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Cannabis, A Breed Apart - Canadian Cannabis Coalition
Cannabis, A Breed Apart - Canadian Cannabis Coalition

... Considering the possible contributions of other cannabis components, such as flavonoids and essential oils to therapeutic effects on mood reviewed in (McPartland, and Pruitt 1999), one must readily assent to Dr. Mechoulam’s quotation (Mechoulam and Ben-Shabat 1999): This type of synergism may play a ...
The human cardiac K2P3.1 (TASK-1) potassium leak channel is a
The human cardiac K2P3.1 (TASK-1) potassium leak channel is a

... Foster City, CA, USA) and Origin (OriginLab, Northampton, MA, USA) software for data acquisition and analysis. Data were sampled at 2 kHz and filtered at 1 kHz. All experiments were carried out at room temperature (20–22°C), and no leak subtraction was done during the experiments. Solutions and drug ...
Chemical Information Review Document  for [CAS No. 15920-93-1]
Chemical Information Review Document for [CAS No. 15920-93-1]

... brain cells, L-BMAA (5 mM [0.6 mg/mL]) increased intracellular calcium levels in a dose-dependent manner in the presence of bicarbonate ion. In rat cerebellar granule cells and ventral spinal cord cells, cell death was induced. Dose-dependent toxicity was also seen in rat neuronal cells and hippoca ...
The relationship between irritable bowel syndrome to clinical manifestations
The relationship between irritable bowel syndrome to clinical manifestations

... factors. Communication between central nervous system and enteric nervous system implies a bidirectional connection system: the brain influences the function of the enteric nervous system, and the gut influences the brain via vagal and sympathetic afferents. The symptoms may be caused by dysfunction ...
Nocturnal Penile Tumescence
Nocturnal Penile Tumescence

... its potent antagonism of serotonin-2 (5-HT 2) receptors and its ability to inhibit the reuptake of serotonin (5HT) (3). Ex vivo animal studies indicate a lack of norepinephrine reuptake inhibition by nefazodone although this effect occurred in vitro (3). Pharmacologically, nefazodone and trazodone a ...
Application
Application

... Many similarities between the product ion MS-MS spectra and the in-source collision ...
Delineation of a frequency-organized region isolated from the
Delineation of a frequency-organized region isolated from the

... right auditory cortex were incised. A piece of metal was attached to the skull with dental resin, and the head was fixed by screwing the metal piece onto a manipulator. The skull over the auditory cortex was removed in mice used for some experiments (see Figs. 2B, 3, 4, 6, 8, 12, and 13) to compare ...
The dual-pathway model of auditory signal
The dual-pathway model of auditory signal

... selectivity respond to speed and direction of stimulus motions[7]. Some striking similarities have been revealed between the human visual cortex and the monkey visual cortex by functional brain-imaging studies. Functional brain imaging techniques using positron emission tomography (PET) and function ...
Campus Location: Wilmington Effective Date: 2018
Campus Location: Wilmington Effective Date: 2018

... 8.1 Discuss the mode of action of selected medications used to treat the endocrine, reproductive, and skeletal systems. 8.2 Identify the potential side effects of endocrine, reproductive, and skeletal medications. 8.3 Describe the contraindications of endocrine, reproductive, and skeletal medication ...
FSC402H Forensic Toxicology of Common Pharmaceuticals
FSC402H Forensic Toxicology of Common Pharmaceuticals

...  Often information on dose, not plasma (blood) concentration is available  No means through law to obtain a blood sample from an individual – seized hospital samples from motor vehicle collisions ...
Clinical Medicine: Therapeutics pharmacotherapy of Fibromyalgia
Clinical Medicine: Therapeutics pharmacotherapy of Fibromyalgia

... and attempts to establish evidence based or practice based guidelines for treatment options. Inside multimodal and multidisciplinary treatments, it is essential to consider drug therapies. Tricyclic antidepressants (TCAs) have been the first daily used drugs to treat fibromyalgia. Main trials conduc ...
Determining the subjective and physiological effects
Determining the subjective and physiological effects

... humans has also not been well described, although it has been shown that BZP is excreted primarily by the kidney (Staack et al. 2002; Tsutsumi et al. 2006). Research by Staack et al. (2002) combined with recent studies conducted at the University of Auckland demonstrate that the hepatic enzyme CYP2D ...
Toward the Neurocomputer: Image Processing and Pattern
Toward the Neurocomputer: Image Processing and Pattern

... Maria Elisabetta Ruaro, Paolo Bonifazi, and Vincent Torre* ...
Selectivity and Tolerance - Penn Arts and Sciences
Selectivity and Tolerance - Penn Arts and Sciences

... pairings) ranged from $0.7432 to 0.8939. This confirms that the algorithm successfully converged for the images we included in this study and that the scrambled version of each image is much closer to its natural counterpart than to all other images in the set [when measured in a Portilla and Simonc ...
Drugs The Straight Facts, Sleep Aids
Drugs The Straight Facts, Sleep Aids

... body enters REM sleep (Figure 1.1). This stage of sleep is like no other state of consciousness and is when most dreaming occurs. REM sleep is so-named because it is characterized by rapid movements of the eyes back and forth (behind closed eyelids, usually). In addition, breathing and heart rate pa ...
Drug Monitoring: Simultaneous Analysis of Lamotrigine
Drug Monitoring: Simultaneous Analysis of Lamotrigine

... with a Supelcosil LC-18 column (25 cm × 4.6 mm internal diameter, 5 µM silica particles; Supelco, Bellefonte, PA). The mobile phase was a mixture of aqueous 3mM potassium phosphate buffer (adjusted to pH 3.7 with 5% phosphoric acid) and acetonitrile (65:35) at a flow rate of 1.2 mL/min. Oxcarbazepin ...
Selectivity and Tolerance - Center for Neural Science
Selectivity and Tolerance - Center for Neural Science

... pairings) ranged from ⫺0.7432 to 0.8939. This confirms that the algorithm successfully converged for the images we included in this study and that the scrambled version of each image is much closer to its natural counterpart than to all other images in the set [when measured in a Portilla and Simonc ...
FLRT proteins act as guidance cues for migrating cortical interneurons
FLRT proteins act as guidance cues for migrating cortical interneurons

... 5.1 Effects of FLRT2 and FLRT3 ablation in the cortical interneurons migration through the SP stream ...................................................................................... 148 5.2 Regulation of the interneurons migration through the SP stream .............. 152 5.3 Late developomenta ...
Effects of uniform extracellular DC electric fields on excitability in rat
Effects of uniform extracellular DC electric fields on excitability in rat

... be emphasized that endogenous fields were not present in intracellular field sensitivity and optical mapping experiments. The term ‘uniform’ is consistently used in the literature to distinguish exogenous fields applied via large parallel wires, as used here, from ‘local’ or ‘radial’ fields applied ...
the 2014 drug trend report
the 2014 drug trend report

Toluene exposure causes mental depression in adult mice
Toluene exposure causes mental depression in adult mice

... compared to vehicle-treated mice at 1 (vehicle-treated control: 93 ± 5.1 s, toluene-treated mice: 139.6 ± 18.4 s; n = 7, p < 0.05) and 4 days (vehicle-treated control: 108.1 ± 3.8 s, toluene-treated mice: 195.6 ± 6.1 s; n = 7, p < 0.001) after injection (Fig. 1A). Similarly, immobility time in the F ...
William Llewellyn`s ANABOLICS
William Llewellyn`s ANABOLICS

... anabolic/androgenic steroids and other drugs. Legitimate pharmaceuticals are labeled and grouped by their country of manufacture. The following terms are used to identify the origin of individual drug products. Real (or no specification other than country): These legitimate pharmaceutical products a ...
Anti-inflammatory and Analgesic Activity of Methanolic Extract of
Anti-inflammatory and Analgesic Activity of Methanolic Extract of

... Analgesics are drugs that selectively relieve pain by acting in the CNS or on peripheral pain mechanisms, without significantly altering consciousness. Analgesics relieve pain, without affecting its cause. Analgesics are divided into two groups, opioid analgesic and non-opioid analgesic [3]. The use ...
Electrolytic lesion of globus pallidus ameliorates the behavioral and
Electrolytic lesion of globus pallidus ameliorates the behavioral and

... astrocytes. To quantify the size of the striatal lesion, images of coronal brain sections that contained the core of the lesions were captured for computer assisted image analysis. Striatal lesion size and the size of dorsal striatum on the right and left hemispheres were measured for each rat. The ...
pdf
pdf

... frequency and bandwidth [24]. One possibility might be that the auditory cortex only codes for tinnitus intensity discrimination [46], and since both groups are characterized by the same VAS intensity scores, subtracting the two groups results in an absence of activation. Yet, another methodological ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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