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297 special transport and neurological significance of two amino
297 special transport and neurological significance of two amino

Biochemists Break the Code
Biochemists Break the Code

... Binding of a new aa-tRNA at the A site -EF-Tu (GTP), EF-Ts Formation of the new peptide bond (Transpeptidation)-23S rRNA Translocation of the Ribosome -EF-G(GTP) Repeat and Repeat until the stop codon enters the A site Binding of a new aa-tRNA at the A site At the start of each cycle, the A site on ...
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... amino acid composition, comparable in biological value with the protein of milk, fish, and beef. The soybean and derived products occupy a special place among legumes because of the high content of valuable protein (up to 40% or more) and fat (20% or more). It is the most common legume in the world. ...
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... (i.e. predictions based on some model). Each amino acid position is equally mutable. Mutations are assumed to be independent of surrounding residues. Forces responsible for sequence evolution over short time are the same as these over longer times. PAM matrices are based on protein sequences availab ...
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... are those at which any of the four nucleotides can be present in a codon for a single amino acid. In some cases there is redundancy in the first codon position, e.g, both AGA and CGA are codons for arginine. Thus, many nucleotide substitutions at third positions do not lead to amino acid substitutio ...
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Urea Cycle Defect: A Case Study

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Amino acid synthesis

Amino acid synthesis is the set of biochemical processes (metabolic pathways) by which the various amino acids are produced from other compounds. The substrates for these processes are various compounds in the organism's diet or growth media. Not all organisms are able to synthesise all amino acids. Humans are excellent example of this, since humans can only synthesise 11 of the 20 standard amino acids (aka non-essential amino acid), and in time of accelerated growth, arginine, can be considered an essential amino acid.A fundamental problem for biological systems is to obtain nitrogen in an easily usable form. This problem is solved by certain microorganisms capable of reducing the inert N≡N molecule (nitrogen gas) to two molecules of ammonia in one of the most remarkable reactions in biochemistry. Ammonia is the source of nitrogen for all the amino acids. The carbon backbones come from the glycolytic pathway, the pentose phosphate pathway, or the citric acid cycle.In amino acid production, one encounters an important problem in biosynthesis, namely stereochemical control. Because all amino acids except glycine are chiral, biosynthetic pathways must generate the correct isomer with high fidelity. In each of the 19 pathways for the generation of chiral amino acids, the stereochemistry at the α-carbon atom is established by a transamination reaction that involves pyridoxal phosphate. Almost all the transaminases that catalyze these reactions descend from a common ancestor, illustrating once again that effective solutions to biochemical problems are retained throughout evolution.Biosynthetic pathways are often highly regulated such that building-blocks are synthesized only when supplies are low. Very often, a high concentration of the final product of a pathway inhibits the activity of enzymes that function early in the pathway. Often present are allosteric enzymes capable of sensing and responding to concentrations of regulatory species. These enzymes are similar in functional properties to aspartate transcarbamoylase and its regulators. Feedback and allosteric mechanisms ensure that all twenty amino acids are maintained in sufficient amounts for protein synthesis and other processes.
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