Low Molecular Weight Heparins : Basic and Applied Considerations
... demonstrates that enoxaparin releases less vWF in comparison to dalteparin or UFH, resulting in reduced platelet aggregation. Thus, each of the LMWHs produces somewhat different effects in terms of their effects on vascular function. The release of such substances has an impact on the overall effect ...
... demonstrates that enoxaparin releases less vWF in comparison to dalteparin or UFH, resulting in reduced platelet aggregation. Thus, each of the LMWHs produces somewhat different effects in terms of their effects on vascular function. The release of such substances has an impact on the overall effect ...
Negative BOLD in Sensory Cortices During
... with predictors convoluted with a typical hemodynamic response function (using parameters as in Boynton et al. 1996). Across-subject statistical parametric maps were calculated by using hierarchical random-effects model analysis (Friston et al. 1999) after transformation into Talairach space (Talair ...
... with predictors convoluted with a typical hemodynamic response function (using parameters as in Boynton et al. 1996). Across-subject statistical parametric maps were calculated by using hierarchical random-effects model analysis (Friston et al. 1999) after transformation into Talairach space (Talair ...
Expanded Access Programs
... ― FDA expects that, for expanded access uses authorized under the emergency procedures, there typically will not be time to obtain prior IRB approval of the use. ― In such cases, the emergency use must be reported to the responsible IRB within 5 working days of initiation of treatment (21 CFR 56.104 ...
... ― FDA expects that, for expanded access uses authorized under the emergency procedures, there typically will not be time to obtain prior IRB approval of the use. ― In such cases, the emergency use must be reported to the responsible IRB within 5 working days of initiation of treatment (21 CFR 56.104 ...
Antisense therapy in oncology: new hope for an old idea?
... recognition and affinity to that target. For most drugs the mechanism of action is not well defined. By contrast, the specificity of Watson-Crick hybridisation is the basis for rational drug design of antisense oligonucleotides, leading to a new class of selective protein synthesis inhibitors. At th ...
... recognition and affinity to that target. For most drugs the mechanism of action is not well defined. By contrast, the specificity of Watson-Crick hybridisation is the basis for rational drug design of antisense oligonucleotides, leading to a new class of selective protein synthesis inhibitors. At th ...
PHAR 7633 Chapter 7 Routes of Drug Administration
... Advantages: Rapid - A quick response is possible. Plasma concentration can be precisely controlled using IV infusion administration. Total dose - The whole dose is delivered to the blood stream. That is the bioavailability is generally considered to 100% after IV administration. Larger doses may be ...
... Advantages: Rapid - A quick response is possible. Plasma concentration can be precisely controlled using IV infusion administration. Total dose - The whole dose is delivered to the blood stream. That is the bioavailability is generally considered to 100% after IV administration. Larger doses may be ...
FOXP2: A gene for language and speech
... activities of a half of their family members (Marcus and Fisher, 2003: 257). The gene FOXP2 located on human chromosome 7q31 encodes a protein of 715 amino acids belonging to a large family of transcription factors that possess a winged-helix or forkhead box (‘fox’) (Newbury et al, 2002). According ...
... activities of a half of their family members (Marcus and Fisher, 2003: 257). The gene FOXP2 located on human chromosome 7q31 encodes a protein of 715 amino acids belonging to a large family of transcription factors that possess a winged-helix or forkhead box (‘fox’) (Newbury et al, 2002). According ...
Document
... Alzheimer’s disease – a progressive degenerative disease of the brain that results in dementia Parkinson’s disease – degeneration of the dopamine-releasing neurons of the substantia nigra Huntington’s disease – a fatal hereditary disorder caused by accumulation of the protein huntingtin that leads t ...
... Alzheimer’s disease – a progressive degenerative disease of the brain that results in dementia Parkinson’s disease – degeneration of the dopamine-releasing neurons of the substantia nigra Huntington’s disease – a fatal hereditary disorder caused by accumulation of the protein huntingtin that leads t ...
The Dialectics of Hebb and Homeostasis within
... 2008; Keck et al., 2013; Hengen et al 2013). In the rodent V1 this process of rebalancing activity unfolds slowly, over a time scale of hours to days, which is likely fast enough to compensate for most perturbations these networks normally encounter during experience-dependent development. However, ...
... 2008; Keck et al., 2013; Hengen et al 2013). In the rodent V1 this process of rebalancing activity unfolds slowly, over a time scale of hours to days, which is likely fast enough to compensate for most perturbations these networks normally encounter during experience-dependent development. However, ...
INTRODUCTION Ziprasidone is second
... performed using CYP3A4 inhibitor (Fluoxetine) and inducer (Carbamazepine). The results of HPLC analysis of ziprasidone and its metabolite in culture extracts of Gliocladium roseum are represented in Figure 1. The peak at retention time of 2.4min. represented solvent peak and peak at 4.4min. represen ...
... performed using CYP3A4 inhibitor (Fluoxetine) and inducer (Carbamazepine). The results of HPLC analysis of ziprasidone and its metabolite in culture extracts of Gliocladium roseum are represented in Figure 1. The peak at retention time of 2.4min. represented solvent peak and peak at 4.4min. represen ...
H1 - Brian Whitworth
... picture which it alone saw). The LH, which controls speech, didn’t see the snow picture, and is disconnected from the RH, so it had no idea why the shovel was chosen, so it formed the best available hypothesis • In general “it does not compute” is not an option for human ...
... picture which it alone saw). The LH, which controls speech, didn’t see the snow picture, and is disconnected from the RH, so it had no idea why the shovel was chosen, so it formed the best available hypothesis • In general “it does not compute” is not an option for human ...
An Overview of Present and Future Drug Testing
... findings and could not be trusted. This initiated a blind study from the Centers for Disease Control (CDC) that highlighted the nature of this problem. The study resulted in a 1985 publication in the Journal of the American Medical Association entitled "Crisis in Drug Testing" which documented the ...
... findings and could not be trusted. This initiated a blind study from the Centers for Disease Control (CDC) that highlighted the nature of this problem. The study resulted in a 1985 publication in the Journal of the American Medical Association entitled "Crisis in Drug Testing" which documented the ...
The role of medicine in respiratory diseases
... limitation of airflow that is not fully reversible • Chronic airflow limitation caused by a mixture of small airway disease and parenchymal destruction • Airflow limitation is often progressive • Associated with an abnormal inflammatory response of lungs to noxious substances • PREVENTABLE and TREAT ...
... limitation of airflow that is not fully reversible • Chronic airflow limitation caused by a mixture of small airway disease and parenchymal destruction • Airflow limitation is often progressive • Associated with an abnormal inflammatory response of lungs to noxious substances • PREVENTABLE and TREAT ...
actively spiking compared with non-spiking human epileptic
... SUMMARY Increased concentration of the excitatory neurotransmitter aspartic acid in actively spiking human epileptic cerebral cortex was recently described.2 I In order to further characterise changes in the aspartergic system in epileptic brain, the behaviour of aspartic acid aminotransferase (AAT) ...
... SUMMARY Increased concentration of the excitatory neurotransmitter aspartic acid in actively spiking human epileptic cerebral cortex was recently described.2 I In order to further characterise changes in the aspartergic system in epileptic brain, the behaviour of aspartic acid aminotransferase (AAT) ...
Spinal motor neurons are regenerated after
... intersegmental vessels had stopped in at 24 h into the treatment (n = 5), but not in MTZ-treated control animals (n = 5). These larvae still survived the treatment for several days. This is likely because small zebrafish larvae do not depend on circulation for oxygen diffusion until about 14 dpf (J ...
... intersegmental vessels had stopped in at 24 h into the treatment (n = 5), but not in MTZ-treated control animals (n = 5). These larvae still survived the treatment for several days. This is likely because small zebrafish larvae do not depend on circulation for oxygen diffusion until about 14 dpf (J ...
Bimal K
... conventional digital computer is very good in solving expert system problems and somewhat less efficient in solving fuzzy logic problems, but its limitations in solving pattern recognition and image processing-type problems have been seriously felt since the late 1980s and early 1990s. As a result, ...
... conventional digital computer is very good in solving expert system problems and somewhat less efficient in solving fuzzy logic problems, but its limitations in solving pattern recognition and image processing-type problems have been seriously felt since the late 1980s and early 1990s. As a result, ...
Adverse Drug Reaction–Related Hospitalizations Among
... Identifying ADRs retrospectively using administrative hospital data is likely to underestimate the prevalence of ADR-related hospitalizations, as necessary data may be missing or inaccurately recorded.5, 6, 18 Although study design has been shown to affect the estimated prevalence of ADRs, results a ...
... Identifying ADRs retrospectively using administrative hospital data is likely to underestimate the prevalence of ADR-related hospitalizations, as necessary data may be missing or inaccurately recorded.5, 6, 18 Although study design has been shown to affect the estimated prevalence of ADRs, results a ...
6: The Mechanics of Patent-Term Extension
... C o m p o s i t i o n C l a i m s : For composition claims, the three different methods would have different effects on the amount of protection provided to the patentee and the availability of the technology for use by others. Assume that a composition claim recites: “A therapeutic composition for ...
... C o m p o s i t i o n C l a i m s : For composition claims, the three different methods would have different effects on the amount of protection provided to the patentee and the availability of the technology for use by others. Assume that a composition claim recites: “A therapeutic composition for ...
INDEX S.No Categories 1 Applications for Investigational New
... causing photosensitivity or the nature of action suggests such a potential) vi. Rectal tolerance test (For all preparations meant for rectal administration) e. Genotoxicity f. Allergenicity/Hypersensitivity g. Carcinogenicity (Carcinogenicity studies should be performed for all drugs that are expect ...
... causing photosensitivity or the nature of action suggests such a potential) vi. Rectal tolerance test (For all preparations meant for rectal administration) e. Genotoxicity f. Allergenicity/Hypersensitivity g. Carcinogenicity (Carcinogenicity studies should be performed for all drugs that are expect ...
Behavioral Response and Transmitter Release During Atonia
... medial medulla in sleep in intact, unrestrained behaving animals has not been reported. The goal of the first part of our study was to address the functional role of the medial medulla in the control of motor activity across the sleep–wake cycle. Chase and colleagues (1986) found that electrical sti ...
... medial medulla in sleep in intact, unrestrained behaving animals has not been reported. The goal of the first part of our study was to address the functional role of the medial medulla in the control of motor activity across the sleep–wake cycle. Chase and colleagues (1986) found that electrical sti ...
Change of vanilloid receptor 1 expression in dorsal root ganglion
... this period of hyperalgesia. From day 1 to day 21 after CFA injection into the hind paw of rats (Fig. 1), VR1 expression in DRG and the superficial layers of the spinal dorsal horn increased, with a peak at days 7–14; the ratio of VR1-positive neurons per DRG at day 1 and day 14 after CFA injection ...
... this period of hyperalgesia. From day 1 to day 21 after CFA injection into the hind paw of rats (Fig. 1), VR1 expression in DRG and the superficial layers of the spinal dorsal horn increased, with a peak at days 7–14; the ratio of VR1-positive neurons per DRG at day 1 and day 14 after CFA injection ...
Seizure control by decanoic acid through direct AMPA
... See Rogawski (doi:10.1093/awv369) for a scientific commentary on this article. *These authors contributed equally to this work. The medium chain triglyceride ketogenic diet is an established treatment for drug-resistant epilepsy that increases plasma levels of decanoic acid and ketones. Recently, dec ...
... See Rogawski (doi:10.1093/awv369) for a scientific commentary on this article. *These authors contributed equally to this work. The medium chain triglyceride ketogenic diet is an established treatment for drug-resistant epilepsy that increases plasma levels of decanoic acid and ketones. Recently, dec ...
RECENT DEVELOPMENTS IN ANTIFUNGAL AGENTS Review Article SMITA TALAVIYA,
... Life threatening invasive fungal infections is a major problem in immunocompromised patients. Standard antifungal agents so far have been quite successful, but some of them have limited use because of toxicity and drug resistance and even their clinical efficacy in some invasive fungal infections, s ...
... Life threatening invasive fungal infections is a major problem in immunocompromised patients. Standard antifungal agents so far have been quite successful, but some of them have limited use because of toxicity and drug resistance and even their clinical efficacy in some invasive fungal infections, s ...
nightmares without atonia as an early symptom of diffuse lewy
... than seen in AD26. Therefore, drugs enhancing central cholinergic function represent a rationally-based therapeutic approach to this disorder26. Carbacol or glutamate-mediated excitation of cholinergic neurons in the pedunculopontine nucleus induces REM sleep, and acetylcholinesterase inhibitors dec ...
... than seen in AD26. Therefore, drugs enhancing central cholinergic function represent a rationally-based therapeutic approach to this disorder26. Carbacol or glutamate-mediated excitation of cholinergic neurons in the pedunculopontine nucleus induces REM sleep, and acetylcholinesterase inhibitors dec ...
Drug induced hyperpigmentation
... • We describe the course of two patients who presented to the dermatology department at our hospital, with antihipertensive drugs induced photodistributed hyperpigmentation • The antihypertensive culprit agents were lercanidipine and telmisartan Photodistributed hyperpigmentation induced by antihype ...
... • We describe the course of two patients who presented to the dermatology department at our hospital, with antihipertensive drugs induced photodistributed hyperpigmentation • The antihypertensive culprit agents were lercanidipine and telmisartan Photodistributed hyperpigmentation induced by antihype ...
- Journal of Clinical Investigation
... More than 30 yr after the first description of central pontine myelinolysis (CPM)' by Adams et al. (1), the pathogenesis of this disease is still not fully understood. CPM is characterized by a loss of oligodendrocytes and myelin with relatively wellpreserved neuronal cell bodies and axons in the ce ...
... More than 30 yr after the first description of central pontine myelinolysis (CPM)' by Adams et al. (1), the pathogenesis of this disease is still not fully understood. CPM is characterized by a loss of oligodendrocytes and myelin with relatively wellpreserved neuronal cell bodies and axons in the ce ...