INQUIRY COMMUNITY IN AN ACTIVITY THEORY FRAME
... activity proposed by A. N. Leont’ev”, Wertsch refers to “goal-directed action” and writes, “human action typically employs ‘mediational means’ such as tools and language”. He goes on to emphasise that “the relationship between action and mediational means is so fundamental that it is more appropriat ...
... activity proposed by A. N. Leont’ev”, Wertsch refers to “goal-directed action” and writes, “human action typically employs ‘mediational means’ such as tools and language”. He goes on to emphasise that “the relationship between action and mediational means is so fundamental that it is more appropriat ...
Fibromyalgia Information Foundation
... symptom severity (SS) scale score 5 or WPI 3–6 and SS scale score 9 2. Symptoms have been present at a similar level for at least 3 months 3. The patient does not have a disorder that would otherwise explain the pain Wolfe F. et al. Arthritis care & Research 2010;62(5):600–610 ...
... symptom severity (SS) scale score 5 or WPI 3–6 and SS scale score 9 2. Symptoms have been present at a similar level for at least 3 months 3. The patient does not have a disorder that would otherwise explain the pain Wolfe F. et al. Arthritis care & Research 2010;62(5):600–610 ...
The Nervous System
... Peripheral Nervous System • The peripheral nervous system (PNS) is all of the parts of the nervous system except for the brain and the spinal cord. • Two parts: – Sensory part (sensory neurons) – Motor part (motor neuron) Neuroscience For Kids - Explore the nervous system Holt, Rinehart, and Winsto ...
... Peripheral Nervous System • The peripheral nervous system (PNS) is all of the parts of the nervous system except for the brain and the spinal cord. • Two parts: – Sensory part (sensory neurons) – Motor part (motor neuron) Neuroscience For Kids - Explore the nervous system Holt, Rinehart, and Winsto ...
PRINCIPLES OF PHARMACOKINETICS Learning Objectives
... 4. The plasma half-life of a drug is inversely proportional to total clearance, and directly proportional to Vd; for a given Vd, the higher the total clearance, the shorter the half-life. B. Biotransformation 1. Elimination of drug by chemical modification of the molecule by spontaneous or (more usu ...
... 4. The plasma half-life of a drug is inversely proportional to total clearance, and directly proportional to Vd; for a given Vd, the higher the total clearance, the shorter the half-life. B. Biotransformation 1. Elimination of drug by chemical modification of the molecule by spontaneous or (more usu ...
Late Activation of Apoptotic Pathways Plays a Negligible Role in
... MDR3 phenotypes and certain -tubulin mutations (3, 8, 13, 14). In vivo studies confirmed that desoxyepothilone B, one of the most potent epothilones, was curative in human tumor xenografts that were refractory to paclitaxel (15, 16). Clinical Phase I and II studies with epothilones are currently on ...
... MDR3 phenotypes and certain -tubulin mutations (3, 8, 13, 14). In vivo studies confirmed that desoxyepothilone B, one of the most potent epothilones, was curative in human tumor xenografts that were refractory to paclitaxel (15, 16). Clinical Phase I and II studies with epothilones are currently on ...
Mammalian multidrug‑resistance proteins (MRPs)
... translocation across the membrane and then substrate release on the opposite side of the membrane (Figure 2A). The transporter then once again assumes its high‑affinity conformation so that another round of transport can take place. These processes are obligatorily coupled to the binding and hydroly ...
... translocation across the membrane and then substrate release on the opposite side of the membrane (Figure 2A). The transporter then once again assumes its high‑affinity conformation so that another round of transport can take place. These processes are obligatorily coupled to the binding and hydroly ...
Hormones - physiology
... There are many types (mechanism) of intercellular communication: 1. Endocrine : circulating “System of glands, each of which secretes different types of hormones directly into the bloodstream … to maintain homeostasis.” So: hormone secreted from endocrine gland circulates in the blood binds to i ...
... There are many types (mechanism) of intercellular communication: 1. Endocrine : circulating “System of glands, each of which secretes different types of hormones directly into the bloodstream … to maintain homeostasis.” So: hormone secreted from endocrine gland circulates in the blood binds to i ...
Neural coding of behavioral relevance in parietal cortex
... features in the parietal cortex As described above, attentional effects are not just restricted to the location of visual stimuli. Saenz et al. [41] asked subjects to attend to a patch of moving dots in one hemifield, while simultaneously viewing a second task-irrelevant patch of moving dots in the ...
... features in the parietal cortex As described above, attentional effects are not just restricted to the location of visual stimuli. Saenz et al. [41] asked subjects to attend to a patch of moving dots in one hemifield, while simultaneously viewing a second task-irrelevant patch of moving dots in the ...
Autonomic Nervous System
... somatic nervous system. Impulses originating in the brain are carried through the spinal cord, where they synapse with the dendrites of motor neurons. The axons from these motor neurons extend from the spinal cord carrying impulses directly to muscles, causing the contractions that produce voluntary ...
... somatic nervous system. Impulses originating in the brain are carried through the spinal cord, where they synapse with the dendrites of motor neurons. The axons from these motor neurons extend from the spinal cord carrying impulses directly to muscles, causing the contractions that produce voluntary ...
Context Dependency in the Globus Pallidus Internal Segment
... analyses if the event-related discharge differed significantly from baseline (small-sample test statistic t for the difference between two means, P ⬍ 0.05). In some cases (8/39), the change in discharge occurred after the presentation of the visual cue, but before movement onset, and could not be de ...
... analyses if the event-related discharge differed significantly from baseline (small-sample test statistic t for the difference between two means, P ⬍ 0.05). In some cases (8/39), the change in discharge occurred after the presentation of the visual cue, but before movement onset, and could not be de ...
Non-steroidal Anti-inflammatory Drugs (NSAIDs) Presentation
... walls, and kidneys Production is also induced by tissue injury ...
... walls, and kidneys Production is also induced by tissue injury ...
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[PDF]
... modulations of neurotransmitter sensitivities [1, 2]. The process of neuronal maturation is regulated by complex mechanisms that are still unclear, and deficits in this step are evident in many neurodevelopmental disorders such as Rett Syndrome, Fragile X syndrome, autism, etc. [3]. MicroRNAs (miRNAs ...
... modulations of neurotransmitter sensitivities [1, 2]. The process of neuronal maturation is regulated by complex mechanisms that are still unclear, and deficits in this step are evident in many neurodevelopmental disorders such as Rett Syndrome, Fragile X syndrome, autism, etc. [3]. MicroRNAs (miRNAs ...
Flag = draft v1.0
... are not included because the experimental plan does not enable the mortality to be analysed [24]. It is useful to note a few points here which might of interest because they illustrate the variety in design: IMPACT was the preliminary phase of an ambitious study which aimed to assess the effects o ...
... are not included because the experimental plan does not enable the mortality to be analysed [24]. It is useful to note a few points here which might of interest because they illustrate the variety in design: IMPACT was the preliminary phase of an ambitious study which aimed to assess the effects o ...
MS_Word ~ 89 KB
... exhibited to varying degrees clinical manifestations of histamine release including flushing of face, neck chest and extremities and a generalised sensation of warmth. Six patients complained of facial itching. It has been postulated that the amount of histamine released relates primarily to the con ...
... exhibited to varying degrees clinical manifestations of histamine release including flushing of face, neck chest and extremities and a generalised sensation of warmth. Six patients complained of facial itching. It has been postulated that the amount of histamine released relates primarily to the con ...
System suitability test
... Chirality exists everywhere in nature and plays a significant role in a number of aspects of our life. The consideration of the aspect of chirality is very important for the environment, as well as for some industries, more concretely for the pharmaceutical industry. More than half of the medicines ...
... Chirality exists everywhere in nature and plays a significant role in a number of aspects of our life. The consideration of the aspect of chirality is very important for the environment, as well as for some industries, more concretely for the pharmaceutical industry. More than half of the medicines ...
Plants: The Potential for Extracting Protein, Medicines, and Other
... $200 million annually and the sale of over-thecounter (OTC) drugs obtained from plants is probably over $1 billion. For example, about one-half of the OTC laxative preparations sold annually in the United States are of plant origin. In 1980, exclusive of prescription sales, the laxative market was a ...
... $200 million annually and the sale of over-thecounter (OTC) drugs obtained from plants is probably over $1 billion. For example, about one-half of the OTC laxative preparations sold annually in the United States are of plant origin. In 1980, exclusive of prescription sales, the laxative market was a ...
04 narc John neuron
... greatly reduce activity. We now report that, in contrast to these other monoaminergic “REM-off” cell groups, histamine neurons are active in cataplexy at a level similar to or greater than that in quiet waking. We hypothesize that the activity of histamine cells is linked to the maintenance of wakin ...
... greatly reduce activity. We now report that, in contrast to these other monoaminergic “REM-off” cell groups, histamine neurons are active in cataplexy at a level similar to or greater than that in quiet waking. We hypothesize that the activity of histamine cells is linked to the maintenance of wakin ...
Proteus, Klebsiella, E. coli
... Sudafed may decrease effect of beta blockers May increase blood pressure, dysrhythmias with MAOIs May increase restlessness, palpitations with caffeine (e.g., coffee, tea) ...
... Sudafed may decrease effect of beta blockers May increase blood pressure, dysrhythmias with MAOIs May increase restlessness, palpitations with caffeine (e.g., coffee, tea) ...
Intra-arterial Cell Transplantation Provides Timing
... at 4 hours, at 1, 3, 5, and 14 days poststroke (0% migration of umbilical cord blood mononuclear cells),8 or during stroke surgery (0% migration of umbilical cord blood cells).19 Nevertheless, functional recovery was obtained with intravenous delivery, indicating that secretion of trophic factors fr ...
... at 4 hours, at 1, 3, 5, and 14 days poststroke (0% migration of umbilical cord blood mononuclear cells),8 or during stroke surgery (0% migration of umbilical cord blood cells).19 Nevertheless, functional recovery was obtained with intravenous delivery, indicating that secretion of trophic factors fr ...
Behavioral and Cognitive Neuroscience
... brains of extinct mammals. Unfortunately, little of the brain’s great internal complexity is revealed by its size, shape, and fissures. Thus, to learn more about brain evolution, it is necessary to study the brains of extant (present-day) species and use comparative methods to deduce the organizatio ...
... brains of extinct mammals. Unfortunately, little of the brain’s great internal complexity is revealed by its size, shape, and fissures. Thus, to learn more about brain evolution, it is necessary to study the brains of extant (present-day) species and use comparative methods to deduce the organizatio ...
p57 regulates radial glia and intermediate precursor
... and intermediate precursors (IPC) was increased, expanding both populations, with greater effect on IPCs. Furthermore, cell cycle re-entry was increased during early corticogenesis, whereas cell cycle exit was augmented at middle stage. Consequently, neurogenesis was reduced early, whereas it was en ...
... and intermediate precursors (IPC) was increased, expanding both populations, with greater effect on IPCs. Furthermore, cell cycle re-entry was increased during early corticogenesis, whereas cell cycle exit was augmented at middle stage. Consequently, neurogenesis was reduced early, whereas it was en ...
The Neurobiology of Cricket Song
... From the work of many laboratories, including our own at the University of California at Berkeley and at Cornell University, it is known that the nerve networks needed for generating the songs of crickets are closely allied to those involved in flight. Both systems de velop in stages as the cricket ...
... From the work of many laboratories, including our own at the University of California at Berkeley and at Cornell University, it is known that the nerve networks needed for generating the songs of crickets are closely allied to those involved in flight. Both systems de velop in stages as the cricket ...
Effect of Brefeldin A on the synthesis and transport of cell wall
... lipids into the endoplasmic reticulum by a mechanism which requires energy and microtubules (Fujiwara et al., 1988; Domse/a/., 1989; Lippincott-Schwartz e? al., 1990); (c) the release of the non-clathrin coated protein jS-COP from the Golgi apparatus (Donaldson et al., 1990); (d) changes in the morp ...
... lipids into the endoplasmic reticulum by a mechanism which requires energy and microtubules (Fujiwara et al., 1988; Domse/a/., 1989; Lippincott-Schwartz e? al., 1990); (c) the release of the non-clathrin coated protein jS-COP from the Golgi apparatus (Donaldson et al., 1990); (d) changes in the morp ...
Computational themes of peripheral processing
... is important because it determines its functional role in the pathway. Subtractive and divisive adaptation The way adaptation changes the onset response curve of the sensory periphery determines which and how much information about a given stimulus is available at more central stages. In most cases, ...
... is important because it determines its functional role in the pathway. Subtractive and divisive adaptation The way adaptation changes the onset response curve of the sensory periphery determines which and how much information about a given stimulus is available at more central stages. In most cases, ...
The role responses of expression and identity in the face
... As tested on a two-way ANOVA, 15 neurons showed response differences to different identities independently of expression, and 9 neurons showed responses to different expressions independently of identity. Three neurons showed significant effects of both factors. Six of the neurons with responses rel ...
... As tested on a two-way ANOVA, 15 neurons showed response differences to different identities independently of expression, and 9 neurons showed responses to different expressions independently of identity. Three neurons showed significant effects of both factors. Six of the neurons with responses rel ...