Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure
... (NYHA) class II, III, or IV symptoms, and an ejection fraction of 40% or less (which was changed to 35% or less by an amendment to the protocol on December 15, 2010). Patients were required to have a plasma B-type natriuretic peptide (BNP) level of at least 150 pg per milliliter (or an N-terminal pr ...
... (NYHA) class II, III, or IV symptoms, and an ejection fraction of 40% or less (which was changed to 35% or less by an amendment to the protocol on December 15, 2010). Patients were required to have a plasma B-type natriuretic peptide (BNP) level of at least 150 pg per milliliter (or an N-terminal pr ...
Pharmacodynamic models
... Models describing relations between intensity of an effect and drug concentrations at the site of action Can be used in in vivo PK/PD modelling when it exists a direct and immediate link between plasma concentrations and effect ...
... Models describing relations between intensity of an effect and drug concentrations at the site of action Can be used in in vivo PK/PD modelling when it exists a direct and immediate link between plasma concentrations and effect ...
Chemmart® ALPRAZOLAM TABLETS
... appropriate animal models. The exact site and mechanism of action of benzodiazepines is unknown. It is known that they act within the central nervous system as selective depressants. Clinical studies in healthy volunteers with alprazolam doses up to 4 mg/day, and in patients with panic disorder at d ...
... appropriate animal models. The exact site and mechanism of action of benzodiazepines is unknown. It is known that they act within the central nervous system as selective depressants. Clinical studies in healthy volunteers with alprazolam doses up to 4 mg/day, and in patients with panic disorder at d ...
Demerol: Is it the Best Analgesic?
... Unreactive pupils (20%) Tachypnea (26%) Hyperpyrexia (45%) ...
... Unreactive pupils (20%) Tachypnea (26%) Hyperpyrexia (45%) ...
the role of statins in the prevention of coronary heart disease
... The absolute risk of CHD is lower in women than men at all ages. Lifetime risk of CHD at the age of 40 is one in three for women and one in two for men.71 However, CHD is the most common cause of death in the female population, incidence increasing markedly post-menopause.72 Moreover, women with CHD ...
... The absolute risk of CHD is lower in women than men at all ages. Lifetime risk of CHD at the age of 40 is one in three for women and one in two for men.71 However, CHD is the most common cause of death in the female population, incidence increasing markedly post-menopause.72 Moreover, women with CHD ...
Non-vitamin K antagonist oral anticoagulants: considerations on
... Adherence to warfarin is suboptimal The consequences of non-adherence are particularly problematic for drugs with a narrow therapeutic window, as is the case for warfarin: anticoagulation levels below the target range of International Normalised Ratio (INR) values are associated with increases in th ...
... Adherence to warfarin is suboptimal The consequences of non-adherence are particularly problematic for drugs with a narrow therapeutic window, as is the case for warfarin: anticoagulation levels below the target range of International Normalised Ratio (INR) values are associated with increases in th ...
Announcing the 50 mg capsule
... Only physicians experienced in the management of systemic immunosuppressive therapy for the indicated disease should prescribe GENGRAF. At doses used in solid organ transplantation, only physicians experienced in immunosuppressive therapy and management of organ transplant recipients should prescrib ...
... Only physicians experienced in the management of systemic immunosuppressive therapy for the indicated disease should prescribe GENGRAF. At doses used in solid organ transplantation, only physicians experienced in immunosuppressive therapy and management of organ transplant recipients should prescrib ...
Peak experiences and the afterglow phenomenon
... Secondly, psychedelic substances such as LSD-25 induce powerful subjective experiences and altered states of consciousness (ASCs) perceived as the ability to ‘expand consciousness’ (Watts, 1968). This triggered their use outside the scientific environment as tools for spiritual practice, so-called s ...
... Secondly, psychedelic substances such as LSD-25 induce powerful subjective experiences and altered states of consciousness (ASCs) perceived as the ability to ‘expand consciousness’ (Watts, 1968). This triggered their use outside the scientific environment as tools for spiritual practice, so-called s ...
Hypophosphataemia in Adults - Nottingham University Hospitals
... Usual dose is one or two tablets three times a day adjusted according to response. Serum phosphate levels should be checked daily. Treatment may be discontinued once the plasma level is above 0.8mmol/L Oral phosphate supplements are often poorly tolerated due to diarrhoea. If this occurs, co ...
... Usual dose is one or two tablets three times a day adjusted according to response. Serum phosphate levels should be checked daily. Treatment may be discontinued once the plasma level is above 0.8mmol/L Oral phosphate supplements are often poorly tolerated due to diarrhoea. If this occurs, co ...
Is prophylactic oxybutynin safe and effective in reducing the severity
... compensatory hyperhidrosis after ETS surgery.2 Although not routinely used, anticholinergic medications are being considered as they have been found to decrease sudoresis in patients treated for micturition disorders.2,3,9 These medications will be evaluated in this literature review. OBJECTIVE The ...
... compensatory hyperhidrosis after ETS surgery.2 Although not routinely used, anticholinergic medications are being considered as they have been found to decrease sudoresis in patients treated for micturition disorders.2,3,9 These medications will be evaluated in this literature review. OBJECTIVE The ...
Marijuana Usage In Chronic Pain Patients: Driving and Work
... accidents. Their comments reinforce my conviction that many children, adolescents, and young adults will be exposed to recreational marijuana more readily than would have been the case when there were established legal sanctions against its use. In an observational study, Pesce et al noted that up t ...
... accidents. Their comments reinforce my conviction that many children, adolescents, and young adults will be exposed to recreational marijuana more readily than would have been the case when there were established legal sanctions against its use. In an observational study, Pesce et al noted that up t ...
Perspectives in Medicinal Chemistry Fentanyl Buccal Tablet for the
... efficacy, safety, and tolerability profile of FBT in the management of BTP. Initially, FBT was studied in patients with chronic cancer-related BTP. The evidence for the effectiveness of FBT in this indication is based primarily on two similarly designed, placebo-controlled studies of opioid-tol ...
... efficacy, safety, and tolerability profile of FBT in the management of BTP. Initially, FBT was studied in patients with chronic cancer-related BTP. The evidence for the effectiveness of FBT in this indication is based primarily on two similarly designed, placebo-controlled studies of opioid-tol ...
Guidelines for Registration of Fixed
... particularly useful in the management of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), malaria and tuberculosis, which are considered to be the foremost infectious disease threats in the world today. FDCs have advantages when there is an identifiable patient population ...
... particularly useful in the management of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), malaria and tuberculosis, which are considered to be the foremost infectious disease threats in the world today. FDCs have advantages when there is an identifiable patient population ...
product information
... RejuveNail Anti-fungal Nail Lacquer should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. Use in lactation It is not known whether this drug is excreted in human milk. Since many drugs are excreted in human milk, caution should be exercised when Re ...
... RejuveNail Anti-fungal Nail Lacquer should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. Use in lactation It is not known whether this drug is excreted in human milk. Since many drugs are excreted in human milk, caution should be exercised when Re ...
PRODUCT MONOGRAPH PrMatulane® Procarbazine
... Therapy may be resumed, at the discretion of the physician, after toxic side effects have cleared on clinical evaluation and appropriate laboratory studies. Carcinogenesis and Mutagenesis Instances of new nonlymphoid malignancy, including lung cancer and acute myelocytic leukemia, have been reported ...
... Therapy may be resumed, at the discretion of the physician, after toxic side effects have cleared on clinical evaluation and appropriate laboratory studies. Carcinogenesis and Mutagenesis Instances of new nonlymphoid malignancy, including lung cancer and acute myelocytic leukemia, have been reported ...
271 KB - International Medical Press
... in nucleoside-sparing regimens, knowledge of clinically significant adverse events such as this is important for HIV clinicians when selecting regimens for patients with highly resistant virus or drug tolerability issues. ...
... in nucleoside-sparing regimens, knowledge of clinically significant adverse events such as this is important for HIV clinicians when selecting regimens for patients with highly resistant virus or drug tolerability issues. ...
A Novel Calcium-Dependent Protein Kinase Inhibitor as a Lead
... cells. Mean values±SD (indicated with vertical bars) are shown. ...
... cells. Mean values±SD (indicated with vertical bars) are shown. ...
INSTILLAGEL
... familial malignant hyperthermia. It has been shown that the use of amide local anaesthetics in malignant hyperthermia patients is safe. However, the development of malignant hyperthermia during surgery may not be prevented by neural blockade. It is also difficult to predict the need for supplemental ...
... familial malignant hyperthermia. It has been shown that the use of amide local anaesthetics in malignant hyperthermia patients is safe. However, the development of malignant hyperthermia during surgery may not be prevented by neural blockade. It is also difficult to predict the need for supplemental ...
Antiarrhythmic therapy in patients with atrial fibrillation
... with increased risk connected with treatment, a shortterm antiarrhythmic drug therapy (4 weeks after cardioversion) can be used. It is also emphasized that the choice of the antiarrhythmic drug should be based more on the predicted safety of its use, rather than on the expected efficacy, although it ...
... with increased risk connected with treatment, a shortterm antiarrhythmic drug therapy (4 weeks after cardioversion) can be used. It is also emphasized that the choice of the antiarrhythmic drug should be based more on the predicted safety of its use, rather than on the expected efficacy, although it ...
Recognition of drug-induced pulmonary disease and
... HLA-A*31:01 allele.20 However, it is difficult to ascertain the true potential for methotrexate to cause pulmonary toxicity, as RA itself may manifest in pulmonary disease in 40% to 70% of patients, and the cause of pulmonary disease is difficult to determine based on clinical presentation.19,20 Met ...
... HLA-A*31:01 allele.20 However, it is difficult to ascertain the true potential for methotrexate to cause pulmonary toxicity, as RA itself may manifest in pulmonary disease in 40% to 70% of patients, and the cause of pulmonary disease is difficult to determine based on clinical presentation.19,20 Met ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.