Neurodevelopmental, emotional, and behavioural
... the most comprehensive picture so far of the neuropsychiatric elements of DMD, by capturing with parent reporting a wide array of CNS characteristics including (1) intellectual difficulties, (2) neurodevelopmental disorders (ASD, ADHD), and (3) emotional behavioural problems such as internalizing an ...
... the most comprehensive picture so far of the neuropsychiatric elements of DMD, by capturing with parent reporting a wide array of CNS characteristics including (1) intellectual difficulties, (2) neurodevelopmental disorders (ASD, ADHD), and (3) emotional behavioural problems such as internalizing an ...
Front Matter
... incidence had greatly increased since 1870, especially among those living in barracks and prisons for more than three months. Two views prevailed as to its aetiology, namely that it was either of bacterial origin or else caused by a toxin in the rice that formed the staple diet of all those who were ...
... incidence had greatly increased since 1870, especially among those living in barracks and prisons for more than three months. Two views prevailed as to its aetiology, namely that it was either of bacterial origin or else caused by a toxin in the rice that formed the staple diet of all those who were ...
HMG-CoA reductase inhibitor pharmacogenomics: overview and
... approximately a third of patients receiving lipidlowering drugs achieve LDL goals, with less than 20% of CHD patients at goal [9]. Starting cholesterol levels and inadequate doses do not fully explain the variable responses to statins. In addition, while statin therapy results in roughly a 25– 35% r ...
... approximately a third of patients receiving lipidlowering drugs achieve LDL goals, with less than 20% of CHD patients at goal [9]. Starting cholesterol levels and inadequate doses do not fully explain the variable responses to statins. In addition, while statin therapy results in roughly a 25– 35% r ...
HTM Neuron paper 12-1
... Neocortical neurons have thousands of excitatory synapses. It is a mystery how neurons integrate the input from so many synapses and what kind of large-scale network behavior this enables. It has been previously proposed that non-linear properties of dendrites enable neurons to recognize multiple pa ...
... Neocortical neurons have thousands of excitatory synapses. It is a mystery how neurons integrate the input from so many synapses and what kind of large-scale network behavior this enables. It has been previously proposed that non-linear properties of dendrites enable neurons to recognize multiple pa ...
recent advances in animal models of drug addiction
... input side of these neuronal circuit(s), ICSS provides a unique tool to investigate the influence of various substances on reward and reinforcement processes. ICSS differs significantly from drug self-administration in that, in the ICSS procedure, the animal is working to directly stimulate presumed ...
... input side of these neuronal circuit(s), ICSS provides a unique tool to investigate the influence of various substances on reward and reinforcement processes. ICSS differs significantly from drug self-administration in that, in the ICSS procedure, the animal is working to directly stimulate presumed ...
RTF - OTC Markets
... adequate safety, efficacy or tolerability in one or more such studies, including vepoloxamer in the EPIC study; the risk that, even if EPIC results are positive, the FDA or other regulatory agencies may determine they are not sufficient to support a new drug application; uncertainties related to fut ...
... adequate safety, efficacy or tolerability in one or more such studies, including vepoloxamer in the EPIC study; the risk that, even if EPIC results are positive, the FDA or other regulatory agencies may determine they are not sufficient to support a new drug application; uncertainties related to fut ...
Do neurons have a reserve of sodium channels for the generation of
... Generation of repetitive action potentials The slowing of the recovery after activation of action potentials in the presence of TTX can be assumed to in¯uence repetitive action potential ®ring. Thus, the effect of the blockade of different fractions of sodium channels on the maximal number of action ...
... Generation of repetitive action potentials The slowing of the recovery after activation of action potentials in the presence of TTX can be assumed to in¯uence repetitive action potential ®ring. Thus, the effect of the blockade of different fractions of sodium channels on the maximal number of action ...
Saccade Target Selection in the Superior - Smith
... interest, selecting one goal from many is clearly a fundamental problem faced by the saccadic system. We recorded from visual, movement, and visuo-movement (VM) neurons in the superior colliculus (SC) of monkeys performing a reaction-time visual-search task requiring them to make saccades to an odd- ...
... interest, selecting one goal from many is clearly a fundamental problem faced by the saccadic system. We recorded from visual, movement, and visuo-movement (VM) neurons in the superior colliculus (SC) of monkeys performing a reaction-time visual-search task requiring them to make saccades to an odd- ...
Layer III Neurons Control Synchronized Waves in the Immature
... its spatiotemporal organization is not fully understood. Using wide-field calcium imaging from acute whole-brain slices of rat pups on postnatal days 1– 6, we found that correlated spikes were initiated in the anterior part of the lateral entorhinal cortex and propagated anteriorly to the frontal co ...
... its spatiotemporal organization is not fully understood. Using wide-field calcium imaging from acute whole-brain slices of rat pups on postnatal days 1– 6, we found that correlated spikes were initiated in the anterior part of the lateral entorhinal cortex and propagated anteriorly to the frontal co ...
- The University of Liverpool Repository
... In 2008, the US Food and Drug Administration issued guidance for industry on new therapies to treat type 2 diabetes (T2D), recommending that sponsors should demonstrate that these treatments are “not associated with an unacceptable increase in cardiovascular risk” (1). This mandate challenges drug d ...
... In 2008, the US Food and Drug Administration issued guidance for industry on new therapies to treat type 2 diabetes (T2D), recommending that sponsors should demonstrate that these treatments are “not associated with an unacceptable increase in cardiovascular risk” (1). This mandate challenges drug d ...
RTF - OTC Markets
... adequate safety, efficacy or tolerability in one or more such studies, including vepoloxamer in the EPIC study; the risk that, even if EPIC results are positive, the FDA or other regulatory agencies may determine they are not sufficient to support a new drug application; uncertainties related to fut ...
... adequate safety, efficacy or tolerability in one or more such studies, including vepoloxamer in the EPIC study; the risk that, even if EPIC results are positive, the FDA or other regulatory agencies may determine they are not sufficient to support a new drug application; uncertainties related to fut ...
Mesodermal and neuronal retinoids regulate the induction and
... in forelimb spinal motor neurons led to a decrease of forelimb LMCl neurons, supporting the idea that motor neuron sources of RA are partly required for LMCl specification (Vermot et al., 2005, Fig. 8A). The homeobox protein Hoxc8 is thought to mediate this process as Hoxc8 expression is lost in LMC ...
... in forelimb spinal motor neurons led to a decrease of forelimb LMCl neurons, supporting the idea that motor neuron sources of RA are partly required for LMCl specification (Vermot et al., 2005, Fig. 8A). The homeobox protein Hoxc8 is thought to mediate this process as Hoxc8 expression is lost in LMC ...
liquid dosage forms - New Age International
... including solutions, syrups, suspensions, elixirs, and concentrates offer unique advantages to many patients. For example, liquids may provide better patient compliance for those with swallowing difficulties and better dosage control versus a fixed tablet dose. However, there are also a number of “c ...
... including solutions, syrups, suspensions, elixirs, and concentrates offer unique advantages to many patients. For example, liquids may provide better patient compliance for those with swallowing difficulties and better dosage control versus a fixed tablet dose. However, there are also a number of “c ...
An introduction to pain pathways and mechanisms
... However, imaging techniques such as functional magnetic resonance imaging (fMRI) have demonstrated that a large brain network is activated during the acute pain experience. This is often called the ‘pain matrix’. The commonest areas activated include the primary and secondary somatosensory cortex (S ...
... However, imaging techniques such as functional magnetic resonance imaging (fMRI) have demonstrated that a large brain network is activated during the acute pain experience. This is often called the ‘pain matrix’. The commonest areas activated include the primary and secondary somatosensory cortex (S ...
Major risk factors (exclusive of LDL cholesterol)
... NA is immediately taken up by adipose tissue ...
... NA is immediately taken up by adipose tissue ...
Intracranial Complications of Suppurative Otitis Media
... • severe headache, vomiting and papilledema. – Terminal stage: • the delirium progresses to coma, • the reflexes become weak or absent, • cranial nerve palsies occur. ...
... • severe headache, vomiting and papilledema. – Terminal stage: • the delirium progresses to coma, • the reflexes become weak or absent, • cranial nerve palsies occur. ...
Chapter 12: Spinal Cord And Spinal Nerves
... 5. Axons supplying the upper limbs enter and exit the cord at _______________ 6. Axons supplying the lower limbs enter and exit the cord at _______________ 7. What is the conus medullaris? _____________________________________ 8. The cauda equina is composed of __________________________________ B. ...
... 5. Axons supplying the upper limbs enter and exit the cord at _______________ 6. Axons supplying the lower limbs enter and exit the cord at _______________ 7. What is the conus medullaris? _____________________________________ 8. The cauda equina is composed of __________________________________ B. ...
Gen. Pharmac. Vol. 27, No. ... ISSN 0306-3623/96 15.00 + .00 0306-3623(95)02019-A
... groups. If control groups for both experiments are compared, the adults clearly exhibit much more aggressive behavior, probably as a consequence of higher endogenous testosterone levels. Small et al. (1984) found that a 14-day treatment with stanozolol (10 mg orally per day) decreased serum testoste ...
... groups. If control groups for both experiments are compared, the adults clearly exhibit much more aggressive behavior, probably as a consequence of higher endogenous testosterone levels. Small et al. (1984) found that a 14-day treatment with stanozolol (10 mg orally per day) decreased serum testoste ...
Guide to Migraine Medications
... no tangible effect on your migraine, your doctor may increase the dosage. ...
... no tangible effect on your migraine, your doctor may increase the dosage. ...
The contribution of intrinsic membrane dynamics to fast network
... of networks of inhibitory LIF neurons depends on the time constants of the recurrent synaptic currents. With physiologically reasonable time constants, the population frequency is ⬎100 Hz and can be as high as 300 Hz, whereas single cells fire irregularly and at a much lower rate than the population ...
... of networks of inhibitory LIF neurons depends on the time constants of the recurrent synaptic currents. With physiologically reasonable time constants, the population frequency is ⬎100 Hz and can be as high as 300 Hz, whereas single cells fire irregularly and at a much lower rate than the population ...
The Ventral Striatopallidum and Extended Amygdala in
... of the putamen and pallidum more caudally. Calleja islands are frequent, the major Calleja island between the nucleus accumbens and septal nuclei is the largest island among all mammalian brains. The nucleus accumbens has attracted much interest in the field of psychiatry in recent years especially ...
... of the putamen and pallidum more caudally. Calleja islands are frequent, the major Calleja island between the nucleus accumbens and septal nuclei is the largest island among all mammalian brains. The nucleus accumbens has attracted much interest in the field of psychiatry in recent years especially ...
a review with emphasis on the projections of specific thalamic nuclei
... DeAmicisZo”), and thus deafferentation might not significantly influence the interpretation of studies using the method of retrograde cell degeneration. There are, however, a number of difficulties which should be kept in mind when considering the results of retrograde degeneration studies. One of t ...
... DeAmicisZo”), and thus deafferentation might not significantly influence the interpretation of studies using the method of retrograde cell degeneration. There are, however, a number of difficulties which should be kept in mind when considering the results of retrograde degeneration studies. One of t ...
Opioid Receptors and Legal Highs - The Salvia divinorum Research
... cord and brain. Stimulation of the kappa- receptor produces psychotomimesis, diuresis and spinal analgesia, but does not result in respiratory depression. Salvinorin A has been demonstrated to have pharmacological activity consistent with known KOR agonists including analgesia, sedation, inhibition ...
... cord and brain. Stimulation of the kappa- receptor produces psychotomimesis, diuresis and spinal analgesia, but does not result in respiratory depression. Salvinorin A has been demonstrated to have pharmacological activity consistent with known KOR agonists including analgesia, sedation, inhibition ...