Therapeutic approaches to Lysosomal Storage Disorders
... deficit of lysosomal or non-lysosomal proteins, resulting in the accumulation of undegraded substrates in lysosomes. Recent studies support the idea that LSDs are associated with a global impairment of the entire endo-lysosomal compartment, specifically of autophagy involved in the principal lysosom ...
... deficit of lysosomal or non-lysosomal proteins, resulting in the accumulation of undegraded substrates in lysosomes. Recent studies support the idea that LSDs are associated with a global impairment of the entire endo-lysosomal compartment, specifically of autophagy involved in the principal lysosom ...
Protein Dynamics in the Plant Extracellular Space
... contamination, such as the analysis of the growth medium of cell cultures. This method allows the study of secreted proteins but has limited biological significance. Extracellular proteins, that should have a signal peptide, are secreted by the endomembrane system formed by the endoplasmic reticulum ...
... contamination, such as the analysis of the growth medium of cell cultures. This method allows the study of secreted proteins but has limited biological significance. Extracellular proteins, that should have a signal peptide, are secreted by the endomembrane system formed by the endoplasmic reticulum ...
Molecular mechanisms of Salmonella invasion
... to be highly relevant to the understanding of the natural infection process [25, 28, 50]. The ability of S. typhimurium to invade ...
... to be highly relevant to the understanding of the natural infection process [25, 28, 50]. The ability of S. typhimurium to invade ...
The water of life: osmoregulation in Saccharomyces cerevisiae
... Interactions between the target of rapamycin (TOR) and the CWI pathways during nutrient stress, and effects on osmotolerance ...
... Interactions between the target of rapamycin (TOR) and the CWI pathways during nutrient stress, and effects on osmotolerance ...
Determination of Symmetric and Asymmetric Division Planes in
... planes that would not be predicted by mother cell shape and generate daughters with distinct sizes, shapes, and/or developmental fates. For example, asymmetric cell divisions in root meristems follow a stereotyped pattern that establishes distinct cell layers with different identities and functions ...
... planes that would not be predicted by mother cell shape and generate daughters with distinct sizes, shapes, and/or developmental fates. For example, asymmetric cell divisions in root meristems follow a stereotyped pattern that establishes distinct cell layers with different identities and functions ...
Enzymatic lysis of microbial cells
... interaction with the cell surface (Iacono et al. 1985). In addition, nonlytic bactericidal mechanism, involving membrane damage without hydrolysis of peptidoglycan, has been reported for c-type lysozymes, including human lysozyme (Laible and Germaine 1985) and hen egg white lysozyme (HEWL) (Ibrahim ...
... interaction with the cell surface (Iacono et al. 1985). In addition, nonlytic bactericidal mechanism, involving membrane damage without hydrolysis of peptidoglycan, has been reported for c-type lysozymes, including human lysozyme (Laible and Germaine 1985) and hen egg white lysozyme (HEWL) (Ibrahim ...
Introduction to Anatomy ontologies
... CARO is a structural classification based on granularity From the bottom up: Cell component Cell Portion of tissue Multi-tissue structure From the top down: Organism subdivision Anatomical system Acellular structures Note: CARO is being updated to be more interoperable, include logical definitions, ...
... CARO is a structural classification based on granularity From the bottom up: Cell component Cell Portion of tissue Multi-tissue structure From the top down: Organism subdivision Anatomical system Acellular structures Note: CARO is being updated to be more interoperable, include logical definitions, ...
Regulated adhesion as a driving force of gastrulation movements
... often used to measure relative ‘adhesiveness’ between cells, because cells with higher affinity end up in the centre of reaggregates, surrounded by cells with lower affinity (Steinberg, 2007). Several variants of the assay exist, for instance, incubating cells in ‘hanging drops’ or re-transplanting ...
... often used to measure relative ‘adhesiveness’ between cells, because cells with higher affinity end up in the centre of reaggregates, surrounded by cells with lower affinity (Steinberg, 2007). Several variants of the assay exist, for instance, incubating cells in ‘hanging drops’ or re-transplanting ...
Plant microtubule organization
... participate in active transport and cytoplasmic streaming but, unlike in animal cells, microtubules, not actin filaments, are the dominant element at the plasma membrane. The concept of a cytoskeleton–plasma-membrane–cell-wall continuum in plant cells (Wyatt and Carpita, 1993) necessarily emphasizes ...
... participate in active transport and cytoplasmic streaming but, unlike in animal cells, microtubules, not actin filaments, are the dominant element at the plasma membrane. The concept of a cytoskeleton–plasma-membrane–cell-wall continuum in plant cells (Wyatt and Carpita, 1993) necessarily emphasizes ...
The water of life: osmoregulation in Saccharomyces cerevisiae
... Interactions between the target of rapamycin (TOR) and the CWI pathways during nutrient stress, and effects on osmotolerance ...
... Interactions between the target of rapamycin (TOR) and the CWI pathways during nutrient stress, and effects on osmotolerance ...
Apoptosis-inducing factor is involved in the regulation of caspase
... In wild-type neurons, treatment with camptothecin resulted in a rapid loss of neuronal survival beginning at 12 h, and within 24 h, survival had decreased to 20% (Fig. 1 A). In contrast, Apaf1-deficient neurons remained largely viable during the first 24 h of treatment. However, after 24 h, cell s ...
... In wild-type neurons, treatment with camptothecin resulted in a rapid loss of neuronal survival beginning at 12 h, and within 24 h, survival had decreased to 20% (Fig. 1 A). In contrast, Apaf1-deficient neurons remained largely viable during the first 24 h of treatment. However, after 24 h, cell s ...
to the complete text
... Max Otto Reinhardt (1892) documented an orthogonal pattern of tip expansion consistent with the action of an isotropic force against the inner surface of the cell wall. He argued, however, that turgor was necessary only to maintain contact between the plasma membrane and the inner surface of the cel ...
... Max Otto Reinhardt (1892) documented an orthogonal pattern of tip expansion consistent with the action of an isotropic force against the inner surface of the cell wall. He argued, however, that turgor was necessary only to maintain contact between the plasma membrane and the inner surface of the cel ...
Full-Text PDF
... (e.g., dermatitis, folliculitis, and abscesses) to life-threatening systemic infections (e.g., endocarditis, pneumonia, atherosclerosis, and septicemia). As a rule, S. aureus (Sa) has been considered an extracellular pathogen, but increasing evidence indicates that this bacterium can invade cells an ...
... (e.g., dermatitis, folliculitis, and abscesses) to life-threatening systemic infections (e.g., endocarditis, pneumonia, atherosclerosis, and septicemia). As a rule, S. aureus (Sa) has been considered an extracellular pathogen, but increasing evidence indicates that this bacterium can invade cells an ...
Auxin-Dependent Cell Division and Cell Elongation. 1
... pathways. In fact, the response of cell division to auxin has been shown recently to require the activity of a putative heterotrimeric G-protein, whereas the response of cell elongation was not dependent on this G-protein (Ullah et al., 2001, 2003). When different receptors are involved, they are ex ...
... pathways. In fact, the response of cell division to auxin has been shown recently to require the activity of a putative heterotrimeric G-protein, whereas the response of cell elongation was not dependent on this G-protein (Ullah et al., 2001, 2003). When different receptors are involved, they are ex ...
Hydrocortisone Diffusion Through Synthetic Membrane
... Higuchi's diffusion controlled model. T h e H C release was faster from 2.5% compared to 1% creams, which in turn was faster than froin 0.5% H C cream [3]. T h e release rate ranged between 0.61 and 2.68 pg/cm'/minO.' for betamethsone dipropionate depending on the percentage of ethanol in the recept ...
... Higuchi's diffusion controlled model. T h e H C release was faster from 2.5% compared to 1% creams, which in turn was faster than froin 0.5% H C cream [3]. T h e release rate ranged between 0.61 and 2.68 pg/cm'/minO.' for betamethsone dipropionate depending on the percentage of ethanol in the recept ...
Limbal stem cell deficiency and its management
... Firstly, the corneal epithelium is renewed by stem cells located at the limbus, the socalled limbal stem cells. Secondly, the limbus also acts as a barrier preventing the conjunctival epithelium and its blood vessels from encroaching on to the corneal surface. When the limbal stem cells become defic ...
... Firstly, the corneal epithelium is renewed by stem cells located at the limbus, the socalled limbal stem cells. Secondly, the limbus also acts as a barrier preventing the conjunctival epithelium and its blood vessels from encroaching on to the corneal surface. When the limbal stem cells become defic ...
Mechanism of action
... Alergy – usually after sensibilisation caused by very small dose and given in not natural way -frequent in PNC -look for them in history -polymorphic exanthema,eosinofília,edema,conjunctivitis photodermatoses,anaphylactic shock... -dangerouse formes in parenteral application of ATB -can arise as ear ...
... Alergy – usually after sensibilisation caused by very small dose and given in not natural way -frequent in PNC -look for them in history -polymorphic exanthema,eosinofília,edema,conjunctivitis photodermatoses,anaphylactic shock... -dangerouse formes in parenteral application of ATB -can arise as ear ...
Journal of Applied Microbiology
... adhesion to and colonization of host surfaces. The mechanisms underlying the adhesion of Aeromonas spp. to epithelial cells are not well understood and seem to be a complex process, apparently involving the occurrence of sequential or simultaneous factors. Aeromonas spp. adhesion factors that have b ...
... adhesion to and colonization of host surfaces. The mechanisms underlying the adhesion of Aeromonas spp. to epithelial cells are not well understood and seem to be a complex process, apparently involving the occurrence of sequential or simultaneous factors. Aeromonas spp. adhesion factors that have b ...
anatomy of the ear
... They are in a uni-compartment fluid system. That is to say, it is a self contained unit in which cells change motion activity into neural activity. That occurs on both the vestibular or balance side as well as on the cochlear or hearing side. These structures are known as the labyrinth. ...
... They are in a uni-compartment fluid system. That is to say, it is a self contained unit in which cells change motion activity into neural activity. That occurs on both the vestibular or balance side as well as on the cochlear or hearing side. These structures are known as the labyrinth. ...
Structure and properties of the outer membranes of Brucella abortus
... Group 3 Two proteins of 25 and 31 kDa with only 34% of identity are included in group 3 [50] and they are coded for by the omp25 and omp31 genes [5]. Based on algorithmic analyses of the predicted amino acid sequences, none of these two proteins would show the hydrophobicity of Omp2b and both would ...
... Group 3 Two proteins of 25 and 31 kDa with only 34% of identity are included in group 3 [50] and they are coded for by the omp25 and omp31 genes [5]. Based on algorithmic analyses of the predicted amino acid sequences, none of these two proteins would show the hydrophobicity of Omp2b and both would ...
BSC 2085 Lab Manual Copy - Lake
... membrane potential of -60 mv. The membrane potential that a cell maintains is known as the resting membrane potential (RMP). In order to get the energy out of a battery you need to connect the opposite poles together with a wire. Charged particles move through the wire traveling from one end of the ...
... membrane potential of -60 mv. The membrane potential that a cell maintains is known as the resting membrane potential (RMP). In order to get the energy out of a battery you need to connect the opposite poles together with a wire. Charged particles move through the wire traveling from one end of the ...
Taipoxin Induces Synaptic Vesicle Exocytosis and Disrupts the
... been generated, and ubiquitous homologs of SV proteins have been identified, leading to the notion that similar sets of proteins are involved in all membrane trafficking events in eukaryotes (Südhof, 2004). A large number of molecular interactions have been shown to occur in vitro among proteins in ...
... been generated, and ubiquitous homologs of SV proteins have been identified, leading to the notion that similar sets of proteins are involved in all membrane trafficking events in eukaryotes (Südhof, 2004). A large number of molecular interactions have been shown to occur in vitro among proteins in ...
The plant Golgi apparatus—Going with the flow
... glycosylated, and the synthesis of complex polysaccharides characteristic of plants is undertaken. The plant Golgi is specialised in the synthesis and the export of complex glycans to the cell surface to organise the cell walls, which are mainly composed of polysaccharides (cellulose, hemicelluloses ...
... glycosylated, and the synthesis of complex polysaccharides characteristic of plants is undertaken. The plant Golgi is specialised in the synthesis and the export of complex glycans to the cell surface to organise the cell walls, which are mainly composed of polysaccharides (cellulose, hemicelluloses ...
Taipoxin Induces Synaptic Vesicle Exocytosis and Disrupts the
... been generated, and ubiquitous homologs of SV proteins have been identified, leading to the notion that similar sets of proteins are involved in all membrane trafficking events in eukaryotes (Südhof, 2004). A large number of molecular interactions have been shown to occur in vitro among proteins in ...
... been generated, and ubiquitous homologs of SV proteins have been identified, leading to the notion that similar sets of proteins are involved in all membrane trafficking events in eukaryotes (Südhof, 2004). A large number of molecular interactions have been shown to occur in vitro among proteins in ...
The Golgi-Localized Arabidopsis Endomembrane
... sorting signals required for retrograde Golgi-to-ER transport of several type I membrane proteins that interact with COPI vesicles (Cosson and Letourneur, 1994; Schröder et al., 1995; Harter and Wieland, 1998; Gomez et al., 2000). Recently, the semiconserved Phe-Leu-Ser-like motifs were identified as ...
... sorting signals required for retrograde Golgi-to-ER transport of several type I membrane proteins that interact with COPI vesicles (Cosson and Letourneur, 1994; Schröder et al., 1995; Harter and Wieland, 1998; Gomez et al., 2000). Recently, the semiconserved Phe-Leu-Ser-like motifs were identified as ...
Cell membrane
The cell membrane (also known as the plasma membrane or cytoplasmic membrane) is a biological membrane that separates the interior of all cells from the outside environment. The cell membrane is selectively permeable to ions and organic molecules and controls the movement of substances in and out of cells. The basic function of the cell membrane is to protect the cell from its surroundings. It consists of the phospholipid bilayer with embedded proteins. Cell membranes are involved in a variety of cellular processes such as cell adhesion, ion conductivity and cell signalling and serve as the attachment surface for several extracellular structures, including the cell wall, glycocalyx, and intracellular cytoskeleton. Cell membranes can be artificially reassembled.