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17.1 Genes and Variation
17.1 Genes and Variation

... Genetic Recombination in Sexual Reproduction • Combination of genes from different parents • Half of the DNA comes from each parent. • Each offspring receives a unique set of genetic information. (Exception = Twins) • This is the result of crossing over and independent assortment during meiosis! ...
Lecture 24: the genetic code
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... function of aminoacyl-tRNA synthetases, encoded by a domain that is distinct from the domain for aminoacylation. If they are not cleared, genetic code ambiguity is introduced (that is, a given codon in the messenger RNA will specify incorporation of more than one amino acid, resulting in the product ...
Chapter 13 Chromatin Structure and its Effects on
Chapter 13 Chromatin Structure and its Effects on

... Chromatin is required for specificity • With DNA, RNA polymerase III transcribes both well ...
Polymer: Macromolecule
Polymer: Macromolecule

... the –COOH group of one amino acid is adjacent to the NH2 group of another, an enzyme will join them via dehydration synthesis to form a Peptide Bond. The resulting molecule is known as a Dipeptide. As many more amino acids are added, a long Polypeptide chain is formed. ● All ...
Genetics Vocabulary
Genetics Vocabulary

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Characterisation of DNA by Agarose Gel Electrophoresis and
Characterisation of DNA by Agarose Gel Electrophoresis and

... Deoxyribonucleic acids (DNA) are the carriers of the genetic material of the cell, i.e. they serve both, the passing on of information to a new cell during mitosis as well as code for anabolic and catabolic processes within the cell. From the fact alone that information about very complex patterns o ...
DNA Transcription All#read
DNA Transcription All#read

... The first step in transcription is initiation, when the RNA pol binds to the DNA upstream (5′) of the gene at a specialized sequence called a promoter (Figure 2a). In bacteria, promoters are usually composed of three sequence elements, whereas in eukaryotes, there are as many as seven elements. In p ...
Mutations - Warren County Schools
Mutations - Warren County Schools

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Elongation factor P mediates a novel post

... macrophages, is not properly controlled in these mutants.47 We also do not currently know whether the lysyl-β-lysine modification of EF-P occurs constitutively or is only triggered under specific conditions. Given that EF-P appears to play a role in stress tolerance and virulence, it will be importa ...
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Statistical machine learning for computational biology
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... Biology is awash in data today. We have ready access to the sequences of the human and other genomes, structures for several thousand proteins, sequences for over 1.5 million proteins, and information on thousands of protein-protein interactions (with over a billion interactions predicted). High-thr ...
Brain architecture and neuroinformatics: applications for
Brain architecture and neuroinformatics: applications for

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What happened to my genes? Insights on gene family dynamics

... 2007) and ALF (Dalquen et al., 2012) have been developed independently of a particular phylogenetic inference method. For example, ALF uses classical models of evolution at the gene sequence level, but allows for the duplication or loss of several consecutive genes at once. However, both ALF and Ev ...
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... Amino acids are linked together by peptide bonds to form one or more macromolecule subunits called polypeptides. Long chains of polypeptides result in the formation of proteins. The primary amimo acid sequence of a protein determines its secondary, tertiary, and quaternary structure, which then in t ...
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Genetics of Color-Blindness

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... A 5-digit limb structured bone is found in many vertebrates such as frogs, whales, dogs, bats and humans, fish. This suggests that they shared a common ancestor. It hints at a shared ancestry ...
E. coli
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... virus causes cancer in chickens, scientists have recognized that some viruses cause animal cancers. • These tumor viruses include retrovirus, papovavirus, adenovirus, and herpesvirus types. • Viruses appear to cause certain human cancers. • The hepatitis B virus is associated with liver cancer. • Th ...
DNA replication - Olympic High School
DNA replication - Olympic High School

... DNA replication: a caste of characters… Replication: Helicase: ATP-dependent separation (“melting”) of DNA strands… Single strand binding protein (SSB): binds and stabilizes ss DNA… Primase: synthesizes RNA primers (may be a component of DNA polymerase)… DNA polymerase: synthesizes and “proof-reads ...
Bio 392: Study Guide for Final
Bio 392: Study Guide for Final

...  Know what you start with and what you end with  Know the role of promoters and mRNA in the process  Know what enzyme is involved and what its function is Describe the process of RNA editing  Distinguish between introns and exons Describe the process of translation  Know what you start with and ...
Slide
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... amino acids conforms to a three-dimensional shape. • Anfinsen’s hypothesis suggests that proteins fold to a minimum energy state. • So, our goal is to find a conformation with minimum energy. • We want to investigate algorithmic aspects of simulating the folding process. • We need to simplify it. ...
- American Institute of Science
- American Institute of Science

... It is not uncommon to have difficulties in digesting DNA with restriction enzymes. At times, the DNA does not appear to be cut at all, or sometimes it is only partially cut. Restriction sites can be predicted if the sequence is known. However, an enzyme may cut more often than it should or at the wr ...
Document
Document

... The term cloning describes a number of processes that can be used to produce genetically identical copies of a biological entity. The copied material, which has the same genetic makeup as the original, is referred to as a clone. ...
Topics in Computational Biology
Topics in Computational Biology

... Topics in Computational Biology (COSI 230a) Pengyu Hong ...
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Artificial gene synthesis

Artificial gene synthesis is a method in synthetic biology that is used to create artificial genes in the laboratory. Currently based on solid-phase DNA synthesis, it differs from molecular cloning and polymerase chain reaction (PCR) in that the user does not have to begin with preexisting DNA sequences. Therefore, it is possible to make a completely synthetic double-stranded DNA molecule with no apparent limits on either nucleotide sequence or size. The method has been used to generate functional bacterial or yeast chromosomes containing approximately one million base pairs. Recent research also suggests the possibility of creating novel nucleobase pairs in addition to the two base pairs in nature, which could greatly expand the possibility of expanding the genetic code.Synthesis of the first complete gene, a yeast tRNA, was demonstrated by Har Gobind Khorana and coworkers in 1972. Synthesis of the first peptide- and protein-coding genes was performed in the laboratories of Herbert Boyer and Alexander Markham, respectively.Commercial gene synthesis services are now available from numerous companies worldwide, some of which have built their business model around this task. Current gene synthesis approaches are most often based on a combination of organic chemistry and molecular biological techniques and entire genes may be synthesized ""de novo"", without the need for precursor template DNA. Gene synthesis has become an important tool in many fields of recombinant DNA technology including heterologous gene expression, vaccine development, gene therapy and molecular engineering. The synthesis of nucleic acid sequences is often more economical than classical cloning and mutagenesis procedures.
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