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Thyroid hormone exerts site-specific effects on SRC
Thyroid hormone exerts site-specific effects on SRC

... response elements in the promoters of responsive genes to affect their transcription (Evans, 1988; Lazar, 1994; Mangelsdorf and Evans, 1995). The ability of these receptors to affect gene transcription requires them to interact with nuclear cofactors, which are requisite mediators of ligand-dependen ...
Some historical perspectives on thermoregulation
Some historical perspectives on thermoregulation

... from all body areas and directing the efferent signals to the appropriate heat production and heat conservation systems in mammals. The evidence for this comes from electrical stimulation and recordings (7, 33, 43) after parts of the hypothalamus were thermally stimulated and after hypothalamic lesi ...
Antifungal Agents
Antifungal Agents

... Mechanism of action Allylamines: Inhibit fungal squalene epoxidase, thereby decreasing the synthesis of ergosterol. This plus the accumulation of toxic amounts of squalene result in the death of the fungal cell. Significantly higher concentrations of terbinafine are needed to inhibit human squalene ...
Dorsal Column Nuclei Neurons Recorded in a Brain Stem–Spinal
Dorsal Column Nuclei Neurons Recorded in a Brain Stem–Spinal

... 1973; Beck 1981). The primary afferent input to dorsal column nuclei (DCN) neurons may use glutamate as the main neurotransmitter since ionophoretic applications of glutamate in the vicinity of these neurons caused excitation (Galindo et al. 1967), while 1-hydroxy-3-aminopyrrolid-2-one (HA-966, an e ...
On the computational architecture of the neocortex
On the computational architecture of the neocortex

... from an area with one sort of concern to another. A persistent theme is to distinguish lower cortical areas, with direct sensory or motor connections from higher ones which are associating information from lower areas, so that information moves first from lower, more sensory areas to higher, more co ...
The Calcium-Release-Activated Calcium Channels Role in
The Calcium-Release-Activated Calcium Channels Role in

... Introduction and Objectives: Urine continence is dependent on urinary bladder (UB) ability to store urine at low pressure (by active relaxation of detrusor) and mechanism resulting in urethral pressure higher than urine pressure in UB. At the cellular level, these processes are strongly associated w ...
Fast and slow neurons in the nucleus of the
Fast and slow neurons in the nucleus of the

... in the nBOR suggests that this functional division is not a speci®c feature of pretectal neurons but of all optokinetic nuclei. Thus, we predict that fast and slow cells would be found in the mammalian AOS as well. Funding provided by NSERC to DRWW. N.A.C. was supported by a summer studentship from ...
Synchronization and coordination of sequences in two neural
Synchronization and coordination of sequences in two neural

... its gravity sensory organs, the statocysts 关13兴. A six receptor neural network model with synaptic inhibitions has been built to describe a single statocyst 关9兴 共see Fig. 1兲. This is a small sphere in which the statolith, a stonelike structure, moves according to the gravitational field. The statoli ...
汤慧芳
汤慧芳

... Significant and at times treatment-limiting adverse effects, including bone marrow suppression and irreversible peripheral and optic neuropathy, have been reported with the prolonged courses of therapy that are necessary for treatment of tuberculosis. Although linezolid may eventually prove to be an ...
Prodrugs II
Prodrugs II

... Prodrugs for (increased) Site Specificity Bodor and co-workers have devised a reversible redox ✵ drug delivery system (RRDDS) for getting drugs into the CNS and then, once in, preventing their efflux. The approach is based on the attachment of a hydrophilic drug to a lipophilic carrier (a dihydropy ...
reflexes_lesson
reflexes_lesson

... Axon: conduct messages away from cell body Three types of neurons: Sensory neuron: connect sensory organs to central nervous system (what are sensory organs? Give examples… like eyes, ears, tongue?) Motor neuron: connect central nervous system to muscles What muscles? ...
caredata CD Full Text - copyright NISW/Russell House Publications
caredata CD Full Text - copyright NISW/Russell House Publications

... may include drugs-related material, or hyperlinks to other more specific sites). For those working with young people in social welfare and those who need to research aspects of their social behaviour, the Internet can be an invaluable resource. However, it may actually exacerbate the tendency to ste ...
Exam-Objectives
Exam-Objectives

... some variables that explain drug use in the behavioral model. 24. What are at least 2 ways of assaying the reinforcing value of a drug? 25. Siegel’s theory of morphine tolerance. Be able to diagram it to explain tolerance. 26. 5 ways that drugs can affect neurotransmission 27. Endorphin theory of SI ...
Pre Test Excerpt
Pre Test Excerpt

... combination of short-term memory processes along with other chemical and transient physical synaptic changes lasting several minutes. Long-term memory represents physical synaptic changes lasting from minutes to days, weeks, or years, thus long-term memory is viewed as scaled physical changes in syn ...
Does Loss of Nerve Growth Factor Receptors Precede Loss of
Does Loss of Nerve Growth Factor Receptors Precede Loss of

... Alzheimer’s disease is not known. Some of these neurons depend, however, on trophic support from NGF via a membrane receptor. We have analyzed the state of these receptors by autoradiography, with Y-NGF as the ligand, in the caudate nucleus, putamen, ventral striatum, nucleus basalis of Meynert, and ...
Memory fields of neurons in the primate prefrontal cortex
Memory fields of neurons in the primate prefrontal cortex

... for complex stimuli that resemble the objects monkeys encounter in their experiences outside the neurophysiological laboratory (14, 15). Little is known about how or whether PF neurons convey their spatial attributes. The PF cortex plays an important role in a variety of functions critical for compl ...
Stress Support Complex - Complementary Prescriptions
Stress Support Complex - Complementary Prescriptions

... Asian cultures have often used teas for their relaxation effects. The pleasant relaxing sensation is caused by the presence of a neurologically active amino acid, L-theanine (gamma-ethyl-amino-L-glutamic acid). Most teas, especially green tea, have the reputation of having less caffeine than coffee; ...
LOCAL ANESTHETICS,IV SEDATION AND PAIN MANAGEMENT
LOCAL ANESTHETICS,IV SEDATION AND PAIN MANAGEMENT

... IV Anesthetics • Their side effects include: • An extrapyramidal syndrome with face and neck dyskinesia. • Oculogyric crises. • Torticollis. • Agitation • Hallucination ...
Hallucinogenic Drugs
Hallucinogenic Drugs

... knowledge of this native psilocybin culture after they experienced the mushrooms themselves through contact with the curandera (healing woman) Maria Sabina in Mexico. Scientific interest followed, leading to the infamous ‘Good Friday’ experiment in which divinity students in Boston were given either ...
The relative advantages of sparse versus distributed encoding for
The relative advantages of sparse versus distributed encoding for

... zero or positive, and this fact sets a limit (which is much below N ) on the maximum number p of independent associations stored in this type of network. In order to keep this number high it becomes necessary to have rather sparse encoding, to ensure that the different pattern vectors are relatively ...
A temporal trace and SOM-based model of complex cell development
A temporal trace and SOM-based model of complex cell development

... i is the trace value for complex cell i. It is the sum of the previous trace value, (t−1) yL i , for this neuron, and an instantaneous activation based on the visual stimuli, yi(t) . is a parameter with a value between 0 and 1 that controls how much memory to retain. According to this equation if ...
two new third-generation antiepileptic drugs
two new third-generation antiepileptic drugs

... 1857 when bromides salts were recognized as having antiseizure activity. Next, two drugs –phenobarbital and phenytoin became available in the first 50 years of the twentieth century. 16 new AEDs were discovered between 1946 and Vol . 21/2012, nr 42 ...
Clinical uses
Clinical uses

... clotting factors.(Ⅱa, Ⅸa, Ⅹa, Ⅺa, Ⅻa ) by enhancing the anticoagulative activity ...
Ch03.pps
Ch03.pps

... Axons gather impulses from dendrites and carry them to other neurons. ...
In summary, the discoveries of Dr. Ryke Geerd Hamer are: 1. The
In summary, the discoveries of Dr. Ryke Geerd Hamer are: 1. The

... MS, angina pectoris, neurodermatitis, diabetes and mental and mood disorders, etc. The warm diseases, especially those of an exanthematous nature, were called rheumatic, infectious or allergic We now have to conclude that this was not correct. These cold and warm diseases were not individual disease ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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