PDF - Journal of Neuroscience
... visualized with the mCherry-EB3 (Fig. 1C,D). Based on the current observations, we conclude that kinesin-5-EGFP is indeed present in both domains of the growth cone and in the transition zone, and hence that kinesin-5 could theoretically function in any or all of these locations. One more issue rele ...
... visualized with the mCherry-EB3 (Fig. 1C,D). Based on the current observations, we conclude that kinesin-5-EGFP is indeed present in both domains of the growth cone and in the transition zone, and hence that kinesin-5 could theoretically function in any or all of these locations. One more issue rele ...
Exploring morphology and drug interactions in pancreatic cancer
... adenocarcinomas are characterised as having a highly dense and poorly vascularised stroma that is made up of extracellular matrix (ECM) components and host cells. This complex tumour microenvironment has been implicated in the chemoresistance profiles observed in pancreatic tumours. An ECM-based thr ...
... adenocarcinomas are characterised as having a highly dense and poorly vascularised stroma that is made up of extracellular matrix (ECM) components and host cells. This complex tumour microenvironment has been implicated in the chemoresistance profiles observed in pancreatic tumours. An ECM-based thr ...
WHO Drug Dictionary User Guide - User Group Portal
... The most important issue in the coding and interpretation of concomitant medication data is that trade names are mapped to their active ingredients. It is also important that these products and substances are placed in a hierarchical classification. This makes it possible to select whole groups of p ...
... The most important issue in the coding and interpretation of concomitant medication data is that trade names are mapped to their active ingredients. It is also important that these products and substances are placed in a hierarchical classification. This makes it possible to select whole groups of p ...
Autonomic Nervous System
... • Found along entire length of chain allowing sympathetic output to reach all areas of the body. ...
... • Found along entire length of chain allowing sympathetic output to reach all areas of the body. ...
PerspectiVe
... of fragments and screening using a biophysical technique such as surface plasmon resonance (SPR), protein-ligand NMR, or even X-ray crystallography is much more achievable compared with assembling and screening a large library in a bioassay. In fact, some of the pioneering work using X-ray crystallo ...
... of fragments and screening using a biophysical technique such as surface plasmon resonance (SPR), protein-ligand NMR, or even X-ray crystallography is much more achievable compared with assembling and screening a large library in a bioassay. In fact, some of the pioneering work using X-ray crystallo ...
Neural Coding of Distinct Statistical Properties of
... reward system. If both the phasic and sustained signals reported in single-cell monkey recordings can be observed in humans, this would support a unified cross-species view in which midbrain neurons obey common basic principles of neural computation and provide important new insights into human rewar ...
... reward system. If both the phasic and sustained signals reported in single-cell monkey recordings can be observed in humans, this would support a unified cross-species view in which midbrain neurons obey common basic principles of neural computation and provide important new insights into human rewar ...
Erasmus_MM - NWU
... intense fear or bodily harm. The disorder is typified by a symptom triad consisting of re-experiencing, hyperarousal and avoidance symptoms. Approximately 15-25% of trauma-exposed individuals go on to develop PTSD, depending on the nature and severity of the trauma. Although dysfunctional adaptive r ...
... intense fear or bodily harm. The disorder is typified by a symptom triad consisting of re-experiencing, hyperarousal and avoidance symptoms. Approximately 15-25% of trauma-exposed individuals go on to develop PTSD, depending on the nature and severity of the trauma. Although dysfunctional adaptive r ...
Downstream EGFR Protein Phosphorylation and Gefitinib - Bio-Rad
... on signal transduction pathways. Gefitinib, an inhibitor of epidermal growth factor receptor (EGFR), is used to treat non-small cell lung cancer (NSCLC). The response of NSCLC to gefitinib is related to mutations occurring within the EGFR kinase domain. Because Bio-Plex phosphoprotein assays (xMAP t ...
... on signal transduction pathways. Gefitinib, an inhibitor of epidermal growth factor receptor (EGFR), is used to treat non-small cell lung cancer (NSCLC). The response of NSCLC to gefitinib is related to mutations occurring within the EGFR kinase domain. Because Bio-Plex phosphoprotein assays (xMAP t ...
An Analysis of the Facilitatory Action of Catechol and Phenol at the
... better than most biological theories and the underlying assumptions about the role of the membrane, which probably seemed speculative to Bernstein's c;omtemporaries would now be accepted without question by the majority of physiologists (Hodgkin, 1965). In 1949, Hodgkin determined by biochemical ana ...
... better than most biological theories and the underlying assumptions about the role of the membrane, which probably seemed speculative to Bernstein's c;omtemporaries would now be accepted without question by the majority of physiologists (Hodgkin, 1965). In 1949, Hodgkin determined by biochemical ana ...
2/10/2015 Tetrahydrocannabinolic acid (THCA) – Plant Precursor to THC
... Extensive heat and/or drying over time further converts THC to CBN (weakly psychoactive). ...
... Extensive heat and/or drying over time further converts THC to CBN (weakly psychoactive). ...
A Literature Review on the Status and Effects of Salvia Divinorum on
... 2006). Salvia divinorum tends to be attractive to adolescents because it is often marketed as an alternative to marijuana and advertised as being highly safe. It is also easy to obtain and legal in most states. However, despite an increase in Salvia divinorum research over the last 20 years, little ...
... 2006). Salvia divinorum tends to be attractive to adolescents because it is often marketed as an alternative to marijuana and advertised as being highly safe. It is also easy to obtain and legal in most states. However, despite an increase in Salvia divinorum research over the last 20 years, little ...
EBOLA and FDA: reviewing the response to the 2014 outbreak, to
... dehydration—‘appeared similar to those of cholera, one of the area’s many endemic infectious diseases’.28 A second, larger investigation also supported the conclusion that the unknown disease was likely cholera.29 An infected member of Emile’s family carried the Ebola virus to the Guinean capital, C ...
... dehydration—‘appeared similar to those of cholera, one of the area’s many endemic infectious diseases’.28 A second, larger investigation also supported the conclusion that the unknown disease was likely cholera.29 An infected member of Emile’s family carried the Ebola virus to the Guinean capital, C ...
Leptin Signaling in the Nucleus Tractus Solitarii
... Allyn L. Mark, Khristofor Agassandian, Donald A. Morgan, Xuebo Liu, Martin D. Cassell, Kamal Rahmouni ...
... Allyn L. Mark, Khristofor Agassandian, Donald A. Morgan, Xuebo Liu, Martin D. Cassell, Kamal Rahmouni ...
Visceral sensitivity and functional dyspepsia
... Disorders of stomach rhythm and myoelectric activity have also been implicated. Some studies found that up to 60% of the patients with functional dyspepsia may have abnormally slow gastric emptying concomitant with abnormalities in gastric electrical activity as shown by the differences between the ...
... Disorders of stomach rhythm and myoelectric activity have also been implicated. Some studies found that up to 60% of the patients with functional dyspepsia may have abnormally slow gastric emptying concomitant with abnormalities in gastric electrical activity as shown by the differences between the ...
1 Anish et al Journal of Drug Delivery & Therapeutics; 2012, 2(1)
... such as, extreme pH environment before it is released at the required site. To this end, the carrier gel must be able to maintain its physical integrity and mechanical strength in order to prove an effective biomaterial. The strength of the material can be increased by incorporating crosslinking age ...
... such as, extreme pH environment before it is released at the required site. To this end, the carrier gel must be able to maintain its physical integrity and mechanical strength in order to prove an effective biomaterial. The strength of the material can be increased by incorporating crosslinking age ...
Drug Abuse Warning Network, 2005: National
... 2005, based on data from the Drug Abuse Warning Network (DAWN). DAWN is a public health surveillance system that monitors drug-related ED visits for the Nation and for selected metropolitan areas. DAWN estimates pertain to the entire United States, including Alaska, Hawaii, and the District of Colum ...
... 2005, based on data from the Drug Abuse Warning Network (DAWN). DAWN is a public health surveillance system that monitors drug-related ED visits for the Nation and for selected metropolitan areas. DAWN estimates pertain to the entire United States, including Alaska, Hawaii, and the District of Colum ...
Comparing Inhaled Corticosteroids
... monary handling of the inhaled drug. Recent work indicates that for some inhaled corticosteroids there is a dissociation between serum concentration of the drug and concentration in lung tissue. Fluticasone propionate has been shown to be retained in lung tissue for much longer than is evident from ...
... monary handling of the inhaled drug. Recent work indicates that for some inhaled corticosteroids there is a dissociation between serum concentration of the drug and concentration in lung tissue. Fluticasone propionate has been shown to be retained in lung tissue for much longer than is evident from ...
Weak orientation and direction selectivity in lateral geniculate
... level of anesthesia. The location of the nasal bulb of each optic streak was charted after paralysis had taken effect. It was found that it was not necessary to adjust the focus of the eyes (Van Hooser et al. 2003). All procedures were approved by the Brandeis University Animal Care and Use Committe ...
... level of anesthesia. The location of the nasal bulb of each optic streak was charted after paralysis had taken effect. It was found that it was not necessary to adjust the focus of the eyes (Van Hooser et al. 2003). All procedures were approved by the Brandeis University Animal Care and Use Committe ...
Molecular Mechanisms Underlying the Acquisition, Extinction and
... obstacle to the effective treatment of drug abuse (Stewart, 2000). An individual’s susceptibility to relapse is governed by both genetic and non-genetic factors (Kendler et al., 2003). Studies have implicated that repeated drug use “hijacks” the neural circuitry involved in learning and memory. This ...
... obstacle to the effective treatment of drug abuse (Stewart, 2000). An individual’s susceptibility to relapse is governed by both genetic and non-genetic factors (Kendler et al., 2003). Studies have implicated that repeated drug use “hijacks” the neural circuitry involved in learning and memory. This ...
Pharmacology and the Nursing Process, 4th ed. Lilley
... sites, similar to a key and lock. B, The better the “fit,” the better the response. Those with complete attachment and response are called agonists. C, Drugs that attach but do not elicit a response are called antagonists. D, Drugs that attach, elicit a small response, and also block other responses ...
... sites, similar to a key and lock. B, The better the “fit,” the better the response. Those with complete attachment and response are called agonists. C, Drugs that attach but do not elicit a response are called antagonists. D, Drugs that attach, elicit a small response, and also block other responses ...
The Wick in the Candle of Learning
... University; and 5Department of Economics, National Taiwan University ...
... University; and 5Department of Economics, National Taiwan University ...
the PDF
... Abstract. Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering from Alzheimer’s disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or aging. Cognition refers to a capacity for information processing, applying knowledge, and changing pref ...
... Abstract. Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering from Alzheimer’s disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or aging. Cognition refers to a capacity for information processing, applying knowledge, and changing pref ...
Pharmacokinetics and pharmacodynamics of oral oxycodone in
... of oral oxycodone in healthy human subjects: Role of circulating active metabolites Background: In vitro experiments suggest that circulating metabolites of oxycodone are opioid receptor agonists. Clinical and animal studies to date have failed to demonstrate a significant contribution of the O-deme ...
... of oral oxycodone in healthy human subjects: Role of circulating active metabolites Background: In vitro experiments suggest that circulating metabolites of oxycodone are opioid receptor agonists. Clinical and animal studies to date have failed to demonstrate a significant contribution of the O-deme ...
Cocaine-Induced Craving
... Gives way to craving in minutes (even when levels are still elevated) Lack of satiation - multiple doses Binge pattern use Intensely rewarding Animals self-administer till death Patients obsessed with euphoria Distinctive features v. heroin/alcohol Manic-like, racing thoughts, energy, vigilance Psyc ...
... Gives way to craving in minutes (even when levels are still elevated) Lack of satiation - multiple doses Binge pattern use Intensely rewarding Animals self-administer till death Patients obsessed with euphoria Distinctive features v. heroin/alcohol Manic-like, racing thoughts, energy, vigilance Psyc ...