The predominant surface glycoproteins of thymocytes and
... by any other cell type (15). This molecule thus fits with the concept of a uniquely expressed molecule mediating a particular function of a differentiated cell. Histocompatibility antigens function as controlling elements in T-lymphocyte responses (2,3). T lymphocytes appear to recognize foreign ant ...
... by any other cell type (15). This molecule thus fits with the concept of a uniquely expressed molecule mediating a particular function of a differentiated cell. Histocompatibility antigens function as controlling elements in T-lymphocyte responses (2,3). T lymphocytes appear to recognize foreign ant ...
Laudatio for Adrian Liston
... VIB (Vlaams Instituut voor Biotechnologie) in Leuven was the best. In the year 2009 he moved to Leuven where he has been ever since, presently as a group leader at the VIB and a professor of Leuven University. He established a vigorous and highly productive research team. His interests have remained ...
... VIB (Vlaams Instituut voor Biotechnologie) in Leuven was the best. In the year 2009 he moved to Leuven where he has been ever since, presently as a group leader at the VIB and a professor of Leuven University. He established a vigorous and highly productive research team. His interests have remained ...
The Immunology of Pregnancy
... proposed that the maternal-fetal interface was perhaps ‘an immunologically privileged site’, or that there was a ‘generalised suppression of maternal immune response’. ...
... proposed that the maternal-fetal interface was perhaps ‘an immunologically privileged site’, or that there was a ‘generalised suppression of maternal immune response’. ...
“Lymphocytes”. In: Encyclopedia of Life Sciences (ELS)
... cytokines. For example, cells that express both CD3 and CD4 are a subpopulation of T cells called T-helper (TH) cells; TH cells that secrete the cytokine IFN-g and have nuclear transcription factor T-bet are called TH type 1 cells. Coexpression of CD3 and CD8 defines the population of cytotoxic T cel ...
... cytokines. For example, cells that express both CD3 and CD4 are a subpopulation of T cells called T-helper (TH) cells; TH cells that secrete the cytokine IFN-g and have nuclear transcription factor T-bet are called TH type 1 cells. Coexpression of CD3 and CD8 defines the population of cytotoxic T cel ...
071300 The Immune System — Second of Two Parts
... firmly established, but the a/b T cells in this population may assist in the production of mucosal IgA and some g/d T cells may participate in the induction of immunologic tolerance to antigens at mucosal surfaces. However, the specificity of many intestinal g/d T cells for microbial antigens indica ...
... firmly established, but the a/b T cells in this population may assist in the production of mucosal IgA and some g/d T cells may participate in the induction of immunologic tolerance to antigens at mucosal surfaces. However, the specificity of many intestinal g/d T cells for microbial antigens indica ...
Mutant Signal Transducer and Activator of Transcription 5b
... Conclusions: The A630P mutation disrupts the src-homology-2 architecture such that: 1) mutant STAT5b most likely cannot dock to phospho-tyrosines on ligand-activated receptors; and 2) stable interactions with DNA are prevented. Because STAT5b (A630P) is an inefficient signal transducer and transcrip ...
... Conclusions: The A630P mutation disrupts the src-homology-2 architecture such that: 1) mutant STAT5b most likely cannot dock to phospho-tyrosines on ligand-activated receptors; and 2) stable interactions with DNA are prevented. Because STAT5b (A630P) is an inefficient signal transducer and transcrip ...
Annelid Immunity
... experiments (four months between two transplants and specimen examination after 1 month), assume the presence of two different cell types, i.e. NK-like cells and CD8+ cells in the medicinal leech (generally classified as cytotoxic lymphocytes in vertebrates) [18, 19]. These coelomocytes are selectiv ...
... experiments (four months between two transplants and specimen examination after 1 month), assume the presence of two different cell types, i.e. NK-like cells and CD8+ cells in the medicinal leech (generally classified as cytotoxic lymphocytes in vertebrates) [18, 19]. These coelomocytes are selectiv ...
Presentation Title Here Presentation Subtitle Here
... Innate Immunity to M. tuberculosis • Promote bacterial killing with phagosomal maturation, producing reactive nitrogen and oxygen intermediates • Several pathways and cell types mediate an innate immune response to MTB • Therefore, many individuals may fail to have an immunodiagnostic evidence of M ...
... Innate Immunity to M. tuberculosis • Promote bacterial killing with phagosomal maturation, producing reactive nitrogen and oxygen intermediates • Several pathways and cell types mediate an innate immune response to MTB • Therefore, many individuals may fail to have an immunodiagnostic evidence of M ...
Chapter I Overview of Immunology
... immune system, specifically by antibodies, B cells, or T cells. The part of an antibody that recognizes the epitope is called a paratope. Although epitopes are ...
... immune system, specifically by antibodies, B cells, or T cells. The part of an antibody that recognizes the epitope is called a paratope. Although epitopes are ...
major histocompatibility complex
... numerous different peptides. The peptide binding cleft in class I molecules is blocked at both ends whereas the cleft is open in class II molecules. Thus class II molecules can bind slightly larger peptides. Class I MHC molecules bind peptides and present these peptides to CD8+ T cells. In general, ...
... numerous different peptides. The peptide binding cleft in class I molecules is blocked at both ends whereas the cleft is open in class II molecules. Thus class II molecules can bind slightly larger peptides. Class I MHC molecules bind peptides and present these peptides to CD8+ T cells. In general, ...
Effect of TGF-beta on interferon-gamma-induced HLA-DR
... There are indications that, in other cell types, IFNy may induce MHC class II antigens through activation of the PKC pathway,23 whereas TGF-/3 may be acting, in part, by PKC inhibition. 26 It has also been proposed that transcriptional regulation of HLA-DR antigen is modulated by PKC.27 Attempts to ...
... There are indications that, in other cell types, IFNy may induce MHC class II antigens through activation of the PKC pathway,23 whereas TGF-/3 may be acting, in part, by PKC inhibition. 26 It has also been proposed that transcriptional regulation of HLA-DR antigen is modulated by PKC.27 Attempts to ...
IJEB 38(10) 999-1002
... stimulation. lFN-y enhances the immune response by increasing THeel! function which can promote expression of lL-2 on T-cells. GM-CSF promotes differentiation of activated B-cells that secrete IgM, lgGza and IgG 3 (Ref. 16) These results indicated that BR, a nontoxic herba l drug preparation, has im ...
... stimulation. lFN-y enhances the immune response by increasing THeel! function which can promote expression of lL-2 on T-cells. GM-CSF promotes differentiation of activated B-cells that secrete IgM, lgGza and IgG 3 (Ref. 16) These results indicated that BR, a nontoxic herba l drug preparation, has im ...
Tumorigenicity of cells transformed by adenovirus type 12 by
... A similar difference in susceptibility to allogeneic CTLs was observed for Ad5- and Ad12-transformed Brown Norway rat cells (RT1" haplotype) as for Ad5- and Ad12-transformed Wag-Rij cell lines (Fig. 2). It seems likely, therefore, that suppression of class I antigen expression by Ad12 region Ela is, ...
... A similar difference in susceptibility to allogeneic CTLs was observed for Ad5- and Ad12-transformed Brown Norway rat cells (RT1" haplotype) as for Ad5- and Ad12-transformed Wag-Rij cell lines (Fig. 2). It seems likely, therefore, that suppression of class I antigen expression by Ad12 region Ela is, ...
Current subjects of research:
... Frequency, Function: Recently, we demonstrated blood CD25+ FOXP3+ Treg cell number to be significantly reduced in all chronic HIV+ subjects tested irrespective of their disease stage, although the suppressive function of these cells was maintained. In addition, we provided novel evidence that CD4+ C ...
... Frequency, Function: Recently, we demonstrated blood CD25+ FOXP3+ Treg cell number to be significantly reduced in all chronic HIV+ subjects tested irrespective of their disease stage, although the suppressive function of these cells was maintained. In addition, we provided novel evidence that CD4+ C ...
(dendritic) cells
... The immune system is the body's defense system. It works on three different levels. The first level is the anatomic response. It consists of anatomical barriers to foreign particles and includes the skin and acid in the stomach. Anatomic barriers prevent foreign substances from entering the body. If ...
... The immune system is the body's defense system. It works on three different levels. The first level is the anatomic response. It consists of anatomical barriers to foreign particles and includes the skin and acid in the stomach. Anatomic barriers prevent foreign substances from entering the body. If ...
Quantification of Drug Response Read
... immune cell populations within the tumor microenvironment Identification of tissue based target modulation / PD biomarkers, which may support selection of translational readouts for use in early clinical studies Detailed characterization of target expression across multiple xenograft models to b ...
... immune cell populations within the tumor microenvironment Identification of tissue based target modulation / PD biomarkers, which may support selection of translational readouts for use in early clinical studies Detailed characterization of target expression across multiple xenograft models to b ...
Is Central Nervous System an Immune-Privileged Site?
... space at the pial surface of the brain and iii) from blood to parenchymal perivascular space.63 The first two pathways seem to be the most relevant under normal physiological conditions [64] whereas extravasation by the third pathway occurs only during an inflammatory event.19,65-67 Normally, lympho ...
... space at the pial surface of the brain and iii) from blood to parenchymal perivascular space.63 The first two pathways seem to be the most relevant under normal physiological conditions [64] whereas extravasation by the third pathway occurs only during an inflammatory event.19,65-67 Normally, lympho ...
Genetic Disorders
... Understand the action manner of cytokines . Understand the effects of cytokines . Know cytokines receptor families. Classify the cytokines based on the biologic actions . Understand the biological function of the most important cytokines . ...
... Understand the action manner of cytokines . Understand the effects of cytokines . Know cytokines receptor families. Classify the cytokines based on the biologic actions . Understand the biological function of the most important cytokines . ...
Unit VI: Immunity and Diseases
... and/or cancer cells that travel through the lymphatic system d. They are clustered in the neck, armpits, abdomen, and groin Copyright © Texas Education Agency, 2012. All rights reserved. ...
... and/or cancer cells that travel through the lymphatic system d. They are clustered in the neck, armpits, abdomen, and groin Copyright © Texas Education Agency, 2012. All rights reserved. ...
Nerve activates contraction
... nonidentical individual will look healthy for a day or two, but it will then be destroyed by immune responses. • Interestingly, a pregnant woman does not reject the fetus as a foreign body, as apparently, the structure of the placenta is the key to this acceptance. ...
... nonidentical individual will look healthy for a day or two, but it will then be destroyed by immune responses. • Interestingly, a pregnant woman does not reject the fetus as a foreign body, as apparently, the structure of the placenta is the key to this acceptance. ...
GALT Fortifier - Julia Hunter, MD
... digestion and assimilation of food and nutrients. During help reduce the symptoms that are gut-associated, this process, it will also be exposed to food antigens, inflammatory and/or impair immunity. bacteria, viruses, fungi, parasites and other pathogens. Most of the immune function of the body is ...
... digestion and assimilation of food and nutrients. During help reduce the symptoms that are gut-associated, this process, it will also be exposed to food antigens, inflammatory and/or impair immunity. bacteria, viruses, fungi, parasites and other pathogens. Most of the immune function of the body is ...
File - Pennington AP Biology
... Damage to the body’s tissues caused by physical agents (e.g. sharp objects), microbial infection, or chemical agents triggers a defensive response called inflammation. Inflammation is usually characterized by four symptoms: pain, redness, heat, and swelling. The inflammatory response is beneficial a ...
... Damage to the body’s tissues caused by physical agents (e.g. sharp objects), microbial infection, or chemical agents triggers a defensive response called inflammation. Inflammation is usually characterized by four symptoms: pain, redness, heat, and swelling. The inflammatory response is beneficial a ...
T cell
T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). The several subsets of T cells each have a distinct function. The majority of human T cells rearrange their alpha/beta T cell receptors and are termed alpha beta T cells and are part of adaptive immune system. Specialized gamma delta T cells, which comprise a minority of T cells in the human body (more frequent in ruminants), have invariant TCR (with limited diversity), can effectively present antigens to other T cells and are considered to be part of the innate immune system.