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DEVELOPMENT AND VALIDATION OF HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC
DEVELOPMENT AND VALIDATION OF HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC

... patients with impaired metabolism of the drug, such as those with liver disease7. Several analytical methods are already available for the determination of RIF in biological fluids and pharmaceutical dosage forms, including methods based on HPTLC8, HPLC9-17, HPLC following SPE18 or SBSE19, UPLC20, LC ...
Metabolic Characteristics of Oxcarbazepine (®Trileptal
Metabolic Characteristics of Oxcarbazepine (®Trileptal

... metabolism, the predominant process being epoxidation ofthe 10,1l-double bond in the central ring (Fig. 2) (Faigle and Feldmann, 1982). The pertinent enzyme is a microsomal mono-oxygenase dependent on cytochrome P-450. The epoxide metabolite, which contributes in part to the therapeutic effects of t ...
Part A - Therapeutic Goods Administration (TGA)
Part A - Therapeutic Goods Administration (TGA)

... evaluation, including guidelines on the evaluation of herbal medicines. The TGA’s (draft) document Evidence required to support indications for listed medicines (excluding sunscreens and disinfectants) (the Evidence requirements) provides information on the evidence required to support the indicatio ...
Full Text  - The Journal of International Advanced Otology
Full Text - The Journal of International Advanced Otology

... receptor antagonists and calcium channel blockers were used for controlled hypotension.[4,5] Because of the disadvantages related to these agents, the ideal pharmacological agent for controlled hypotension is still to be found. [6] Dexmedetomidine is an α2-adrenoceptor agonist and is more specific t ...
Guideline on the management of bleeding in patients on
Guideline on the management of bleeding in patients on

... Bivalirudin Bivalirudin is a recombinant peptide thrombin inhibitor and is the only licensed hirudin in the UK. The lepirudin licence was recently withdrawn and so it is not considered in this guideline. Bivalirudin is cleared predominantly through proteolysis by thrombin (80%) and only 20% is excre ...
Dose-Response Study of N,N-Dimethyltryptamine in Humans
Dose-Response Study of N,N-Dimethyltryptamine in Humans

... presented by clinical cluster, to demonstrate the heuristic value of such grouping. ...
The Holistic Approach to Prostate Health Aaron E. Katz, GUEST ARTICLE
The Holistic Approach to Prostate Health Aaron E. Katz, GUEST ARTICLE

... arrived in the U.S. It has long been a popular natural remedy for prostate enlargement in France, and it is well validated by curBuyer Beware rent science. At the Center for Holistic Urology, men who have Keep in mind as you read on that a lot of companies are try- been doing their own research into ...
Tutorial Planner - Collegiate Medical Centre
Tutorial Planner - Collegiate Medical Centre

... outpatients who are unable to absorb oral agents because of gastric atony or vomiting. Injectables are used in the emergency room or inpatient settings. The new agents are used when all else fails. Some antihistamines commonly used as vestibular suppressants have significant antiemetic properties (e ...
Drug Resistance
Drug Resistance

... • the mechanism of drug action for antiprotozoal drugs is not known • examples of available drugs – some antibiotics that inhibit bacterial protein synthesis are used against protozoa – chloroquine and mefloquine – malaria ...
ANTI-INFLAMMATORIES Alison Clode, DVM, DACVO Port City
ANTI-INFLAMMATORIES Alison Clode, DVM, DACVO Port City

... Ocular Bioavailability of Topical Steroid Preparations The efficacy of a topically applied ophthalmic corticosteroid depends upon multiple drug- and patientrelated factors, which influence transcorneal and intraocular penetration and anti-inflammatory activity. Of the drug-related factors, the base ...
Ocular Side Effects of Sildenafil: A Prospective Study
Ocular Side Effects of Sildenafil: A Prospective Study

... impairment of color discrimination in the blue/green range was detected using the Farnsworth-Munsell Hue test. However, these effects were fully reversible, dose related. Further study also failed to demonstrate any side effect on visual performance in any of the subjects.18 Overall, sildenafil was ...
CSPS
CSPS

... Effect of a lipoidic excipient on the absorption profile of compound UK81252 in dogs after oral administration. Biliary excretion of irinotecan and its metabolites. Definition of a novel atomic index for QSAR: the refractotopological state. Systemic bone formation with weekly PTH administration in o ...
drug-supplement interactions: a counter-offensive
drug-supplement interactions: a counter-offensive

... glucocorticoids. Glycyrrhetinic acid (the aglycone of glycyrrhizin), a component of licorice, increases the half-life and area under the curve (AUC) of orally administered prednisolone, presumably by inhibiting renal 11 beta-hydroxysteroid dehydrogenase and hepatic enzymes involved in beta-hydroxyst ...
Study on The Effect of Paliurus spina
Study on The Effect of Paliurus spina

... In conclusion, it seems that Paliurus spinachristi fruit could be a good candidate for clinical investigation towards the treatment of hyperlipidemia. This can explain the reason for its use in traditional medicine as a lipidlowering plant. Further studies are needed to understand the exact mechanis ...
Systemic Antibiotics
Systemic Antibiotics

... of the drug to reach its site of action. Aerobic Gram-negative bacilli (AGNB) have an outer membrane that is an impenetrable barrier for some antibiotics while other antibiotics (i.e. broad spectrum penicillins and cephalosporins) diffuse through aqueous channels in the outer membrane termed porins. ...
Chemotherapy Safety
Chemotherapy Safety

... ▪Cytotoxic agents should be separated from noncytotoxic agents. Proper storage and handling or oral chemotherapeutic agents should be ensured by healthcare professionals in order to prevent accidental exposure and to ensure the integrity of these medications. Safe handling of oral chemotherapeutic a ...
Clinical Implications of Dihydropyrimidine
Clinical Implications of Dihydropyrimidine

... in 5-FU–susceptible host tissue, such as gastrointestinal (GI) mucosa and bone marrow, should make dosing from patient to patient less variable, avoiding the typical (with 5-FU and many other cancer chemotherapeutic agents) dosing decisions based on observed toxicity. Inhibition of DPD in tumor spec ...
How long does liquid amoxicillin last
How long does liquid amoxicillin last

... How long does liquid amoxicillin last How long does liquid amoxicillin last Amoxicillin is prescribed to treat or control infections caused by susceptible bacteria. Infections treated with amoxicillin often include wounds, tooth abscesses and. Your TEEN needs to take the medicine called amoxicillin. ...
Skin Barrier and Transdermal Drug Delivery
Skin Barrier and Transdermal Drug Delivery

... in turn, are surrounded by a lipid-enriched extracellular matrix, organized largely into lamellar membranes, which derive from secreted lamellar body precursor lipids (Fig. 124.2). Following secretion, lamellar body contents fuse end-to-end, forming progressively elongated membrane sheets3, a sequen ...
Airways Register Search update 2008
Airways Register Search update 2008

... Abstract: OBJECTIVE: To evaluate the safety and efficacy of sublingual immunotherapy with 'Dermatophagoides Farinae Drops' in D. farinae allergic asthma and/or rhinitis patients. METHODS: A 25-week double-blind, placebo-controlled, multi-centered trail was conducted in 278 children (aged 4 - 18 yr) ...
DOXYCYCLINE CAPSULES, USP
DOXYCYCLINE CAPSULES, USP

... hours. This reaction was shown to be reversible when the drug was discontinued. Results of animal studies indicate that tetracyclines cross the placenta, are found in fetal tissues, and can have toxic effects on the developing fetus (often related to retardation of skeletal development). Evidence of ...
AuspAR: Cabazitaxel - Therapeutic Goods Administration
AuspAR: Cabazitaxel - Therapeutic Goods Administration

... cabazitaxel and polysorbate 80 (pH adjusted with citric acid). The use of nitrogen is probably prudent given that peroxides can be generated in polysorbate 80, although peroxide degradation studies reported show that cabazitaxel is not sensitive to oxidation.2,3 The polysorbate used has a vegetable ...
Secundum Artem
Secundum Artem

... The stability data presented in this and subsequent Secundum Artem issues resulted from a two year long stability study involving thirty different drugs and their stability as 1:1 mixtures of Ora Sweet:Ora Plus and Ora Sweet SF:Ora Plus. A survey mailed to community and hospital pharmacies was used ...
Cucurbit[n]urils as excipients in pharmaceutical dosage forms
Cucurbit[n]urils as excipients in pharmaceutical dosage forms

... A physical characteristic of cucurbit[n]urils that was once thought to limit their medical application is their poor water solubility. Cucurbit[n]urils composed of an odd number of subunits are more soluble than the cucurbit[n]urils with an even number of subunits. Cucurbit[5]uril and CB[7] have a ...
The role of metabolic inhibition
The role of metabolic inhibition

... Muhammad Umer Naeem: The role of metabolic inhibition-interactions on toxicity Supervisors: Professor Markku Pasanen and Doctor Risto Juvonen ...
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Pharmacognosy



Pharmacognosy is the study of medicinal drugs derived from plants or other natural sources. The American Society of Pharmacognosy defines pharmacognosy as ""the study of the physical, chemical, biochemical and biological properties of drugs, drug substances or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources.""It is also defined as the study of crude drugs.
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