Immune responses to vaccines involving a combined antigen
... to antigen presenting cells (APCs) and regulate the antigen presentation pathway, or as immune potentiators that enhance the subsequent antigen-specific immune responses [3,10,11]. Ever since Kreuter et al. evaluated the adjuvanticity of polymethylmethacrylate nanoparticles for the influenza virus in ...
... to antigen presenting cells (APCs) and regulate the antigen presentation pathway, or as immune potentiators that enhance the subsequent antigen-specific immune responses [3,10,11]. Ever since Kreuter et al. evaluated the adjuvanticity of polymethylmethacrylate nanoparticles for the influenza virus in ...
Endometrial dendritic cell populations during the normal menstrual
... migration out of peripheral tissues to secondary lymphoid organs, so the number of mature DCs in the uterus at any one time is likely to be small (Banchereau et al., 2000). The density of CD83þ DCs was higher in the basal layer during both the proliferative and secretory phases, which is also consis ...
... migration out of peripheral tissues to secondary lymphoid organs, so the number of mature DCs in the uterus at any one time is likely to be small (Banchereau et al., 2000). The density of CD83þ DCs was higher in the basal layer during both the proliferative and secretory phases, which is also consis ...
Psoriasis - New England Journal of Medicine
... Numerous family studies have provided compelling evidence of a genetic predisposition to psoriasis, although the inheritance pattern is still unclear.5 The illness develops in as many as half of the siblings of persons with psoriasis when both parents are affected, but prevalence falls to 16 percent ...
... Numerous family studies have provided compelling evidence of a genetic predisposition to psoriasis, although the inheritance pattern is still unclear.5 The illness develops in as many as half of the siblings of persons with psoriasis when both parents are affected, but prevalence falls to 16 percent ...
Skeletal System
... The lymphocyte receives its antigen from an antigen presenting cell, such as a macrophage that has recently phagocytized the antigen, or a star shaped dendritic cell, a professional antigen gathered that patrols the body seeking antigens and carries them to places where lymphocytes gather ...
... The lymphocyte receives its antigen from an antigen presenting cell, such as a macrophage that has recently phagocytized the antigen, or a star shaped dendritic cell, a professional antigen gathered that patrols the body seeking antigens and carries them to places where lymphocytes gather ...
ABSTRACT Title of Document:
... required for WASP and N-WASP activation. Inhibition of Btk activity by a point mutation or a specific inhibitor prevents BCR-induced increases in PtdIns-4,5-P2 as well as in phosphorylated WASP, N-WASP and Vav. Furthermore, Btk deficiency or inhibition leads to a severe reduction in BCR-mediated an ...
... required for WASP and N-WASP activation. Inhibition of Btk activity by a point mutation or a specific inhibitor prevents BCR-induced increases in PtdIns-4,5-P2 as well as in phosphorylated WASP, N-WASP and Vav. Furthermore, Btk deficiency or inhibition leads to a severe reduction in BCR-mediated an ...
The roles of platelets in inflammation, immunity, wound healing and
... 20]. Additionally, platelet activation by pathogen-associated molecular patterns (via Toll-like receptors, TLRs) leads to the release of other cytokines, such as platelet factor 4 (PF-4), and CCL5 or RANTES (Regulated upon Activation Normal T cell Expressed and Secreted), that leads to recruitment o ...
... 20]. Additionally, platelet activation by pathogen-associated molecular patterns (via Toll-like receptors, TLRs) leads to the release of other cytokines, such as platelet factor 4 (PF-4), and CCL5 or RANTES (Regulated upon Activation Normal T cell Expressed and Secreted), that leads to recruitment o ...
Deep Insight Section
... In the past few years, it has been highlighted that HLAG1 forms dimers at cell-surface of transfected cells but also of trophoblast cells (Boyson et al., 2002; Apps et al., 2007). The HLA-G dimers exhibit higher overall affinity to ILT-2 and -4 receptors than the monomers by significant avidity effe ...
... In the past few years, it has been highlighted that HLAG1 forms dimers at cell-surface of transfected cells but also of trophoblast cells (Boyson et al., 2002; Apps et al., 2007). The HLA-G dimers exhibit higher overall affinity to ILT-2 and -4 receptors than the monomers by significant avidity effe ...
Essential role of Toll-like receptor 2 in
... shown that IFN-γ is not essential for the cell-stimulating activity of ESG, whereas this cytokine is essential for the production of NO in response to ESG. The cell-activation mechanism of glycogen is different from that of LPS, and TLR4 is irrelevant to the activity of glycogen To investigate wheth ...
... shown that IFN-γ is not essential for the cell-stimulating activity of ESG, whereas this cytokine is essential for the production of NO in response to ESG. The cell-activation mechanism of glycogen is different from that of LPS, and TLR4 is irrelevant to the activity of glycogen To investigate wheth ...
4 results 28.06.13
... 4.1.1.4. Effect on intracellular Th1 and Th2 cytokines (Flow cytometric analysis) Measurement of intracellular Th1 and Th2 cytokines also acts as an important parameter for immunomodulation indicating the nature of T cell response whether pro-inflammatory (Th1) or anti-inflammatory (Th2) type. The p ...
... 4.1.1.4. Effect on intracellular Th1 and Th2 cytokines (Flow cytometric analysis) Measurement of intracellular Th1 and Th2 cytokines also acts as an important parameter for immunomodulation indicating the nature of T cell response whether pro-inflammatory (Th1) or anti-inflammatory (Th2) type. The p ...
Human Monoclonal Antibody Reactivity With
... eplet-bearing antigens that share a given self-configuration of amino acids, which is critical for the binding with antibody. Thus, there seems to be an autoreactive component of the alloantibody response to some HLA mismatches. These findings might be viewed in context with current concepts of anti ...
... eplet-bearing antigens that share a given self-configuration of amino acids, which is critical for the binding with antibody. Thus, there seems to be an autoreactive component of the alloantibody response to some HLA mismatches. These findings might be viewed in context with current concepts of anti ...
Biomarkers and mechanisms of natural disease resistance in dairy
... The complement system involves a large set of proteins that can recognise microbes via three different pathways: the classical, the mannose-binding lectin and the alternative pathway. These pathways differ in the way of activation, but they all lead to the activation of key player C3b and subsequent ...
... The complement system involves a large set of proteins that can recognise microbes via three different pathways: the classical, the mannose-binding lectin and the alternative pathway. These pathways differ in the way of activation, but they all lead to the activation of key player C3b and subsequent ...
Granulocyte Macrophage Colony-Stimulating Factor
... activated with GM-CSF in vitro, and gene expression, phenotype, and function of GM-CSF-activated monocytes (GMaM) were analyzed. Therapeutic effects of GMaM were assessed in a model of chronic colitis induced by repeated cycles of DSS. Monocytes were administered intravenously and their immunomodula ...
... activated with GM-CSF in vitro, and gene expression, phenotype, and function of GM-CSF-activated monocytes (GMaM) were analyzed. Therapeutic effects of GMaM were assessed in a model of chronic colitis induced by repeated cycles of DSS. Monocytes were administered intravenously and their immunomodula ...
Characterization of thymic hyperplasia associated with autoimmune
... overexpression of chemokines and the abnormal development of high endothelial venules (HEV) in the MG thymus. The aim of my thesis was to better understand the mechanisms that lead to thymic hyperplasia in MG by analyzing the role of chemokines in peripheral cell recruitment. We demonstrated that th ...
... overexpression of chemokines and the abnormal development of high endothelial venules (HEV) in the MG thymus. The aim of my thesis was to better understand the mechanisms that lead to thymic hyperplasia in MG by analyzing the role of chemokines in peripheral cell recruitment. We demonstrated that th ...
Regulation of macrophage development and function in peripheral
... crucial for maintaining a balanced response to homeostatic or tissue-damaging signals and, when this delicate balance is disturbed, inflammatory disease can occur. Recent studies have revealed the ontogeny and functional diversity of tissue-resident macrophages. These studies have established that t ...
... crucial for maintaining a balanced response to homeostatic or tissue-damaging signals and, when this delicate balance is disturbed, inflammatory disease can occur. Recent studies have revealed the ontogeny and functional diversity of tissue-resident macrophages. These studies have established that t ...
Allergic disease: the diagnosis of peanut allergy and the role of heat
... Figure 2 | The diagnosis of a food allergy like peanut allergy stands and falls with a well performed DBPCFC. Often the diagnosis is only made on the history of symptoms and on specific IgE. Not all allergens are known however and many extracts are incomplete, which sometimes results in false negati ...
... Figure 2 | The diagnosis of a food allergy like peanut allergy stands and falls with a well performed DBPCFC. Often the diagnosis is only made on the history of symptoms and on specific IgE. Not all allergens are known however and many extracts are incomplete, which sometimes results in false negati ...
Hannah Akuffo Publications 1990 to 1999
... diagnosis of leishmaniasis in Ethiopia.Trans R Soc Trop Med Hyg. 1992 Mar-Apr;86(2):154-7. 41. Akuffo HO, Britton SF. Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans. Clin Exp Immunol. 1992 Jan;87(1):58-64. 42. Maasho K, Akuffo HO. Cells from healthy ...
... diagnosis of leishmaniasis in Ethiopia.Trans R Soc Trop Med Hyg. 1992 Mar-Apr;86(2):154-7. 41. Akuffo HO, Britton SF. Contribution of non-Leishmania-specific immunity to resistance to Leishmania infection in humans. Clin Exp Immunol. 1992 Jan;87(1):58-64. 42. Maasho K, Akuffo HO. Cells from healthy ...
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... mucosal epithelium HIV-‐1 interacts with potential target cells, i.e. dendritic cells (DCs) and CD4+ T cells. The complement system, a key component of the innate immune system, is immediately a ...
... mucosal epithelium HIV-‐1 interacts with potential target cells, i.e. dendritic cells (DCs) and CD4+ T cells. The complement system, a key component of the innate immune system, is immediately a ...
The Biochemical and Biophysical Mechanisms of Macrophage
... MOTIVATION An effective immune response is necessary for maintaining homeostasis and health in the human body. In order to protect against disease and persistent inflammation, cells of the immune system must be able to migrate efficiently to sites of infection and injury [1]. Macrophages are members ...
... MOTIVATION An effective immune response is necessary for maintaining homeostasis and health in the human body. In order to protect against disease and persistent inflammation, cells of the immune system must be able to migrate efficiently to sites of infection and injury [1]. Macrophages are members ...
The Equine Endometrial Cup Reaction
... action, they break through the basement membrane of the glands and stream out into the surrounding endometrial stroma. Here, within only one to two days, and as though tripped by an inbuilt development switch, they suddenly become sessile, cease to divide, enlarge greatly, assume a rounded, epitheli ...
... action, they break through the basement membrane of the glands and stream out into the surrounding endometrial stroma. Here, within only one to two days, and as though tripped by an inbuilt development switch, they suddenly become sessile, cease to divide, enlarge greatly, assume a rounded, epitheli ...
IL-17/IL-17 receptor system in autoimmune disease
... cells and Th17 [81]. IL-27 inhibits the production of IL-17A and IL-17F by suppressing the expression of the Th17-specific transcription factor RORγ t in a STAT1-dependent manner [82,83]. IFNγ and IL-4, the cytokines for Th1 and Th2 lineage respectively, also mediate transcriptional-factor-dependent ...
... cells and Th17 [81]. IL-27 inhibits the production of IL-17A and IL-17F by suppressing the expression of the Th17-specific transcription factor RORγ t in a STAT1-dependent manner [82,83]. IFNγ and IL-4, the cytokines for Th1 and Th2 lineage respectively, also mediate transcriptional-factor-dependent ...
autoimmunity - Thyroid Disease Manager
... differentiate into mature cell types during residence in the thymus. Mature T lymphocytes are present in thymus, spleen, lymph nodes, throughout skin and other lymphatic organs, and in the bloodstream. B lymphocytes (immunoglobulin producing cells) develop from precursor cells in fetal liver and bon ...
... differentiate into mature cell types during residence in the thymus. Mature T lymphocytes are present in thymus, spleen, lymph nodes, throughout skin and other lymphatic organs, and in the bloodstream. B lymphocytes (immunoglobulin producing cells) develop from precursor cells in fetal liver and bon ...
T cell
T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). The several subsets of T cells each have a distinct function. The majority of human T cells rearrange their alpha/beta T cell receptors and are termed alpha beta T cells and are part of adaptive immune system. Specialized gamma delta T cells, which comprise a minority of T cells in the human body (more frequent in ruminants), have invariant TCR (with limited diversity), can effectively present antigens to other T cells and are considered to be part of the innate immune system.