Information for couples where one partner carries
... disorders are healthy at birth, but most become anaemic in the first year of life. This means they have less haemoglobin in their blood than other people. They may be thinner than others, and may tire more easily. People with sickle cell disorders get infections more easily than others (for example, ...
... disorders are healthy at birth, but most become anaemic in the first year of life. This means they have less haemoglobin in their blood than other people. They may be thinner than others, and may tire more easily. People with sickle cell disorders get infections more easily than others (for example, ...
Auxin signals — turning genes on and turning cells around
... Key to our present understanding of auxin-controlled gene expression are transcripts that are rapidly induced by auxin, which are collectively referred to as primary auxin-response genes [4]. In Arabidopsis, these include several families of well-characterized genes [5], including many of the 29 mem ...
... Key to our present understanding of auxin-controlled gene expression are transcripts that are rapidly induced by auxin, which are collectively referred to as primary auxin-response genes [4]. In Arabidopsis, these include several families of well-characterized genes [5], including many of the 29 mem ...
Functional features of RUNX1 mutants in acute
... the disease, but progression from the chronic phase to blast crisis (BC) is believed to require additional mutations. To explore the underlying mechanisms for BC, which is characterized by a blockage of blood cell differentiation, we screened several genes crucial to hematopoiesis ...
... the disease, but progression from the chronic phase to blast crisis (BC) is believed to require additional mutations. To explore the underlying mechanisms for BC, which is characterized by a blockage of blood cell differentiation, we screened several genes crucial to hematopoiesis ...
glo-3, a novel Caenorhabditis elegans gene, is required for lysosome
... 15(n484), and unc-27(e159). Glo non-Dpy, Glo non-Egl, or Glo non-Unc F2 progeny of this cross were isolated. Single Dpy, Egl, or Unc progeny were selected from the next generation and should be glo double mutants. At least two independent double mutant lines were isolated from each cross, and in all ...
... 15(n484), and unc-27(e159). Glo non-Dpy, Glo non-Egl, or Glo non-Unc F2 progeny of this cross were isolated. Single Dpy, Egl, or Unc progeny were selected from the next generation and should be glo double mutants. At least two independent double mutant lines were isolated from each cross, and in all ...
The Zn Finger protein Iguana impacts Hedgehog signaling by
... Smed-iguana is required for ciliogenesis in planarians The Smed-iguana gene (abbreviated as “iguana”) encodes an Iguana-like Zn finger protein (Fig. S1) and is required for normal planarian locomotion (Reddien and Sánchez Alvarado, 2004). Inhibition of iguana with RNAi in adult planarians results in ...
... Smed-iguana is required for ciliogenesis in planarians The Smed-iguana gene (abbreviated as “iguana”) encodes an Iguana-like Zn finger protein (Fig. S1) and is required for normal planarian locomotion (Reddien and Sánchez Alvarado, 2004). Inhibition of iguana with RNAi in adult planarians results in ...
What is p53
... transformation of cells. In the late 1980s, however, several critical discoveries defined the normal function of p53 to be anti-oncogenic. Wild-type p53 genes, when introduced into cells, were found to be growth suppressive. The screening of DNA from colon cancer patients revealed that p53 mutations ...
... transformation of cells. In the late 1980s, however, several critical discoveries defined the normal function of p53 to be anti-oncogenic. Wild-type p53 genes, when introduced into cells, were found to be growth suppressive. The screening of DNA from colon cancer patients revealed that p53 mutations ...
A glucagon-like endocrine pathway in Drosophila modulates both
... To probe the expression pattern of AKHR, we generated transgenic flies that expressed the transcriptional activator Gal4 under the control of a region of DNA upstream of the Akhr gene likely to contain all the transcriptional elements needed to recapitulate the expression pattern of AKHR. Three inde ...
... To probe the expression pattern of AKHR, we generated transgenic flies that expressed the transcriptional activator Gal4 under the control of a region of DNA upstream of the Akhr gene likely to contain all the transcriptional elements needed to recapitulate the expression pattern of AKHR. Three inde ...
A glucagon-like endocrine pathway in Drosophila
... To probe the expression pattern of AKHR, we generated transgenic flies that expressed the transcriptional activator Gal4 under the control of a region of DNA upstream of the Akhr gene likely to contain all the transcriptional elements needed to recapitulate the expression pattern of AKHR. Three inde ...
... To probe the expression pattern of AKHR, we generated transgenic flies that expressed the transcriptional activator Gal4 under the control of a region of DNA upstream of the Akhr gene likely to contain all the transcriptional elements needed to recapitulate the expression pattern of AKHR. Three inde ...
Depolarization of the actin cytoskeleton is a specific phenotype in
... (Waddle et al., 1996). We also prepared a strain carrying CAP2-GFP and the sac6∆ mutation to serve as a positive control in this screen. This strain, YJC1435, was obtained by inserting GFP (S65T) and HIS3 at the C terminus of CAP1 in AAY1046, sac6∆ (Adams et al., 1993). The cassette with GFP (S65T) ...
... (Waddle et al., 1996). We also prepared a strain carrying CAP2-GFP and the sac6∆ mutation to serve as a positive control in this screen. This strain, YJC1435, was obtained by inserting GFP (S65T) and HIS3 at the C terminus of CAP1 in AAY1046, sac6∆ (Adams et al., 1993). The cassette with GFP (S65T) ...
Cytokinins: Regulators of Cell Division
... double bond, it can exist in either the cis or the trans configuration. In higher plants, zeatin occurs in both the cis and the trans configurations, and these forms can be interconverted by an enzyme known as zeatin isomerase. Although the trans form of zeatin is much more active in biological assa ...
... double bond, it can exist in either the cis or the trans configuration. In higher plants, zeatin occurs in both the cis and the trans configurations, and these forms can be interconverted by an enzyme known as zeatin isomerase. Although the trans form of zeatin is much more active in biological assa ...
Cytokinins: Regulators of Cell Division
... double bond, it can exist in either the cis or the trans configuration. In higher plants, zeatin occurs in both the cis and the trans configurations, and these forms can be interconverted by an enzyme known as zeatin isomerase. Although the trans form of zeatin is much more active in biological assa ...
... double bond, it can exist in either the cis or the trans configuration. In higher plants, zeatin occurs in both the cis and the trans configurations, and these forms can be interconverted by an enzyme known as zeatin isomerase. Although the trans form of zeatin is much more active in biological assa ...
Changes in retinoic acid signaling alter otic patterning
... Otic defects generated by changes in RA signaling are considered mostly secondary consequences due to changes in Fgf signaling, because hindbrain patterning is disturbed in RA gain- and loss-offunction studies. In embryos with no RA signaling, such as mouse Aldh1a2 mutants, expression of Fgf3, which ...
... Otic defects generated by changes in RA signaling are considered mostly secondary consequences due to changes in Fgf signaling, because hindbrain patterning is disturbed in RA gain- and loss-offunction studies. In embryos with no RA signaling, such as mouse Aldh1a2 mutants, expression of Fgf3, which ...
PINK1- and Parkin- mediated mitophagy at a glance
... protect cells under stress, are not known to function in mitophagy. Presumably, substrates involved in PINK1-mediated Parkin recruitment would be located either on the OMM or in the cytosol. For Parkin, as suggested above, it has not been fully elucidated how many proteins are subject to ubiquitylat ...
... protect cells under stress, are not known to function in mitophagy. Presumably, substrates involved in PINK1-mediated Parkin recruitment would be located either on the OMM or in the cytosol. For Parkin, as suggested above, it has not been fully elucidated how many proteins are subject to ubiquitylat ...
Cross talk between the sporophyte and the
... The importance of the integument to promote gametophyte formation is clearly exemplified by aintegumenta (ant) mutant (Fig. 1). The ANT gene encodes a putative transcription factor that shares homology with the floral homeotic gene APETALA2 (AP2) (Elliott et al. 1996; Jofuku et al. 1994; Klucher et ...
... The importance of the integument to promote gametophyte formation is clearly exemplified by aintegumenta (ant) mutant (Fig. 1). The ANT gene encodes a putative transcription factor that shares homology with the floral homeotic gene APETALA2 (AP2) (Elliott et al. 1996; Jofuku et al. 1994; Klucher et ...
A TaqI polymorphism in the 3 UTR of the IL-12
... polymorphism in the coding sequence, indicating a high level of conservation in humans. Several intronic polymorphisms however were identified, as well as a TaqI RFLP at position 1188 in the 30 UTR.14 The latter is of particular interest, since it has been shown to be associated with susceptibility ...
... polymorphism in the coding sequence, indicating a high level of conservation in humans. Several intronic polymorphisms however were identified, as well as a TaqI RFLP at position 1188 in the 30 UTR.14 The latter is of particular interest, since it has been shown to be associated with susceptibility ...
Swartzlander_ku_0099D_15051_DATA_1
... To further examine the differences in desatF and eloF expression, in the second set of experiments I introgressed the D. simulans alleles of desatF and eloF into a D. sechellia background. Introgression lines did not express the D. simulans desatF and/or eloF alleles. To determine the effect of desa ...
... To further examine the differences in desatF and eloF expression, in the second set of experiments I introgressed the D. simulans alleles of desatF and eloF into a D. sechellia background. Introgression lines did not express the D. simulans desatF and/or eloF alleles. To determine the effect of desa ...
The development and evolutionary origin of barbels in
... LeClair and Topczewski 2010). While most barbels are unbranched, secondary through quaternary branching is found in some species. The point in ontogeny during which barbels develop also varies from embryonic through adult stages. Uses of barbels beyond food detection include luring prey and obtainin ...
... LeClair and Topczewski 2010). While most barbels are unbranched, secondary through quaternary branching is found in some species. The point in ontogeny during which barbels develop also varies from embryonic through adult stages. Uses of barbels beyond food detection include luring prey and obtainin ...
PDF
... allata glands causes ectopic BR-C induction as well as precocious pupation, whereas exposure of larvae to JH prevents both BR-C transcription and pupation. BR-C is therefore thought of as the JHdependent switch between larval and pupal programs (Zhou and Riddiford, 2002; Dubrovsky, 2005), but causal ...
... allata glands causes ectopic BR-C induction as well as precocious pupation, whereas exposure of larvae to JH prevents both BR-C transcription and pupation. BR-C is therefore thought of as the JHdependent switch between larval and pupal programs (Zhou and Riddiford, 2002; Dubrovsky, 2005), but causal ...
euglena wksheet
... Evidence that suggests Euglena is an animal Evidence that suggests Euglena is either a plant or animal Evidence that suggests Euglena is neither a plant nor an animal ...
... Evidence that suggests Euglena is an animal Evidence that suggests Euglena is either a plant or animal Evidence that suggests Euglena is neither a plant nor an animal ...
Document
... understanding is incomplete. Plant hormones are known to be implicated in these processes, but only the initial connections necessary for this understanding have been made. I am interested in adding to this area of essential knowledge by studying how the plant hormone cytokinin is involved in contro ...
... understanding is incomplete. Plant hormones are known to be implicated in these processes, but only the initial connections necessary for this understanding have been made. I am interested in adding to this area of essential knowledge by studying how the plant hormone cytokinin is involved in contro ...
FUNCTIONAL INVESTIGATION OF ARABIDOPSIS
... Callose synthesis occurs at specific stages of cell wall development in all cell types, and in response to pathogen attack, wounding and physiological stresses. We isolated promoters of 12 Arabidopsis callose synthase (CalS1-12) genes and demonstrated that different callose synthases are expressed s ...
... Callose synthesis occurs at specific stages of cell wall development in all cell types, and in response to pathogen attack, wounding and physiological stresses. We isolated promoters of 12 Arabidopsis callose synthase (CalS1-12) genes and demonstrated that different callose synthases are expressed s ...
Information for Couples where one partner carries
... every characteristic, one from each parent. Most people have inherited two genes for haemoglobin A. A haemoglobin S carrier has inherited a gene for haemoglobin A from one parent and a gene for haemoglobin S from the other. This is why they are sometimes said to “be AS”. A delta-beta thalassaemia ca ...
... every characteristic, one from each parent. Most people have inherited two genes for haemoglobin A. A haemoglobin S carrier has inherited a gene for haemoglobin A from one parent and a gene for haemoglobin S from the other. This is why they are sometimes said to “be AS”. A delta-beta thalassaemia ca ...
Stamina pistilloida, the Pea Ortholog of Fim and
... stamen was often completely converted to a carpel. Abaxial stamens formed groups of two or three connected by tube tissue that normally joins the nine fused stamens in wildtype flowers. The central carpel was unaffected and able to produce seed after pollination. The floral phenotype of stp-3 mutant ...
... stamen was often completely converted to a carpel. Abaxial stamens formed groups of two or three connected by tube tissue that normally joins the nine fused stamens in wildtype flowers. The central carpel was unaffected and able to produce seed after pollination. The floral phenotype of stp-3 mutant ...
The role of Grainy head in epithelial tissue growth
... The grainy head (grh) gene family encodes an important group of transcription factors that play a remarkably conserved role in epithelial organ development, epithelial barrier formation and epithelial repair upon damage in different organisms. The regulation and molecular targets of Grh are numerous ...
... The grainy head (grh) gene family encodes an important group of transcription factors that play a remarkably conserved role in epithelial organ development, epithelial barrier formation and epithelial repair upon damage in different organisms. The regulation and molecular targets of Grh are numerous ...
Mir-92 microRNA precursor family
The miR-92 microRNAs are short single stranded non-protein coding RNA fragments initially discovered incorporated into an RNP complex with a proposed role of processing RNA molecules and further RNP assembly. Mir-92 has been mapped to the human genome as part of a larger cluster at chromosome 13q31.3, where it is 22 nucleotides in length but exists in the genome as part of a longer precursor sequence. There is an exact replica of the mir-92 precursor on the X chromosome. MicroRNAs are endogenous triggers of the RNAi pathway which involves several ribonucleic proteins (RNPs) dedicated to repressing mRNA molecules via translation inhibition and/or induction of mRNA cleavage. miRNAs are themselves matured from their long RNA precursors by ribonucleic proteins as part of a 2 step biogenesis mechanism involving RNA polymerase 2.Most miRNAs are grouped into clusters in the human genome or within families that share functions, expression profiles, promotors, or are incorporated into the same ribonucleic protein. The purpose of having a variety of miRNAs in a single piece of RNA processing machinery is to act as complementary strands to the recognition elements of a variety of target RNA molecules.The recognition elements of target mRNAs are typically within the 3' untranslated regions and with 678 human miRNAs and 472 mouse miRNAs confidently identified so far (miRBASE) there are extensive efforts taking place using bioinformatics tools to scan genomes for potential recognition elements for families of miRNAs in order to identify potential target genes.Mir-92 is no exception and currently identified gene targets have been among those involved in cell cycle regulation and cell signalling, and thus necessary during all stages of mammalian development and essential for the proliferation of cells. miRNAs can be oncogenes or tumor suppressor genes depending on their targets while mir-92 has been implicated as the former in leukaemia forms AML and ALL, Hepatocellular carcinoma (HCC) and several other cancers.The search for noninvasive tools for diagnosis and management of cancer is extremely important for reducing the worldwide health burden of cancer. miRNAs show potential as biomarkers and can even be found circulating in the serum. Some circulating miRNAs are specific to tumour patients, while miR-92 on the other-hand is present in healthy individuals in the serum, but levels are variable and appear to change in response to the onset of some cancers.