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Heme Redox State Triggers Conformational Changes in the Ec DOS
Heme Redox State Triggers Conformational Changes in the Ec DOS

... protein responsible for phosphodiesterase (PDE) activity. The Ec DOS is composed of two domains, an N-terminal sensor domain and a C-terminal PDE catalytic domain. PDE activity is dependent on the redox state of Ec DOS. The enzyme is active only when the heme is in the reduced state. The crystal str ...
ch_12 - WordPress.com
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CHAPTER 1 THE MAIN THEMES OF MICROBIOLOGY

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Organic Compounds

... • pH – too high or too low the H+ or OH – ions react with the amino acid side chains (R groups) – improper folding occurs – reaction slows • Salt conc. – too much or too little causes improper folding of protein • Substrate concentration – lower the substrate conc., the slower the reaction ...
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Metalloprotein



Metalloprotein is a generic term for a protein that contains a metal ion cofactor. A large number of all proteins are part of this category.
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