Zidovudine Concentration in Brain Extracellular Fluid Measured by
... dural incision permitted insertion of the microdialysis probe without damaging the probe membrane. The microdialysis probe was lowered into the cerebral cortex using the stereotaxic carrier. No guide probe was used. The top of the probe membrane was positioned 3 mm below the surface of the brain and ...
... dural incision permitted insertion of the microdialysis probe without damaging the probe membrane. The microdialysis probe was lowered into the cerebral cortex using the stereotaxic carrier. No guide probe was used. The top of the probe membrane was positioned 3 mm below the surface of the brain and ...
- Seminars in Nephrology
... than targeted in nonpregnant individuals to minimize fetal exposure to antihypertensive medications. In this setting, antihypertensive medications are mainly used to prevent or treat severe hypertension, to prolong pregnancy for as long as safely possible thereby maximizing the gestational age of th ...
... than targeted in nonpregnant individuals to minimize fetal exposure to antihypertensive medications. In this setting, antihypertensive medications are mainly used to prevent or treat severe hypertension, to prolong pregnancy for as long as safely possible thereby maximizing the gestational age of th ...
Divergent Projections from the Anterior Inferotemporal Area TE to
... visual recognition memory of objects (delayed-matching- or nonmatching-to-sample task). There is also behavioral evidence that the perirhinal cortex is the most important for performance of the visual recognition memory task (Murray et al., 1993; Eacott et al., 1994; Gaffan, 1994; Leonard et al., 19 ...
... visual recognition memory of objects (delayed-matching- or nonmatching-to-sample task). There is also behavioral evidence that the perirhinal cortex is the most important for performance of the visual recognition memory task (Murray et al., 1993; Eacott et al., 1994; Gaffan, 1994; Leonard et al., 19 ...
Best practice use of veterinary drugs
... results of detailed safety and efficacy studies to support their registration claims. Directions for use, dose rates and any necessary safety precautions and warnings must be provided. The company must also demonstrate that the product will be produced using good manufacturing practice. This ensures ...
... results of detailed safety and efficacy studies to support their registration claims. Directions for use, dose rates and any necessary safety precautions and warnings must be provided. The company must also demonstrate that the product will be produced using good manufacturing practice. This ensures ...
The Emerging Neuroscience of Intrinsic Motivation: A New Frontier
... motivation. To anticipate our main conclusions, affective neuroscience suggests that human intrinsic motivation is based in ancient mammalian systems that govern exploration and play. Neuroimaging studies, which have up to now focused on curiosity and mastery tendencies, indicate that intrinsically ...
... motivation. To anticipate our main conclusions, affective neuroscience suggests that human intrinsic motivation is based in ancient mammalian systems that govern exploration and play. Neuroimaging studies, which have up to now focused on curiosity and mastery tendencies, indicate that intrinsically ...
The role of the basal ganglia in reinforcement learning
... of rate modulations. A simulation suggests that the changes in dopaminergic synchronization could provide an additional mechanism for controlling their concentrations in the striatum, beyond firing rate and pattern. Thus, the difference between the response properties of the basal ganglia subsystems ...
... of rate modulations. A simulation suggests that the changes in dopaminergic synchronization could provide an additional mechanism for controlling their concentrations in the striatum, beyond firing rate and pattern. Thus, the difference between the response properties of the basal ganglia subsystems ...
Hydroxyzine Dihydrochloride
... In isolated canine Purkinje fibres, hydroxyzine at 3µM increased action potential duration suggesting that there was an interaction with potassium channels involved with the repolarisation phase. At a higher concentration, 30µM, there was a marked decrease in the action potential duration suggesting ...
... In isolated canine Purkinje fibres, hydroxyzine at 3µM increased action potential duration suggesting that there was an interaction with potassium channels involved with the repolarisation phase. At a higher concentration, 30µM, there was a marked decrease in the action potential duration suggesting ...
Poonam et al - Galaxy of Pharmaceutical Innovations
... of one compound will not influence the bitterness of a second because many different classes of compound impart bitterness. Sodium salts such as sodium chloride, sodium acetate, sodium gluconate have been shown to be potent inhibitors of some bitter compounds. The mechanism is not known, however, re ...
... of one compound will not influence the bitterness of a second because many different classes of compound impart bitterness. Sodium salts such as sodium chloride, sodium acetate, sodium gluconate have been shown to be potent inhibitors of some bitter compounds. The mechanism is not known, however, re ...
The Ergogenic Effects of Caffeine During Sport and Exercise
... (Chapman & Mickleborough 2009). Furthermore, most of the studies trying to determine the specific mechanism that may induce ergogenic effects focus on caffeine’s effect in skeletal muscle and the central nervous system. In the central nervous system, caffeine stimulates the release of excess seroton ...
... (Chapman & Mickleborough 2009). Furthermore, most of the studies trying to determine the specific mechanism that may induce ergogenic effects focus on caffeine’s effect in skeletal muscle and the central nervous system. In the central nervous system, caffeine stimulates the release of excess seroton ...
Aalborg Universitet Assessment of sensory convergence in the spinal cord
... tissue damage, or described in terms as such” (Merskey and Bogduk, 1994). It has also been emphasized that pain is a personal experience that depends on genetic differences, past experience, anxiety, expectation etc. However, specific aspects of pain can be conceptualized (Loeser and Melzack, 1999). ...
... tissue damage, or described in terms as such” (Merskey and Bogduk, 1994). It has also been emphasized that pain is a personal experience that depends on genetic differences, past experience, anxiety, expectation etc. However, specific aspects of pain can be conceptualized (Loeser and Melzack, 1999). ...
EO 003.01 - Part 28 - Nervous System Drugs
... Mechanism of Action Opioids alter the perception of pain and response to pain. They do this by affecting the nerve pathways for pain transmission in the body. All narcotics work on the same chemical process in the body, but they do it in different ways. Some of these medicines are made from a plant ...
... Mechanism of Action Opioids alter the perception of pain and response to pain. They do this by affecting the nerve pathways for pain transmission in the body. All narcotics work on the same chemical process in the body, but they do it in different ways. Some of these medicines are made from a plant ...
Functional Microarchitecture of Cat Primary Visual Cortex
... direction selectivity, relative modulation (F1/DC), and spatial frequency preference and tuning width showed no such clustering. By investigating the temporal patterns of neighbouring neurons in response to movies, visual noise and gratings, we found that stimulus-dependent responses, called “signal ...
... direction selectivity, relative modulation (F1/DC), and spatial frequency preference and tuning width showed no such clustering. By investigating the temporal patterns of neighbouring neurons in response to movies, visual noise and gratings, we found that stimulus-dependent responses, called “signal ...
Rewarding properties of sildenafil citrate in mice
... preferred compartments. Place conditioning was conducted using an unbiased procedure. The CPP paradigm took place in nine consecutive days, which consisted of three phases: familiarization and preconditioning, conditioning, and postconditioning. All trials were done between Zeitgeber Time (ZT) 4 and ...
... preferred compartments. Place conditioning was conducted using an unbiased procedure. The CPP paradigm took place in nine consecutive days, which consisted of three phases: familiarization and preconditioning, conditioning, and postconditioning. All trials were done between Zeitgeber Time (ZT) 4 and ...
An overview of interactions between grapefruit juice and drugs ReView Abstract
... reduce the formation of artherosclerotic plaques.3,4 It may also inhibit cancer cell proliferation.5,6 As many as 15 years ago, investigators found that grapefruit juice can markedly augment oral drug bioavailability. This was an unexpected observation from an interaction study between the dihydropy ...
... reduce the formation of artherosclerotic plaques.3,4 It may also inhibit cancer cell proliferation.5,6 As many as 15 years ago, investigators found that grapefruit juice can markedly augment oral drug bioavailability. This was an unexpected observation from an interaction study between the dihydropy ...
Antidote–Opioids
... Pure opioid antagonists produce no clinical effects in opioid-naïve or nondependent patients even when administered in massive doses.7 When patients dependent on opioid agonists are exposed to opioid antagonists or agonist– antagonists such as pentazocine, they exhibit opioid withdrawal, including ...
... Pure opioid antagonists produce no clinical effects in opioid-naïve or nondependent patients even when administered in massive doses.7 When patients dependent on opioid agonists are exposed to opioid antagonists or agonist– antagonists such as pentazocine, they exhibit opioid withdrawal, including ...
(Cannabis genus) for use as animal feed
... studies by Beal et al. (1995, 1997), in which HIV patients received oral THC. The first study was a placebo controlled study with 139 patients, who received either THC (2 x 2.5 mg/person daily) or placebo for 42 days (Beal et al. 1995). The second study was an open long-term study, where patients re ...
... studies by Beal et al. (1995, 1997), in which HIV patients received oral THC. The first study was a placebo controlled study with 139 patients, who received either THC (2 x 2.5 mg/person daily) or placebo for 42 days (Beal et al. 1995). The second study was an open long-term study, where patients re ...
Traumatic Injuries to the Spinal Cord
... During World War I, Riddoch, and later Head and Riddoch, gave what are now considered the classic descriptions of spinal transection in humans; Lhermitte and Guillain and Barré are credited with refining those observations. Little could be done during this period with fully 80% dying in the first fe ...
... During World War I, Riddoch, and later Head and Riddoch, gave what are now considered the classic descriptions of spinal transection in humans; Lhermitte and Guillain and Barré are credited with refining those observations. Little could be done during this period with fully 80% dying in the first fe ...
... DRUG INTERACTIONS: When administered concomitantly with alcohol, loratadine has no potentiating effects as measured by psychomotor performance studies. Increases in plasma concentrations of loratadine has been reported after concomitant use with ketoconazole, erythromycin or cimetidine in controlled ...
Playing the electric light orchestra—how electrical stimulation of
... in mammals. In primates, visual cortex has been delineated into more than 30 distinct areas based on their anatomical and functional properties [1,2]. Research into visual cortical function reveals fundamental mechanisms underlying perceptual experience and also has the potential to improve our trea ...
... in mammals. In primates, visual cortex has been delineated into more than 30 distinct areas based on their anatomical and functional properties [1,2]. Research into visual cortical function reveals fundamental mechanisms underlying perceptual experience and also has the potential to improve our trea ...
Methylergonovine Heathcare Professional Letter
... A number of case reports have documented inadvertent administration of Methylergonovine Maleate Injection, USP to newborn infants when in fact this medication was intended for use in the mother. Toxic doses of ergot compounds may cause serious adverse effects in newborn infants such as respiratory d ...
... A number of case reports have documented inadvertent administration of Methylergonovine Maleate Injection, USP to newborn infants when in fact this medication was intended for use in the mother. Toxic doses of ergot compounds may cause serious adverse effects in newborn infants such as respiratory d ...
2 Long-acting agonists: a new perspective
... Salmeterol was shown to have a long duration of effect on isolated guinea-pig trachea and human bronchial tissue, and a sustained effect for many hours has been shown [9]. Also with formoterol a prolonged bronchodilator effect has been demonstrated in vitro [15, 16]. In one study the remaining ~-sti ...
... Salmeterol was shown to have a long duration of effect on isolated guinea-pig trachea and human bronchial tissue, and a sustained effect for many hours has been shown [9]. Also with formoterol a prolonged bronchodilator effect has been demonstrated in vitro [15, 16]. In one study the remaining ~-sti ...
Abstract: Long Project
... Dr. Jean-Christophe Leroux, "Injectable nanocarriers for biodetoxification" nature nanotechnology | VOL 2 | NOVEMBER 2007 doi:10.1038/nnano.2007.339 Image 1: http://media-2.web.britannica.com/eb-media/37/96837-004-AAC9A5BB.jpg ,Image 2: http://www.pharmoscorp.com/development/nanotechnology.html ,Ima ...
... Dr. Jean-Christophe Leroux, "Injectable nanocarriers for biodetoxification" nature nanotechnology | VOL 2 | NOVEMBER 2007 doi:10.1038/nnano.2007.339 Image 1: http://media-2.web.britannica.com/eb-media/37/96837-004-AAC9A5BB.jpg ,Image 2: http://www.pharmoscorp.com/development/nanotechnology.html ,Ima ...
The Ophthalmology Market
... Limited (although the latter two companies are closely associated). It could it be expected that this is a growing market for epidemiological reasons, but also there is an economic argument for testing to allow effective treatment in the early stages of disease. ...
... Limited (although the latter two companies are closely associated). It could it be expected that this is a growing market for epidemiological reasons, but also there is an economic argument for testing to allow effective treatment in the early stages of disease. ...
19 CORTICAL PROJECTIONS FROM TWO PRESTRIATE AREAS IN
... rior bank of the superior temporal sulcus, which appears to receive projections from all these areas, regions of vertical meridian representation in area 18 project to two strips outside (anterior to) area 19 and that a third, separate, field receives a small projection (anterior part of prelunate g ...
... rior bank of the superior temporal sulcus, which appears to receive projections from all these areas, regions of vertical meridian representation in area 18 project to two strips outside (anterior to) area 19 and that a third, separate, field receives a small projection (anterior part of prelunate g ...
Decondensed DNA Release of Proteases Associated with Triggers
... and it reduced the possibility of IL-1 carried over after activation. This allowed us to determine the effects of activated versus nonactivated endothelial-derived factors on nonmigrated neutrophil phenotypes. A purified neutrophil suspension containing 3.5 3 106 cells was added to the luminal (top) ...
... and it reduced the possibility of IL-1 carried over after activation. This allowed us to determine the effects of activated versus nonactivated endothelial-derived factors on nonmigrated neutrophil phenotypes. A purified neutrophil suspension containing 3.5 3 106 cells was added to the luminal (top) ...