Epithelial cell adhesion molecule-targeted drug delivery for cancer
... Figure 2. Schematic overview of EpCAM-targeting drug delivery systems and bispecific binding constructs. (A) ADCs, (B) immunocytokines, (C) DARPin--toxin fusion proteins, (D) DARPin--protamine fusion proteins (E) scFv--enzyme fusion proteins for ADEPT, (F) scFv--sTRAIL, (G) scFv--toxin fusion protei ...
... Figure 2. Schematic overview of EpCAM-targeting drug delivery systems and bispecific binding constructs. (A) ADCs, (B) immunocytokines, (C) DARPin--toxin fusion proteins, (D) DARPin--protamine fusion proteins (E) scFv--enzyme fusion proteins for ADEPT, (F) scFv--sTRAIL, (G) scFv--toxin fusion protei ...
Creativity and emotion: Reformulating the Romantic theory of art
... multiple levels of analysis. Emotion can be observed in primitive animals who prepare to attack for food, escape from danger, or approach to reproduce. Emotions are primary causes within the animal: The key characteristic is that the action wells up from within the organism. It is not a reflex. It i ...
... multiple levels of analysis. Emotion can be observed in primitive animals who prepare to attack for food, escape from danger, or approach to reproduce. Emotions are primary causes within the animal: The key characteristic is that the action wells up from within the organism. It is not a reflex. It i ...
Integrated Dual Disorder Treatment
... fix at the home of a friend on a recent day. The woman uses a hypodermic needle to inject heroin, which she had heated in a spoonful of water, into a vein in her hand. However, the increased purity of the drug and a fear of contracting HIV from contaminated needles, along with the social stigma asso ...
... fix at the home of a friend on a recent day. The woman uses a hypodermic needle to inject heroin, which she had heated in a spoonful of water, into a vein in her hand. However, the increased purity of the drug and a fear of contracting HIV from contaminated needles, along with the social stigma asso ...
Tumor necrosis factor-alpha in normal and diseased brain
... CNS and thus act directly on brain parenchyma by crossing the blood-brain barrier (BBB), either by active transport mechanisms or passive diffusion in the circumventricular organs, including areas of the hypothalamus, pituitary, and pineal gland (Sternberg, 1997). Although much of this action occurs ...
... CNS and thus act directly on brain parenchyma by crossing the blood-brain barrier (BBB), either by active transport mechanisms or passive diffusion in the circumventricular organs, including areas of the hypothalamus, pituitary, and pineal gland (Sternberg, 1997). Although much of this action occurs ...
Computational themes of peripheral processing
... is important because it determines its functional role in the pathway. Subtractive and divisive adaptation The way adaptation changes the onset response curve of the sensory periphery determines which and how much information about a given stimulus is available at more central stages. In most cases, ...
... is important because it determines its functional role in the pathway. Subtractive and divisive adaptation The way adaptation changes the onset response curve of the sensory periphery determines which and how much information about a given stimulus is available at more central stages. In most cases, ...
Peripheral Nervous System
... The peripheral nervous system and its subdivisions The PNS includes all nervous structures found outside the CNS. It requires Three components: sensory receptors (pick up stimuli and send signals to CNS), motor endings (axons synapse with effectors like muscle and glands), and nerves and ganglia ( ...
... The peripheral nervous system and its subdivisions The PNS includes all nervous structures found outside the CNS. It requires Three components: sensory receptors (pick up stimuli and send signals to CNS), motor endings (axons synapse with effectors like muscle and glands), and nerves and ganglia ( ...
Correlation between auditory threshold and the auditory brainstem
... After hypoxic-ischemic (HI) injury, diverse mechanisms produce cell damage [31], perinatal brain is especially susceptible to energy failure (decrease of ATP levels), cellular excitotoxicity and oxidative stress which can in turn promote cellular death [32,33], as we can see in Fig 4. Neurons are th ...
... After hypoxic-ischemic (HI) injury, diverse mechanisms produce cell damage [31], perinatal brain is especially susceptible to energy failure (decrease of ATP levels), cellular excitotoxicity and oxidative stress which can in turn promote cellular death [32,33], as we can see in Fig 4. Neurons are th ...
Slides - National Lipid Association
... • Levels of evidence and gradings for recommendations based on previous consensus, published literature and expert opinion. • Writing committee reached full consensus on recommendations, which were then approved by all contributors. • Guidance endorsed by the National Lipid Association (August 20 ...
... • Levels of evidence and gradings for recommendations based on previous consensus, published literature and expert opinion. • Writing committee reached full consensus on recommendations, which were then approved by all contributors. • Guidance endorsed by the National Lipid Association (August 20 ...
Multiplication and stimulus invariance in a looming
... Invariance appears to be in part due to non-linear integration of synaptic inputs within the dendritic tree of this neuron. 2004 Elsevier Ltd. All rights reserved. Keywords: Looming; LGMD; DCMD; Multiplication; Invariance; Single neuron computation ...
... Invariance appears to be in part due to non-linear integration of synaptic inputs within the dendritic tree of this neuron. 2004 Elsevier Ltd. All rights reserved. Keywords: Looming; LGMD; DCMD; Multiplication; Invariance; Single neuron computation ...
identification of cell types in brain slices of the inferior colliculus
... adapting or regular. Onset discharges distinguished another group of neurons. Onset neurons can also entrain to higher frequency stimuli than sustained neurons. Discharge patterns are correlated with distinctive current±voltage relationships and with some aspects of dendritic morphology. However, th ...
... adapting or regular. Onset discharges distinguished another group of neurons. Onset neurons can also entrain to higher frequency stimuli than sustained neurons. Discharge patterns are correlated with distinctive current±voltage relationships and with some aspects of dendritic morphology. However, th ...
Amo, Neuron, 2014
... by the active avoidance of potentially dangerous environments is often more effective for animal survival than panic behavior alone. A candidate site responsible for active avoidance is the lateral habenula (LHb). In mammals, LHb neurons are phasically activated to negative or aversive emotional eve ...
... by the active avoidance of potentially dangerous environments is often more effective for animal survival than panic behavior alone. A candidate site responsible for active avoidance is the lateral habenula (LHb). In mammals, LHb neurons are phasically activated to negative or aversive emotional eve ...
Toward a Developmental Evolutionary Psychology
... permissible mechanisms underlying evolutionary alterations to neural structures. I then present an alternative, hierarchical behavioral systems view of the evolved human cognitive architecture that is based on integrating developmental cognitive neuroscience and evolutionary developmental biology in ...
... permissible mechanisms underlying evolutionary alterations to neural structures. I then present an alternative, hierarchical behavioral systems view of the evolved human cognitive architecture that is based on integrating developmental cognitive neuroscience and evolutionary developmental biology in ...
How tDCS polarizes a highly folded cortex
... Anode to Cathode • Inward under Anode, Outward under Cathode • TangenPal between electrodes ...
... Anode to Cathode • Inward under Anode, Outward under Cathode • TangenPal between electrodes ...
Section 11.3
... The cell body controls the cell’s basic functions. Axon Impulses travel along axons toward other cells. ...
... The cell body controls the cell’s basic functions. Axon Impulses travel along axons toward other cells. ...
Application of label-free detection to HTS using live cells
... Are we at risk of ‘missing’ interesting hits without high content read? Potentially identify ‘extra hits’ missed in non-label free screens? ...
... Are we at risk of ‘missing’ interesting hits without high content read? Potentially identify ‘extra hits’ missed in non-label free screens? ...
Research on Yoga as a Therapeutic Intervention: Past, Present
... Brigham and Women's Hospital. He has been involved in efficacy studies of yoga for a number of conditions including chronic insomnia and anxiety disorders. His current studies include clinical trials of yoga for post-traumatic stress disorder and chronic stress and ongoing research funded by the Kri ...
... Brigham and Women's Hospital. He has been involved in efficacy studies of yoga for a number of conditions including chronic insomnia and anxiety disorders. His current studies include clinical trials of yoga for post-traumatic stress disorder and chronic stress and ongoing research funded by the Kri ...
The Value of Phenotypic Screening to Drug Discovery
... phenotypic screening iden;fies chemical en;;es that have desirable biological (phenotypic) effects on cells or organisms without having prior knowledge of their biological ac;vity or mode of ac;on against a specifi ...
... phenotypic screening iden;fies chemical en;;es that have desirable biological (phenotypic) effects on cells or organisms without having prior knowledge of their biological ac;vity or mode of ac;on against a specifi ...
Effects of Various Drugs on Alcohol-induced Oxidative Stress in the
... mellitus, hypertension, and cancer genesis, as well as in the aging process [1, 2]. Alcohol, the most commonly consumed xenobiotic, generates ROS species whether it is used over a long period of time or whether it is taken acutely in a single large dose. Three metabolic pathways are involved in alco ...
... mellitus, hypertension, and cancer genesis, as well as in the aging process [1, 2]. Alcohol, the most commonly consumed xenobiotic, generates ROS species whether it is used over a long period of time or whether it is taken acutely in a single large dose. Three metabolic pathways are involved in alco ...
What Is the Nervous System?
... The cell body controls the cell’s basic functions. Axon Impulses travel along axons toward other cells. ...
... The cell body controls the cell’s basic functions. Axon Impulses travel along axons toward other cells. ...
Guidance for the Management of Insomnia
... after stopping a long acting hypnotic or a few hours after stopping a short acting hypnotic. The withdrawal syndrome includes anxiety, depression, nausea and perceptual changes. Rebound insomnia also occurs and is characterised by a worsening of the original symptoms of insomnia. 5.7.3. The risk of ...
... after stopping a long acting hypnotic or a few hours after stopping a short acting hypnotic. The withdrawal syndrome includes anxiety, depression, nausea and perceptual changes. Rebound insomnia also occurs and is characterised by a worsening of the original symptoms of insomnia. 5.7.3. The risk of ...
What Is the Nervous System?
... The cell body controls the cell’s basic functions. Axon Impulses travel along axons toward other cells. ...
... The cell body controls the cell’s basic functions. Axon Impulses travel along axons toward other cells. ...
Efforts to Support the Development of Fusidic Acid in the United States
... .15–30 mg/L would be required to provide sufficient free drug to limit the development of resistance in patients. A Cempra-sponsored survey of US and Canadian S. aureus isolates showed that in Canada, where FA had been approved for use for decades, the resistance rates were a manageable 8%, while in ...
... .15–30 mg/L would be required to provide sufficient free drug to limit the development of resistance in patients. A Cempra-sponsored survey of US and Canadian S. aureus isolates showed that in Canada, where FA had been approved for use for decades, the resistance rates were a manageable 8%, while in ...
What is the cause of the changes in membrane potential during an
... A NERVE is a bundle of axons. Most commonly they extend from the brain or spinal cord to the periphery. ...
... A NERVE is a bundle of axons. Most commonly they extend from the brain or spinal cord to the periphery. ...
Chapter 10
... regions of the motor homunculus are involved in activating motor neurons the arms, hands, and legs primarily on the ________, while the trunk the motor homunculus are primarily involved in activating motor neurons the trunk primarily on the _________. ...
... regions of the motor homunculus are involved in activating motor neurons the arms, hands, and legs primarily on the ________, while the trunk the motor homunculus are primarily involved in activating motor neurons the trunk primarily on the _________. ...