药效学2
... the component of a cell or organism that interacts with a drug and initiates the chain of biochemical events leading to the drug’s observed effects. （受体：细胞膜或细胞质的特异性蛋白质，具有识别、结合配体，并 发生信号转导的作用） Function: recognizing and binding with a specific ligand; signal transduction Structure: a protein with ...
... the component of a cell or organism that interacts with a drug and initiates the chain of biochemical events leading to the drug’s observed effects. （受体：细胞膜或细胞质的特异性蛋白质，具有识别、结合配体，并 发生信号转导的作用） Function: recognizing and binding with a specific ligand; signal transduction Structure: a protein with ...
THESIS OUTLINE
... In Chapter 7, the effects of chronic treatment with the opioid antagonist NTX upon opioid receptor levels were determined using quantitative autoradiography. Chronic NTX treatment has been shown to induce supersensitivity to morphine’s analgesic effects and is known to increase opioid receptor numbe ...
... In Chapter 7, the effects of chronic treatment with the opioid antagonist NTX upon opioid receptor levels were determined using quantitative autoradiography. Chronic NTX treatment has been shown to induce supersensitivity to morphine’s analgesic effects and is known to increase opioid receptor numbe ...
Basic Pharmacology of the Alpha
... Beta antagonists should not be used prior to establishing effective α -receptor blockade, since unopposed β receptor blockade could theoretically cause blood pressure elevation from increased vasoconstriction. Metyrosine (α -methyltyrosine), a competitive inhibitor of tyrosine hydroxylase, is especi ...
... Beta antagonists should not be used prior to establishing effective α -receptor blockade, since unopposed β receptor blockade could theoretically cause blood pressure elevation from increased vasoconstriction. Metyrosine (α -methyltyrosine), a competitive inhibitor of tyrosine hydroxylase, is especi ...
Document
... H1 receptor antagonists have a low specificity, that is, they interact not only with histamine receptor but also with muscarinic cholinergic receptors, α-adrenergic receptors and serotonin receptors. ...
... H1 receptor antagonists have a low specificity, that is, they interact not only with histamine receptor but also with muscarinic cholinergic receptors, α-adrenergic receptors and serotonin receptors. ...
Title: Directly observable behavioral effects of lorcaserin in rats
... lorcaserin has agonist properties in vivo that are mediated by 5-HT2A receptors. In humans, drugs with agonist effects at 5-HT2A receptors are sometimes abused and can produce hallucinations (Kennett and Clifton, 2010). In rodents, drugs with agonist activity at 5-HT2A receptors (e.g., DOI, DOM and ...
... lorcaserin has agonist properties in vivo that are mediated by 5-HT2A receptors. In humans, drugs with agonist effects at 5-HT2A receptors are sometimes abused and can produce hallucinations (Kennett and Clifton, 2010). In rodents, drugs with agonist activity at 5-HT2A receptors (e.g., DOI, DOM and ...
answers - UCSD Cognitive Science
... Indirect -chemical that binds to a receptor site other than the primary receptor site or indirectly affects the effectiveness of a drug -example: benzodiazepines promote the activity of the GABAa receptor and therefore is an indirect agonist ...
... Indirect -chemical that binds to a receptor site other than the primary receptor site or indirectly affects the effectiveness of a drug -example: benzodiazepines promote the activity of the GABAa receptor and therefore is an indirect agonist ...
Antidepressants and neuroleptic
... Dopamine receptor blocking activity in the brain:. D1 and D5 receptors activate adenylyl cyclase, often exciting neurons, whereas D2, D3 and D4 receptors inhibit adenylyl cyclase, or mediate membrane K+ channel opening leading to neuronal hyperpolarization. The neuroleptic drugs bind to these recept ...
... Dopamine receptor blocking activity in the brain:. D1 and D5 receptors activate adenylyl cyclase, often exciting neurons, whereas D2, D3 and D4 receptors inhibit adenylyl cyclase, or mediate membrane K+ channel opening leading to neuronal hyperpolarization. The neuroleptic drugs bind to these recept ...
Physiological Psychology
... fiber synapses but not at afferent fiber synapses. Postsynaptic activation suppresses normal adaptation of pyramidal cell firing by blocking voltage- and Ca+dependent K+ currents. Combined, these effects may prevent recall of previous memory from interfering with the learning of new memories. (Adapt ...
... fiber synapses but not at afferent fiber synapses. Postsynaptic activation suppresses normal adaptation of pyramidal cell firing by blocking voltage- and Ca+dependent K+ currents. Combined, these effects may prevent recall of previous memory from interfering with the learning of new memories. (Adapt ...
What are examples of common agonists and antogonists?
... • Agonists facilitate the effects of neurotransmitters. Antagonists inhibit the effects of neurotransmitters. • Agonists and antagonists may influence synaptic transmission in a number of ways: ...
... • Agonists facilitate the effects of neurotransmitters. Antagonists inhibit the effects of neurotransmitters. • Agonists and antagonists may influence synaptic transmission in a number of ways: ...
181lec11
... Only short-term tolerance to LSD, no withdrawal, dependence or addiction LSD not lethal at very high doses Cross tolerance for hallucinogenic effect Focus on 5-HT systems (structural similarity) ...
... Only short-term tolerance to LSD, no withdrawal, dependence or addiction LSD not lethal at very high doses Cross tolerance for hallucinogenic effect Focus on 5-HT systems (structural similarity) ...
kuliah farmakologi antidepresan
... because of clonazepam's long elimination half-life. ◦ Clonazepam displays low lipid solubility, it is less likely to cause anterograde amnesia compared to the other high-potency BZDs. For example, clonazepam is half as lipid soluble as alprazolam, so patients' amnesic side effects are reduced. ◦ Clo ...
... because of clonazepam's long elimination half-life. ◦ Clonazepam displays low lipid solubility, it is less likely to cause anterograde amnesia compared to the other high-potency BZDs. For example, clonazepam is half as lipid soluble as alprazolam, so patients' amnesic side effects are reduced. ◦ Clo ...
Pharmacodynamics
... the interaction between drug and receptor can be described mathematically and graphically agonists have both affinity (kd) and intrinsic activity () antagonists have affinity only antagonists can be competitive (change kd) or non-competitive (change ) when mixed with agonists agonists ...
... the interaction between drug and receptor can be described mathematically and graphically agonists have both affinity (kd) and intrinsic activity () antagonists have affinity only antagonists can be competitive (change kd) or non-competitive (change ) when mixed with agonists agonists ...
DOSE *RESPONSE CURVES
... curves, in what is now known as classical receptor theory. Clark assumed that the effect of a drug is directly proportional to the concentration of drug–receptor complex and that the maximum effect occurs when all the receptors are occupied. ...
... curves, in what is now known as classical receptor theory. Clark assumed that the effect of a drug is directly proportional to the concentration of drug–receptor complex and that the maximum effect occurs when all the receptors are occupied. ...
Opioids – anal-gesics (lol) ©2010 Mark Tuttle Mechanism of action
... o CPY2D6 morphine - Neuroendocrine / hypothalamic actions o Metabolite can cause CNS stimulation - Presynaptic μ,κ,δ: Ca2+ channels - Dextromethorphan o ↑ Prolactin and vasopressin (ADH) - Morphine-6-glucuronide is also an active - Postsynaptic: κ only: K+ channels o Selective antitussive ↓ GnRH ...
... o CPY2D6 morphine - Neuroendocrine / hypothalamic actions o Metabolite can cause CNS stimulation - Presynaptic μ,κ,δ: Ca2+ channels - Dextromethorphan o ↑ Prolactin and vasopressin (ADH) - Morphine-6-glucuronide is also an active - Postsynaptic: κ only: K+ channels o Selective antitussive ↓ GnRH ...
Slide () - Access Emergency Medicine
... JWH-018 and AM2201 metabolism. Aminoalkylindole synthetic cannabinoid JWH-018 and its omega fluorinated analog AM2201 undergo oxidation by CYP2C9 and CYP1A9 to primary metabolites that retain affinity and ability to bind with cannabinoid receptors. One JWH-018 primary metabolite, acts as a antagonis ...
... JWH-018 and AM2201 metabolism. Aminoalkylindole synthetic cannabinoid JWH-018 and its omega fluorinated analog AM2201 undergo oxidation by CYP2C9 and CYP1A9 to primary metabolites that retain affinity and ability to bind with cannabinoid receptors. One JWH-018 primary metabolite, acts as a antagonis ...
Opioid Anelgesics
... – Act in part via receptors for endogenous opiopeptides such as enkephalins, dynoprhins, and β endorphins ...
... – Act in part via receptors for endogenous opiopeptides such as enkephalins, dynoprhins, and β endorphins ...
Losartar is an angiotensin II receptor antagonist drug used mainly to
... Losartar may be used first-line in patients with increased cardiovascular risk. The LIFE study demonstrated that Losartar was significantly superior to atenolol in the primary prevention of adverse cardiovascular events (myocardial infarction or stroke), with a significant reduction in cardiovascula ...
... Losartar may be used first-line in patients with increased cardiovascular risk. The LIFE study demonstrated that Losartar was significantly superior to atenolol in the primary prevention of adverse cardiovascular events (myocardial infarction or stroke), with a significant reduction in cardiovascula ...
Pharmaco lecture 2 - pharmacology1lecnotes
... receptor, thereby preventing a natural neurotransmitter or hormones or drug from exerting its effect. It binds to site but does not cause any action. It has no efficacy because it generates no change in physiological action e.g. Atropine. ...
... receptor, thereby preventing a natural neurotransmitter or hormones or drug from exerting its effect. It binds to site but does not cause any action. It has no efficacy because it generates no change in physiological action e.g. Atropine. ...
The pharmacology of type I hypersensitivity
... IgE-mediated reactions affect both the respiratory and the cardiovascular systems. This usually respond rapidly to the parenteral administration of epinephrine. Epinephrine is the physiological antagonist of histamine on smooth muscles,and it acts on different receptors. It is the drug of choice in ...
... IgE-mediated reactions affect both the respiratory and the cardiovascular systems. This usually respond rapidly to the parenteral administration of epinephrine. Epinephrine is the physiological antagonist of histamine on smooth muscles,and it acts on different receptors. It is the drug of choice in ...
Specific NT systems
... death of dopaminergic cells in Parkinson’s disease amphetamine, cocaine (agonist) anti-psychotic drugs (antagonists) metylphenidate (ritalin) ...
... death of dopaminergic cells in Parkinson’s disease amphetamine, cocaine (agonist) anti-psychotic drugs (antagonists) metylphenidate (ritalin) ...
Experimental method and procedure
... Fixing samples: Wash your hands and dip some nutrient fluid on your finger tips; Fetch a piece of intestinal samples and tie a thread at each end; Fix the sample, bung the Magnus tube with rubber stopper, pour enough nutrient fluid into the Magnus tube and adjust the length of the thread to make the ...
... Fixing samples: Wash your hands and dip some nutrient fluid on your finger tips; Fetch a piece of intestinal samples and tie a thread at each end; Fix the sample, bung the Magnus tube with rubber stopper, pour enough nutrient fluid into the Magnus tube and adjust the length of the thread to make the ...