Cocaine-Induced Craving
... Gives way to craving in minutes (even when levels are still elevated) Lack of satiation - multiple doses Binge pattern use Intensely rewarding Animals self-administer till death Patients obsessed with euphoria Distinctive features v. heroin/alcohol Manic-like, racing thoughts, energy, vigilance Psyc ...
... Gives way to craving in minutes (even when levels are still elevated) Lack of satiation - multiple doses Binge pattern use Intensely rewarding Animals self-administer till death Patients obsessed with euphoria Distinctive features v. heroin/alcohol Manic-like, racing thoughts, energy, vigilance Psyc ...
Neurophysiology of synesthesia. - Hal-CEA
... Synesthesia is an experience in which stimulation in one sensory or cognitive stream leads to associated experiences in a second, unstimulated stream. The stimulus which elicits a synesthetic experience is called the inducer, the additional sensations are called concurrents, and various forms of syn ...
... Synesthesia is an experience in which stimulation in one sensory or cognitive stream leads to associated experiences in a second, unstimulated stream. The stimulus which elicits a synesthetic experience is called the inducer, the additional sensations are called concurrents, and various forms of syn ...
... volume fill [9] and the optimal volume fill is between 12 mL [10] and 18 mL [11]. In this study, we did not use the "control dose" which was designed by the nebulizer company to improve the efficiency of DP100® for small fill volumes. DP100® was, therefore, not used in our study in optimal condition ...
DISCLAIMER STATEMENT
... The Discussion Topics describes potential clinical trial design elements, primary and secondary efficacy endpoints, and analysis populations (ITT and micro-ITT) for CABP trials (see Appendix 2). The summary below provides an overview of the important areas where we seek information based on the AIDA ...
... The Discussion Topics describes potential clinical trial design elements, primary and secondary efficacy endpoints, and analysis populations (ITT and micro-ITT) for CABP trials (see Appendix 2). The summary below provides an overview of the important areas where we seek information based on the AIDA ...
Anabolic Steroids: Lets Get the Facts Right
... present definite risks of permanent liver damage and liver cancer. It is not safe to share needles with any drug. If you inject anabolic steroids and share needles, you are at risk of getting blood transmitted infections such as hepatitis B, hepatitis C or HIV/AIDS. While it is true that many of the ...
... present definite risks of permanent liver damage and liver cancer. It is not safe to share needles with any drug. If you inject anabolic steroids and share needles, you are at risk of getting blood transmitted infections such as hepatitis B, hepatitis C or HIV/AIDS. While it is true that many of the ...
Expression of pituitary adenylate cyclase activating
... PACAP has been identifi in nerves in the female genital tract [7,8,9], autonomic neurons of the paracervical ganglia [8] and sensory neurons of the dorsal root ganglia [6,11,25] and dorsal horn of the spinal cord [6,13,18,25,40]. PACAP, first identified by Miyata and co-workers [23,24], was isolated ...
... PACAP has been identifi in nerves in the female genital tract [7,8,9], autonomic neurons of the paracervical ganglia [8] and sensory neurons of the dorsal root ganglia [6,11,25] and dorsal horn of the spinal cord [6,13,18,25,40]. PACAP, first identified by Miyata and co-workers [23,24], was isolated ...
Timing and Characteristics of Cumulative Evidence Available on
... approval of agents treating severely debilitating diseases after a single study. Such expedited approval programs have become more common in recent years.5 Over half of new agents entering the market benefit from expedited approval programs. ...
... approval of agents treating severely debilitating diseases after a single study. Such expedited approval programs have become more common in recent years.5 Over half of new agents entering the market benefit from expedited approval programs. ...
B.Pharmacy Syllabus 2015
... Module 01: Quantitative Analysis and Data Handling {Introduction to concept of Quality Control and Assurance in Pharmaceutical Industry and role of Statistics in pharmaceutical analysis. Significance of quantitative analysis in quality control, different techniques of analysis, preliminaries and def ...
... Module 01: Quantitative Analysis and Data Handling {Introduction to concept of Quality Control and Assurance in Pharmaceutical Industry and role of Statistics in pharmaceutical analysis. Significance of quantitative analysis in quality control, different techniques of analysis, preliminaries and def ...
... used as a narcotic and a purgative, which may be opium, but it can also be attributed to another plant. It seems though that Hippocrates found little use of that substance. In the Hebrew culture the use of a bitter-tasting plant called rosh, meaning head, could be identical with opium. There is a th ...
How to Protect Yourself Against Malaria
... microscopic crystals, made surfaces lethal to mosquitoes for months. But, although this residual insecticide reversed the odds in the struggle, within a few years the Anopheles had developed a resistance to these chemicals. Other pesticides followed, always with the same inglorious result. Today, ma ...
... microscopic crystals, made surfaces lethal to mosquitoes for months. But, although this residual insecticide reversed the odds in the struggle, within a few years the Anopheles had developed a resistance to these chemicals. Other pesticides followed, always with the same inglorious result. Today, ma ...
Active Transport of Fentanyl by the Blood-Brain Barrier1
... observation that uptake of [3H]fentanyl was significantly increased in Mg21-free medium, a condition known to reduce P-gp activity. However, release of [3H]fentanyl was significantly increased when incubated with either unlabeled fentanyl or verapamil. These results suggest that the active P-gp-medi ...
... observation that uptake of [3H]fentanyl was significantly increased in Mg21-free medium, a condition known to reduce P-gp activity. However, release of [3H]fentanyl was significantly increased when incubated with either unlabeled fentanyl or verapamil. These results suggest that the active P-gp-medi ...
Document
... Indication: Reduction of frequency of relapses in patients with RRMS Dose: 20 mcg SC once daily Reduces the frequency of exacerbations Moderately reduces the development of new lesions ...
... Indication: Reduction of frequency of relapses in patients with RRMS Dose: 20 mcg SC once daily Reduces the frequency of exacerbations Moderately reduces the development of new lesions ...
Deadly pediatric poisons: nine common agents that kill at low doses
... As a result, it commonly is believed that ingestion of one or two tablets by a toddler is a benign act and not expected to produce any significant toxicity. Although this is true for most exposures, certain common agents have the potential to cause life-threatening toxicity or death despite the inges ...
... As a result, it commonly is believed that ingestion of one or two tablets by a toddler is a benign act and not expected to produce any significant toxicity. Although this is true for most exposures, certain common agents have the potential to cause life-threatening toxicity or death despite the inges ...
SEIKO ABUBAKARI - Kwame Nkrumah University of Science
... around a million of people a year, of which 75% are children under 5 years of age, drug assessment in this group is lower which complicate the choice of appropriate treatment. Quinine is re-emerging as an important drug in the treatment of multiple-drug resistant or severe Plasmodium falciparum mala ...
... around a million of people a year, of which 75% are children under 5 years of age, drug assessment in this group is lower which complicate the choice of appropriate treatment. Quinine is re-emerging as an important drug in the treatment of multiple-drug resistant or severe Plasmodium falciparum mala ...
Pathfinding by cranial nerve VII (facial) motorneurons
... molecules that are fixed in place, or they could exist as diffusible molecules. In order to function as a guidance cue, immobilized molecules would be expected to be distributed in a restricted spatial pattern, and diffusible molecules in a gradient. Evidence that both these types of guidance cues m ...
... molecules that are fixed in place, or they could exist as diffusible molecules. In order to function as a guidance cue, immobilized molecules would be expected to be distributed in a restricted spatial pattern, and diffusible molecules in a gradient. Evidence that both these types of guidance cues m ...
10.4103_0975-1483.63169
... atorvastatin is CYP3A4. Glimepiride alone was showed a high metabolism but when coadministered with atorvastatin, atorvastatin inhibits its own metabolism as well as the metabolism of glimepiride. So, this shows that, atorvastatin acts as an enzyme inhibitor. Atorvastatin strongly inhibited CYP2C9-m ...
... atorvastatin is CYP3A4. Glimepiride alone was showed a high metabolism but when coadministered with atorvastatin, atorvastatin inhibits its own metabolism as well as the metabolism of glimepiride. So, this shows that, atorvastatin acts as an enzyme inhibitor. Atorvastatin strongly inhibited CYP2C9-m ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... Malaria is still one of the major health problems in the developing countries as well as in developed countries. The 2010 World Malaria Report summarizes information received from 106 malaria-endemic countries/areas and other partners and it updates the analyses presented in the 2009 Report 1. The ...
... Malaria is still one of the major health problems in the developing countries as well as in developed countries. The 2010 World Malaria Report summarizes information received from 106 malaria-endemic countries/areas and other partners and it updates the analyses presented in the 2009 Report 1. The ...
Treatment of Giardiasis
... determination of pathogenesis difficult. However, several theories have been put forward (83, 115). Some of the most likely include the ability of the protozoan to cause direct damage to the intestinal mucosa via adherence with the disk, disaccharidase enzyme reduction following brush border damage, ...
... determination of pathogenesis difficult. However, several theories have been put forward (83, 115). Some of the most likely include the ability of the protozoan to cause direct damage to the intestinal mucosa via adherence with the disk, disaccharidase enzyme reduction following brush border damage, ...
ULTRACET C IV
... dextromethorphan, and tricyclic antidepressants, among other drugs. Based on a population PK analysis of Phase 1 studies in healthy subjects, concentrations of tramadol were approximately 20% higher in “poor metabolizers” versus “extensive metabolizers,” while M1 concentrations were 40% lower. In vi ...
... dextromethorphan, and tricyclic antidepressants, among other drugs. Based on a population PK analysis of Phase 1 studies in healthy subjects, concentrations of tramadol were approximately 20% higher in “poor metabolizers” versus “extensive metabolizers,” while M1 concentrations were 40% lower. In vi ...
322 PHT Tablet
... • Strong tablets are obtained if fine particles are used due to increase in surface area and surface energy. 6. Spherical shape Spherical shaped particles exhibit good flow as compared to needle shaped particles. • Particles with irregular shape may exhibit hindered flow due to interlocking between ...
... • Strong tablets are obtained if fine particles are used due to increase in surface area and surface energy. 6. Spherical shape Spherical shaped particles exhibit good flow as compared to needle shaped particles. • Particles with irregular shape may exhibit hindered flow due to interlocking between ...
Synopsis of Some Recent Tactical Application of Bioisosteres in
... CH2 in the context of artificial antigens derived by reacting diazonium ions with proteins, a process that derivatized the ortho position of tyrosine, as summarized in Figure 11,2,4,5 The term “bioisostere” was introduced by Harris Friedman in 1950 who defined it as compounds eliciting a similar biolo ...
... CH2 in the context of artificial antigens derived by reacting diazonium ions with proteins, a process that derivatized the ortho position of tyrosine, as summarized in Figure 11,2,4,5 The term “bioisostere” was introduced by Harris Friedman in 1950 who defined it as compounds eliciting a similar biolo ...
A. INTRODUCTION 1. History of Use of Traditional Herbal Medicines
... to develop criteria and general principles to guide research work on evaluating herbal medicines (WHO, 1993). This group recognized the importance of herbal medicines to the health of many people throughout the world, stating: ‘A few herbal medicines have withstood scientific testing, but others are ...
... to develop criteria and general principles to guide research work on evaluating herbal medicines (WHO, 1993). This group recognized the importance of herbal medicines to the health of many people throughout the world, stating: ‘A few herbal medicines have withstood scientific testing, but others are ...
Mucosal Protective Agents Prevent Exacerbation of NSAID
... according to the method described in our previous article (Takeuchi et al., 2002). In brief, rats were anesthetized with urethane (1.25 g/kg i.p.) and a midline incision was performed to expose the small intestine. A thin, water-filled balloon, made from silicone rubber and attached to a polyethylen ...
... according to the method described in our previous article (Takeuchi et al., 2002). In brief, rats were anesthetized with urethane (1.25 g/kg i.p.) and a midline incision was performed to expose the small intestine. A thin, water-filled balloon, made from silicone rubber and attached to a polyethylen ...
Behavioural Brain Research Ventral pallidum roles in reward and
... well as early lateral hypothalamic lesions, in published histological figures indicates the aphagia-inducing lesions damaged ventral pallidum as well as their intended target structure. These data, ...
... well as early lateral hypothalamic lesions, in published histological figures indicates the aphagia-inducing lesions damaged ventral pallidum as well as their intended target structure. These data, ...