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Contributions of Retinal Ganglion Cells to
Contributions of Retinal Ganglion Cells to

... axonless and modulate the response of ganglion cells via feedback and feedforward mechanisms. Ganglion cells are the sole output neuron of the retina, and their axons form the optic nerve, which transmits information to visual processing centers in the brain. (b) The cells and circuits in the retina ...


... Stanford´s somnolence scale. A possible explanation for these results could be that benzodiazepine elimination half-life has not much relation with the psychophysiological effects that they produce, and they may be caused by the interaction of other factors such as age, health, or simply be a conseq ...
Matching mind to world and vice versa: Functional dissociations
Matching mind to world and vice versa: Functional dissociations

... With the aim of understanding how different mental or intentional states are processed in the brain, the present functional magnetic resonance imaging (fMRI) study examined the brain correlates during the ascription of belief intentional states relative to desire intentional states as well as the ef ...
Nonsteroidal anti-inflammatory drugs
Nonsteroidal anti-inflammatory drugs

... could be a treatment option since the response mechanism of sensitivity to ASA particularly involves the COX 1 ...
The Nervous System
The Nervous System

... How do researchers identify the major parts and functions of the brain? What are the major parts of the brain, and for what behaviours is each part responsible? How do the two halves of the brain operate ...
Multi-Layer Feed-Forward - Teaching-WIKI
Multi-Layer Feed-Forward - Teaching-WIKI

... – They must learn decision surfaces from training data, so that training data (and test data) are classified correctly; – They must be able to generalize based on the learning process, in order to classify data sets it has never seen before. • Note that there is an important trade-off between the le ...
Part 2 - OoCities
Part 2 - OoCities

... greater solubility in water. The hydrophilic nature of charged amoxicillin allows it to readily associate with water, increasing its solubility. Hydrophobic interaction, which is the most important “driving force” of protein binding, has a lesser effect on molecules that are hydrophilic. A drug incl ...
QA50_8_Hypersalivationgeneral
QA50_8_Hypersalivationgeneral

... owing to the normal production of saliva. Hyoscine hydrobromide can also be given by non-topical routes but there is less evidence to support this. Glycopyrronium (see separate Q&A 52 for more detailed information) Glycopyrronium (glycopyrrolate) is slower in onset and produces less tachycardia than ...
A local circuit approach to understanding integration of
A local circuit approach to understanding integration of

... and suppression effects tend to be strongest for iso-orientation surrounds. (a) Typical data from a cell in cat V1 obtained by Toth et al. (1996) but presented here for the first time. Increasing the contrast of an optimally oriented grating stimulus (presented to the classical receptive field in co ...
In VivoCalcium Imaging Reveals Functional Rewiring of Single
In VivoCalcium Imaging Reveals Functional Rewiring of Single

... taking on the functional roles of lost tissues. Although this model is well supported by data, it is not clear how activity in single neurons is altered in relation to cortical functional maps. It is conceivable that individual surviving neurons could adopt new roles at the expense of their usual fu ...
Lecture_16.Alicyclic_antibiotics
Lecture_16.Alicyclic_antibiotics

... the depressor substances (histamine, serotonin, bradykinin) at the production. The investigation is realized on a cat, its mass is not more than 2 kg. The cat was narcotized by a chloralose, barbiturates or urethane to maintain a constant blood pressure. Through the carotid artery, the animal is att ...
- Wiley Online Library
- Wiley Online Library

... was modeled by including six movement regressors of no interest in the model. Moreover, it is known that intrinsic, spontaneous fMRI activity might be confounded by signal variance related to spurious signal components residing foremost in cerebrospinal fluid (CSF), vascular space and white matter (s ...
challenges in adc development
challenges in adc development

... relapsed or refractory CD30þ HL following autologous stem cell transplant (ASCT) or patients not legible for ASCT who have failed at least two other chemotherapy treatments. Also approved for patients with anaplastic large cell lymphoma (ALCL) as a second line – Approval for Hodgkin’s lymphoma was b ...
brain - FIAS
brain - FIAS

... Jochen Triesch, UC San Diego, http://cogsci.ucsd.edu/~triesch ...
Long?Term, Stable Differentiation of Human Embryonic Stem Cell
Long?Term, Stable Differentiation of Human Embryonic Stem Cell

... HESCs have been demonstrated in recent in vitro studies where these cells were induced to evolve into specific neuronal and glial lineages to become mesencephalic dopaminergic neurons [6–8], motor neurons [9–11], and oligodendrocytes [12]. The traditional ES cell differentiation paradigm involves the ...
sleeping pills and minor tranquillisers
sleeping pills and minor tranquillisers

... (gamma amino butyric acid). This reduces brain activity in the areas of the brain responsible for rational thought, memory, the emotions, and essential functions, such as breathing, which in turn slows down how your body and brain work. Benzodiazepines are very effective in the short term, but they ...
AN INTEGRATIVE THEORY OF LOCUS
AN INTEGRATIVE THEORY OF LOCUS

... phasic and tonic. Phasic LC activation is driven by the outcome of task-related decision processes and is proposed to facilitate ensuing behaviors and to help optimize task performance (exploitation). When utility in the task wanes, LC neurons exhibit a tonic activity mode, associated with disengage ...
Changes in Intracellular pH Associated with Glutamate Excitotoxicity
Changes in Intracellular pH Associated with Glutamate Excitotoxicity

... large deviations in [Ca*+], and high potassium or cyanide induced increasesin [Ca*+], do not produce toxicity (Michaels and Rothman, 1990; Dubinsky and Rothman, 1991). Intracellular acidification hasbeen postulated to contribute to ischemicneuronal death (Tombaugh and Sapolsky, 1990; Nedergaardet al ...
PRODUCT MONOGRAPH ELAVIL® Amitriptyline Hydrochloride
PRODUCT MONOGRAPH ELAVIL® Amitriptyline Hydrochloride

... possibly promoting more rapid elimination of the drug from the body. If the patient is not alert, a cuffed endotracheal tube should be inserted before lavage is performed, and emesis should not be induced. An open airway should be maintained. Standard measures (oxygen, i.v. fluids, corticosteroids) ...
Morphometric Investigation of Neurons in the Hippocampal
Morphometric Investigation of Neurons in the Hippocampal

... KAFA, I. M.; ARI, I. & KURT, M. A. Morphometric investigation of neurons in the hippocampal CA1, CA3 areas and dentate gyrus in a rat model of sepsis. Int. J. Morphol., 28(1):183-192, 2010. SUMMARY: Approximately, half of the patients with progressive sepsis develop encephalopathy, but there is scar ...
Crapse (2008) Corollary discharge across the animal kingdom
Crapse (2008) Corollary discharge across the animal kingdom

... “corollary discharge” (CD) to denote motor-related signals that influence sensory processing, but his conception was less specific as to where the branch from motor to sensory pathways should emerge. In this Review we compare motor-to-sensory circuits across different species and different levels of ...
7. Nervous Tissue, Overview of the Nervous System.
7. Nervous Tissue, Overview of the Nervous System.

... The functionality of nervous tissue rests largely on its ability of its cells (neurons) to generate, transmit and process information. “Information” gathered from body or its surroundings is described as sensations. Information which directs body tissues into activity is described as being ‘motor’ i ...
“CRIME SCENE INVESTIGATION” AT AN ANESTHETIC COCKTAIL PARTY WITH ATRIOVENTRICULAR DISSOCIATION c
“CRIME SCENE INVESTIGATION” AT AN ANESTHETIC COCKTAIL PARTY WITH ATRIOVENTRICULAR DISSOCIATION c

... is not easy to define and might rather be a change in sympathetic nervous activity27. Diclofenac is not known to have any direct impact on cardiac arrhythmia, besides the possible hyperkalemia after non-steroidal anti-inflammatory drug-induced renal dysfunction28. Investigator: What do you think was ...
Basal ganglia discharge abnormalities in Parkinson`s disease
Basal ganglia discharge abnormalities in Parkinson`s disease

... model, pallidal lesions would be expected to result in involuntary movements, but, in fact, have little effect on normal motor behavior. Similarly, thalamic inactivation, although predicted to induce parkinsonism, does not. Pattern changes Given that changes in discharge rate of basal ganglia neuron ...
MIrror neuRons based RObot Recognition - LIRA-Lab
MIrror neuRons based RObot Recognition - LIRA-Lab

... activating the brain’s motor representations. In favor of this idea are electrophysiological studies of monkey premotor area F5 (see also Figure 1), showing that a subset of neurons (the so called canonical neurons) are activated not only when the monkey executes a goal directed hand action (such as ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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