PSYC550 Psychopharmacology
... Psychopharmacology • Psychopharmacology is the study of the effects of drugs on the nervous system and on behavior • The term drug has many meanings: – Medication to treat a disease – A chemical that is likely to be abused – An “exogenous” chemical that significantly alters the function of certain ...
... Psychopharmacology • Psychopharmacology is the study of the effects of drugs on the nervous system and on behavior • The term drug has many meanings: – Medication to treat a disease – A chemical that is likely to be abused – An “exogenous” chemical that significantly alters the function of certain ...
PPT
... receptor tyrosine kinase and a cytokine receptor. Activation of the EGF receptor. The extracellular structure of the unliganded receptor (a) contains four domains (I-IV), which rearrange significantly upon binding two EGF molecules. (b). The conformational changes lead to activation of the cytoplas ...
... receptor tyrosine kinase and a cytokine receptor. Activation of the EGF receptor. The extracellular structure of the unliganded receptor (a) contains four domains (I-IV), which rearrange significantly upon binding two EGF molecules. (b). The conformational changes lead to activation of the cytoplas ...
Antidepressant
... monoamine release arise via a variety of mechanisms (monoamine oxidase inhibition, reuptake blockade, presynaptic or somatodendritic autoreceptor downregulation), and result in activation of a range of post-synaptic receptors that are coupled to ‘second messenger’ signal transduction mechanisms. Act ...
... monoamine release arise via a variety of mechanisms (monoamine oxidase inhibition, reuptake blockade, presynaptic or somatodendritic autoreceptor downregulation), and result in activation of a range of post-synaptic receptors that are coupled to ‘second messenger’ signal transduction mechanisms. Act ...
Antidepressant Drugs
... cerebellum and limbic areas (hippocampus, amygdala, hypothalamus, thalamus). Mood: -- higher functions performed by the cortex. Cognitive function: -- function of cortex. Drive and motivation: -- function of brainstem Memory and emotion: -- function of the hippocampus and amygdala. ...
... cerebellum and limbic areas (hippocampus, amygdala, hypothalamus, thalamus). Mood: -- higher functions performed by the cortex. Cognitive function: -- function of cortex. Drive and motivation: -- function of brainstem Memory and emotion: -- function of the hippocampus and amygdala. ...
Chapter 4 Lecture Notes Page
... Epinephrine – hormone secreted by adrenal medulla – can also serve as neurotransmitter in brain Norepinephrine – increases vigilance – attentiveness to environment Dopamine (can generate excitatory and inhibitory postsynaptic potentials depending on postsynaptic receptors.) Nigrostriatal system – su ...
... Epinephrine – hormone secreted by adrenal medulla – can also serve as neurotransmitter in brain Norepinephrine – increases vigilance – attentiveness to environment Dopamine (can generate excitatory and inhibitory postsynaptic potentials depending on postsynaptic receptors.) Nigrostriatal system – su ...
Antidepressant agents - به سامانه مديريت
... In CNS: blocks presynaptic 5-HT, DA and NE receptors Blocking of ACh receptors leads to dry mouth, confusion, blurry vision and mental confusion Blocking of histamine receptors leads to drowsiness and ...
... In CNS: blocks presynaptic 5-HT, DA and NE receptors Blocking of ACh receptors leads to dry mouth, confusion, blurry vision and mental confusion Blocking of histamine receptors leads to drowsiness and ...
Pharmacology II - 4-12
... Which of the following describes the studied effect of MDMA on serotonin in the brain? a. Increases the number of serotonin transporters b.Decreases the number of serotonin transporters c. Increases the number of serotonin receptors d.Decreases the number of serotonin receptors ...
... Which of the following describes the studied effect of MDMA on serotonin in the brain? a. Increases the number of serotonin transporters b.Decreases the number of serotonin transporters c. Increases the number of serotonin receptors d.Decreases the number of serotonin receptors ...
Lecture 4
... are not suitable for long-term pain management as they cause complete numbness and can have serious side-effects over time. • Opioid painkillers such as morphine are highly effective at reducing pain, but longterm use can lead to dependence and tolerance. As the body becomes used to the drug it beco ...
... are not suitable for long-term pain management as they cause complete numbness and can have serious side-effects over time. • Opioid painkillers such as morphine are highly effective at reducing pain, but longterm use can lead to dependence and tolerance. As the body becomes used to the drug it beco ...
Adrenergic receptor antagonists
... other α1-adrenoceptor antagonists, urapidil does not elicit reflex tachycardia, and this may be related to its weak β1-adrenoceptor antagonist activity as well as its effect on cardiac vagal drive. Urapidil is currently not approved by the U.S. Food and Drug Administration • but it is available in E ...
... other α1-adrenoceptor antagonists, urapidil does not elicit reflex tachycardia, and this may be related to its weak β1-adrenoceptor antagonist activity as well as its effect on cardiac vagal drive. Urapidil is currently not approved by the U.S. Food and Drug Administration • but it is available in E ...
determination of CB 1 receptor binding and agonist activity of
... July 9, 2012, which is the most recent attempt by the United States government to control synthetic drugs, including cannabinoids. This legislation places synthetic cannabinoids into Schedule I of the Controlled Substances Act (21 U.S.C. 812(c)) based on structure, receptor binding, and function. Th ...
... July 9, 2012, which is the most recent attempt by the United States government to control synthetic drugs, including cannabinoids. This legislation places synthetic cannabinoids into Schedule I of the Controlled Substances Act (21 U.S.C. 812(c)) based on structure, receptor binding, and function. Th ...
Drugs Affecting Uterine Contraction
... 1 agonist effects are indicated by +, antagonist by -, no effect by 0. Relative affinity for the receptor is indicated by the number of + or – signs. PA means partial agonist (both agonist and antagonist effects can be detected). ...
... 1 agonist effects are indicated by +, antagonist by -, no effect by 0. Relative affinity for the receptor is indicated by the number of + or – signs. PA means partial agonist (both agonist and antagonist effects can be detected). ...
Pharmacology
... Theory and assumptions of drug-receptor interactions. • Drug Receptor interaction follows simple mass-action relationships, i.e. only one drug molecule occupies each receptor and binding is reversible (We know now there are ...
... Theory and assumptions of drug-receptor interactions. • Drug Receptor interaction follows simple mass-action relationships, i.e. only one drug molecule occupies each receptor and binding is reversible (We know now there are ...
5th Lecture 1433
... equilibrium from the active (R*) to resting state (R) state A neutral antagonist has equal affinity for R and R* so does not by itself affect the conformational equilibrium but reduces by competition the binding of other ligands ...
... equilibrium from the active (R*) to resting state (R) state A neutral antagonist has equal affinity for R and R* so does not by itself affect the conformational equilibrium but reduces by competition the binding of other ligands ...
Capsicum
... transmission, another mode of action that may be involved in the abortive treatment of migraine ...
... transmission, another mode of action that may be involved in the abortive treatment of migraine ...
Document
... • Dose response relationship; relationship between drug concentration and magnitude of drug effect • Provides scientific basis for the selection and use of drugs to counteract specific pathophysiologic mechanisms in particular ...
... • Dose response relationship; relationship between drug concentration and magnitude of drug effect • Provides scientific basis for the selection and use of drugs to counteract specific pathophysiologic mechanisms in particular ...
Pharmacodynamics What the drug does to the body?
... The occupancy curve is for both drugs, the response curves a and b are for full and partial agonist, respectively. The relationship between response and occupancy for full and partial agonist, corresponding to the response curves in A. Note that curve a produces maximal response at about 20% occupan ...
... The occupancy curve is for both drugs, the response curves a and b are for full and partial agonist, respectively. The relationship between response and occupancy for full and partial agonist, corresponding to the response curves in A. Note that curve a produces maximal response at about 20% occupan ...
drug_action_notes
... chord. The brain’s natural endorphins appear to have a similar action. The brain neurotransmitter dopamine has a number of roles, including muscle control, pain inhibition and general stimulation. Some psychosis disorders such as schizophrenia and manic depression are caused by an excess of dopamine ...
... chord. The brain’s natural endorphins appear to have a similar action. The brain neurotransmitter dopamine has a number of roles, including muscle control, pain inhibition and general stimulation. Some psychosis disorders such as schizophrenia and manic depression are caused by an excess of dopamine ...
DRUG RECEPTOR INTERACTIONS
... receptor is occupied. Many substance possess different effect , some have high affinity for the receptor, some have low affinity and some are not effective, and those ineffective substances block or inhibit the receptor.” It is also called Occupation Theory. ...
... receptor is occupied. Many substance possess different effect , some have high affinity for the receptor, some have low affinity and some are not effective, and those ineffective substances block or inhibit the receptor.” It is also called Occupation Theory. ...