hepatoprotective effects of aqueous extract of andrographis
... Healthy albno wistar rats of either sex weighing 100 to 120 gm maintained under standard laboratory conditions were used for acute oral toxicity12 test according to organisation for economic co‐ operation and development guidelines 423 ,a total of three animals were used which ...
... Healthy albno wistar rats of either sex weighing 100 to 120 gm maintained under standard laboratory conditions were used for acute oral toxicity12 test according to organisation for economic co‐ operation and development guidelines 423 ,a total of three animals were used which ...
BuTrans 5 10 20
... removal of BuTrans patches. As with other CNS depressants, patients who have received BuTrans should be monitored especially for signs of respiratory depression until a stable maintenance dose is reached. BuTrans patches are intended for transdermal use on intact skin only; use on compromised skin c ...
... removal of BuTrans patches. As with other CNS depressants, patients who have received BuTrans should be monitored especially for signs of respiratory depression until a stable maintenance dose is reached. BuTrans patches are intended for transdermal use on intact skin only; use on compromised skin c ...
Pharmacology
... (A) Absorption & Metabolism & Distribution & Excretion (B) Absorption only (C) Distribution only (D) Metabolism only (6) Pharmacodynamic is defined as effect of the drug on the: (A) Car (B) Book (C) Body (D) Pen ...
... (A) Absorption & Metabolism & Distribution & Excretion (B) Absorption only (C) Distribution only (D) Metabolism only (6) Pharmacodynamic is defined as effect of the drug on the: (A) Car (B) Book (C) Body (D) Pen ...
T Th he eo
... of selectivity of theophylline for any of the PDE isoenzyme families, although it remains a possibility that unique PDE isoenzymes may be discovered that are more sensitive to theophylline. It is also possible that certain PDE isoenzymes are induced in asthmatic airways, and this may increase the se ...
... of selectivity of theophylline for any of the PDE isoenzyme families, although it remains a possibility that unique PDE isoenzymes may be discovered that are more sensitive to theophylline. It is also possible that certain PDE isoenzymes are induced in asthmatic airways, and this may increase the se ...
CyberKnife® information Guide
... And compared to High-Dose-Rate brachytherapy (HDR) the CyberKnife System delivers the same dose of killing radiation to the prostate, but does so without the insertion of multiple catheters. HDR typically involves a hospital stay, over a 24 hour period, and places 15-20 catheters into the prostate, ...
... And compared to High-Dose-Rate brachytherapy (HDR) the CyberKnife System delivers the same dose of killing radiation to the prostate, but does so without the insertion of multiple catheters. HDR typically involves a hospital stay, over a 24 hour period, and places 15-20 catheters into the prostate, ...
Ritalin LA - Novartis Pharmaceuticals Corporation
... Renal Insufficiency: Ritalin LA has not been studied in renally-impaired patients. Renal insufficiency is expected to have minimal effect on the pharmacokinetics of methylphenidate since less than 1% of a radiolabeled dose is excreted in the urine as unchanged compound, and the major metabolite (rit ...
... Renal Insufficiency: Ritalin LA has not been studied in renally-impaired patients. Renal insufficiency is expected to have minimal effect on the pharmacokinetics of methylphenidate since less than 1% of a radiolabeled dose is excreted in the urine as unchanged compound, and the major metabolite (rit ...
Ritalin LA
... Renal Insufficiency: Ritalin LA has not been studied in renally-impaired patients. Renal insufficiency is expected to have minimal effect on the pharmacokinetics of methylphenidate since less than 1% of a radiolabeled dose is excreted in the urine as unchanged compound, and the major metabolite (rit ...
... Renal Insufficiency: Ritalin LA has not been studied in renally-impaired patients. Renal insufficiency is expected to have minimal effect on the pharmacokinetics of methylphenidate since less than 1% of a radiolabeled dose is excreted in the urine as unchanged compound, and the major metabolite (rit ...
current and experimental therapeutics of alzheimer disease
... Indeed, it is even possible to readminister tacrine to many patients who previously had ‘‘transaminitis,’’ with a subsequent benign course. Given these data, it is not surprising that fatal hepatotoxicity has been extremely rare (11). Extensive experience with tacrine has led to the conclusion that ...
... Indeed, it is even possible to readminister tacrine to many patients who previously had ‘‘transaminitis,’’ with a subsequent benign course. Given these data, it is not surprising that fatal hepatotoxicity has been extremely rare (11). Extensive experience with tacrine has led to the conclusion that ...
Inhaled corticosteroids reduce growth. Or do they? REVIEW P.L.P. Brand
... example. Increasing the daily dose of an ICS from, say, 100 to 200 mg will markedly improve its efficacy with little or no increased risk of systemic effects, whereas an increase from, say, 800 to 1600 mg will yield little extra efficacy at the expense of a markedly increased risk of systemic side e ...
... example. Increasing the daily dose of an ICS from, say, 100 to 200 mg will markedly improve its efficacy with little or no increased risk of systemic effects, whereas an increase from, say, 800 to 1600 mg will yield little extra efficacy at the expense of a markedly increased risk of systemic side e ...
The Effectiveness of Diphenhydramine (a sleeping pill) on Mice
... Although the parent's overall sleep quality was assessed, this article showed that the antihistamine was a significant sedative. Children’s and parent's sleep quality was better for the children who received diphenhydramine compared to the children who received the dextromethorphan or placebo. This ...
... Although the parent's overall sleep quality was assessed, this article showed that the antihistamine was a significant sedative. Children’s and parent's sleep quality was better for the children who received diphenhydramine compared to the children who received the dextromethorphan or placebo. This ...
Advances in Natural and Applied Sciences Allium Sativum Hyperglycemic Mice
... where We and Wc represents the blood glucose concentration in glibenclamide or ASME administered mice (Groups 2-6), and control mice (Group 1), respectively. Statistical analysis: Experimental values are expressed as mean ± SEM. Independent Sample t-test was carried out for statistical comparison. S ...
... where We and Wc represents the blood glucose concentration in glibenclamide or ASME administered mice (Groups 2-6), and control mice (Group 1), respectively. Statistical analysis: Experimental values are expressed as mean ± SEM. Independent Sample t-test was carried out for statistical comparison. S ...
10158-28698-1
... in CYP2C9 genotype in 24 patients after taking 40 mg of fluvastatin daily for 14 days (P < 0.00001). Subjects carrying the CYP2C9*3/*3 genotype had a three-fold increase of the AUC of fluvastatin compared to subjects with the wild-type CYP2C9*1/*1 genotype. In our study, after treatment with 10 mg r ...
... in CYP2C9 genotype in 24 patients after taking 40 mg of fluvastatin daily for 14 days (P < 0.00001). Subjects carrying the CYP2C9*3/*3 genotype had a three-fold increase of the AUC of fluvastatin compared to subjects with the wild-type CYP2C9*1/*1 genotype. In our study, after treatment with 10 mg r ...
Can breastfeeding mothers take paracetamol?
... Despite paracetamol being so widely available and used in all age groups for a wide range of painassociated conditions, direct evidence for its safety in breastfeeding infants is relatively poor. It is largely based on small, uncontrolled studies using only single doses of paracetamol. In five small ...
... Despite paracetamol being so widely available and used in all age groups for a wide range of painassociated conditions, direct evidence for its safety in breastfeeding infants is relatively poor. It is largely based on small, uncontrolled studies using only single doses of paracetamol. In five small ...
Diuretics - JUdoctors
... their diuretic effect (low ceiling) They are ineffective in pts with impaired renal function ( even in minimal renal dysfunction )or pts with GFR< 20 ml/min They are highly effective in lowering BP when combined with other antihypertensive drugs ...
... their diuretic effect (low ceiling) They are ineffective in pts with impaired renal function ( even in minimal renal dysfunction )or pts with GFR< 20 ml/min They are highly effective in lowering BP when combined with other antihypertensive drugs ...
GLUCAGON FOR INJECTION (rDNA ORIGIN)
... Pregnancy Category B — Reproduction studies have not been performed with recombinant glucagon. However, studies with animal-sourced glucagon were performed in rats at doses up to 2 mg/kg glucagon administered two times a day (up to 40 times the human dose based on body surface area, mg/m2), and have ...
... Pregnancy Category B — Reproduction studies have not been performed with recombinant glucagon. However, studies with animal-sourced glucagon were performed in rats at doses up to 2 mg/kg glucagon administered two times a day (up to 40 times the human dose based on body surface area, mg/m2), and have ...
Approved Drug Utilization Review Board Edits
... and Candida infections in patients who are at high risk of developing these infections due to being severely immunocompromised, such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from ch ...
... and Candida infections in patients who are at high risk of developing these infections due to being severely immunocompromised, such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from ch ...
ATACAND HCT® 16-12.5 candesartan cilexetil−hydrochlorothiazide TABLETS ATACAND HCT® 32-12.5
... Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, car ...
... Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, car ...
How do smoking cessation medicines compare with respect to their
... of the different smoking cessation medicines. The ongoing debate regarding the neuropsychiatric safety of drugs for smoking cessation among drug regulators, researchers, prescribers and patients may be due to the inconsistent research findings in this area [8]. Whereas studies without control groups ...
... of the different smoking cessation medicines. The ongoing debate regarding the neuropsychiatric safety of drugs for smoking cessation among drug regulators, researchers, prescribers and patients may be due to the inconsistent research findings in this area [8]. Whereas studies without control groups ...
Devil`s claw
... • Assessment of EMA limited to documented interactions. Not theoretical. • EMA concluded: Interaction with oral anticoagulants (heparin, coumarine derivatives) is plausible and of therapeutic importance. • Clinical trials demonstrated: • Willow bark significantly AA- and ADP-induced aggregation bu ...
... • Assessment of EMA limited to documented interactions. Not theoretical. • EMA concluded: Interaction with oral anticoagulants (heparin, coumarine derivatives) is plausible and of therapeutic importance. • Clinical trials demonstrated: • Willow bark significantly AA- and ADP-induced aggregation bu ...
Clinical Research And Treatment
... Reporting Requirements What are the post-approval reporting requirements? The UCLA IRB and the FDA require adverse events (AE) associated with the use of drugs under an IND be reported in a timely manner. When an IND is issued, there are additional and separate federal requirements for reporting ad ...
... Reporting Requirements What are the post-approval reporting requirements? The UCLA IRB and the FDA require adverse events (AE) associated with the use of drugs under an IND be reported in a timely manner. When an IND is issued, there are additional and separate federal requirements for reporting ad ...
OsmoPrep - Salix Pharmaceuticals
... In controlled colon preparation trials of OsmoPrep, 228 (24%) of 931 patients were 65 years of age or older. In addition, 49 (5%) of the 931 patients were 75 years of age or older. Of the 228 geriatric patients in the trials, 134 patients (59%) received at least 48 grams of OsmoPrep. Of the 49 patie ...
... In controlled colon preparation trials of OsmoPrep, 228 (24%) of 931 patients were 65 years of age or older. In addition, 49 (5%) of the 931 patients were 75 years of age or older. Of the 228 geriatric patients in the trials, 134 patients (59%) received at least 48 grams of OsmoPrep. Of the 49 patie ...
Chloral hydrate has general CNS depressant effects believed to be
... Trichloroethanol is 70 to 80% bound to plasma proteins and is widely distributed to all body tissues including CSF, breast milk and placenta. The half-life of trichloroacetic acid is longer, up to 100 hours. It is highly plasma protein bound (94%), primarily to albumin and may be responsible for int ...
... Trichloroethanol is 70 to 80% bound to plasma proteins and is widely distributed to all body tissues including CSF, breast milk and placenta. The half-life of trichloroacetic acid is longer, up to 100 hours. It is highly plasma protein bound (94%), primarily to albumin and may be responsible for int ...
Attention-Deficit Hyperactivity Disorder (ADHD) Drug
... Remillard (PharmD, College of Pharmacy, U of S.), C. Evans (BSP,PHD Cand ) & the RxFiles Advisory Committee. Prepared by: Monica Lee PharmD Cand L. Regier BSP, BA, B. Jensen BSP DISCLAIMER: The content of this newsletter represents the research, experience and opinions of the authors and not those o ...
... Remillard (PharmD, College of Pharmacy, U of S.), C. Evans (BSP,PHD Cand ) & the RxFiles Advisory Committee. Prepared by: Monica Lee PharmD Cand L. Regier BSP, BA, B. Jensen BSP DISCLAIMER: The content of this newsletter represents the research, experience and opinions of the authors and not those o ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.