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How the Brain Makes Play Fun
How the Brain Makes Play Fun

... heroin, cocaine, nicotine, alcohol—as well as food and sex induce conditioned place preference. Therefore, if a stimulus, drug, or event induces conditioned place preference, we usually interpret that stimulus, drug, or event as having positive subjective or pleasurable effects. The precise psycho ...
TABERNAEMONTANA DIVARICATA R. BR. FLOWER EXTRACT  Research Article   
TABERNAEMONTANA DIVARICATA R. BR. FLOWER EXTRACT  Research Article   

... Epilepsy  is  a  neurological  disorder  that  affects  a  wide  range  of  people throughout the world. It is a disorder of brain characterize by  unpredictable  and  periodic  occurrence  of  a  transient  alteration  of  behaviour due to the disordered, synchronous and rhythmic firing of  populat ...
The Glutamatergic System and Alzheimer`s Disease
The Glutamatergic System and Alzheimer`s Disease

... Glutamate can be neurotoxic through a stimulatory effect on NMDA, AMPA, kainate or group 1 metabotropic receptors (mGluR1), but selective neuronal death in Alzheimer’s disease appears to be dependent primarily on NMDA receptor activation.[55] Indeed, a recent study suggests that NMDA receptor activa ...
rainfall-runoff modelling in batang layar and oya sub
rainfall-runoff modelling in batang layar and oya sub

... Alhamdulillah, first and foremost, thank you to ALLAH S.W.T. with His companion and guidance this project complete successfully. My special appreciation goes to my supervisor, Mdm. Rosmina Ahmad Bustami for her assistance and attention in accomplishing this project. The author also likes to dedicate ...
HYMAN, PHELPS 8 MCNAMARA, P. C.
HYMAN, PHELPS 8 MCNAMARA, P. C.

... enzymes, or antigens, altered by a disease are also included in this category. ...
Neurobiomechanical Influences on Nerve Conduction
Neurobiomechanical Influences on Nerve Conduction

... • At this point I always struggled to picture everything in its entirety. – If Molecule transfers provided electrochemical gradients which created the action potentials what constrained them? Intracellular fluids/contents where controlled by membrane physiology but what happens outside of the cell? ...
Visual Categorization and the Primate Prefrontal Cortex
Visual Categorization and the Primate Prefrontal Cortex

... meaningful groupings or categories. This process of abstracting and storing the commonalities among like-themed individuals is fundamental to cognitive processing because it imparts knowledge. For example, knowing that a new gadget is a “camera” instantly and effortlessly provides a great deal of in ...
Overview Synaptic plasticity Synaptic strength
Overview Synaptic plasticity Synaptic strength

... Biophysical models explain STDP using the principles of ion channel dynamics and intracellular processes. Usually contains a large parameter space. ...
Bisgaier 1998
Bisgaier 1998

... catabolic product of triglyceride-rich lipoproteins (11– 15). Although existing evidence suggests that HDL are derived directly from liver (16, 17) and intestine (18– 20), the importance of phospholipid–apolipoprotein surface generated during triglyceride-rich lipoprotein lipolysis cannot be underes ...
Serex Film Coated Tablets 25-100-200-300 mg, 30 tablets
Serex Film Coated Tablets 25-100-200-300 mg, 30 tablets

... for deterioration in glucose table. Quetiapine may cause dizziness, tachycardia and sometimes hypotension accompanied by syncope, especially in dose increasing period at the start of treatment. As in with other antipsychotics, quetiapine also should be used carefully in patients that have seizures o ...
The addictive behaviour induced by food monosodium glutamate
The addictive behaviour induced by food monosodium glutamate

... solution from bottle A increased statistically significant (p < 0.0001), for all three test groups (II, III, IV), as seen in Figures 1 and 2. The intensity of the effect is in a direct relation with the concentration of the solution of MSG given (the greatest increase in MSG consumption, 71.02%, is n ...
neural representation and the cortical code
neural representation and the cortical code

... middle temporal cortical area (MT), an area believed to be involved in the representation of visual motion. The response properties of these two neurons to stimuli are identical by construction, yet neuron B2 has no axon and hence serves no functional role whatsoever. Can one say what these two neur ...
Effects of Advanced Liver Disease on drug PK
Effects of Advanced Liver Disease on drug PK

... function maintained metabolic activity and the ability to secrete liver-specific proteins, whereas hepatocytes derived from cirrhotic livers with decompensated function failed to maintain metabolic or secretory activity. The latter showed signs of replicative senescence and express genes that simult ...
Glial Cell Line-derived Neurotrophic Factor (GDNF) Therapy for
Glial Cell Line-derived Neurotrophic Factor (GDNF) Therapy for

... the neurtralizing antibody remains to be explored. In addition, cerebellar lesions were found in monkeys receiving a high dose of GDNF [46, 48]. These results and the decision of Amgen disappointed the patients and researchers involved in this study, and there has been fierce controversy over the dec ...
IMPROVING OF ARTIFICIAL NEURAL NETWORKS
IMPROVING OF ARTIFICIAL NEURAL NETWORKS

... William developed the known algorithm called back propagation. This can be considered as second generation of ANN. The third generation was studied since 1930, with British scientists Alan Lloyd Hodgkin (1914-1998) y Andrew Fielding Huxley (he was born in 1917), nowadays SNN are based on this model. ...
Fluorescent in situ hybridization technique for cell type identification
Fluorescent in situ hybridization technique for cell type identification

... specificity? What exactly is “cell type” of neurons? Our laboratory has been trying to identify the unique features of the primate neocortex using molecular biological techniques. Specifically, we have been searching for area- and/or layer-specific genes and using them as probes for comparative ISH ...
A visual motion detection circuit suggested by Drosophila
A visual motion detection circuit suggested by Drosophila

... connectome of the repeating module of the medulla. Within this module, we identified cell types constituting a motion detection circuit, and showed that the connections onto individual motion-sensitive neurons in this circuit were consistent with their direction selectivity. Our results identify cel ...
Introduction and review of Matlab
Introduction and review of Matlab

... 5. If sufficient excitatory neurotransmitter binds to receptors, an action potential is produced in the postsynaptic membrane and travels along the axon of the second neuron. 6. To prevent continuous stimulation or inhibition of the postsynaptic membrane, neurotransmitters are broken down by enzymes ...
J.P. MORGAN 34TH ANNUAL HEALTHCARE CONFERENCE
J.P. MORGAN 34TH ANNUAL HEALTHCARE CONFERENCE

... market potential of our product candidates, the impact of competitive products and pricing, new product development, uncertainties related to the regulatory approval process and other risks detailed from time to time in the Company’s ongoing quarterly filings and annual reports. Forward-looking stat ...
A Motion-sensitive Area in Ferret Extrastriate
A Motion-sensitive Area in Ferret Extrastriate

... Preferred directions of visual stimulus motion were determined utilizing the weighted average method. Each spike time was assigned a vector corresponding to the stimulus direction at this time corrected by the neuron’s response latency. In other words: a response at time t = x ms was related to a st ...
Foundations for a Circuit Complexity Theory of Sensory
Foundations for a Circuit Complexity Theory of Sensory

... The complexity bounds for circuits that can realistically be implemented in VLSI are typically even more severe than for “wetware”, and linear or almost linear bounds for the total wire length are desirable for that purpose. In this article we begin the investigation of algorithms for basic sensory ...
ANTICONVULSANT ACTIVITY OF AQUEOUS ROOT EXTRACT OF CALOTROPIS GIGANTEA IN
ANTICONVULSANT ACTIVITY OF AQUEOUS ROOT EXTRACT OF CALOTROPIS GIGANTEA IN

... Assessment of anticonvulsant activity Maximal electro shock induced seizures (MES MODEL) Swiss albino mice weighing 25 – 30 gms were used. The animals were pre-screened for their ability to develop full tonic extension in the maximal electro shock test and only those which showed good response were ...
Editorial Commentary
Editorial Commentary

... 13 mm Hg); thus, there were some patients in whom the response observed was modest at best. Mindful of this broad range of responses, interindividual variability, and the absence of predictors of response, the number of patients required for chronic dosing studies would indeed be quite large. As to ...
DIENCEPHALON
DIENCEPHALON

... • Distributing most of afferent inputs to cerebral cortex • Control of electrocortical activity of cerebral cortex – plays important roles in arousal, consciousness and sleep mechanisms • Integration of motor functions by providing the relays – impulses from the basal ganglia and cerebellum can reac ...
Opioid-Induced Constipation - American College of Gastroenterology
Opioid-Induced Constipation - American College of Gastroenterology

... movements (SBMs) per week and requiring ≥30 mg oral morphineequivalent unit/day, participants were randomized to alvimopan, 0.5 mg b.i.d., 1 mg once daily, 1 mg b.i.d., or placebo for 6 weeks (63). There was a significant increase in mean SBM/week over the initial 3 weeks of treatment with all 3 dos ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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