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Journal of Experimental and Clinical Medicine Is phenylketonuria
Journal of Experimental and Clinical Medicine Is phenylketonuria

... to the excessive use of glutamine in the formation of phenylglutamine may be a direct cause of brain injury in PKU (Ney et al., 2014). The accumulation of phenylalanine in non brain tissues and the decreased production of tyrosine can cause other clinical symptoms. Increased levels of phenylalanin ...
Effects of excess vitamin B6 intake on cerebral cortex neurons in rat
Effects of excess vitamin B6 intake on cerebral cortex neurons in rat

... cortex of forty-eight healthy albino rats which were included in the study. Saline solution was injected to to the control groups (CG-10, n=12 for 10 days; CG-15, n=12 for 15 days; CG-20, n=12 for 20 days). The three experimental groups (EG-10, n=12; EG-15, n=12; EG-20, n=12) were treated with 5 mg/ ...
An action perspective on motor development
An action perspective on motor development

... fail, at least to begin with. For the same reason, children abandon established patterns of behaviour in favour of new ones. For instance, infants often try to walk at an age when they can locomote much more efficiently by crawling. In these examples there is no external reward. It is as if the infa ...
Full Prescribing Information
Full Prescribing Information

... ORBACTIV has been shown to artificially prolong aPTT for up to 120 hours, PT and INR for up to12 hours, and activated clotting time (ACT) for up to 24 hours following administration of a single 1200 mg dose by binding to and preventing action of the phospholipid reagents commonly used in laboratory ...
DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR
DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR

... Both drugs showed good regression values at their respective wavelengths and the results of recovery study revealed that any small change in the drug concentration in the solution could be accurately determined by the proposed method and low values of LOD and LOQ indicated good sensitivity of propos ...
The Neuropsychology of Reading Disorders
The Neuropsychology of Reading Disorders

... are close to the cell body and analogous to roots of a tree. Cell body - wide area of neuron which contains the nucleus, the command center of the cell that houses our genes. Axons - relatively long processes that carry proteins, chemicals, and electrical signals generated by nucleus to axon termina ...
Drugs Shatter Lives - East Point Police Department
Drugs Shatter Lives - East Point Police Department

... accessible and widely abused drug. It provides a long-lasting, and relatively cheap high, with the average dose costing between five and ten dollars. Its mild, depressant effects appeal to every age group and socio-economic group.Users become psychologically addicted and are blissfully unaware of th ...
PRODUCT MONOGRAPH Pr TRELSTAR® 3.75 mg
PRODUCT MONOGRAPH Pr TRELSTAR® 3.75 mg

... subsequently menstruation. However, contraception cannot be insured. Women should use nonhormonal methods of contraception while on therapy and should be advised to see their physician if they think they may be pregnant. If a woman becomes pregnant while receiving TRELSTAR, therapy should be discont ...
development of polymeric drug delivery systems for biotech products
development of polymeric drug delivery systems for biotech products

... these advantages and the particular characteristics of PEG, to date, there are on the market 12 pegylated compounds: 9 are proteins, one peptide, one aptamer and a liposomal formulation, containing doxorubicin. The improvements in the pharmacokinetic profile of these drugs, thanks to the use of drug ...
Pharmacokinetic–pharmacodynamic modelling of the hypothermic
Pharmacokinetic–pharmacodynamic modelling of the hypothermic

... receptor agonists using the effect on body temperature as a pharmacodynamic endpoint (Fig. 1; Zuideveld et al., 2001). Briefly, this model is based on the principle of a set-point control in an indirect physiological response model (Dayneka et al., 1993) and is able to characterise quantitatively th ...
Biology 358 — Neuroanatomy First Exam
Biology 358 — Neuroanatomy First Exam

Neurological Understanding of Surrogate Healing in
Neurological Understanding of Surrogate Healing in

... demonstrating as to be false - more about that in another article). Another interesting fact here is that in order for the child with autism to experience the relief in the symptoms he/she may be struggling with, it is not necessary for the child to be physically present or watch the parents’ sessio ...
PRODUCT MONOGRAPH TRELSTAR 3.75 mg Triptorelin for
PRODUCT MONOGRAPH TRELSTAR 3.75 mg Triptorelin for

... subsequently menstruation. However, contraception cannot be insured. Women should use nonhormonal methods of contraception while on therapy and should be advised to see their physician if they think they may be pregnant. If a woman becomes pregnant while receiving TRELSTAR, therapy should be discont ...
The effect of fasting on the ultrastructure of the hypothalamic arcuate
The effect of fasting on the ultrastructure of the hypothalamic arcuate

... 4A, C, 5A, 6A) among other ultrastructural changes. They were formed by two cisternae of the RER attached closely to each other. Their outer membranes were irregularly studded with ribosomes. The narrow cleft between two adjacent membranes was often filled with moderately dense material. In the cont ...
Dissociable effects of monoamine reuptake inhibitors on distinct
Dissociable effects of monoamine reuptake inhibitors on distinct

... subtypes of impulsive behavior are distinguished, i.e., impulsive choice and impulsive action. Impulsive choice refers to the inability to delay gratification, which is behaviorally apparent as a preference for a small, immediate gain over a larger reward that one has to wait for. Impulsive action c ...
Complexins: Cytosolic Proteins That Regulate
Complexins: Cytosolic Proteins That Regulate

... phospholipid membranes. For example, at most synapses more than five synaptic vesicles are docked at the active zone, apparently ready for fusion at any given time, yet on the average fewer than one vesicle fuses upon CaZf influx (Allen and Stevens, 1994). These and other findings suggest a tight co ...
Event-Driven Simulation Scheme for Spiking Neural Networks Using
Event-Driven Simulation Scheme for Spiking Neural Networks Using

Afferents of dopamine neurons
Afferents of dopamine neurons

... Actions mediated through at least two classes of receptors ...
Developmental mechanics of the primate cerebral cortex
Developmental mechanics of the primate cerebral cortex

... sidelined by the rapid progress of research into the genetic control of brain development. It may, however, be worthwhile to take a second look at developmental mechanics to understand how the intricate complexity of brain shape and function can arise from a finite number of genes controlling neural ...
Thunbergia laurifolia extract minimizes the adverse effects of
Thunbergia laurifolia extract minimizes the adverse effects of

... Antitoxicity effect of Thunbergia laurifolia extract ...
Neuronal Activity and Ion Homeostasis in the Hypoxic Brain
Neuronal Activity and Ion Homeostasis in the Hypoxic Brain

... difficult to analyze the underlying dynamics. Furthermore, including all relevant interactions at a similar detailed level for e.g. diffusion, synaptic activity, metabolism and cell damage, would result in a very complicated and impractical model. The model of Vatov et al. [9, 10] is an example of a ...
The Bifurcating Neuron Network 1q
The Bifurcating Neuron Network 1q

... follow the other option, a network of chaotic neurons, for the following reason. Chaotic activity will be more useful in the `ready-state' of a network where the network is ready to respond to an external stimulus. In other words, we have the following scenario in mind: a stimulus known to a network ...
PATIENT INFORMATION LEAFLET NELABOCIN CEFUROXIME
PATIENT INFORMATION LEAFLET NELABOCIN CEFUROXIME

... Cefuroxime axetil may be used in elderly patients. 2.4.3 Pregnancy: In experimental studies, no embryopathies or teratogenesis caused by cefuroxime axetil were reported but as with all drugs, it should be administered with caution during the first months of pregnancy. 2.4.4 Lactation: Cefuroxime is ...
Autonomic nervous system
Autonomic nervous system

... Joined to ventral rami by white and gray rami communicantes Fusion of ganglia  fewer ganglia than spinal nerves ...
Natural Products for the Treatment of Trachoma and Chlamydia
Natural Products for the Treatment of Trachoma and Chlamydia

... nontoxic compounds for the treatment of chlamydial infections remains an important goal. 1.3. Drug Resistance and Biopharmaceuticals Many conventional modern antibiotics are natural compounds obtained from microbial sources [21], with perhaps the most well-known being penicillin. This highlights the ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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