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The Biology of Extracellular Molecular Chaperones. Novartis Foundation
The Biology of Extracellular Molecular Chaperones. Novartis Foundation

... molecular chaperones such as Hsp60, Hsp70 or Hsp90 could inhibit experimental autoimmune diseases and cancer. More recently evidence has accumulated to show that certain molecular chaperones are also present on the surface of cells or in extracellular fluids. A new paradigm is emerging: at least som ...
Exam 3 Study Guide
Exam 3 Study Guide

... Pyruvate Dehydrogenase Complex: Overall reaction, purpose of cofactors, metabolic purpose Citric acid Cycle: Structures of all intermediates, names of all intermediates, names of regulated enzymes, mechanisms presented in slides only Electron transport chain: know complexes by number, mobile carrier ...
Networks Dynamics
Networks Dynamics

... Farach-Colton, and Mishra gives an efficient and robust algorithm for extracting from physical interaction networks groups of proteins that work together in the same context as protein complexes. Gene expression data has been proven to be useful in untangling other aspects related to the dynamics of ...
Anaerobic and Aerobic Glycolysis
Anaerobic and Aerobic Glycolysis

... Using pyruvate in this way (to keep glycolysis running at a paltry 2ATP per glucose) may seem wasteful considering the much larger amount of ATP generated should it enter the citric acid cycle (as acetyl CoA). However, glycolysis can run at a very high rate and thus meet the ATP demands of the cell ...
SG 7,8,9,10
SG 7,8,9,10

... liver in the Cori cycle? Describe the Pentose Phosphate Pathway; importance in production of NADPH and 5C sugars, reaction pathway, enzymes involved. List other important sugars for vertebrates and their metabolism. Describe glycogenesis; process of glycogen synthesis and breakdown. What is Cori’s d ...
photosynresp jeopardy
photosynresp jeopardy

... Four Carbon Compound that combines with ...
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Document

... a) Protein molecules are made up of long chains of amino acids. These long chains are folded to produce a specific shape that enables other molecules to fit into the protein. Proteins act as: ...
Biology Keystone Exam Review Packet
Biology Keystone Exam Review Packet

... electrical gradient where one side of the cell is more positive than the other side ...
Biology Keystone Practice PowerPoint
Biology Keystone Practice PowerPoint

... electrical gradient where one side of the cell is more positive than the other side ...
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complement

... If Ag/Ab complexes are formed , complement will be fixed by these complexes & some of the complement will be consumed by these complexes so : Not all RBCs of the indicator system will be lysed & the test is POSITIVE ...
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... ATP is very important as it acts as the link between catabolic energy releasing reactions (e.g. respiration) and anabolic energy-consuming reactions (e.g. protein synthesis) ...
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answer key

... i. dissociation of G proteins into their subunits -- CORRECT ii. activation of protein kinase B iii. phosphorylation of glycogen synthase iv. translocation of glucose transporters to the cell membrane v. transcription of glycolytic enzymes M. Arrestin helps "reset" signal transduction pathways invol ...
exploring protein structure
exploring protein structure

... Not enough of this protein gets inserted into the membranes of people suffering Cystic fibrosis. This causes secretions to become thick as they are not hydrated. The lungs and secretory ducts become blocked as a ...
Preparation for Exam 1
Preparation for Exam 1

... mannose. Know the signals that tell a cell to synthesize or breakdown glycogen. Know the mechanism of glucagon, insulin in regulating these events. Below are some specifics that cover this overview. Review the 6 tutorials. In chapter 13 know high energy compounds, biological oxidations, coupled reac ...
Gene Section SH3GL2 (SH3-domain GRB2-like 2) Atlas of Genetics and Cytogenetics
Gene Section SH3GL2 (SH3-domain GRB2-like 2) Atlas of Genetics and Cytogenetics

... recycling of synaptic vesicles. SH3GL2 by its LPAAT activity may induce negative membrane curvature by converting an inverted cone shaped lipid to a cone shaped lipid in the cytoplasmic leaflet of the bilayer. Through this action, SH3GL2 works with dynamin to mediate synaptic vesicle invagination fr ...
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CARBOHYDRATES: METABOLISM (cont.)

... – Thyroid-stimulating hormone and thyroid hormones have complex effects on metabolism • Some raise and some lower blood glucose ...
Three Dimensional Protein Structures
Three Dimensional Protein Structures

... Glu) are normally located on the surface of the protein in contact with water. • Uncharged polar residues (Ser, Thr, Asn, Gln, and Tyr) are usually on the protein surface but also occur in the interior of the protein. ...
Carbohydrate Metabolism
Carbohydrate Metabolism

... • Under anaerobic condition, e.g. in exercising muscles and in erythrocytes, the pyruvate is reduced to lactate. • In aerobic condition, cell pyruvate is oxidized to acetyl-CoA and CO2 by multienzyme complex pyruvate dehydrogenase, instead of being reduced to lactate. • In erythrocytes, the first si ...
Full-text PDF
Full-text PDF

... The cellular slime mold Dictyostelium discoideum has both multicellular and unicellular characteristics in its life cycle and hence it is considered as a powerful system for studying development, differenciation, and inter- or intra-cellular signaling. We have analyzed cDNA sequences of Dictyostelium ...
03-1 - Pierce College
03-1 - Pierce College

... 49. Regarding the Na+-K+ pump mechanism, which is not true? a. Three Na+ bind inside cell and are moved out of cell. b. Two K+ bind outside of cell and are move into cell. c. Na+ binding causes phosphate to be released. 50. Uses concentration gradient of a second substance, such as Na+ or H+, to pow ...
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... The active site is not a rigid structure, it is flexible. When the substrate enters the active site, the enzyme molecule and the active site change slightly making the active site fit very closely round the substrate molecule. The induced fit ensures that the active site comes into very close contac ...
Chapter 49 The Neuromuscular Junction and Muscle Contraction
Chapter 49 The Neuromuscular Junction and Muscle Contraction

... 4) The resulting action potential can only be triggered only if the membrane potential increases enough to open a sufficient number of voltagegated cation channels. ...
BCH 405 – REGULATION OF METABOLIC PROCESSES
BCH 405 – REGULATION OF METABOLIC PROCESSES

... When the binding of the regulator results in more substrates being bound, then it is +ve cooperativity and the reverse as –ve cooperativity. (4) Inhibition of a regulatory enzyme does not conform to any normal inhibition pattern and the inhibitor does not bear any obvious structural relationship to ...
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Slide 1

... from pyruvate carboxylase using UCSC table browser and Notepad++ 1.5 Construct in both cases sequence logo and frequency plot. Can you identify (regulatory) sequence motifs? ...
Gene Section ALOX15 (arachidonate 15-lipoxygenase) Atlas of Genetics and Cytogenetics
Gene Section ALOX15 (arachidonate 15-lipoxygenase) Atlas of Genetics and Cytogenetics

... Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene. J Biol Chem 2001;276:4275342760. Shureiqi I, Xu X, Chen D, Lotan R, Morris JS, Fischer SM, Lippman SM. Nonsteroidal anti-inflammatory drugs induce apo ...
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Biochemical cascade

A biochemical cascade (or a signaling pathway) is a series of chemical reactions which are initiated by a stimulus (first messenger) acting on a receptor that is transduced to the cell interior through second messengers (which amplify the initial signal) and ultimately to effector molecules, resulting in a cell response to the initial stimulus. At each step of the signaling cascade, various controlling factors are involved to regulate cellular actions, responding effectively to cues about their changing internal and external environments.
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