Pathway-Dependent Inhibition of Paclitaxel Hydroxylation by Kinase
... thought to be associated with different expressions and activities of CYP2C8, CYP3A4, and P-gp, and numerous studies have been conducted to examine the role of polymorphisms in CYP enzymes and their relationship with intersubject variability in efficacy and neurotoxicity. Recent reports suggest that ...
... thought to be associated with different expressions and activities of CYP2C8, CYP3A4, and P-gp, and numerous studies have been conducted to examine the role of polymorphisms in CYP enzymes and their relationship with intersubject variability in efficacy and neurotoxicity. Recent reports suggest that ...
The effect of oral midazolam ... on respiration in normal subjects
... reversed the sedation. It may be argued that the failure of our study to detect a depressant effect on the HVR is due to intrasubject variability; the coefficient of variation (COV) of repeated studies being about 20- 30%. Indeed, in our laboratory, the HVR was repeated three times within the same d ...
... reversed the sedation. It may be argued that the failure of our study to detect a depressant effect on the HVR is due to intrasubject variability; the coefficient of variation (COV) of repeated studies being about 20- 30%. Indeed, in our laboratory, the HVR was repeated three times within the same d ...
PRODUCT MONOGRAPH PrLUVOX
... of acetylsalicylic acid (ASA), nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin and other anticoagulants may add to the risk. Case reports and epidemiological studies (case-control and cohort design) have demonstrated an association between use of drugs that interfere with serotonin reuptake ...
... of acetylsalicylic acid (ASA), nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin and other anticoagulants may add to the risk. Case reports and epidemiological studies (case-control and cohort design) have demonstrated an association between use of drugs that interfere with serotonin reuptake ...
Voluntary Movement: The Primary Motor Cortex
... Thus the neural control of voluntary movement involves far more than simply generating a particular pattern of muscle activity. It also involves processes that are usually considered to be more sensory, perceptual, and cognitive in nature. As we shall see, these processes are not rigidly compartment ...
... Thus the neural control of voluntary movement involves far more than simply generating a particular pattern of muscle activity. It also involves processes that are usually considered to be more sensory, perceptual, and cognitive in nature. As we shall see, these processes are not rigidly compartment ...
Behavioural analysis of the acute and chronic effects of MDMA
... 5-HT transporter sites (McCann et al. 1998). In animal studies MDMA has been shown to be selectively neurotoxic to 5-HT neurones (Battaglia et al. 1987a), while sparing dopamine neurones (Nash and Brodkin 1991). The regional activity of tryptophan hydroxylase and corresponding concentrations of 5-HT ...
... 5-HT transporter sites (McCann et al. 1998). In animal studies MDMA has been shown to be selectively neurotoxic to 5-HT neurones (Battaglia et al. 1987a), while sparing dopamine neurones (Nash and Brodkin 1991). The regional activity of tryptophan hydroxylase and corresponding concentrations of 5-HT ...
Drug-resistant leprosy: Monitoring and current status
... MB leprosy patients and rifampicin and dapsone for PB leprosy patients. Among these drugs, rifampicin is the most important anti-leprosy drug and, therefore, is included in the treatment of both types of leprosy. Experience strongly suggest that treatment of leprosy with either dapsone15,16 or rifam ...
... MB leprosy patients and rifampicin and dapsone for PB leprosy patients. Among these drugs, rifampicin is the most important anti-leprosy drug and, therefore, is included in the treatment of both types of leprosy. Experience strongly suggest that treatment of leprosy with either dapsone15,16 or rifam ...
Substance P and Cholecystokinin-like lmmunoreactive Varicosities
... In recent years, the neuropeptides substance P (SP) and cholecystokinin octapeptide (CCK-8) have been suggested as neurotransmitters or neuromodulators of primary afferent neurons. Immunohistochemical studies have provided anatomical evidence in support of this hypothesis. SP-like immunoreactivity ( ...
... In recent years, the neuropeptides substance P (SP) and cholecystokinin octapeptide (CCK-8) have been suggested as neurotransmitters or neuromodulators of primary afferent neurons. Immunohistochemical studies have provided anatomical evidence in support of this hypothesis. SP-like immunoreactivity ( ...
sodium valproate in childhood epilepsy
... incidence cases are partial seizures. Partial and generalised seizures vary with age. Generalised seizures have the highest incidence in the first year of life. With the exception of absence seizures, for which incidence rates peak in 5-10 year olds, the incidence of generalised seizures in childhoo ...
... incidence cases are partial seizures. Partial and generalised seizures vary with age. Generalised seizures have the highest incidence in the first year of life. With the exception of absence seizures, for which incidence rates peak in 5-10 year olds, the incidence of generalised seizures in childhoo ...
Mycobacterium tuberculosis from Tshwane Metropolitan OLUWASEGUN OLAYINKA ATANDA
... the African region (72%), which can be partly attributed to HIV coinfection and in the European region (75%) partly due to drug resistance (Espinal et al., 2000). Treatment strategies that include the use of second-line drugs in the directly observed treatment of MDRTB (DOTS-Plus restorative strateg ...
... the African region (72%), which can be partly attributed to HIV coinfection and in the European region (75%) partly due to drug resistance (Espinal et al., 2000). Treatment strategies that include the use of second-line drugs in the directly observed treatment of MDRTB (DOTS-Plus restorative strateg ...
ATTENTIONAL MODULATION OF VISUAL PROCESSING John H
... Single-unit recording studies in the monkey have provided detailed, quantitative descriptions of how attention alters visual cortical neuron responses. When attention is directed to a location inside the receptive field (RF), the neuron’s contrast-response threshold is reduced, enabling it to respon ...
... Single-unit recording studies in the monkey have provided detailed, quantitative descriptions of how attention alters visual cortical neuron responses. When attention is directed to a location inside the receptive field (RF), the neuron’s contrast-response threshold is reduced, enabling it to respon ...
PROPOSAL FOR THE INCLUSION OF RISPERIDONE FOR THE
... The maximum dose of risperidone is 16 mg daily, though doses higher than 8 mg daily are rarely used. In elderly patients, it is recommended to start risperidone at 0.5 mg initially once or twice daily, and this dose may be increased by 0.5 mg twice daily. The typical dose for elderly patients ranges ...
... The maximum dose of risperidone is 16 mg daily, though doses higher than 8 mg daily are rarely used. In elderly patients, it is recommended to start risperidone at 0.5 mg initially once or twice daily, and this dose may be increased by 0.5 mg twice daily. The typical dose for elderly patients ranges ...
Calcium Influx and Protein Phosphorylation Mediate the Metabolic
... AChRs in rat muscle. The nerve-induced metabolic stability of synaptic AChRs is a remarkably persistent phenomenon. Although it is at least partially reversed by denervation (Loring and Salpeter, 1980; Stanley and Drachman, 1981) the reversal takes several days to begin. The half-life of the origina ...
... AChRs in rat muscle. The nerve-induced metabolic stability of synaptic AChRs is a remarkably persistent phenomenon. Although it is at least partially reversed by denervation (Loring and Salpeter, 1980; Stanley and Drachman, 1981) the reversal takes several days to begin. The half-life of the origina ...
Morphine - ISpatula
... have teratogenic properties (i.e. may deform a fetus) has resulted in noscapine preparations being deleted. * It has no analgesic or narcotic action so its original name ‘narcotine’ was changed to reflect this lack of narcotic action. *based on the fact that all toxic substances are investigated for ...
... have teratogenic properties (i.e. may deform a fetus) has resulted in noscapine preparations being deleted. * It has no analgesic or narcotic action so its original name ‘narcotine’ was changed to reflect this lack of narcotic action. *based on the fact that all toxic substances are investigated for ...
APTAMERS ROLE IN BASIC DRUG RESEARCH AND DEVELOPMENT - AN... Review Article STALIN.C*, DINESHKUMAR.P.
... Aptamers in 1990, there has been a steady annual increase in the number of publications related to Aptamers. During the last 10 years Aptamers binding to for example cells, proteins, peptides, low molecular weight molecules (like antibiotics, amino acids, and dyes) or nucleic acids have been isolate ...
... Aptamers in 1990, there has been a steady annual increase in the number of publications related to Aptamers. During the last 10 years Aptamers binding to for example cells, proteins, peptides, low molecular weight molecules (like antibiotics, amino acids, and dyes) or nucleic acids have been isolate ...
PEGylation of Biopharmaceuticals: A Review of Chemistry and
... depends on the specific protein. Lysines are almost always available on the protein surface but naturally occurring free thiols are very reactive and therefore usually “buried.”30 Conditions which allow reaction with a particular reagent may not be compatible with the native conformation of the prote ...
... depends on the specific protein. Lysines are almost always available on the protein surface but naturally occurring free thiols are very reactive and therefore usually “buried.”30 Conditions which allow reaction with a particular reagent may not be compatible with the native conformation of the prote ...
Adult Congenital Hydrocephalus
... Further imaging studies might involve performing MR quantification of CSF flow through the aqueduct of Sylvius. ...
... Further imaging studies might involve performing MR quantification of CSF flow through the aqueduct of Sylvius. ...
Hemispheric asymmetries of cortical volume in the human brain
... 0010-9452/$ e see front matter ª 2011 Elsevier Ltd. All rights reserved. doi:10.1016/j.cortex.2011.11.002 ...
... 0010-9452/$ e see front matter ª 2011 Elsevier Ltd. All rights reserved. doi:10.1016/j.cortex.2011.11.002 ...
h) Implementation of a Quality Systems Model for Use in
... component in Viagra which was patented in 1996 and approved for use in males for erectile dysfunction by the FDA on March 27, 1998. ...
... component in Viagra which was patented in 1996 and approved for use in males for erectile dysfunction by the FDA on March 27, 1998. ...
Interpreting the significance of increased alveolar macrophages in
... Findings at the lower exposures to inert, insoluble material were typical of findings at the highest doses in inhalation tox studies of PS pharmaceuticals in rats – However, inert particle represent “worst case” because even PS pharmaceuticals are slightly soluble such that dissolution is the predom ...
... Findings at the lower exposures to inert, insoluble material were typical of findings at the highest doses in inhalation tox studies of PS pharmaceuticals in rats – However, inert particle represent “worst case” because even PS pharmaceuticals are slightly soluble such that dissolution is the predom ...
Towards an Understanding of Parkinson's Disease
... “….involuntary tremulous motion, with lessened muscular power, in parts not in action …… with a propensity to bend the trunk forward, and to pass from a walking to a running pace …… the senses and intellect being uninjured.” ...
... “….involuntary tremulous motion, with lessened muscular power, in parts not in action …… with a propensity to bend the trunk forward, and to pass from a walking to a running pace …… the senses and intellect being uninjured.” ...
Enhancement of Taste Masking by A newly
... In the two types of effervescent tablets (wet granulation method and direct compression method) the zone of inhibition was slightly larger in wet granulation method than in direct compression method. This might be due to good distribution of active ingredient in the tablet formulation. In wet granul ...
... In the two types of effervescent tablets (wet granulation method and direct compression method) the zone of inhibition was slightly larger in wet granulation method than in direct compression method. This might be due to good distribution of active ingredient in the tablet formulation. In wet granul ...
zidovudine and lamivudine - WHO archives
... children had received treatment. A prospective observational cohort study was undertaken to assess the feasibility, effectiveness, adherence, toxicity and viral resistance of antiretroviral therapy. The clinical and biological results of the study were comparable to those seen in western cohorts, de ...
... children had received treatment. A prospective observational cohort study was undertaken to assess the feasibility, effectiveness, adherence, toxicity and viral resistance of antiretroviral therapy. The clinical and biological results of the study were comparable to those seen in western cohorts, de ...
Caudate Tracing Guidelines
... three components of the striatum: (1) caudate (at this level, the head of the caudate nucleus), (2) putamen, and (3) nucleus accumbens. Although the internal capsule courses between the caudate nucleus and the putamen, striatal cell bridges connect the two structures. The cell bridges are a reminder ...
... three components of the striatum: (1) caudate (at this level, the head of the caudate nucleus), (2) putamen, and (3) nucleus accumbens. Although the internal capsule courses between the caudate nucleus and the putamen, striatal cell bridges connect the two structures. The cell bridges are a reminder ...
Site-specific conjugation of a cytotoxic drug to an antibody improves
... fractions for in vivo efficacy, tolerability in mice and pharmacokinetics8. The most heavily conjugated species had the lowest maximum tolerated IgG dose and most rapid clearance but did not confer a proportional increase in efficacy. This suggests that it would be desirable to selectively generate ...
... fractions for in vivo efficacy, tolerability in mice and pharmacokinetics8. The most heavily conjugated species had the lowest maximum tolerated IgG dose and most rapid clearance but did not confer a proportional increase in efficacy. This suggests that it would be desirable to selectively generate ...
The effect of morphine on the activity evoked in
... from Th n to L~ for the recording of activity from axons in the ventrolateral tract; 9 animals were spinalized at the level of Th10, and in 5 the spinal cord was additionally exposed from Th 7 to Thlo for reversible spinalization by cooling the spinal cord. In the latter experiments, two separate po ...
... from Th n to L~ for the recording of activity from axons in the ventrolateral tract; 9 animals were spinalized at the level of Th10, and in 5 the spinal cord was additionally exposed from Th 7 to Thlo for reversible spinalization by cooling the spinal cord. In the latter experiments, two separate po ...