Ingenuity Pathway Analysis of metabolomics data including cross
... and environmental influences (6, 8, 10) and may also reflect function more directly than gene and protein effects (7). Metabolomics technologies are currently experiencing an exponential increase in their incorporation into biological studies, with applications ranging from physiological genomics an ...
... and environmental influences (6, 8, 10) and may also reflect function more directly than gene and protein effects (7). Metabolomics technologies are currently experiencing an exponential increase in their incorporation into biological studies, with applications ranging from physiological genomics an ...
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... maturation of the Toll receptor-ligand Spätzle (Spz) [7,8]. Toll activation by ligand binding is followed by the recruitment of a receptor–adaptor complex consisting of three death-domain proteins: MyD88, Tube and Pelle [8,9] (Figure 1). Pelle phosphorylates the ΙκB-like protein Cactus, leading to i ...
... maturation of the Toll receptor-ligand Spätzle (Spz) [7,8]. Toll activation by ligand binding is followed by the recruitment of a receptor–adaptor complex consisting of three death-domain proteins: MyD88, Tube and Pelle [8,9] (Figure 1). Pelle phosphorylates the ΙκB-like protein Cactus, leading to i ...
How do glycolytic enzymes favour cancer cell proliferation by
... sequences.71,75 This association may have a role in the stabilisation of transcripts76 and could also be involved in agents such as ultraviolet radiation77 (Figure 1b). ALDO A seems to be related with the activation of transcription of certain genes involved in S phase and may also be correlated wit ...
... sequences.71,75 This association may have a role in the stabilisation of transcripts76 and could also be involved in agents such as ultraviolet radiation77 (Figure 1b). ALDO A seems to be related with the activation of transcription of certain genes involved in S phase and may also be correlated wit ...
uric acid stimulates vascular smooth muscle cell proliferation by
... acid, [3H]thymidine incorporation and the endothelin-1 (ET-1) gene expression was examined. Antioxidants pretreatment on uric acid-induced extracellular signal-regulated kinase (ERK) phosphorylation were performed to elucidate the redox-sensitive pathway in proliferation and ET-1 gene expression. Cr ...
... acid, [3H]thymidine incorporation and the endothelin-1 (ET-1) gene expression was examined. Antioxidants pretreatment on uric acid-induced extracellular signal-regulated kinase (ERK) phosphorylation were performed to elucidate the redox-sensitive pathway in proliferation and ET-1 gene expression. Cr ...
Proteins
... Functions of proteins… • Contractile or motile proteins: Some proteins endow cells and organisms with the ability to contract, change shape, or move about. Actin and myosin function in the contractile system of skeletal muscle and in many other cells. • Structural proteins: Many proteins serve as s ...
... Functions of proteins… • Contractile or motile proteins: Some proteins endow cells and organisms with the ability to contract, change shape, or move about. Actin and myosin function in the contractile system of skeletal muscle and in many other cells. • Structural proteins: Many proteins serve as s ...
Integrity and purity of the mitochondrial fraction
... positive for MitoTracker staining (Fig. S1A). The mitochondrial fraction was also essentially free of cytoplasmic contaminants such as GAPDH (absent by western blot, Fig. S1B), and the cytosolic enzyme lactate dehydrogenase. The activity of the latter enzyme accounted for < 20% of that found in cyto ...
... positive for MitoTracker staining (Fig. S1A). The mitochondrial fraction was also essentially free of cytoplasmic contaminants such as GAPDH (absent by western blot, Fig. S1B), and the cytosolic enzyme lactate dehydrogenase. The activity of the latter enzyme accounted for < 20% of that found in cyto ...
... Choice A: Briefly describe how the regulation of glycolysis and gluconeogenesis in a liver cell is responsive to the energy needs of the cell. Choice B: Briefly describe how the glycolysis and gluconeogenesis in a liver cell is responsive to hormonal signals that regulate blood glucose levels. Selec ...
Transforming growth factor β1
... As mentioned previously the mechanism of cell injury in NAFLD involve excess fatty acids in the liver induces formation of free radicals, which cause lipid peroxidation and induce proinflammatory cytokines (Tolman et al., 2007). TGF-β1 is one of the cytokines secreted as a response to cell injury an ...
... As mentioned previously the mechanism of cell injury in NAFLD involve excess fatty acids in the liver induces formation of free radicals, which cause lipid peroxidation and induce proinflammatory cytokines (Tolman et al., 2007). TGF-β1 is one of the cytokines secreted as a response to cell injury an ...
Purines/Pyrimidines LIGAND-SET™ (L2538)
... of each ligand per well. Stock solutions can be readily prepared by adding 1 ml of DMSO to each well. The set also comes with a diskette containing a structural database, or SD file and a Microsoft Excel file containing the catalog number, name, rack position and pharmacological characteristics of e ...
... of each ligand per well. Stock solutions can be readily prepared by adding 1 ml of DMSO to each well. The set also comes with a diskette containing a structural database, or SD file and a Microsoft Excel file containing the catalog number, name, rack position and pharmacological characteristics of e ...
Novel Amycolatopsis balhimycina biochemical abilities
... contrast, this study identified a NAD-specific glutamate dehydrogenase, a key enzyme to grow on glutamate as sole carbon source. This enzyme catalyses the conversion of glutamate into alpha-ketoglutarate and NH3+ and was missed from previous 2-DE-based proteomic investigations because of its molecul ...
... contrast, this study identified a NAD-specific glutamate dehydrogenase, a key enzyme to grow on glutamate as sole carbon source. This enzyme catalyses the conversion of glutamate into alpha-ketoglutarate and NH3+ and was missed from previous 2-DE-based proteomic investigations because of its molecul ...
Chap 76 - Thyroid Metabolic Hormones
... c. proteinases digest the thyroglobulin and release the thyroxine and triiodothyronine d. thyroid hormones are released into the blood 1. 90% is thyroxine 2. 10% is triiodothyronine III. Transport A. most all T3 & T4 bind to plasma proteins 1. 80% with thyroxine-binding globulin 2. 10 - 15% with thy ...
... c. proteinases digest the thyroglobulin and release the thyroxine and triiodothyronine d. thyroid hormones are released into the blood 1. 90% is thyroxine 2. 10% is triiodothyronine III. Transport A. most all T3 & T4 bind to plasma proteins 1. 80% with thyroxine-binding globulin 2. 10 - 15% with thy ...
CELLULAR RESPIRATION
... metabolized to lactate or to CO2 and alcohol (it is species specific)…result can be net gain of only 2 ATP per molecule verses 32 – 34 under normal cycle just described ...
... metabolized to lactate or to CO2 and alcohol (it is species specific)…result can be net gain of only 2 ATP per molecule verses 32 – 34 under normal cycle just described ...
03-232 Biochemistry Exam III - S2014 Name:________________________
... Choice A: Glycolysis, gluconeogenesis, and the TCA cycle are all regulated by “energy sensing”. Select one of the three pathways and describe: i) the step that is regulated (1 pt). ii) the compounds that regulate that step, and whether they activate or inhibit the step (4 pts). iii) why this regulat ...
... Choice A: Glycolysis, gluconeogenesis, and the TCA cycle are all regulated by “energy sensing”. Select one of the three pathways and describe: i) the step that is regulated (1 pt). ii) the compounds that regulate that step, and whether they activate or inhibit the step (4 pts). iii) why this regulat ...
Endocrine System
... Describe the anatomy of the adrenal gland and name its parts. Describe the location and the function of the adrenal gland. Where is the thyroid located? How does it control metabolic rate? Is the pancreas an endocrine gland and/or an exocrine gland? Describe the cellular organization of the pancreas ...
... Describe the anatomy of the adrenal gland and name its parts. Describe the location and the function of the adrenal gland. Where is the thyroid located? How does it control metabolic rate? Is the pancreas an endocrine gland and/or an exocrine gland? Describe the cellular organization of the pancreas ...
Chapter 2 Cell Structure and Function
... 3.3 Cellular Metabolism Chemical reactions in cell are organized into metabolic pathways where every reaction has its own enzyme. Enzymes and Coenzymes Enzymes are named for their substrates and have an active site specific for the substrate. Many enzymes have nonprotein molecules, called coenzymes, ...
... 3.3 Cellular Metabolism Chemical reactions in cell are organized into metabolic pathways where every reaction has its own enzyme. Enzymes and Coenzymes Enzymes are named for their substrates and have an active site specific for the substrate. Many enzymes have nonprotein molecules, called coenzymes, ...
Identification of Genes Potentially Regulated by Human
... mitochondrial inter membrane space (IMS) where it is primarily located [9,10]. In the cytoplasm this protein performs a myriad of functions, which include but are not restricted to degradation of mRNA and miRNA species [11,12]. Adenoviral-mediated overexpression of hPNPaseold-35 causes growth inhibi ...
... mitochondrial inter membrane space (IMS) where it is primarily located [9,10]. In the cytoplasm this protein performs a myriad of functions, which include but are not restricted to degradation of mRNA and miRNA species [11,12]. Adenoviral-mediated overexpression of hPNPaseold-35 causes growth inhibi ...
Chapter 2 Cell Structure and Function
... 3.3 Cellular Metabolism Chemical reactions in cell are organized into metabolic pathways where every reaction has its own enzyme. Enzymes and Coenzymes Enzymes are named for their substrates and have an active site specific for the substrate. Many enzymes have nonprotein molecules, called coenzymes, ...
... 3.3 Cellular Metabolism Chemical reactions in cell are organized into metabolic pathways where every reaction has its own enzyme. Enzymes and Coenzymes Enzymes are named for their substrates and have an active site specific for the substrate. Many enzymes have nonprotein molecules, called coenzymes, ...
Metabolism: the Degradation and Synthesis of Living Cells
... Issues for current and future investigation on metabolism • Continue to unveil new pathways and new regulation strategies of metabolism. • Studies on enzymes. • Observation of metabolic processes in intact living organisms (e.g., in the brains under various states) • Metabolism differences among va ...
... Issues for current and future investigation on metabolism • Continue to unveil new pathways and new regulation strategies of metabolism. • Studies on enzymes. • Observation of metabolic processes in intact living organisms (e.g., in the brains under various states) • Metabolism differences among va ...
Nutritional Control of Growth and Development in Yeast
... simply by activating this pathway. Similarly, blocking signaling through the pathway concurrent with glucose addition eliminates most, albeit not all, of the responses. Thus, the PKA pathway is both necessary and sufficient for a majority of the transcriptional responses of the cell to glucose (Zama ...
... simply by activating this pathway. Similarly, blocking signaling through the pathway concurrent with glucose addition eliminates most, albeit not all, of the responses. Thus, the PKA pathway is both necessary and sufficient for a majority of the transcriptional responses of the cell to glucose (Zama ...
Genetically Encoded Fluorescent Reporters of Histone
... the flanking CFP and YFP units, and changing the FRET level. Reversal of this FRET change would be evidence for a conjectured but so far undetected histone demethylase activity. This general design, in which a conformationally sensitive natural or engineered protein is sandwiched between two GFP mut ...
... the flanking CFP and YFP units, and changing the FRET level. Reversal of this FRET change would be evidence for a conjectured but so far undetected histone demethylase activity. This general design, in which a conformationally sensitive natural or engineered protein is sandwiched between two GFP mut ...
DEFINITIONS - Microbiology Book
... Immunoglobulins:Structure and Function • Definition: Glycoprotein molecules that are produced by plasma cells in response to an immunogen and which function as antibodies ...
... Immunoglobulins:Structure and Function • Definition: Glycoprotein molecules that are produced by plasma cells in response to an immunogen and which function as antibodies ...
Human epidermal growth factor receptor (HER-1:HER
... The human epidermal growth factor (EGF) receptor (HER) family is composed of EGFR/HER-1/ErbB1, HER-2/ErbB2, HER-3/ErbB3, and HER-4/ErbB4 (1 – 3). This family of proteins share common structural features consisting of an extracellular ligand binding domain, a transmembrane domain, and a cytoplasmic k ...
... The human epidermal growth factor (EGF) receptor (HER) family is composed of EGFR/HER-1/ErbB1, HER-2/ErbB2, HER-3/ErbB3, and HER-4/ErbB4 (1 – 3). This family of proteins share common structural features consisting of an extracellular ligand binding domain, a transmembrane domain, and a cytoplasmic k ...