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Role of Feedforward and Feedback Projections in Figure
Role of Feedforward and Feedback Projections in Figure

... reflected by the fact that the majority of neurons in the primary visual cortex are sensitive to such contextual influences from surrounding regions. Surrounding stimuli outside the classical receptive field do not activate the cell but modulate the response to the stimulus that falls within it. Thi ...
A computational model of action selection in the basal ganglia. I. A
A computational model of action selection in the basal ganglia. I. A

... central nervous system. The overall activity level of the neural representation of a given action may determine its salience or propensity to be selected for execution, as proposed by Koechlin and Burnod (1996). Rather than dealing directly with the neural codes for each action, we propose that the ...
Neuronsderivedfromradialglialcells establish radial units in neocortex
Neuronsderivedfromradialglialcells establish radial units in neocortex

... process, and usually resembled pyramidal neurons with rudimentary apical and basal dendrites. Cells resembling neurons migrating along GFP-labelled radial ®bres were also found in the cortical plate (Fig. 1A, a). These morphological features suggest that individual clones contain cells of mixed iden ...
Neural Crest_Origin, Migration and Differentiation
Neural Crest_Origin, Migration and Differentiation

... and a reorganization of the actin cytoskeleton that would allow these cells to generate sufficient tractional force to pull away from (actually rupture) their adhesions. There are several studies that document an upregulation of integrins at the time of the EMT. In addition, the cells of the dorsal ...
Supplementary Table S7 (doc 170K)
Supplementary Table S7 (doc 170K)

... neuromyotonia, intermittent explosive disorder, borderline personality disorder and post-traumatic stress disorder A pyrrolidine with antiepileptic activity. The exact mechanism through which levetiracetam exerts its effects is unknown but does not involve inhibitory and excitatory neurotransmitter ...
Dopaminergic control of the globus pallidus and its impact
Dopaminergic control of the globus pallidus and its impact

... The work of my thesis is a part of integrative neurobiology and focuses on studying the control exerted by dopamine on basal ganglia (BG), especially the "external part of globus pallidus or GPe". GPe being a nucleus, which plays a key role in the control of movement by exerting an inhibitory influe ...
04diureticsII
04diureticsII

... Mechanism of action:  acts via inhibition of Na/Cl co-transporter on the luminal membrane of distal convoluted tubules  Efficacy: Moderate 5% natriuresis  Drugs as: hydrochlorothiazide -metolazone ...
The polyvagal theory: phylogenetic substrates of
The polyvagal theory: phylogenetic substrates of

... that can rapidly regulate cardiac output to foster engagement and disengagement with the environment. The mammalian vagus is neuroanatomically linked to the cranial nerves that regulate social engagement via facial expression and vocalization. As the autonomic nervous system changed through the proc ...
Cover 1 - Fast Facts
Cover 1 - Fast Facts

... Cigarette smoking is one of the most significant preventable causes of death and illness in the world. It accounts for some 400 000 deaths per year in the USA, approximately 100 000 in the UK and 4.9 million worldwide. In industrialized countries cigarette smoking accounts for 12–13% of life-years l ...
VALIDATED EXTRACTIVE SPECTROPHOTOMETRIC ESTIMATION OF CINITAPRIDE IN PURE  AND ITS SOLID DOSAGE FORM  Research Article   
VALIDATED EXTRACTIVE SPECTROPHOTOMETRIC ESTIMATION OF CINITAPRIDE IN PURE  AND ITS SOLID DOSAGE FORM  Research Article   

... Unlike  the  gas  chromatographic  and  HPLC  procedures,  the  instrument  is  simple  and  affordable.  The  importance  lies  in  the  chemical reactions upon which the procedures are based rather than  upon  the  sophistication  of  the  instrument.  This  aspect  of  spectrophotometric  analysi ...
How Do Short-Term Changes at Synapses Fine
How Do Short-Term Changes at Synapses Fine

... Klyachko and Stevens (2006) then extended the analysis of STP functions to neurodevelopmental disorders, specifically fragile X syndrome (FXS). FXS is the most common inherited form of intellectual disability and the leading genetic cause of autism. Despite the importance of STP in synaptic informat ...
The polyvagal theory: phylogenetic substrates of a
The polyvagal theory: phylogenetic substrates of a

... that can rapidly regulate cardiac output to foster engagement and disengagement with the environment. The mammalian vagus is neuroanatomically linked to the cranial nerves that regulate social engagement via facial expression and vocalization. As the autonomic nervous system changed through the proc ...
bioavailability enhancdement of poorly soluble drugs by smedds
bioavailability enhancdement of poorly soluble drugs by smedds

... preparing solid solutions with poorly soluble drugs. One potential problem with this type of formulation is that the drug may favor a more thermodynamically stable state, which can result in the compound crystallizing in the polymer matrix. Therefore the physical stability of such formulations needs ...
Time-course and mechanisms of homeostatic plasticity in layers 2/3
Time-course and mechanisms of homeostatic plasticity in layers 2/3

... potentiation (EDP) and depression in the cerebral cortex have largely examined the possibility that LTP and LTD fulfil this role [1,2]. Studies have shown that LTP and LTD mechanisms certainly do exist in the cortex. For example, in the barrel cortex the layer 4 to layer 2/3 pathway is capable of un ...
5th Annual Endocrine Conference
5th Annual Endocrine Conference

... Resources, support system ...
State-Dependent Computation Using Coupled Recurrent Networks
State-Dependent Computation Using Coupled Recurrent Networks

... effected by the excitory neighbor connections enhances the features of the input that match patterns embedded in the excitatory synaptic weights. The overall strength of the excitatory response is used to suppress outliers via the dynamical inhibitory threshold imposed by the global inhibitory neuro ...
RNAi technology: A Novel approaches against fungal infections
RNAi technology: A Novel approaches against fungal infections

... are present in S. pombe. Indeed, it has recently been documented that RNAi machinery is required for heterochromatic gene silencing in fission yeast (49) and is associated with small interfering RNAs (siRNA) homologous to these centromeric regions (60). In addition, it has been shown that the format ...
Renaissance of antibiotics against difficult infections: Focus on
Renaissance of antibiotics against difficult infections: Focus on

... acute hepatic failure and severe liver injury, as well as of visual disturbance, transient loss of consciousness, and life-threatening respiratory failure in patients with myasthenia gravis. It has been suggested that these adverse effects could result from a blockade of nicotinic acetylcholine rece ...
Mechanisms of Sleep Control - UCLA Integrative Center for
Mechanisms of Sleep Control - UCLA Integrative Center for

... Raphe—Locus ceruleus—Basal forebrain—Acetylcholine—Norepi-nephrine. ...
leptin
leptin

... In leptin-melanocortin circuit, the most critical receptors for regulation are expressed in the arcuate nucleus of the hypothalamus. There are two major types of neurons in this locus that bear leptin receptors - the first order neurons and the second order neurons. The first order neurons, which ar ...
An Integrative Theory on Prefrontal Cortex Function
An Integrative Theory on Prefrontal Cortex Function

... maintenance of patterns of activity that represent goals and the means to achieve them. They provide bias signals throughout much of the rest of the brain, affecting not only visual processes but also other sensory modalities, as well as systems responsible for response execution, memory retrieval, ...
American Journal of Public Health Research
American Journal of Public Health Research

... processes such as prior memories and it has great influence on enhancing, suppressing or even independently generating a stress response but it is highly susceptible to damage by chronic stress (McEwen, 2012). Another organ of interest in the regulation of cognitive processes is the prefrontal corte ...
Alternative Medications for Medications in the Use of High‐Risk
Alternative Medications for Medications in the Use of High‐Risk

... Older persons who take multiple drugs with anticholinergic activity, be they strong, moderate, or weak in potency, are at greater risk of physical, functional, and cognitive decline.11 Two types of highly anticholinergic drugs (firstgeneration antihistamines, drugs used for Parkinson’s disease) are ...
Neural Control of Eye Movements
Neural Control of Eye Movements

... Oculomotor control strategies: Top-down and boeom-up influences •  A common feature of neural control systems are top-down and boeom-up influences •  Boeom-up control à Gather parameters of the sensory signal to develop the motor command –  Decoding of error signals; for example reDnal error p ...
Hydroquinine hydrobromide and hypoglycaemia
Hydroquinine hydrobromide and hypoglycaemia

... reduces the need for large volumes of intravenous dextrose [3]. ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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