Salomon Z
... are targeting; in the striatum or putamen for dopamine; the occipital cortex for norepinephrine and the frontal cortex for serotonin. It all boils down to having a very richly innervated area of the brain as a model. But, then, you have to compare your findings to other areas of the brain and make s ...
... are targeting; in the striatum or putamen for dopamine; the occipital cortex for norepinephrine and the frontal cortex for serotonin. It all boils down to having a very richly innervated area of the brain as a model. But, then, you have to compare your findings to other areas of the brain and make s ...
26 Somatic-neurological syndromes
... Hypothyroidism results in asthenic, myopathic syndromes or encephalopathy. There are neurasthenic syndrome, diabetic polyneuropathy, metabolic encephalopathy, diabetic coma and cerebral stroke in pancreatic diabetes. Diabetic (hyperglycemic) coma is due to fast increase of hyperglycemia, abnormality ...
... Hypothyroidism results in asthenic, myopathic syndromes or encephalopathy. There are neurasthenic syndrome, diabetic polyneuropathy, metabolic encephalopathy, diabetic coma and cerebral stroke in pancreatic diabetes. Diabetic (hyperglycemic) coma is due to fast increase of hyperglycemia, abnormality ...
MOLLY- "NOT YOUR BEST FRIEND"
... news media has turned the spotlight on a resurgence of an obsolete drug, MDMA. In the latest development, a three-day electronic music event in New York City was forced to cut short after two concertgoers died and at least four others were placed under intensive care from suspected Molly (MDMA) over ...
... news media has turned the spotlight on a resurgence of an obsolete drug, MDMA. In the latest development, a three-day electronic music event in New York City was forced to cut short after two concertgoers died and at least four others were placed under intensive care from suspected Molly (MDMA) over ...
Acute Dystonic Reaction Associated with Increase in Trazodone
... was thought to be related to dose increase of trazadone instead of discontinuation of venlafaxine, because in the past there were periods of several weeks during which the patient had not use both of the medications, but no dystonia was observed. Also the patient had a contractions after he had take ...
... was thought to be related to dose increase of trazadone instead of discontinuation of venlafaxine, because in the past there were periods of several weeks during which the patient had not use both of the medications, but no dystonia was observed. Also the patient had a contractions after he had take ...
TRICYCLIC ANTIDEPRESSANTS
... A 70 kg man presents on 1-2 hours following a TCA overdose (3000 mg Amitryptilline) – Unconscious – Seizure – BP 60 Systolic ...
... A 70 kg man presents on 1-2 hours following a TCA overdose (3000 mg Amitryptilline) – Unconscious – Seizure – BP 60 Systolic ...
Combining antidepressants: a review of evidence
... BOX 1 Serotonin syndrome Definition A predictable consequence of excessive serotonergic agonism in the central nervous system ...
... BOX 1 Serotonin syndrome Definition A predictable consequence of excessive serotonergic agonism in the central nervous system ...
Antipsychotics - TOP Recommended Websites
... of neuroleptic treatment • Variable prognosis • More females (?) • Patients with mood disorders may be more susceptible • Anticholinergics usually worsen condition ...
... of neuroleptic treatment • Variable prognosis • More females (?) • Patients with mood disorders may be more susceptible • Anticholinergics usually worsen condition ...
Lectures 8 and 9
... oxidation of the tert-butyl group, is the active species. This compound, fexofenadine, has little hERG activity as it is a zwitterion, and is now a medicine in its own right. ...
... oxidation of the tert-butyl group, is the active species. This compound, fexofenadine, has little hERG activity as it is a zwitterion, and is now a medicine in its own right. ...
Weber`s Syndrome Due to Low
... Interestingly, despite being highly regarded as a stroke syndrome, the incidence of stroke causing Weber's syndrome is actually quite rare [3]. There are even fewer reported cases in the literature describing alternative causes of Weber's syndrome. We present a case of Weber's syndrome that is due t ...
... Interestingly, despite being highly regarded as a stroke syndrome, the incidence of stroke causing Weber's syndrome is actually quite rare [3]. There are even fewer reported cases in the literature describing alternative causes of Weber's syndrome. We present a case of Weber's syndrome that is due t ...
Slide 1 - Texas Tech University Health Sciences Center
... There is no commercial support and/or relevant financial relationships related to this educational activity. Commercial support is defined as financial (or in-kind) contributions given by a commercial interest, which is used to pay all or part of the costs of a CNE activity. Relevant financial relat ...
... There is no commercial support and/or relevant financial relationships related to this educational activity. Commercial support is defined as financial (or in-kind) contributions given by a commercial interest, which is used to pay all or part of the costs of a CNE activity. Relevant financial relat ...
Korsakoff Syndrome Topic Sheet
... remember. They are not “lying” but may actually believe their invented explanations. Scientists don’t yet understand the mechanism by which Korsakoff syndrome may cause confabulation. The person may also see or hear things that are not there (hallucinations). Diagnosis Korsakoff syndrome is a clinic ...
... remember. They are not “lying” but may actually believe their invented explanations. Scientists don’t yet understand the mechanism by which Korsakoff syndrome may cause confabulation. The person may also see or hear things that are not there (hallucinations). Diagnosis Korsakoff syndrome is a clinic ...
The Serotonergic System and Mysticism: Could LSD and the
... piloerection (hairs standing on end, such as can be found in reports of religious ecstasy), sweating, increased heart rate with palpitations, and elevation of blood pressure and blood glucose levels. These reactions of the autonomic nervous system are not as significant as other effects upon the bod ...
... piloerection (hairs standing on end, such as can be found in reports of religious ecstasy), sweating, increased heart rate with palpitations, and elevation of blood pressure and blood glucose levels. These reactions of the autonomic nervous system are not as significant as other effects upon the bod ...
Pharmacology and Toxicology
... Pharmacokinetics: definition of pharmacokinetics. Absorption: different sites of absorption, pH-partioning, factors that affect absorption. Distribution: Plasma-protein binding and other factors that affect distribution. Entry of drugs into special tissues: the brain and the foetus. Elimination of d ...
... Pharmacokinetics: definition of pharmacokinetics. Absorption: different sites of absorption, pH-partioning, factors that affect absorption. Distribution: Plasma-protein binding and other factors that affect distribution. Entry of drugs into special tissues: the brain and the foetus. Elimination of d ...
What is mental life
... Prolonged muscle spasms of the neck, eyelids, pharynx, eyes, jaw, tongue or whole body Treated with benztropine or diphenhydramine (IM) o 3) Tardive dyskinesia: prolonged blockade of D2 receptors in hypothalamus and striatum compensatory upregulation of D2 receptors Abnormal writhing movemen ...
... Prolonged muscle spasms of the neck, eyelids, pharynx, eyes, jaw, tongue or whole body Treated with benztropine or diphenhydramine (IM) o 3) Tardive dyskinesia: prolonged blockade of D2 receptors in hypothalamus and striatum compensatory upregulation of D2 receptors Abnormal writhing movemen ...
Herb-Drug Interactions
... Kava (Piper sp.) – popular use as a relaxant but in 2002 FDA issued a warning about its association with liver toxicity. In 2003, Kava was banned in Germany. It’s toxicity has not been established so care in its use should be standard procedure. ...
... Kava (Piper sp.) – popular use as a relaxant but in 2002 FDA issued a warning about its association with liver toxicity. In 2003, Kava was banned in Germany. It’s toxicity has not been established so care in its use should be standard procedure. ...
Major Depressive Disorders
... May be due to sudden decrease in available synaptic 5HT in face of down-regulated receptors Onset in 24 to 72 hours and last up to 7-14 days Symptoms: dizziness, nausea, lethargy, headache, flu-like symptoms, parasthesia (electrical “shocklike” sensations) ...
... May be due to sudden decrease in available synaptic 5HT in face of down-regulated receptors Onset in 24 to 72 hours and last up to 7-14 days Symptoms: dizziness, nausea, lethargy, headache, flu-like symptoms, parasthesia (electrical “shocklike” sensations) ...
Pharmacology—Antipsychotic Drug Therapy
... Acute EPS is present in 50-90% of patients receiving conventional, or typical, antipsychotics. Characterized by akathisia, dystonia, or Parkinsonism. These side effects commonly reduce patient compliance. Increase risk of development to chronic EPS (tardive dyskinesia). Can treat with Diphenhydramin ...
... Acute EPS is present in 50-90% of patients receiving conventional, or typical, antipsychotics. Characterized by akathisia, dystonia, or Parkinsonism. These side effects commonly reduce patient compliance. Increase risk of development to chronic EPS (tardive dyskinesia). Can treat with Diphenhydramin ...
Substance Abuse - Mother Baby University
... Absence of typical dysmorphic facial features Normal Growth CNS abnormalities: Decreased cranial size at birth Structural brain abnormalities Impairment of neurologic status in relation to age Behavioral or cognitive abnormalities inconsistent with age/developmental level Confirmed p ...
... Absence of typical dysmorphic facial features Normal Growth CNS abnormalities: Decreased cranial size at birth Structural brain abnormalities Impairment of neurologic status in relation to age Behavioral or cognitive abnormalities inconsistent with age/developmental level Confirmed p ...
Presentation
... drug. Often, if something feels good, one wants to do it again! Unfortunately, the increased dose also increases the adverse effects, and some of these can become life-threatening. For example, repeated doses or a high dose of Ecstasy can cause heat injury due to hyperthermia, hypertension (high blo ...
... drug. Often, if something feels good, one wants to do it again! Unfortunately, the increased dose also increases the adverse effects, and some of these can become life-threatening. For example, repeated doses or a high dose of Ecstasy can cause heat injury due to hyperthermia, hypertension (high blo ...
Document name: ANTIDEPRESSANTS FOR THE TREATMENT OF
... ulcers. The risk of gastric bleeding is increased when aspirin, clopidogrel or NSAIDS are co-prescribed. The elderly and those with a previous history of bleeding are at greatest risk. Gastroprotective drugs such as omeprazole or lansoprazole should be considered in patients taking SSRIs with risk f ...
... ulcers. The risk of gastric bleeding is increased when aspirin, clopidogrel or NSAIDS are co-prescribed. The elderly and those with a previous history of bleeding are at greatest risk. Gastroprotective drugs such as omeprazole or lansoprazole should be considered in patients taking SSRIs with risk f ...
Smiles, Bath Salts, Spice, Molly, Foxey, Krokodil, Kratom, Dragonfly
... Suzanne Doyon M.D. & Christopher Welsh M.D. To the Editor: The Maryland Poison Center was called about a 49-year-old, usually calm prison inmate who was described as being "red-eyed," "loony," "combative," and "intoxicated, lecturing everyone about life." Other inmates and staff reported seeing this ...
... Suzanne Doyon M.D. & Christopher Welsh M.D. To the Editor: The Maryland Poison Center was called about a 49-year-old, usually calm prison inmate who was described as being "red-eyed," "loony," "combative," and "intoxicated, lecturing everyone about life." Other inmates and staff reported seeing this ...
Review: smooth muscle relaxants improve symptoms and reduce
... et al, differs from its predecessors by excluding peppermint oil and dyciclomide bromide and including 6 additional randomised, non-English language trials. Although smooth muscle relaxants appear superior to placebo, Poynard et al suggest that only approximately 50% of treated patients will experie ...
... et al, differs from its predecessors by excluding peppermint oil and dyciclomide bromide and including 6 additional randomised, non-English language trials. Although smooth muscle relaxants appear superior to placebo, Poynard et al suggest that only approximately 50% of treated patients will experie ...
Drugs of Abuse - California Society of Addiction Medicine
... More often H. flu, S. aureus, Ps. aeruginosa relative to nonIDUs IDU’s have increased risk of TB activation, unknown why ...
... More often H. flu, S. aureus, Ps. aeruginosa relative to nonIDUs IDU’s have increased risk of TB activation, unknown why ...
Serotonin research: contributions to understanding psychoses
... more psychotic ego dissolution including fear and paranoid ideation associated with experiences of split ego [4]. Such experiential phenomena are otherwise rarely reported except in dreams, contemplative or religious exaltation, and acute psychoses [5–7]. Thus, the discovery of the effects of LSD le ...
... more psychotic ego dissolution including fear and paranoid ideation associated with experiences of split ego [4]. Such experiential phenomena are otherwise rarely reported except in dreams, contemplative or religious exaltation, and acute psychoses [5–7]. Thus, the discovery of the effects of LSD le ...
Short communication
... higher than those of previous putative SERT radioligands. These ratios are estimates of the total-to-nonspecific binding since the cerebellum is relatively devoid of SERT sites [7, 8]. These high signal-to-noise ratios and the favorable kinetics of [11C]DAPP and [11C]DASB should facilitate the quant ...
... higher than those of previous putative SERT radioligands. These ratios are estimates of the total-to-nonspecific binding since the cerebellum is relatively devoid of SERT sites [7, 8]. These high signal-to-noise ratios and the favorable kinetics of [11C]DAPP and [11C]DASB should facilitate the quant ...
Serotonin syndrome
Serotonin syndrome is a potential symptom of any number of life-threatening drug interactions which may follow therapeutic drug use, combination, overdose of particular drugs, or the recreational use of certain drugs. Serotonin syndrome is not an idiopathic drug reaction; it is a predictable consequence of excess serotonin on the CNS and/or peripheral nervous system. For this reason, some experts strongly prefer the terms serotonin toxicity or serotonin toxidrome which more accurately reflect that it is a form of poisoning. Other names include serotonin sickness, serotonin storm, serotonin poisoning, hyperserotonemia, or serotonergic syndrome.Excessive levels of serotonin produce a spectrum of specific symptoms including cognitive, autonomic, and somatic effects. Symptoms may range from barely perceptible to fatal. Numerous drugs and drug combinations have been reported to produce serotonin syndrome, though the exact mechanism is not well understood in many instances.Diagnosis includes observing symptoms and investigating patient history for causal factors (interacting drugs). The syndrome has a characteristic picture but can be mistaken for other illnesses in some people, particularly those with neuroleptic malignant syndrome. No laboratory tests can currently confirm the diagnosis. Hence it is diagnosed based on symptoms, disease course (that is, the progression of the disease) and the exclusion of other possible causes of the presenting symptoms.Treatment consists of discontinuing medications which may contribute and in moderate to severe cases administering a serotonin antagonist. An important adjunct treatment includes controlling agitation with benzodiazepine sedation. The high-profile case of Libby Zion, who is generally accepted to have died from serotonin syndrome, resulted in changes to graduate medical education in New York State.