Reprogramming somatic cells into iPS cells to generate an in vitro
... disorders, due to the loss of upper and lower motor neurons. A subset of familial ALS cases is linked to mutations in the FUS/TLS and TARDP genes, both encoding for putative regulators of microRNA (miRNA) biogenesis. In the nervous system, miRNAs fine-tune neuronal gene expression in a spatially and ...
... disorders, due to the loss of upper and lower motor neurons. A subset of familial ALS cases is linked to mutations in the FUS/TLS and TARDP genes, both encoding for putative regulators of microRNA (miRNA) biogenesis. In the nervous system, miRNAs fine-tune neuronal gene expression in a spatially and ...
basic characterisation of hiPSC.
... Expression of key endogenous pluripotency-associated genes Evidence of transgene silencing ...
... Expression of key endogenous pluripotency-associated genes Evidence of transgene silencing ...
Role of MicroRNA Expression in Acute Myeloid Leukemia Victoria
... Acute myelogenous leukemia (AML) is characterized by aberrant proliferation of abnormal myeloid progenitor cells and decreased production of normal blood cells in the bone marrow. Chromosomal abnormalities in AML create fusion oncoproteins that have been linked with upregulation of certain microRNAs ...
... Acute myelogenous leukemia (AML) is characterized by aberrant proliferation of abnormal myeloid progenitor cells and decreased production of normal blood cells in the bone marrow. Chromosomal abnormalities in AML create fusion oncoproteins that have been linked with upregulation of certain microRNAs ...
A functional polymorphism in miRNA
... elucidated. MicroRNAs (miRNAs) serve as key post-transcriptional regulators of gene expression and are involved in various biological processes. Genetic variation in miRNArelated sequences has been shown to interfere with miRNA gene regulation and subsequently affect disease risk. Here, we investiga ...
... elucidated. MicroRNAs (miRNAs) serve as key post-transcriptional regulators of gene expression and are involved in various biological processes. Genetic variation in miRNArelated sequences has been shown to interfere with miRNA gene regulation and subsequently affect disease risk. Here, we investiga ...
same genes, different fates final evaluation assignment
... You have been hired as a science writer for the Discovery Channel. The company is introducing a new line of children’s educational products in different areas of biology. Your job is to create a product that will teach children (about 10 years of age) about stem cells and differential gene expressio ...
... You have been hired as a science writer for the Discovery Channel. The company is introducing a new line of children’s educational products in different areas of biology. Your job is to create a product that will teach children (about 10 years of age) about stem cells and differential gene expressio ...
myPresentation
... Very important: stress that the agreement between miRNA and mRNA expression direction illustrate that the experimental data (and conclusions) are trustworthy Underexpressed miRNA-overexpressed gene network ...
... Very important: stress that the agreement between miRNA and mRNA expression direction illustrate that the experimental data (and conclusions) are trustworthy Underexpressed miRNA-overexpressed gene network ...
Biology Chapter 11- Gene Expression Miss Ventrone
... Discovered in the early 1960’s by Francois __________ and Jacques _____________ They were studying how __________ ______________ the _______________ of sugar lactose (found in milk) in _________________ Absence of Lactose ...
... Discovered in the early 1960’s by Francois __________ and Jacques _____________ They were studying how __________ ______________ the _______________ of sugar lactose (found in milk) in _________________ Absence of Lactose ...
PDF
... Epidermal growth factor receptor (EGFR) signalling regulates numerous processes throughout Drosophila development. For example, during oogenesis, an EGFR activation gradient induced by Gurken (a TGF-like ligand secreted from the oocyte) patterns the follicular epithelium. On p. 2814, Stanislav Shva ...
... Epidermal growth factor receptor (EGFR) signalling regulates numerous processes throughout Drosophila development. For example, during oogenesis, an EGFR activation gradient induced by Gurken (a TGF-like ligand secreted from the oocyte) patterns the follicular epithelium. On p. 2814, Stanislav Shva ...
Abstract - cse.sc.edu - University of South Carolina
... Repression of gene expression is an important regulatory mechanism that controls many biological processes such as development, cell proliferation and differentiation. The discovery of microRNAs (miRNAs) has broadened our perspectives on the mechanisms of down-regulation of gene expression and shed ...
... Repression of gene expression is an important regulatory mechanism that controls many biological processes such as development, cell proliferation and differentiation. The discovery of microRNAs (miRNAs) has broadened our perspectives on the mechanisms of down-regulation of gene expression and shed ...
MicroRNAs (miRNAs) are one of the most abundant groups of
... The specific reason I write to you concerns one of the topics we work on – miRNA and gene regulation. As it is known now, the microRNAs (miRNAs) are one of the most abundant groups of regulatory molecules in multicellular organisms, playing important roles in many fundamental cellular processes. Mor ...
... The specific reason I write to you concerns one of the topics we work on – miRNA and gene regulation. As it is known now, the microRNAs (miRNAs) are one of the most abundant groups of regulatory molecules in multicellular organisms, playing important roles in many fundamental cellular processes. Mor ...
The analysis of exosomal micro-RNAs in peripheral blood
... and the sequences in FASTQ format were run against the mature human miRNA sequences available in miRBase using BLAST software using a Linux operating system. Micro-RNAs were identified using E = 0.01 or 1. Results Infection of MDMs with BCG lead to the release of a number of exosomal miRNAs. These m ...
... and the sequences in FASTQ format were run against the mature human miRNA sequences available in miRBase using BLAST software using a Linux operating system. Micro-RNAs were identified using E = 0.01 or 1. Results Infection of MDMs with BCG lead to the release of a number of exosomal miRNAs. These m ...
Mir-92 microRNA precursor family
The miR-92 microRNAs are short single stranded non-protein coding RNA fragments initially discovered incorporated into an RNP complex with a proposed role of processing RNA molecules and further RNP assembly. Mir-92 has been mapped to the human genome as part of a larger cluster at chromosome 13q31.3, where it is 22 nucleotides in length but exists in the genome as part of a longer precursor sequence. There is an exact replica of the mir-92 precursor on the X chromosome. MicroRNAs are endogenous triggers of the RNAi pathway which involves several ribonucleic proteins (RNPs) dedicated to repressing mRNA molecules via translation inhibition and/or induction of mRNA cleavage. miRNAs are themselves matured from their long RNA precursors by ribonucleic proteins as part of a 2 step biogenesis mechanism involving RNA polymerase 2.Most miRNAs are grouped into clusters in the human genome or within families that share functions, expression profiles, promotors, or are incorporated into the same ribonucleic protein. The purpose of having a variety of miRNAs in a single piece of RNA processing machinery is to act as complementary strands to the recognition elements of a variety of target RNA molecules.The recognition elements of target mRNAs are typically within the 3' untranslated regions and with 678 human miRNAs and 472 mouse miRNAs confidently identified so far (miRBASE) there are extensive efforts taking place using bioinformatics tools to scan genomes for potential recognition elements for families of miRNAs in order to identify potential target genes.Mir-92 is no exception and currently identified gene targets have been among those involved in cell cycle regulation and cell signalling, and thus necessary during all stages of mammalian development and essential for the proliferation of cells. miRNAs can be oncogenes or tumor suppressor genes depending on their targets while mir-92 has been implicated as the former in leukaemia forms AML and ALL, Hepatocellular carcinoma (HCC) and several other cancers.The search for noninvasive tools for diagnosis and management of cancer is extremely important for reducing the worldwide health burden of cancer. miRNAs show potential as biomarkers and can even be found circulating in the serum. Some circulating miRNAs are specific to tumour patients, while miR-92 on the other-hand is present in healthy individuals in the serum, but levels are variable and appear to change in response to the onset of some cancers.