Gal staining micrographs of T19 cells at days 0 (left) and 8 (right) after doxycycline removal. D) Kinetics of population d ...
... and H2AX foci (green) after 8 days doxycycline removal. White indicates significant overlap according to a pixel-by-pixel Pearson correlation analysis. C) Representative sen--Gal staining micrographs of T19 cells at days 0 (left) and 8 (right) after doxycycline removal. D) Kinetics of population d ...
Regulation of Action-Potential Firing in Spiny Neurons of the Rat
... firing in spiny neurons of the rat neostriatum in vivo. J. Neurophysiol. 79: 2358–2364, 1998. Both silent and spontaneously firing spiny projection neurons have been described in the neostriatum, but the reason for their differences in firing activity are unknown. We compared properties of spontaneo ...
... firing in spiny neurons of the rat neostriatum in vivo. J. Neurophysiol. 79: 2358–2364, 1998. Both silent and spontaneously firing spiny projection neurons have been described in the neostriatum, but the reason for their differences in firing activity are unknown. We compared properties of spontaneo ...
Resonate-and-fire neurons
... potential, and it makes many non-trivial ideas easy to understand and illustrate. Its computational ef®ciency is comparable with that of the integrate-and-®re model, which makes it suitable for simulations of large networks of spiking neurons. 2. Integrators versus resonators Neurons generate action ...
... potential, and it makes many non-trivial ideas easy to understand and illustrate. Its computational ef®ciency is comparable with that of the integrate-and-®re model, which makes it suitable for simulations of large networks of spiking neurons. 2. Integrators versus resonators Neurons generate action ...
Regulation of Action-Potential Firing in Spiny Neurons of the Rat
... Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, Dunedin, New Zealand; and 2 Department of Anatomy and Neurobiology, University of Tennessee, Memphis, Tennessee 38163 Wickens, J. R. and C. J. Wilson. Regulation of action-potential firing in spiny neurons ...
... Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, Dunedin, New Zealand; and 2 Department of Anatomy and Neurobiology, University of Tennessee, Memphis, Tennessee 38163 Wickens, J. R. and C. J. Wilson. Regulation of action-potential firing in spiny neurons ...
Slide 1
... 2. Tamir Gabay, et.al, “Engineering the Neural Network with Patterned Nano Carbontubes Substrates,” Physica A, 350, 611, 2005. 3. Miguel A. Correa-Duarte, et. al, “Fabrication and Biocompatibility of Carbon NanotubeBased 3D Networks as Scaffolds for Cell Seeding and Growth,” Nano Lett., 4, 2233, ...
... 2. Tamir Gabay, et.al, “Engineering the Neural Network with Patterned Nano Carbontubes Substrates,” Physica A, 350, 611, 2005. 3. Miguel A. Correa-Duarte, et. al, “Fabrication and Biocompatibility of Carbon NanotubeBased 3D Networks as Scaffolds for Cell Seeding and Growth,” Nano Lett., 4, 2233, ...
Glial Signaling Take Home Messages
... iii. Astrocytes and D-serine necessary for neuronal LTP c. D-serine binds the Gly site on neuronal NMDA receptors → ↑ LTP 2. Astrocyte signaling → ↑ LTP is limited to local astrocyte networks 3. Astrocytes are required for some types of synaptic plasticity (like LTP) 4. Human Astrocytes (hAstrocyt ...
... iii. Astrocytes and D-serine necessary for neuronal LTP c. D-serine binds the Gly site on neuronal NMDA receptors → ↑ LTP 2. Astrocyte signaling → ↑ LTP is limited to local astrocyte networks 3. Astrocytes are required for some types of synaptic plasticity (like LTP) 4. Human Astrocytes (hAstrocyt ...
the original powerpoint file
... – Task 1: Learn generative weights that can convert the posterior distribution over the hidden units back into the data. – Task 2: Learn to model the posterior distribution over the hidden units. – The RBM does a good job of task 1 and a not so good job of task 2. • Task 2 is easier (for the next RB ...
... – Task 1: Learn generative weights that can convert the posterior distribution over the hidden units back into the data. – Task 2: Learn to model the posterior distribution over the hidden units. – The RBM does a good job of task 1 and a not so good job of task 2. • Task 2 is easier (for the next RB ...
The Nervous System
... The nervous system is made up of nervous tissues that are, in turn, made up of many types of neutrons. There are billions of neutrons connected throughout your body. Your peripheral nervous system has two types of neurons that are constantly at work. Neurons that send impulses from the central ...
... The nervous system is made up of nervous tissues that are, in turn, made up of many types of neutrons. There are billions of neutrons connected throughout your body. Your peripheral nervous system has two types of neurons that are constantly at work. Neurons that send impulses from the central ...
Conversion of Mouse and Human Fibroblasts into Functional Spinal
... 8These authors contributed equally to this work *Correspondence: [email protected] DOI 10.1016/j.stem.2011.07.014 2Harvard ...
... 8These authors contributed equally to this work *Correspondence: [email protected] DOI 10.1016/j.stem.2011.07.014 2Harvard ...
Design Features in Vertebrate Sensory Systems
... contain a topologically organized repre- of the MLD lacks an orderly representasentation of the gustatory receptor sheet tion of auditory frequency. It is instead in which the representation of the head "space mapped" in that there is an orderly and barbels is disproportionately large representation ...
... contain a topologically organized repre- of the MLD lacks an orderly representasentation of the gustatory receptor sheet tion of auditory frequency. It is instead in which the representation of the head "space mapped" in that there is an orderly and barbels is disproportionately large representation ...
MN20, a D2 Cyclin, Is Transiently Expressed in Selected Neural
... action of numerous cell cycle regulatory proteins in response to signals both intrinsic and extrinsic to the cell. Thus, proteins that regulate the cell cycle are well suited to provide a link between processes that control neuroblast proliferation and differentiation. We reported previously the iso ...
... action of numerous cell cycle regulatory proteins in response to signals both intrinsic and extrinsic to the cell. Thus, proteins that regulate the cell cycle are well suited to provide a link between processes that control neuroblast proliferation and differentiation. We reported previously the iso ...
Presentation Slides
... • Anxiety – behavioural state arising in anticipation of potential threat ...
... • Anxiety – behavioural state arising in anticipation of potential threat ...
Nervous System
... acuity; composed mostly of cone cells s. Optic disc: the “blind spot” where neurons exit the eyeball as the optic nerve D. Sense of sight 1. Light waves bent first by the cornea, the eye’s fixed outer lens; bending of the light rays = refraction. Iris, whose pigment gives an eye its color, contracts ...
... acuity; composed mostly of cone cells s. Optic disc: the “blind spot” where neurons exit the eyeball as the optic nerve D. Sense of sight 1. Light waves bent first by the cornea, the eye’s fixed outer lens; bending of the light rays = refraction. Iris, whose pigment gives an eye its color, contracts ...
Saccade-related activity of periaqueductal gray matter of the
... sec before the saccades. Tonic discharge rates varied from cell to cell (mean values from 30-79 spikes/sec, with an average of 57.8 spikes/sec). One cell showed fluctuating discharge frequencies (Fig. 2). This cell exhibited presaccadic discharges at 50-190 spikes/sec. The discharge rates did not ch ...
... sec before the saccades. Tonic discharge rates varied from cell to cell (mean values from 30-79 spikes/sec, with an average of 57.8 spikes/sec). One cell showed fluctuating discharge frequencies (Fig. 2). This cell exhibited presaccadic discharges at 50-190 spikes/sec. The discharge rates did not ch ...
Long?Term, Stable Differentiation of Human Embryonic Stem Cell
... Multiple-antigen ICC confirmed further the predominant phenotypes of P2 NPs (Fig. 3E). For example, nestin was found to colocalize extensively with musashi-1 and vimentin, a pattern confirming the neural stemness of our NPs, whereas these cells were negative for pax6, an early marker of neuroepitheliu ...
... Multiple-antigen ICC confirmed further the predominant phenotypes of P2 NPs (Fig. 3E). For example, nestin was found to colocalize extensively with musashi-1 and vimentin, a pattern confirming the neural stemness of our NPs, whereas these cells were negative for pax6, an early marker of neuroepitheliu ...
Nerve activates contraction
... • What do you think the major functions of the nervous system are? • Name one other body system and how you think it works with the nervous system ...
... • What do you think the major functions of the nervous system are? • Name one other body system and how you think it works with the nervous system ...
Cautionary Observations on Preparing and Interpreting Brain
... In situ RNA Hybridization. The in situ RNA hybridization (ISH) technique visualizes cells that possess a particular messenger RNA. It is, thus, a powerful tool for directly detecting gene expression. Until recently, probes for hybridization were generated only after particular genes were cloned. The ...
... In situ RNA Hybridization. The in situ RNA hybridization (ISH) technique visualizes cells that possess a particular messenger RNA. It is, thus, a powerful tool for directly detecting gene expression. Until recently, probes for hybridization were generated only after particular genes were cloned. The ...
Barnes TD, Kubota Y, Hu D, Jin DZ, Graybiel AM. Activity of striatal
... To identify neural mechanisms that might underlie such learning dynamics, we made long-term recordings from multiple neurons in the sensorimotor striatum, a basal ganglia structure implicated in habit formation4–8, in rats successively trained on a rewardbased procedural task, given extinction train ...
... To identify neural mechanisms that might underlie such learning dynamics, we made long-term recordings from multiple neurons in the sensorimotor striatum, a basal ganglia structure implicated in habit formation4–8, in rats successively trained on a rewardbased procedural task, given extinction train ...
FIGURE LEGENDS FIGURE 40.1 Periodic activation in sleep cycles
... are shown as red circles; postulated excitatory connections as green circles; and cholinergic pontine nuclei are shown as blue circles. It should be noted that the actual synaptic signs of many of the aminergic and reticular pathways remain to be demonstrated, and, in many cases, the neuronal archit ...
... are shown as red circles; postulated excitatory connections as green circles; and cholinergic pontine nuclei are shown as blue circles. It should be noted that the actual synaptic signs of many of the aminergic and reticular pathways remain to be demonstrated, and, in many cases, the neuronal archit ...
Neurotransmitters and Sleep
... visual tracking and spatial location. It is not surprising, then, that such a pathway would be associated with the jerky rapid eye movement which may, very possibly, represent the pseudo-tracking of objects occurring during dreams. ...
... visual tracking and spatial location. It is not surprising, then, that such a pathway would be associated with the jerky rapid eye movement which may, very possibly, represent the pseudo-tracking of objects occurring during dreams. ...
Channelrhodopsin
Channelrhodopsins are a subfamily of retinylidene proteins (rhodopsins) that function as light-gated ion channels. They serve as sensory photoreceptors in unicellular green algae, controlling phototaxis: movement in response to light. Expressed in cells of other organisms, they enable light to control electrical excitability, intracellular acidity, calcium influx, and other cellular processes. Channelrhodopsin-1 (ChR1) and Channelrhodopsin-2 (ChR2) from the model organism Chlamydomonas reinhardtii are the first discovered channelrhodopsins. Variants have been cloned from other algal species, and more are expected.