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M:\Biology 3201.June 2009.wpd
M:\Biology 3201.June 2009.wpd

... 77.(a) Stem cell researchers in independent labs have made great strides in creating stem cells without using embryos. One group was able to reprogram mature skin cells in mice into pluripotent cells. The reprogrammed cells were indistinguishable from embryonic stem cells. Name and explain two benef ...
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Exam 3 Essay Questions pdf

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BIO 1 ESSAY QUESTIONS – EXAM 1

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11165_2014_9398_MOESM1_ESM

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Supplementary Information (doc 62K)

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Genetics Review Questions March 2013

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Cellular ageing processes - Homepages | The University of Aberdeen

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Why clone in eukaryotes?

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Exam Review – Part 1

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Epigenetics in stem-cell differentiation

Embryonic stem cells are capable of self-renewing and differentiating to the desired fate depending on its position within the body. Stem cell homeostasis is maintained through epigenetic mechanisms that are highly dynamic in regulating the chromatin structure as well as specific gene transcription programs. Epigenetics has been used to refer to changes in gene expression, which are heritable through modifications not affecting the DNA sequence.The mammalian epigenome undergoes global remodeling during early stem cell development that requires commitment of cells to be restricted to the desired lineage. There has been multiple evidence suggesting that the maintenance of the lineage commitment of stem cells are controlled by epigenetic mechanisms such as DNA methylation, histone modifications and regulation of ATP-dependent remolding of chromatin structure. Based on the histone code hypothesis, distinct covalent histone modifications can lead to functionally distinct chromatin structures that influence the fate of the cell.This regulation of chromatin through epigenetic modifications is a molecular mechanism that will determine whether the cell will continue to differentiate into the desired fate. A research study performed by Lee et al. examined the effects of epigenetic modifications on the chromatin structure and the modulation of these epigenetic markers during stem cell differentiation through in vitro differentiation of murine embryonic stem (ES) cells.
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