Vascular Targeting Agents as Cancer Therapeutics
... toward experimental tumors but was toxic in cancer patients (70). The antivascular effects of FAA in experimental tumors are mediated via the release of tumor necrosis factor ␣ from activated mouse macrophages (71, 72). The lack of clinical activity of FAA led to the development of the FAA analogue ...
... toward experimental tumors but was toxic in cancer patients (70). The antivascular effects of FAA in experimental tumors are mediated via the release of tumor necrosis factor ␣ from activated mouse macrophages (71, 72). The lack of clinical activity of FAA led to the development of the FAA analogue ...
Fast Network Oscillations in the Hippocampal CA1
... events correlated with the relative increase in firing frequency of neurons (Fig. 3B,C). The correlation with pyramidal cell discharges was linear, except for the lowest-amplitude events (,4 SD). Interneurons also increased their firing rate as a f unction of the field amplitude, but rate of the inc ...
... events correlated with the relative increase in firing frequency of neurons (Fig. 3B,C). The correlation with pyramidal cell discharges was linear, except for the lowest-amplitude events (,4 SD). Interneurons also increased their firing rate as a f unction of the field amplitude, but rate of the inc ...
4: Central nervous system - Gateshead Health NHS Foundation Trust
... pharmacodynamic interactions (serotonin syndrome, hypotension, drowsiness) and pharmacokinetic interactions (e.g. elevation of tricyclic plasma levels by some SSRIs). The serotonin syndrome may include restlessness, diaphoresis, tremor, shivering, myoclonus, confusion, convulsions and death. ...
... pharmacodynamic interactions (serotonin syndrome, hypotension, drowsiness) and pharmacokinetic interactions (e.g. elevation of tricyclic plasma levels by some SSRIs). The serotonin syndrome may include restlessness, diaphoresis, tremor, shivering, myoclonus, confusion, convulsions and death. ...
Urine Drug Monitoring: Opioids
... illness. Pharmacotherapy is, and continues to be, one of the most powerful methods we have to treat and/or cure disease. Recent advances in technology, molecular biology, pharmacology, chemistry, biophysics and analytical chemistry have made available to prescribers the same powerful diagnostic proc ...
... illness. Pharmacotherapy is, and continues to be, one of the most powerful methods we have to treat and/or cure disease. Recent advances in technology, molecular biology, pharmacology, chemistry, biophysics and analytical chemistry have made available to prescribers the same powerful diagnostic proc ...
THE ROLE OF CYP3A4/5 IN ALPRAZOLAM METABOLISM
... Single nucleotide polymorphism Therapeutic drug monitoring Thiopurine methyltransferase UDP-glucuronosyltranseferase enzymes Maximum rate of formation ...
... Single nucleotide polymorphism Therapeutic drug monitoring Thiopurine methyltransferase UDP-glucuronosyltranseferase enzymes Maximum rate of formation ...
Chemical, pharmacokinetic and pharmacodynamic properties of
... triglyceride-rich lipoproteins [5,6]. In addition, statins may exert beneficial cardiovascular effects independent of their lipid-modifying properties [7]. These pleiotropic properties may be explained by inhibition of synthesis of nonsteroidal isoprenoid compounds, which are also produced from meva ...
... triglyceride-rich lipoproteins [5,6]. In addition, statins may exert beneficial cardiovascular effects independent of their lipid-modifying properties [7]. These pleiotropic properties may be explained by inhibition of synthesis of nonsteroidal isoprenoid compounds, which are also produced from meva ...
Understanding Stimulant Drugs
... circulation- an effect that historically has made cocaine the preferred local anesthetic agent for eye surgery and other delicate procedures. The local anesthetic effects of cocaine are most pronounced when it is applied to the skin or mucous membranes. Thus, when cocaine is “snorted” it temporarily ...
... circulation- an effect that historically has made cocaine the preferred local anesthetic agent for eye surgery and other delicate procedures. The local anesthetic effects of cocaine are most pronounced when it is applied to the skin or mucous membranes. Thus, when cocaine is “snorted” it temporarily ...
Material and methods
... Solubility plays a vital role in the drug effectiveness and is applicable to dosage forms administered by different routes. It also possesses a major challenge for developing new pharmaceutical products, since nearly 60% of the drugs obtained directly from synthesis are either insoluble or poorly so ...
... Solubility plays a vital role in the drug effectiveness and is applicable to dosage forms administered by different routes. It also possesses a major challenge for developing new pharmaceutical products, since nearly 60% of the drugs obtained directly from synthesis are either insoluble or poorly so ...
The Organization of Behavioral Repertoire in Motor Cortex
... may emphasize different ethologically relevant categories of behavior, such as interactions between the hand and the mouth, reaching motions, or defensive maneuvers to protect the body surface from impending impact. Single neurons in motor cortex may contribute to these behaviors by means of their b ...
... may emphasize different ethologically relevant categories of behavior, such as interactions between the hand and the mouth, reaching motions, or defensive maneuvers to protect the body surface from impending impact. Single neurons in motor cortex may contribute to these behaviors by means of their b ...
Neural stem cell engineering: directed differentiation of adult and
... emphasis will be on approaches to direct cell differentiation into therapeutically valuable cell types, as well as on their subsequent implantation into animal models. Furthermore, the role of signals from the stem cell niche or microenvironment in controlling cell behavior will be discussed, in par ...
... emphasis will be on approaches to direct cell differentiation into therapeutically valuable cell types, as well as on their subsequent implantation into animal models. Furthermore, the role of signals from the stem cell niche or microenvironment in controlling cell behavior will be discussed, in par ...
How Do Atrial-Selective Drugs Differ From Antiarrhythmic
... Current pharmacologic strategies for the management of atrial fibrillation (AF) include use of 1) sodium channel blockers, which are contraindicated in patients with coronary artery or structural heart disease because of their potent effect to slow conduction in the ventricles, 2) potassium channel ...
... Current pharmacologic strategies for the management of atrial fibrillation (AF) include use of 1) sodium channel blockers, which are contraindicated in patients with coronary artery or structural heart disease because of their potent effect to slow conduction in the ventricles, 2) potassium channel ...
A European Respiratory Review on ...
... to develop long-acting beta-agonists. The pharmacology of these agents has been extensively reviewed in this journal [5). A thoroughly investigated long acting beta-agonists is salmeterol. Pharmacological development of this molecule, led by Or R Brittain of Glaxo Group Research, was on the rational ...
... to develop long-acting beta-agonists. The pharmacology of these agents has been extensively reviewed in this journal [5). A thoroughly investigated long acting beta-agonists is salmeterol. Pharmacological development of this molecule, led by Or R Brittain of Glaxo Group Research, was on the rational ...
Document Content Authoring and Hybrid Knowledge Bases
... authoring, in which the flow of information is strictly from the knowledge base to the document. The MDA approach is briefly presented, and we show how the document specification can be interfaced with an “informationally complete” KB, using a Datalog representation [3]; then we present conditions o ...
... authoring, in which the flow of information is strictly from the knowledge base to the document. The MDA approach is briefly presented, and we show how the document specification can be interfaced with an “informationally complete” KB, using a Datalog representation [3]; then we present conditions o ...
Estrogens, Progestins, and Specific Estrogen
... hormone gene transcription. Gene activation is mediated by the ability of steroid hormone receptor complexes to recruit nuclear coactivator proteins to the transcription complex. Gene repression occurs in a ligand-dependent fashion by the recruitment of nuclear corepressor proteins to the transcript ...
... hormone gene transcription. Gene activation is mediated by the ability of steroid hormone receptor complexes to recruit nuclear coactivator proteins to the transcription complex. Gene repression occurs in a ligand-dependent fashion by the recruitment of nuclear corepressor proteins to the transcript ...
Extraction of Sensory Parameters from a Neural Map by Primary
... Figure 1. Functional organization of the cricket cercal sensory system. A, Schematic diagram of the common house cricket, Acheta domestica, showing the location of the abdominal nerve cord. The cerci are two abdominal appendages projecting from the rear of the animal’s body. Both cerci are covered w ...
... Figure 1. Functional organization of the cricket cercal sensory system. A, Schematic diagram of the common house cricket, Acheta domestica, showing the location of the abdominal nerve cord. The cerci are two abdominal appendages projecting from the rear of the animal’s body. Both cerci are covered w ...
Electroencephalography - Department of Computational and
... from the currents within a single dendritic spine to the relatively gross potentials that the EEG records from the scalp, much the same way that economics can be studied from the level of a single individual's personal finances to the macro-economics of nations. Neurons, or nerve cells, are electric ...
... from the currents within a single dendritic spine to the relatively gross potentials that the EEG records from the scalp, much the same way that economics can be studied from the level of a single individual's personal finances to the macro-economics of nations. Neurons, or nerve cells, are electric ...
Resonance Effect for Neural Spike Time Reliability
... responses are also observed in motion-sensitive neurons in response to time-varying visual stimuli in the fly (de Ruyter van Steveninck et al. 1997). These results suggest that the intrinsic noise in the spike-generating mechanism is low relative to the intensity of the fluctuating input currents. I ...
... responses are also observed in motion-sensitive neurons in response to time-varying visual stimuli in the fly (de Ruyter van Steveninck et al. 1997). These results suggest that the intrinsic noise in the spike-generating mechanism is low relative to the intensity of the fluctuating input currents. I ...
Pharm in Orofacial Pain Final
... • Opioid rotation is a potential strategy for patients who have intolerable side effects or inadequate benefit. The theory is based on concepts of incomplete cross-tolerance to the analgesic and non-analgesic effects and the high degree of individual variation in patient ...
... • Opioid rotation is a potential strategy for patients who have intolerable side effects or inadequate benefit. The theory is based on concepts of incomplete cross-tolerance to the analgesic and non-analgesic effects and the high degree of individual variation in patient ...
Prenatal Substance Abuse
... effects on the placental and umbilical vessels all play a role.37,38 Nicotine also has been shown to have significant deleterious effects on brain development, including alterations in brain metabolism and neurotransmitter systems and abnormal brain development.39–43 Additional toxicity from compound ...
... effects on the placental and umbilical vessels all play a role.37,38 Nicotine also has been shown to have significant deleterious effects on brain development, including alterations in brain metabolism and neurotransmitter systems and abnormal brain development.39–43 Additional toxicity from compound ...
Prenatal Substance Abuse: Short- and Long
... effects on the placental and umbilical vessels all play a role.37,38 Nicotine also has been shown to have significant deleterious effects on brain development, including alterations in brain metabolism and neurotransmitter systems and abnormal brain development.39–43 Additional toxicity from compound ...
... effects on the placental and umbilical vessels all play a role.37,38 Nicotine also has been shown to have significant deleterious effects on brain development, including alterations in brain metabolism and neurotransmitter systems and abnormal brain development.39–43 Additional toxicity from compound ...
M a s t
... phenomenon of brain drain (from the traditional to contemporary approaches). In doing so, I will present and evaluate the significance and effects of skilled migration while considering the debates in academic deliberations on brain drain perspectives. This means that a theoretical debate with it’s ...
... phenomenon of brain drain (from the traditional to contemporary approaches). In doing so, I will present and evaluate the significance and effects of skilled migration while considering the debates in academic deliberations on brain drain perspectives. This means that a theoretical debate with it’s ...
Butorphanol-Mediated Antinociception in Mice: Partial Agonist
... are mediated by mu receptors, a finding supported by its sensitivity to the antagonist effects of the competitive antagonist quadazocine and by an apparent pA2 value that has been associated with activity at mu receptors (Butelman et al., 1995). Conversely, in squirrel monkeys, butorphanol attenuate ...
... are mediated by mu receptors, a finding supported by its sensitivity to the antagonist effects of the competitive antagonist quadazocine and by an apparent pA2 value that has been associated with activity at mu receptors (Butelman et al., 1995). Conversely, in squirrel monkeys, butorphanol attenuate ...
Drug Update Management of Intracranial Hypertension: Focus on Pharmacologic Strategies
... and renal dysfunction. Barbiturates as a pharmacologic class cause widespread suppression of all excitable tissue, including the central nervous system. This central nervous system depression may range from calmness and sleep to unconsciousness and coma, which may progress in a dose-dependent fashio ...
... and renal dysfunction. Barbiturates as a pharmacologic class cause widespread suppression of all excitable tissue, including the central nervous system. This central nervous system depression may range from calmness and sleep to unconsciousness and coma, which may progress in a dose-dependent fashio ...
Inhalation rate of sodium cromoglycate ... plasma pharmacokinetics and protection against
... central particle deposition. In a recent study we have shown that bronchoconstriction produced more central deposition of inhaled SCG but did not affect its plasma pharmacokinetics, suggesting that the site of deposition is not important in determining the amount absorbed into the circulation [17]. ...
... central particle deposition. In a recent study we have shown that bronchoconstriction produced more central deposition of inhaled SCG but did not affect its plasma pharmacokinetics, suggesting that the site of deposition is not important in determining the amount absorbed into the circulation [17]. ...