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article pdf - ONdrugDelivery
article pdf - ONdrugDelivery

... blindness. Drugs that reduce pressure can slow down or halt this process. Two strategies are either to reduce the production of aqueous humour (drugs such as Timolol®) or speed up its drainage from the eye (drugs like Xalatan® (latanoprost). Since the process that governs both aqueous production and ...
Antidementia
Antidementia

... • For continued authority to prescribe it is necessary to demonstrate an improvement in MMSE score of at least 2 points from baseline. • For patients >24, a decrease in the ADAS-Cog score of 4 points or greater is required. • The optimal time to perform tests is 4-8 weeks after maximum dose achieved ...
Teacher notes and student sheets
Teacher notes and student sheets

... 4 Confirms if the compound is being absorbed and excreted by the body in the way predicted by Lab tests. Effects of different doses are monitored. 5 A review of the data collected is made by the UK Medicines and Healthcare Products Regulatory Agency. The agency recommends proceeding to Phase II tria ...
Designer and look
Designer and look

...  Others hope that additional investigation of MDMA will reveal that the drug has some medicinal benefits. They hope the drug might someday be approved for legitimate use in psychotherapy.  Therapists have proposed, for example, that MDMA—given in low, infrequent doses under controlled conditions—c ...
Pharmacodynamics
Pharmacodynamics

... Data derived from within the country or region may have greater relevance and educational value and may encourage national regulatory decision-making. International monitoring such as the WHO International Drug Monitoring Programme may provide information on possible safety issues which may not yet ...
fct - WordPress.com
fct - WordPress.com

... • Ethics – Client has right to leave and withdraw, consent is given for treatment, therapy itself is protecting the individual from harm, although could be open to psychological abuse and therapy should confidential. A competent therapist should always be used. • Socially sensitive – yes, potential ...
Drug Discovery and Development
Drug Discovery and Development

... Example: Thalidomide Researchers, however, continued to work with the drug. Soon after its banishment, an Israeli doctor discovered anti-inflammatory effects of thalidomide and began to look for uses of the medication despite its teratogenic effects. He found that patients with erythema nodosum lep ...
FEDERAL REGULATIONS OF MEDICATIONS
FEDERAL REGULATIONS OF MEDICATIONS

... rare diseases or conditions  A rare disease or condition is one that affects less than 200,000 persons in the U. S  One that affects more than 200,000 persons in the U. S. and for which there is no reasonable expectation of recovering the development costs ...
FACTORS MODIFYING DRUG EFFECTS
FACTORS MODIFYING DRUG EFFECTS

... increase or decrease in number of receptor sites or alteration in efficiency of coupling of receptor to distal effectors mechanism. e.g. 1) Receptors for hormones Thyroid hormones cause increase in number of βadrenergic receptors and hence increase in cardiac sensitivity to catecholamines ii) Agonis ...
Pharmacy 451 Lecture 2 & 3
Pharmacy 451 Lecture 2 & 3

... rare diseases or conditions  A rare disease or condition is one that affects less than 200,000 persons in the U. S  One that affects more than 200,000 persons in the U. S. and for which there is no reasonable expectation of recovering the development costs ...
Chemistry in every day life - Kendriya Vidyalaya, Bailey Road, Patna
Chemistry in every day life - Kendriya Vidyalaya, Bailey Road, Patna

... (i)ANTIBIOTICS-These are the chemical substances which are produced wholly or partially from microorganisms and used for the treatment of disease caused by other micro-organism . Eg- pencillin , ofloxacin chloramphenicol,tetracyclin etc. NARROW SPECTRUM ANTI-BIOTICS-These are effective mainly again ...
Better Humans
Better Humans

... healthy individuals. Nevertheless, some prescription drugs can be more readily obtained than others because they are licensed for more broadly defined illnesses. For example, the licence for modafinil was recently extended to include the condition of excessive daytime sleepiness, potentially opening ...
In vitro susceptibility testing and totally drug-resistant tuberculosis
In vitro susceptibility testing and totally drug-resistant tuberculosis

... drug-resistant tuberculosis To the Editor: We find the article by MIGLIORI et al. [1], on extensively drug-resistant tuberculosis (XDR-TB), very informative and would like to commend them for the excellent meta-analysis. Without any doubt, XDR-TB is an extensive global problem; the use of the lower ...
Chapter 17: Pharmacology, Drugs and Sports
Chapter 17: Pharmacology, Drugs and Sports

... – Little evidence that expectorants are any more effective on reducing cough than simply drinking water ...
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... to convert breath alcohol level to an approximate blood alcohol level. o Urine analysis – A urine sample can be analyzed to determine alcohol content, although it can take up to two hours for alcohol to show up in urine. This test is also an indirect measurement of blood alcohol concentration throu ...
Pharmacokinetics
Pharmacokinetics

... Two Drug Agonists Attach to the Receptor Site. The drug agonist that has an exact fit is a strong agonist and is more biologically active than the weak agonist. ...
Kartong - Farmacie Mondiaal
Kartong - Farmacie Mondiaal

... reorganised in cooperation with the two nurses and a second hand Dutch pharmacy drawer cupboard has been installed and put to use. Visits, talks and discussions to and with people at other healthcare clinics (e.g. The Jammeh Foundation for Peace-hospital in Serrakunda and a German sponsored healthca ...
Analysing the Investigational New Drug (IND) Application IND
Analysing the Investigational New Drug (IND) Application IND

... indicated Use Š No commercial distribution or test marketing Š No prolongation of study Š Prior written approval from FDA required to “charge”  for drug, unless being used under “treatment” IND ...
A PRIMER OF DRUG ACTION
A PRIMER OF DRUG ACTION

... • The endogenous neurotransmitter (and presumably drugs also) attaches inside the space between these coils and is held in pace by ionic attractions • This reversible ionic binding of the neurotransmitter specific for that receptor may activate the receptor, usually by changing the structure of the ...
Psychopharm Study Guide
Psychopharm Study Guide

... 34. The process by which drugs are absorbed, distributed within the body, metabolized, and excreted is called: 35. The ratio provided by dividing the dose which is toxic for 50% of the population by the dose which is therapeutic for 50% of the population is called the: 36. The reduction in the numbe ...
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... digestive motility that would be encountered in the gastro intestinal (GI) tract. ...
Creatinine Clearance
Creatinine Clearance

... to protein and results in decreased renal excretion. In hypoalbuminaemia an acidic drug such as phenytoin will have a lower total drug concentration because of lower protein binding. ...
TI: Drug utilization patterns in Israel
TI: Drug utilization patterns in Israel

... RF: 14 Refs. AB: The medication behavior of 183 elderly apartment residents was assessed for problems in medication regimen compliance, regimen comprehension, drug interactions, and drug storage. Following an initial assessment, the residents were given instructions in drug utilization and access to ...
DNDi’s R&D Strategy
DNDi’s R&D Strategy

...  These diseases are of no strategic (military, security) interest ...
5 Legal Documents Every Family Caregiver Needs
5 Legal Documents Every Family Caregiver Needs

... Your risk of a drug interaction depends largely on how many medicines you take. The more medicines you take, the greater your chance of a harmful drug interaction. Older adults are at an increased risk because they often take more than one medicine. Preventing drug interactions You can lower your ri ...
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Orphan drug

An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.In the US and EU it is easier to gain marketing approval for an orphan drug, and there may be other financial incentives, such as extended exclusivity periods, all intended to encourage the development of drugs which might otherwise lack a sufficient profit motive. The assignment of orphan status to a disease and to any drugs developed to treat it is a matter of public policy in many countries, and has resulted in medical breakthroughs that may not have otherwise been achieved due to the economics of drug research and development.According to Thomson Reuters in their 2012 publication ""The Economic Power of Orphan Drugs"", there has been increased investing in orphan drug Research and Development partly due to the U. S. Orphan Drug Act (ODA) 1983 and similar Acts in other regions of the world and also driven by ""high-profile philanthropic funding."" The period between 2001 to 2011 was the ""most productive period in the history of orphan drug development, in terms of average annual orphan drug designations and orphan drug approvals."" For the same decade the compound annual growth rate (CAGR) of the orphan drugs was an ""impressive 25.8 percent, compared to only 20.1 percent for a matched control group of non-orphan drugs."" By 2012 the market for orphan drugs was worth USD$637 million compared to the USD$638 million matched control group of non-orphan drugs, Thomson Reuters.By 2012, ""the revenue-generating potential of orphan drugs [was] as great as for non-orphan drugs, even though patient populations for rare diseases are significantly smaller. Moreover, we suggest that orphan drugs have greater profitability when considered in the full context of developmental drivers including government financial incentives, smaller clinical trial sizes, shorter clinical trial times and higher rates of regulatory success.""
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