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attention - CMU Graphics
attention - CMU Graphics

... ● Changes strength of neurons’ response without changing underlying response properties ● Enhances synchronization of neuronal activity ● Spatial attention will increase the gain of all neurons whose receptive field overlaps the current attentional focus, creating an enhanced representation at that ...
Microbiology Guide to Interpreting Minimum Inhibitory Concentration
Microbiology Guide to Interpreting Minimum Inhibitory Concentration

... Next to each antibiotic is the susceptibility interpretation: S (sensitive), I (intermediate) or R (resistant), followed by the MIC in μg/ml. Sensitive implies that the organism is inhibited by the serum concentration of the drug that is achieved using the recommended dosage; intermediate includes i ...
In vitrocytotoxicity of ranpirnase (onconase) in combination with
In vitrocytotoxicity of ranpirnase (onconase) in combination with

... Nowadays, in patients with DLBCL treated with R-CHOP as a first line immunochemotherapy the cure rate is approximately 50%. Despite these advances, half of the patients will experience an early relapse, partial response, or are refractory after the initial treatment. In this context, innovative agen ...
Central Sleep Apnea Syndromes
Central Sleep Apnea Syndromes

... wakefulness and sleep, without upper airway obstruction If decrescendo effort is accompanied by apnea during sleep, it is a type of central sleep apnea syndrome Mainly seen is stage N1 and N2 sleep Cycle time – 60-90 seconds (longer than other forms of CSA); correlation with severity of HF Arousal t ...
Antimalarial Drug Combination Therapy
Antimalarial Drug Combination Therapy

... poses a serious challenge to the effectiveness of early diagnosis and prompt treatment as a priority strategy within current malaria control efforts (2-4). In November 2000, an Informal Consultation on the Use of Antimalarial Drugs was convened by WHO in Geneva. This meeting reviewed and updated rec ...
Neural correlates of social exclusion during adolescence
Neural correlates of social exclusion during adolescence

... might aid in regulatory processes among our sample of young adolescents. In terms of individual differences in how adolescents responded to an experience of peer rejection, we first expected that adolescents who reported being more sensitive to rejection would display more evidence of sensitivity to ...
Evidence for time division multiplexing of multiple simultaneous
Evidence for time division multiplexing of multiple simultaneous

... bioRxiv preprint first posted online Feb. 9, 2017; doi: http://dx.doi.org/10.1101/107185. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission. ...
The Calcium Rationale in Aging and Alzheimer`s Disease
The Calcium Rationale in Aging and Alzheimer`s Disease

... kinase 11, which phosphorylates presynaptic synapsin I, leading to further glutamate release; (4) activation of endonucleases that cause DNA fragmentation; and (5) production of nitric oxide synthase, which inhibits mitochondria1 respiration, the citric acid cycle enzyme aconitase, and DNA synthesi~ ...
http://www.utdallas.edu/~tres/papers/Disterhoftetal1994.pdf
http://www.utdallas.edu/~tres/papers/Disterhoftetal1994.pdf

... kinase 11, which phosphorylates presynaptic synapsin I, leading to further glutamate release; (4) activation of endonucleases that cause DNA fragmentation; and (5) production of nitric oxide synthase, which inhibits mitochondria1 respiration, the citric acid cycle enzyme aconitase, and DNA synthesi~ ...
1: gastro-intestinal system
1: gastro-intestinal system

... The naturally-occurring belladonna alkaloids, atropine and scopolamine (hyoscine) hydrobromide, are tertiary amines, whereas the numerous semisynthetic and synthetic derivatives fall into both categories. Thus, dicyclomine, oxybutynin and tolterodine are tertiary amines, and glycopyrrolate, propanth ...
presentation source
presentation source

... – Why did this problem occur? ...
Axonal Membranes and Their Domains: Assembly and Function of
Axonal Membranes and Their Domains: Assembly and Function of

... members including KCNQ2/3 channels, NF186, NrCAM, βIVspectrin and Nav channels in the proximal axon (Zhou et al., 1998; Jenkins and Bennett, 2001; Pan et al., 2006; Jenkins et al., 2015). Genetic deletion of ankyrin-G in mice or silencing ankyrin-G using short hairpin RNA (shRNA) in dissociated neur ...
Cortical afferents to the smooth-pursuit region of the macaque
Cortical afferents to the smooth-pursuit region of the macaque

... implanted in one eye. To enhance the accuracy and reproducibility of electrode penetrations and subsequent injections, a plastic grid with 1-mm spacing between adjacent holes (Crist Instrument) was secured inside the recording well. The microelectrodes and injection needles traveled inside 23-gauge ...
Using light to tell the time of day: sensory coding in the mammalian
Using light to tell the time of day: sensory coding in the mammalian

... Fig. 2. Colour and brightness as indicators of time of day. (A) Spectral irradiance of ‘average’ daylight measured when the sun is 6 deg above or below the horizon. Note that, in addition to the pronounced difference in the amount of light, there is also a substantial change in spectral composition, ...
tWallace B. Mendelson, tHerbert Weingartner
tWallace B. Mendelson, tHerbert Weingartner

... drug-administration days 2 and 3, and this effect was evident in both short-term and long-term memory functions. On the other hand, on the sixth day of drug withdrawal, subjects' performance on serial learning was slightly but significantly better than baseline. Daytime performance-Psychomotor tests ...
Approaches to Drug Dosing in Renal Dysfunction
Approaches to Drug Dosing in Renal Dysfunction

... prescribers to adjust doses of renally excreted drugs in patients with reduced renal function are frequently accepted and that the outcomes of the patients are ...
HIGH-MOLECULAR WEIGHT OF BIOPOLYMER
HIGH-MOLECULAR WEIGHT OF BIOPOLYMER

... enzymatic degradation. Hyaluronidase (HYAL) is considered as most powerful degradation enzyme for the hyaluronan reported that Hyaluronidase cleaves high molecular weight HA into smaller fragments of varying size via hydrolyzing the hexosaminidic b(1-4) linkages between N-acetylD-glucosamine and D-g ...
Cortical interactions underlying the production of speech sounds
Cortical interactions underlying the production of speech sounds

... with specific anatomical locations in the brain. These locations, specified in the Montreal Neurological Institute (MNI) coordinate frame, are based on the results of neurophysiological and neuroanatomical studies of speech production and articulation (see Guenther et al., 2006, for details). Since ...
Hedonic Hotspots Regulate Cingulate-driven
Hedonic Hotspots Regulate Cingulate-driven

... The integrated coding of cognitive demands and hedonic processing might operate via well-known anatomical connections that loop between these rostral cingulate regions and the basal ganglia (cf. Heimer et al. 1982; Botvinick et al. 2009; Haber and Knutson 2010). We hypothesized that the counter-regu ...
Viewpoint Synaptic Connectivity and Neuronal Morphology: Two
Viewpoint Synaptic Connectivity and Neuronal Morphology: Two

... computation, requirements. In particular, dendrites may perform nonlinear operations (Koch et al., 1982; Mel, 1993; Polsky et al., 2004), axons may serve as delay lines or frequency-dependent filters (Carr and Konishi, 1988; Debanne, 2004), and spines may be filtering compartments (Koch and Zador, 1 ...
Distinct core thalamocortical pathways to central and dorsal primary
Distinct core thalamocortical pathways to central and dorsal primary

... Core auditory cortices are an essential first level of cortical processing of sound location, context and pattern and yet their functional organization has not been fully elucidated (Griffiths and Warren, 2004; King and Nelken, 2009; Rauschecker et al., 1997; Schreiner and Winer, 2007). All core audit ...
Cyclosporin Nephrotoxicity
Cyclosporin Nephrotoxicity

... is smaller, with a 30-50% reduction in cyclosporine dose achieved. ...
Interactive Association of Drugs Binding to Human
Interactive Association of Drugs Binding to Human

... biliary excretion or glomerular filtration in kidney [7,15,16]. The unbound drugs can also be distributed intracellularly via specific transport systems. Only free drug molecules interact with therapeutic targets to produce therapeutic effects [7,17]. In most instances, the unbound drug concentratio ...
PDF
PDF

... lesioning is performed in an animal with experimental autoimmune encephalomyelitis (EAE), a significant number of motoneurons can be rescued despite an intense inflammatory reaction. This rescue effect has been attributed to production of a number of neurotrophic factors by invading T cells. Synapto ...
Impact of acute inflammation on spinal motoneuron synaptic
Impact of acute inflammation on spinal motoneuron synaptic

... lesioning is performed in an animal with experimental autoimmune encephalomyelitis (EAE), a significant number of motoneurons can be rescued despite an intense inflammatory reaction. This rescue effect has been attributed to production of a number of neurotrophic factors by invading T cells. Synapto ...
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Neuropsychopharmacology

Neuropsychopharmacology, an interdisciplinary science related to psychopharmacology (how drugs affect the mind) and fundamental neuroscience, is the study of the neural mechanisms that drugs act upon to influence behavior. It entails research of mechanisms of neuropathology, pharmacodynamics (drug action), psychiatric illness, and states of consciousness. These studies are instigated at the detailed level involving neurotransmission/receptor activity, bio-chemical processes, and neural circuitry. Neuropsychopharmacology supersedes psychopharmacology in the areas of ""how"" and ""why"", and additionally addresses other issues of brain function. Accordingly, the clinical aspect of the field includes psychiatric (psychoactive) as well as neurologic (non-psychoactive) pharmacology-based treatments.Developments in neuropsychopharmacology may directly impact the studies of anxiety disorders, affective disorders, psychotic disorders, degenerative disorders, eating behavior, and sleep behavior.The way fundamental processes of the brain are being discovered is creating a field on par with other “hard sciences” such as chemistry, biology, and physics, so that eventually it may be possible to repair mental illness with ultimate precision. An analogy can be drawn between the brain and an electronic device: neuropsychopharmacology is tantamount to revealing not only the schematic diagram, but the individual components, and every principle of their operation. The bank of amassed detail and complexity involved is huge; mere samples of some of the details are given in this article.
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