File - Wk 1-2
... Quantitative Aspects of Drug-Receptor Interactions The binding reaction: Binding of drugs to receptors necessarily obeys the Law of Mass Action (the rate of chemical reaction is proportional to the product of concentrations of the reactants) Example from book: A piece of heart muscle contains a tot ...
... Quantitative Aspects of Drug-Receptor Interactions The binding reaction: Binding of drugs to receptors necessarily obeys the Law of Mass Action (the rate of chemical reaction is proportional to the product of concentrations of the reactants) Example from book: A piece of heart muscle contains a tot ...
Neurochemical Neutralization of Methamphetamine With High
... The major finding reported here is that indatraline, a reuptake inhibitor with high affinity for NE, DA, and 5-HT transporters (Hyttel and Larsen, 1985), blocks the ability of METH and MDMA to release these neurotransmitters. The results demonstrate that an indatraline, or a similarly acting agent, ...
... The major finding reported here is that indatraline, a reuptake inhibitor with high affinity for NE, DA, and 5-HT transporters (Hyttel and Larsen, 1985), blocks the ability of METH and MDMA to release these neurotransmitters. The results demonstrate that an indatraline, or a similarly acting agent, ...
教案- Pharmacologic Management of Parkinsonism
... Multimedia and writing on the blackboard design elements: the use of drugs in various dosage forms show powerpoint software to guide students into this new discipline, for some preliminary understanding a few basic concepts to master. ...
... Multimedia and writing on the blackboard design elements: the use of drugs in various dosage forms show powerpoint software to guide students into this new discipline, for some preliminary understanding a few basic concepts to master. ...
classical vs. neuropeptides
... Ex) Gene regulatory proteins can activate transcription factors such as CREB, (cAMP response element binding protein) leading to enhancement or suppression of transcription. If transcription is enhanced, new gene products are made. Signaling pathways can alter gene transcription via same transcripti ...
... Ex) Gene regulatory proteins can activate transcription factors such as CREB, (cAMP response element binding protein) leading to enhancement or suppression of transcription. If transcription is enhanced, new gene products are made. Signaling pathways can alter gene transcription via same transcripti ...
Adrenergic System Adrenoceptor Blocking Drugs
... Adrenoceptor Blocking Drugs: 1) Alpha-Adrenoceptor Blocking Drugs: The first generation of alpha-blockers were non-selective, blocking both alpha1 and alpha2 receptors. In general, blockade of alpha-receptor reduces the sympathetic tone of blood vessels resulting in decreased TPR. When subjects take ...
... Adrenoceptor Blocking Drugs: 1) Alpha-Adrenoceptor Blocking Drugs: The first generation of alpha-blockers were non-selective, blocking both alpha1 and alpha2 receptors. In general, blockade of alpha-receptor reduces the sympathetic tone of blood vessels resulting in decreased TPR. When subjects take ...
lec#9 done by Dareen Mashaqbeh
... A and B produce an excellent potency , however Vmax is lower in B “B is a partial agonist that binds to the same receptor and back to the definition of the partial agonist ,it produces lower Vmax than the full agonist “ . Therefore both are potent by having similar ED50 . The difference between A an ...
... A and B produce an excellent potency , however Vmax is lower in B “B is a partial agonist that binds to the same receptor and back to the definition of the partial agonist ,it produces lower Vmax than the full agonist “ . Therefore both are potent by having similar ED50 . The difference between A an ...
Direct cholinergic agonists
... allergic reactions and shock. The control of localized bleeding and the prolongation of the action of local anesthetics. Norepinephrine has a relatively low affinity for b2 receptors. The main effect of al stimulation (with an agonist such as phenylephrine) is vasoconstriction. Local application of ...
... allergic reactions and shock. The control of localized bleeding and the prolongation of the action of local anesthetics. Norepinephrine has a relatively low affinity for b2 receptors. The main effect of al stimulation (with an agonist such as phenylephrine) is vasoconstriction. Local application of ...
Antidepressant Drugs
... pathway that function in the expression of mood. -Functional decrease in activity of such amines result in depression while functional increase in activity result in mood elevation. ...
... pathway that function in the expression of mood. -Functional decrease in activity of such amines result in depression while functional increase in activity result in mood elevation. ...
Dr Richard Stevenson
... AMT/5-IT AMT – Alphamethyltryptamine 5-IT – 5-aminopropylindole AMT researched as antidepressant in 1960’s ...
... AMT/5-IT AMT – Alphamethyltryptamine 5-IT – 5-aminopropylindole AMT researched as antidepressant in 1960’s ...
Beta blockers
... antagonists. For scientific experiments, there exist antagonists with selective binding to B2 or B3 receptors. These, however, are not in clinical use. Some B blockers can weakly increase B receptor activity => these are termed partial agonists or blockers with some intrinsic sympathomimetic activit ...
... antagonists. For scientific experiments, there exist antagonists with selective binding to B2 or B3 receptors. These, however, are not in clinical use. Some B blockers can weakly increase B receptor activity => these are termed partial agonists or blockers with some intrinsic sympathomimetic activit ...
The Cerebral Cortex and Higher Intellectual Functions
... • Drugs either facilitate or inhibit activity at the synapse. – Antagonistic drugs block the effects of neurotransmitters (e.g., novacaine, caffeine). – Agonist drugs mimic or increase the effects of neurotransmitters (e.g., receptors in the brain respond to heroin, LSD and cocaine) – Allosteric mod ...
... • Drugs either facilitate or inhibit activity at the synapse. – Antagonistic drugs block the effects of neurotransmitters (e.g., novacaine, caffeine). – Agonist drugs mimic or increase the effects of neurotransmitters (e.g., receptors in the brain respond to heroin, LSD and cocaine) – Allosteric mod ...
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... Schedule II Drug – legal, but under strict control Types – include Adderal, Dexedrine, Desoxyn can be given for ADHD Cocaine QUIZ: Pharmacokinetics – fastest form smoking (8 seconds)...IV (15 s), sniff (3-5 min), swallow (20 m) Rapid-acting – because it is so rapid-acting, very addictive ...
... Schedule II Drug – legal, but under strict control Types – include Adderal, Dexedrine, Desoxyn can be given for ADHD Cocaine QUIZ: Pharmacokinetics – fastest form smoking (8 seconds)...IV (15 s), sniff (3-5 min), swallow (20 m) Rapid-acting – because it is so rapid-acting, very addictive ...
to file - Planet Ross 2K2
... Effects presynaptic terminals and pancreatic cells; hits 2 and/or imidazoline receptors Cause a decrease in central adrenergic tone Adverse effects: sedation, xerostomia, drowsiness, dizziness, impotence, (hypertension) 1. Clonidine and apraclonidine – used for withdrawal from tobacco, alcohol a ...
... Effects presynaptic terminals and pancreatic cells; hits 2 and/or imidazoline receptors Cause a decrease in central adrenergic tone Adverse effects: sedation, xerostomia, drowsiness, dizziness, impotence, (hypertension) 1. Clonidine and apraclonidine – used for withdrawal from tobacco, alcohol a ...
1. Neurotransmitter released from the pre
... 13. Ways by which the effects on the postsynaptic cell can be enhanced are: a. Presynaptic facilitation b. High frequency of action potentials in the presynaptic terminal c. Adding an agonist for the receptors on the postsynaptic cell d. Blocking the reuptake of NT into the presynaptic terminal e. ...
... 13. Ways by which the effects on the postsynaptic cell can be enhanced are: a. Presynaptic facilitation b. High frequency of action potentials in the presynaptic terminal c. Adding an agonist for the receptors on the postsynaptic cell d. Blocking the reuptake of NT into the presynaptic terminal e. ...
Topic 7
... receptors are responsible for the glutamate-mediated post-synaptic excitation of neural cells, and are important for neural communication, memory formation, learning, and regulation. Glutamate receptors are implicated in the pathologies of several neurodegenerative diseases. It is believed their rel ...
... receptors are responsible for the glutamate-mediated post-synaptic excitation of neural cells, and are important for neural communication, memory formation, learning, and regulation. Glutamate receptors are implicated in the pathologies of several neurodegenerative diseases. It is believed their rel ...
ADRENERGIC SYSTEM - LEC.2 2008
... 3 – it is non- selective B- receptors agonist ( stimulate B1- and B2 , insignificant stimulation to alpha receptors ) . Pharmacokinetic : 1- it can be absorbed systemically by the sublingual mucosa . 2- it is more reliably absorbed when given parentrally . 3- good absorption when given as an inhale ...
... 3 – it is non- selective B- receptors agonist ( stimulate B1- and B2 , insignificant stimulation to alpha receptors ) . Pharmacokinetic : 1- it can be absorbed systemically by the sublingual mucosa . 2- it is more reliably absorbed when given parentrally . 3- good absorption when given as an inhale ...
Spare Receptors
... with a diuretic drug. Drugs X and Y have the same mechanism of diuretic action. Drug X in a dose of 5 mg produces the same magnitude of diuresis as 500 mg of drug Y. This suggests that: Drug Y is less efficacious than drug X Drug X is about 100 times more potent than drug Y Toxicity of drug X is les ...
... with a diuretic drug. Drugs X and Y have the same mechanism of diuretic action. Drug X in a dose of 5 mg produces the same magnitude of diuresis as 500 mg of drug Y. This suggests that: Drug Y is less efficacious than drug X Drug X is about 100 times more potent than drug Y Toxicity of drug X is les ...
87 - VCU
... You have been asked to present a lecture to the MCV Mini-Med School on the topic of NMDA receptors and their role in neuronal signal transduction. Present in an outline form five (5) key points that you would present during your lecture that would provide a non-scientist with a working understanding ...
... You have been asked to present a lecture to the MCV Mini-Med School on the topic of NMDA receptors and their role in neuronal signal transduction. Present in an outline form five (5) key points that you would present during your lecture that would provide a non-scientist with a working understanding ...
CATECHOLAMINES - Drexel University College of Medicine
... Hsiao, M.D., for the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators* ...
... Hsiao, M.D., for the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators* ...
Drugs - BIDD - National University of Singapore
... • Competitive antagonists – which compete for the agonist binding site, and require higher agonist concentration to elicit a given response. • Non-competitive agonists – these bind at a site other than the agonist binding site, or even to a completely different molecular target. The result is the lo ...
... • Competitive antagonists – which compete for the agonist binding site, and require higher agonist concentration to elicit a given response. • Non-competitive agonists – these bind at a site other than the agonist binding site, or even to a completely different molecular target. The result is the lo ...
Mouse party Summary-the Effect of Drug use on Neurotransmitters
... Summary of the Effect of Drug/Toxin use on Neurotransmitters KEY Drug ...
... Summary of the Effect of Drug/Toxin use on Neurotransmitters KEY Drug ...