- Journal of Pharmacognosy and Phytochemistry
... Paracetamol 100 mg/kg per orally was used for comparison. The reduction in pyrexia after Clerodendrum serratum administration indicated the antipyretic activity of this plant. The response at higher doses was almost comparable to that of paracetamol (Narayanan et al, 1999) [14]. 6.7 Analgesic activi ...
... Paracetamol 100 mg/kg per orally was used for comparison. The reduction in pyrexia after Clerodendrum serratum administration indicated the antipyretic activity of this plant. The response at higher doses was almost comparable to that of paracetamol (Narayanan et al, 1999) [14]. 6.7 Analgesic activi ...
Fentanyl Patch - Doctors Foster and Smith
... antihistamines, or seizure medication. Do not use fentanyl for 14 days after using monoamine oxidase inhibitors (MAOIs) such as selegiline (deprenyl, Anipryl), isoniazid, or amitraz (an ingredient in some flea collars and in Mitaban, used to treat mange). No known food interactions. Signs of Toxicit ...
... antihistamines, or seizure medication. Do not use fentanyl for 14 days after using monoamine oxidase inhibitors (MAOIs) such as selegiline (deprenyl, Anipryl), isoniazid, or amitraz (an ingredient in some flea collars and in Mitaban, used to treat mange). No known food interactions. Signs of Toxicit ...
4th Amino Acid Assessment Workshop
... chronically diabetic rats. Rats (male, initial weight 150 g) were made diabetic with streptozotocin (65 mg/kg intracardiac) 3 wk before euthanasia. Food (standard rat diet, about 25% protein) and water were available ad libitum. They were killed at the indicated times. Horizontal black bars indicate ...
... chronically diabetic rats. Rats (male, initial weight 150 g) were made diabetic with streptozotocin (65 mg/kg intracardiac) 3 wk before euthanasia. Food (standard rat diet, about 25% protein) and water were available ad libitum. They were killed at the indicated times. Horizontal black bars indicate ...
Clinical Medicine: Therapeutics Management of Transfusional
... the feces (83%), predominantly as the unchanged drug.25,26 A small proportion (6%–8%) of unchanged Deferasirox and metabolites is excreted in urine25,27,28 with phenol glucuronide as main metabolite.26 As the iron–Deferasirox complex has a mean elimination half-life of 17.2 hours after a single dose ...
... the feces (83%), predominantly as the unchanged drug.25,26 A small proportion (6%–8%) of unchanged Deferasirox and metabolites is excreted in urine25,27,28 with phenol glucuronide as main metabolite.26 As the iron–Deferasirox complex has a mean elimination half-life of 17.2 hours after a single dose ...
... The development of the inhalation profile simulator (or Electronic Lung™) [7] has enabled us to rigorously test powder inhalers in a realistic model of inhalation behaviour by using inhalation profiles collected from our patients. Patient ability to inhale a dose of drug as respirable particles is a ...
Efficacy of methylsulfonylmethane (MSM)
... inflammatory conditions such as rheumatoid arthritis and lupus16,17. One randomized controlled trial of MSM and OA has been published18. In Usha and Naidu’s18 12-week trial (n ¼ 118), patients with knee OA received either 1.5 g MSM, 1.5 g glucosamine sulfate, 1.5 g MSM plus glucosamine sulfate, or pl ...
... inflammatory conditions such as rheumatoid arthritis and lupus16,17. One randomized controlled trial of MSM and OA has been published18. In Usha and Naidu’s18 12-week trial (n ¼ 118), patients with knee OA received either 1.5 g MSM, 1.5 g glucosamine sulfate, 1.5 g MSM plus glucosamine sulfate, or pl ...
ABT-450, Ritonavir, Ombitasvir, and Dasabuvir Achieves 97% and
... in hemoglobin to below the lower limit of normal were more frequent in Group 1 (42.0% vs 5.5% in Group 2, P<.001), although only 2 patients had hemoglobin levels below 10 g/dL. Conclusions: The interferon-free regimen of ABT-450, ritonavir, ombitasvir, and dasabuvir, with or without RBV, produces a ...
... in hemoglobin to below the lower limit of normal were more frequent in Group 1 (42.0% vs 5.5% in Group 2, P<.001), although only 2 patients had hemoglobin levels below 10 g/dL. Conclusions: The interferon-free regimen of ABT-450, ritonavir, ombitasvir, and dasabuvir, with or without RBV, produces a ...
Bisgaier 1998
... DNA (0.58 mg pLT-ACO-luciferase, 0.12 mg CMVhPPARa and 0.1 mg of a b-galactosidase reference plasmid) per well. Transfections were carried out for 4 h in serum-free medium. After transfection, cells were washed once and transferred to MEM plus FBS containing PD 72953, WY14643, or dimethylsulfoxide v ...
... DNA (0.58 mg pLT-ACO-luciferase, 0.12 mg CMVhPPARa and 0.1 mg of a b-galactosidase reference plasmid) per well. Transfections were carried out for 4 h in serum-free medium. After transfection, cells were washed once and transferred to MEM plus FBS containing PD 72953, WY14643, or dimethylsulfoxide v ...
JAMA. 2000
... in the protocol as consisting of all patients who received at least 1 dose of assigned study medication. An additional prespecified analysis was performed on the population of patients not taking aspirin (since aspirin use was a predefined risk factor for GI events). Time-to-event analyses of upper ...
... in the protocol as consisting of all patients who received at least 1 dose of assigned study medication. An additional prespecified analysis was performed on the population of patients not taking aspirin (since aspirin use was a predefined risk factor for GI events). Time-to-event analyses of upper ...
Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the
... inflammatory conditions such as rheumatoid arthritis and lupus16,17. One randomized controlled trial of MSM and OA has been published18. In Usha and Naidu’s18 12-week trial (n ¼ 118), patients with knee OA received either 1.5 g MSM, 1.5 g glucosamine sulfate, 1.5 g MSM plus glucosamine sulfate, or pl ...
... inflammatory conditions such as rheumatoid arthritis and lupus16,17. One randomized controlled trial of MSM and OA has been published18. In Usha and Naidu’s18 12-week trial (n ¼ 118), patients with knee OA received either 1.5 g MSM, 1.5 g glucosamine sulfate, 1.5 g MSM plus glucosamine sulfate, or pl ...
Using a Tritiated Compound to Elucidate Its Preclinical Metabolic
... Control plasma was harvested from blood collected from untreated dogs. Determination of Radioactivity within Urine and Plasma from Animals Receiving [3H]1a. Due to the exploratory nature of the [3H]1a studies, only urine was subjected to lyophilization to determine its HTO concentration. Therefore, ...
... Control plasma was harvested from blood collected from untreated dogs. Determination of Radioactivity within Urine and Plasma from Animals Receiving [3H]1a. Due to the exploratory nature of the [3H]1a studies, only urine was subjected to lyophilization to determine its HTO concentration. Therefore, ...
the functional abdominal pain syndrome
... pain signals that was modulated by changes in psychological distress. In one study, patients with abuse history and IBS had greater activation of the cingulate cortex than those with IBS only, abuse only, or neither, and notably this activation correlated strongly with patient reports of pain to rec ...
... pain signals that was modulated by changes in psychological distress. In one study, patients with abuse history and IBS had greater activation of the cingulate cortex than those with IBS only, abuse only, or neither, and notably this activation correlated strongly with patient reports of pain to rec ...
Skeletal Muscle Relaxants and Associated Medications for
... and musculoskeletal pain. Other available benzodiazepines have not proved superior to diazepam for this indication.7 The muscle-relaxant effects of this drug are thought to result from enhancement of GABA-mediated presynaptic inhibition at spinal and supraspinal sites. Diazepam also has antiepilepti ...
... and musculoskeletal pain. Other available benzodiazepines have not proved superior to diazepam for this indication.7 The muscle-relaxant effects of this drug are thought to result from enhancement of GABA-mediated presynaptic inhibition at spinal and supraspinal sites. Diazepam also has antiepilepti ...
product info
... stress, improves the quality of sleep, diminishes the symptoms of PMS (premenstrual syndrome), heightens mental acuity, and reduces the negative side effects of caffeine. At typical dosages, e.g., 100 to 200 mg, L-theanine does not act as a sedative, but it does significantly improve sleep quality. ...
... stress, improves the quality of sleep, diminishes the symptoms of PMS (premenstrual syndrome), heightens mental acuity, and reduces the negative side effects of caffeine. At typical dosages, e.g., 100 to 200 mg, L-theanine does not act as a sedative, but it does significantly improve sleep quality. ...
PROPECIA
... prostate cancer was higher in men treated with finasteride (1.8%) than in those treated with placebo (1.1%). In a 4-year placebo-controlled clinical trial with another 5α-reductase inhibitor (dutasteride, AVODART*), similar results for Gleason score 8-10 prostate cancer were observed (1% dutasteride ...
... prostate cancer was higher in men treated with finasteride (1.8%) than in those treated with placebo (1.1%). In a 4-year placebo-controlled clinical trial with another 5α-reductase inhibitor (dutasteride, AVODART*), similar results for Gleason score 8-10 prostate cancer were observed (1% dutasteride ...
2: Cardiovascular system - Gateshead Health NHS Foundation Trust
... - Disopyramide capsules 100mg: orally 300-800mg daily in divided doses - Lidocaine injection 10mg/mL (1%), 20mg/mL (2%); infusion 1mg/mL (0.1%) and 2mg/mL (0.2%) in glucose 5%, 500mL. - Flecainide tablets 50mg, 100mg; injection 10mg/mL: orally, ventricular arrhythmias, 100mg twice daily; max 400mg d ...
... - Disopyramide capsules 100mg: orally 300-800mg daily in divided doses - Lidocaine injection 10mg/mL (1%), 20mg/mL (2%); infusion 1mg/mL (0.1%) and 2mg/mL (0.2%) in glucose 5%, 500mL. - Flecainide tablets 50mg, 100mg; injection 10mg/mL: orally, ventricular arrhythmias, 100mg twice daily; max 400mg d ...
Pravachol
... cardiovascular events (eg, fatal and non-fatal myocardial infarction). The mechanism responsible for the beneficial effects of PRAVACHOL in hypercholesterolaemic patients is not known. Atherosclerosis In the Pravastatin Limitation of Atherosclerosis in the Coronary Arteries (PLAC I) study, the effec ...
... cardiovascular events (eg, fatal and non-fatal myocardial infarction). The mechanism responsible for the beneficial effects of PRAVACHOL in hypercholesterolaemic patients is not known. Atherosclerosis In the Pravastatin Limitation of Atherosclerosis in the Coronary Arteries (PLAC I) study, the effec ...
ANNEX I TO PSUR CORE SAFETY PROFILE (EU SPC Sections 4.2
... midazolam after rectal and intramuscular administration. It is expected that these interactions will be less pronounced for the rectal than for the oral route because the gastro-intestinal tract is by-passed whereas after IM administration the effects of CYP3A4 modulation should not substantially di ...
... midazolam after rectal and intramuscular administration. It is expected that these interactions will be less pronounced for the rectal than for the oral route because the gastro-intestinal tract is by-passed whereas after IM administration the effects of CYP3A4 modulation should not substantially di ...
MIC (mg/L) - STD Prevention Online
... (Leu 421 to Pro 421) - less significant than the mosaic penA changes Takahata S et al., Antimicrob. Agents Chemother. 2006;50:3638-3645 ...
... (Leu 421 to Pro 421) - less significant than the mosaic penA changes Takahata S et al., Antimicrob. Agents Chemother. 2006;50:3638-3645 ...
Tritace - Product Information
... Blood concentrations of ramipril and ramiprilat increase with increased dose, but are not strictly doseproportional. The 24-hour AUC for ramiprilat, however, is dose-proportional over the 2.5 - 20 mg dose range. The absolute bioavailabilities of ramipril and ramiprilat were 28 % and 44 %, respective ...
... Blood concentrations of ramipril and ramiprilat increase with increased dose, but are not strictly doseproportional. The 24-hour AUC for ramiprilat, however, is dose-proportional over the 2.5 - 20 mg dose range. The absolute bioavailabilities of ramipril and ramiprilat were 28 % and 44 %, respective ...
Alcohol
... High lipid solubility promotes rapid entry to the brain Eliminated by the liver Has rapid onset of action and recovery M.O.A.= potentiates GABA, decrease glutamate activity, increase chloride ion conductance Adverse reactions: decreased myocardial and respiratory activity ...
... High lipid solubility promotes rapid entry to the brain Eliminated by the liver Has rapid onset of action and recovery M.O.A.= potentiates GABA, decrease glutamate activity, increase chloride ion conductance Adverse reactions: decreased myocardial and respiratory activity ...
Hypertension
... 1997;24:987-988; National Health Survey 1998, Singapore. Epidemiology and Disease Department, Ministry of Health, Singapore.; Lim TO, et al. Singapore Med J 2004;45:20-27; Tatsanavivat P, et al. Int J Epidemiol 1998;27:405-409; Muhilal H. Asia Pacific J Clin Nutr 1996;5:132-134; Gupta R. J Hum Hyper ...
... 1997;24:987-988; National Health Survey 1998, Singapore. Epidemiology and Disease Department, Ministry of Health, Singapore.; Lim TO, et al. Singapore Med J 2004;45:20-27; Tatsanavivat P, et al. Int J Epidemiol 1998;27:405-409; Muhilal H. Asia Pacific J Clin Nutr 1996;5:132-134; Gupta R. J Hum Hyper ...
appendix - iii
... This study is done to know the perinatal outcome in cases of amniotic fluid index < 8 cm at term. Oligohydramnios is associated with increased incidence of adverse perinatal outcome, and hence this study is done to establish the need. ...
... This study is done to know the perinatal outcome in cases of amniotic fluid index < 8 cm at term. Oligohydramnios is associated with increased incidence of adverse perinatal outcome, and hence this study is done to establish the need. ...
Statins And Liver Disease - Healthcare Professionals
... Lovastatin Mevacor • Isolated from Aspergillus terreus 1982 • 1987- received FDA accelerated approval – Toxicology Studies abnormal – “Liver function tests be performed before initiation of treatment, at 6 and 12 weeks after initiation of treatment or elevation in dose, and periodically thereafter. ...
... Lovastatin Mevacor • Isolated from Aspergillus terreus 1982 • 1987- received FDA accelerated approval – Toxicology Studies abnormal – “Liver function tests be performed before initiation of treatment, at 6 and 12 weeks after initiation of treatment or elevation in dose, and periodically thereafter. ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.