Journal of Chromatography
... specific nature, their number and their relative positions to each other will be decisive for the range of bond-length variations within the liquid_ The type of salt and its concentration, pH, temperature and other agents present in the media may influence the carbohydrate-lectin association either ...
... specific nature, their number and their relative positions to each other will be decisive for the range of bond-length variations within the liquid_ The type of salt and its concentration, pH, temperature and other agents present in the media may influence the carbohydrate-lectin association either ...
Section Abstracts: Structural Biology, Biochemistry, and Biophysics
... James Madison University, Harrisonburg VA 22801. RecA is an Escherichia coli protein that catalyzes the strand exchange reaction utilized in DNA repair. Previous studies have shown that the presence of salts influence RecA activity, aggregation, and stability. Here we utilized attenuated total refle ...
... James Madison University, Harrisonburg VA 22801. RecA is an Escherichia coli protein that catalyzes the strand exchange reaction utilized in DNA repair. Previous studies have shown that the presence of salts influence RecA activity, aggregation, and stability. Here we utilized attenuated total refle ...
... Choice A: Briefly describe the major thermodynamic factor that destabilizes the native (folded) state of a protein. Use an equation if appropriate. Choice B: Explain what thermodynamic factor(s) are responsible for the fact that most proteins have well packed cores. Choice C: The energy to break a h ...
Structure and Function of Salivary Proteins Outline Basic salivary
... • There are specific proteins (biomarkers) expressed in diseased or tumor tissues that are different from or absent in normal tissues ...
... • There are specific proteins (biomarkers) expressed in diseased or tumor tissues that are different from or absent in normal tissues ...
Choose the best answer for the following questions
... (A) aminoacyl-tRNA synthetases transfer the amino acids to the A on the 3’ end of tRNA via an aminoacyl-AMP intermediate. (B) the aminoacyl-tRNA synthetase is specific for a given amino acid. (C) there may be more than one kind of tRNA for a given amino acid. (D) The activation step requires the hyd ...
... (A) aminoacyl-tRNA synthetases transfer the amino acids to the A on the 3’ end of tRNA via an aminoacyl-AMP intermediate. (B) the aminoacyl-tRNA synthetase is specific for a given amino acid. (C) there may be more than one kind of tRNA for a given amino acid. (D) The activation step requires the hyd ...
Protein turnover Nitrogen Balance G/N ratio (D/N ratio)
... 2. Traces of inorganic nitrogen in the form of nitrates and nitrites Nitrogen loss 1. In urine in the form of non-protein nitrogenous substances as urea, uric acid, creatine, creatinine and ammonia 2. In stools in the form of digestive juices 3. In sweat in the form of urea Positive nitrogen balance ...
... 2. Traces of inorganic nitrogen in the form of nitrates and nitrites Nitrogen loss 1. In urine in the form of non-protein nitrogenous substances as urea, uric acid, creatine, creatinine and ammonia 2. In stools in the form of digestive juices 3. In sweat in the form of urea Positive nitrogen balance ...
`Meta` Approaches to Protein Structure Prediction
... the field of protein fold recognition. From the series of CASP experiments, it has become clear that often a correct protein fold prediction can be obtained by one server but not by the others. It has also been observed that no server can reliably distinguish between weak hits (predictions with belo ...
... the field of protein fold recognition. From the series of CASP experiments, it has become clear that often a correct protein fold prediction can be obtained by one server but not by the others. It has also been observed that no server can reliably distinguish between weak hits (predictions with belo ...
Powerpoint
... Dennehy, M. K., Richards, K. A., Wernke, G. R., Shyr, Y. and Liebler, D. C. (2006) Cytosolic and nuclear protein targets of thiol-reactive electrophiles. Chem Res Toxicol 19, 20-29 Use of mass spectrometry proteomics analysis to define the electrophile responsive proteome in cells. Levonen, A. L., L ...
... Dennehy, M. K., Richards, K. A., Wernke, G. R., Shyr, Y. and Liebler, D. C. (2006) Cytosolic and nuclear protein targets of thiol-reactive electrophiles. Chem Res Toxicol 19, 20-29 Use of mass spectrometry proteomics analysis to define the electrophile responsive proteome in cells. Levonen, A. L., L ...
Chapter 2: Chemical Basis of Life
... Thibodeau: Anatomy and Physiology, 5/e Chapter 2: Chemical Basis of Life It would be difficult to appreciate fully the characteristics of living matter and its functions without looking at the basic principles of chemistry as they apply to life processes. In fact, it is almost impossible to speak of ...
... Thibodeau: Anatomy and Physiology, 5/e Chapter 2: Chemical Basis of Life It would be difficult to appreciate fully the characteristics of living matter and its functions without looking at the basic principles of chemistry as they apply to life processes. In fact, it is almost impossible to speak of ...
The Druggable Genome - European Bioinformatics Institute
... • Manually curated efficacy targets for FDA approved drugs and WHO antimalarials • Targets with which drug interacts directly • Targets responsible for efficacy in approved indication • NOT targets responsible for adverse-effects or non-approved ...
... • Manually curated efficacy targets for FDA approved drugs and WHO antimalarials • Targets with which drug interacts directly • Targets responsible for efficacy in approved indication • NOT targets responsible for adverse-effects or non-approved ...
No Slide Title
... Inclusion cell disease (I cell disease) - rare disorder in which almost all hydrolytic enzymes are missing from lysosome I cell disease - single gene, recessive defect ...
... Inclusion cell disease (I cell disease) - rare disorder in which almost all hydrolytic enzymes are missing from lysosome I cell disease - single gene, recessive defect ...
The Human Cell Poster Advertisements
... estimated to be many times more—possibly as many as a million*. This is because a single gene might produce multiple variants of a particular protein through, for example, alternative splicing of the messenger RNA. Posttranslational modification of the nascent protein, such as phosphorylation and gl ...
... estimated to be many times more—possibly as many as a million*. This is because a single gene might produce multiple variants of a particular protein through, for example, alternative splicing of the messenger RNA. Posttranslational modification of the nascent protein, such as phosphorylation and gl ...
Evolution of paralogous proteins
... interactions with cofactors, substrates or inhibitors: Vitamin K-dependent calcium-binding domains of prothrombin, coagulation factors VII, IX, X and protein C anchor proteinases to phospholipid membranes ensuring proper regulation of cascade Kringle domains of plasmin and plasminogen are critical f ...
... interactions with cofactors, substrates or inhibitors: Vitamin K-dependent calcium-binding domains of prothrombin, coagulation factors VII, IX, X and protein C anchor proteinases to phospholipid membranes ensuring proper regulation of cascade Kringle domains of plasmin and plasminogen are critical f ...
The mammalian oxysterol-binding protein
... binding occurs within a pocket similar to that reported for the yeast S. cerevisiae ORP Osh4p [16]. We have previously characterized human ORP2, and demonstrated functional effects of ORP2 overexpression on cholesterol, phospholipid and neutral lipid metabolism [11,12,27]. We therefore chose to mode ...
... binding occurs within a pocket similar to that reported for the yeast S. cerevisiae ORP Osh4p [16]. We have previously characterized human ORP2, and demonstrated functional effects of ORP2 overexpression on cholesterol, phospholipid and neutral lipid metabolism [11,12,27]. We therefore chose to mode ...
Powerpoint slides - School of Engineering and Applied Science
... - X-ray crystallography (low to very high resolution) Problem: requires crystals; difficult to crystallize proteins by maintaining their native conformation; not all protein can be crystallized; - Nuclear magnetic resonance (NMR) spectroscopy of proteins in solution (medium to high resolution) Probl ...
... - X-ray crystallography (low to very high resolution) Problem: requires crystals; difficult to crystallize proteins by maintaining their native conformation; not all protein can be crystallized; - Nuclear magnetic resonance (NMR) spectroscopy of proteins in solution (medium to high resolution) Probl ...
Document
... - X-ray crystallography (low to very high resolution) Problem: requires crystals; difficult to crystallize proteins by maintaining their native conformation; not all protein can be crystallized; - Nuclear magnetic resonance (NMR) spectroscopy of proteins in solution (medium to high resolution) Probl ...
... - X-ray crystallography (low to very high resolution) Problem: requires crystals; difficult to crystallize proteins by maintaining their native conformation; not all protein can be crystallized; - Nuclear magnetic resonance (NMR) spectroscopy of proteins in solution (medium to high resolution) Probl ...
Carbohydrate Fans
... What forms to proteins take? What are their functions? What is the monomer (building block) of proteins? Where do we get them? Why are some amino acids essential or nonessential? How does this relate to vegetarianism/veganism? What determines a protein’s function? How can it be lost? Explain denatur ...
... What forms to proteins take? What are their functions? What is the monomer (building block) of proteins? Where do we get them? Why are some amino acids essential or nonessential? How does this relate to vegetarianism/veganism? What determines a protein’s function? How can it be lost? Explain denatur ...
The database of epoxide hydrolases and
... Although the enzyme families of the EH/HD database are different in sequence and function, they are highly conserved in structure. All structures consist of the modular architecture described for EHs (Barth et al., 2004), such as N-terminal catalytic domain, NC-loop, cap domain, cap-loop and C-termi ...
... Although the enzyme families of the EH/HD database are different in sequence and function, they are highly conserved in structure. All structures consist of the modular architecture described for EHs (Barth et al., 2004), such as N-terminal catalytic domain, NC-loop, cap domain, cap-loop and C-termi ...
New Title - Gravette School District
... Organic Compounds.” Column heads should read Group Name, Chemical Composition, Examples, and Function in Living Things. As students read the rest of the section, they should use the table to organize the information they learn about the groups of macromolecules. ...
... Organic Compounds.” Column heads should read Group Name, Chemical Composition, Examples, and Function in Living Things. As students read the rest of the section, they should use the table to organize the information they learn about the groups of macromolecules. ...
Crossing Membranes 1 – Passive Processes
... This powerpoint was kindly donated to www.worldofteaching.com http://www.worldofteaching.com Is home to well over a thousand powerpoints submitted by teachers. This a free site. Please visit and I hope it will help in your teaching ...
... This powerpoint was kindly donated to www.worldofteaching.com http://www.worldofteaching.com Is home to well over a thousand powerpoints submitted by teachers. This a free site. Please visit and I hope it will help in your teaching ...
Coordination Chemistry of Life Processes: Bioinorganic Chemistry
... synthetic system has proven more difficult. The problem becomes more demanding when catalysis is involved. The purpose of models is not necessarily to duplicate natural properties but to sharpen or focus certain questions. A synergistic approach (Figure 1) to the study of metalloproteins can and has ...
... synthetic system has proven more difficult. The problem becomes more demanding when catalysis is involved. The purpose of models is not necessarily to duplicate natural properties but to sharpen or focus certain questions. A synergistic approach (Figure 1) to the study of metalloproteins can and has ...
Gene7-26
... PDGF receptor creates SH2binding sites for several proteins. Some sites can bind more than one type of SH2 domain. Some SH2-containing proteins can bind to more than one site. The kinase domain consists of two separated regions (shown in blue), and is activated by the phosphorylation site in it. ...
... PDGF receptor creates SH2binding sites for several proteins. Some sites can bind more than one type of SH2 domain. Some SH2-containing proteins can bind to more than one site. The kinase domain consists of two separated regions (shown in blue), and is activated by the phosphorylation site in it. ...
Functions and inhibitors of SecA, an essential protein in bacterial
... efficient, and like Prl suppressors, lack signal peptide specificity; they function in the absence of functional signal peptides. The addition of SecYEG-SecDF•YajC coverts the low affinity SecAonly channels to the high-affinity channels to restore efficiency and specificity. The 901 aminoacyl residu ...
... efficient, and like Prl suppressors, lack signal peptide specificity; they function in the absence of functional signal peptides. The addition of SecYEG-SecDF•YajC coverts the low affinity SecAonly channels to the high-affinity channels to restore efficiency and specificity. The 901 aminoacyl residu ...
Cyclol
The cyclol hypothesis is the first structural model of a folded, globular protein. It was developed by Dorothy Wrinch in the late 1930s, and was based on three assumptions. Firstly, the hypothesis assumes that two peptide groups can be crosslinked by a cyclol reaction (Figure 1); these crosslinks are covalent analogs of non-covalent hydrogen bonds between peptide groups. These reactions have been observed in the ergopeptides and other compounds. Secondly, it assumes that, under some conditions, amino acids will naturally make the maximum possible number of cyclol crosslinks, resulting in cyclol molecules (Figure 2) and cyclol fabrics (Figure 3). These cyclol molecules and fabrics have never been observed. Finally, the hypothesis assumes that globular proteins have a tertiary structure corresponding to Platonic solids and semiregular polyhedra formed of cyclol fabrics with no free edges. Such ""closed cyclol"" molecules have not been observed either.Although later data demonstrated that this original model for the structure of globular proteins needed to be amended, several elements of the cyclol model were verified, such as the cyclol reaction itself and the hypothesis that hydrophobic interactions are chiefly responsible for protein folding. The cyclol hypothesis stimulated many scientists to research questions in protein structure and chemistry, and was a precursor of the more accurate models hypothesized for the DNA double helix and protein secondary structure. The proposal and testing of the cyclol model also provides an excellent illustration of empirical falsifiability acting as part of the scientific method.