Relevance of sexual dimorphism to regulatory T cells: estradiol
... Mechanisms accounting for gender dimorphism during immune responses are still poorly understood. Since invariant natural killer T (iNKT) cells exert important regulatory functions through their capacity to produce both T helper 1 (Th1) and Th2 cytokines, we addressed the question of whether these ac ...
... Mechanisms accounting for gender dimorphism during immune responses are still poorly understood. Since invariant natural killer T (iNKT) cells exert important regulatory functions through their capacity to produce both T helper 1 (Th1) and Th2 cytokines, we addressed the question of whether these ac ...
IL-23 modulated myelin-specific T cells induce - Bio
... we have found that treating mice that have received IL-23 modulated effector T cells with an anti-IL-17 antibody is only partially effective in suppressing EAE (Kroenke et al., 2008). It is not known whether this antibody penetrates the CNS and/ or other tissues in sufficient quantities to neutralize ...
... we have found that treating mice that have received IL-23 modulated effector T cells with an anti-IL-17 antibody is only partially effective in suppressing EAE (Kroenke et al., 2008). It is not known whether this antibody penetrates the CNS and/ or other tissues in sufficient quantities to neutralize ...
THE OPTIMISATION OF IMMUNE FUNCTION ASSAYS IN MURRAY
... also existing in invertebrates (Roitt et al. 1998). It is also highly sensitive to insult from chemical exposures and many drugs have been used to modulate various aspects of the immune response (Dean and Murray 2001). Numerous assays have been developed to measure the activity of its various compon ...
... also existing in invertebrates (Roitt et al. 1998). It is also highly sensitive to insult from chemical exposures and many drugs have been used to modulate various aspects of the immune response (Dean and Murray 2001). Numerous assays have been developed to measure the activity of its various compon ...
Differentiation of M1
... Macrophages are tissue-resident professional phagocytes and antigen-presenting cells (APC), which differentiate from circulating peripheral blood monocytes. They perform important active and regulatory functions in innate as well as adaptive immunity [1]. Activated macrophages of different phenotype ...
... Macrophages are tissue-resident professional phagocytes and antigen-presenting cells (APC), which differentiate from circulating peripheral blood monocytes. They perform important active and regulatory functions in innate as well as adaptive immunity [1]. Activated macrophages of different phenotype ...
The Phylogeny of Thymic Dependence The use of amphibians in
... Xenopus is combatting environmental antigens with an incomplete immune system, some non-specific component may become in short supply, resulting in an overall reduction of specific antibody formation. Ruben et al. (1973) have shown that cellular co-operation in antibody production occurs in the newt ...
... Xenopus is combatting environmental antigens with an incomplete immune system, some non-specific component may become in short supply, resulting in an overall reduction of specific antibody formation. Ruben et al. (1973) have shown that cellular co-operation in antibody production occurs in the newt ...
Sex hormone modulation of human uterine epithelial cell immune
... discomfort to death. The female reproductive tract has evolved innate and adaptive immune mechanisms that protect from microbial infection, thereby reducing infection and disease. Central to this protection are the epithelial cells that line the female reproductive tract. In the uterus, columnar epi ...
... discomfort to death. The female reproductive tract has evolved innate and adaptive immune mechanisms that protect from microbial infection, thereby reducing infection and disease. Central to this protection are the epithelial cells that line the female reproductive tract. In the uterus, columnar epi ...
Micronucleus induction in the bone marrow of rats by
... with a Pasteur pipette and a small drop spread onto a clean microscope slide, air dried and then fixed with methanol. After drying again, slides were dipped in fresh phosphate buffer pH 6.4, stained with 12.5% acridine orange and then rinsed in two changes of fresh phosphate buffer and air dried. Pr ...
... with a Pasteur pipette and a small drop spread onto a clean microscope slide, air dried and then fixed with methanol. After drying again, slides were dipped in fresh phosphate buffer pH 6.4, stained with 12.5% acridine orange and then rinsed in two changes of fresh phosphate buffer and air dried. Pr ...
Immunology and Immunodeficiency for the Hematologist
... cells, are intact. Common gamma chain mutation leads to a profile with absent T cells and present but non-functional B cells. Adenosine deaminase mutation affects the ability of all lymphocytes to detoxify the products of purine breakdown, and thus typically those patients lack all lymphocytes inclu ...
... cells, are intact. Common gamma chain mutation leads to a profile with absent T cells and present but non-functional B cells. Adenosine deaminase mutation affects the ability of all lymphocytes to detoxify the products of purine breakdown, and thus typically those patients lack all lymphocytes inclu ...
(CGD) Patients - cloudfront.net
... src-family kinases expressed on all hematopoietic cells. CD45 can have many isoforms (CD45RA, CD45RB, CD45RC and CD45RO) Based on alternative splicing of exons that comprise the extracellular domain. ...
... src-family kinases expressed on all hematopoietic cells. CD45 can have many isoforms (CD45RA, CD45RB, CD45RC and CD45RO) Based on alternative splicing of exons that comprise the extracellular domain. ...
Mastic gum suppresses secretion of thymic stromal lymphopoietin in
... immune system. Previous studies have shown that exposure to rhinovirus infection or dsRNA in vitro induces TSLP production in bronchial epithelial cells from healthy subjects [24], suggesting that this TSLP may link the innate antiviral response and the type 2 adaptive immune response. TSLP was orig ...
... immune system. Previous studies have shown that exposure to rhinovirus infection or dsRNA in vitro induces TSLP production in bronchial epithelial cells from healthy subjects [24], suggesting that this TSLP may link the innate antiviral response and the type 2 adaptive immune response. TSLP was orig ...
Copyright © 2014 Cognizant Communication Corporation CT
... Umbilical cord matrix or Wharton’s jelly-derived stromal cells (WJ-MSCs) are an easily accessible source of mesenchymal-like stem cells. Recent studies describe a hypoimmunogenic phenotype, multipotent differentiation potential and trophic support function for WJ-MSCs, with variable clinical benefit ...
... Umbilical cord matrix or Wharton’s jelly-derived stromal cells (WJ-MSCs) are an easily accessible source of mesenchymal-like stem cells. Recent studies describe a hypoimmunogenic phenotype, multipotent differentiation potential and trophic support function for WJ-MSCs, with variable clinical benefit ...
No Slide Title
... ‘‘Milky spot’’: They consist of macrophages, B and T lymphocytes and mast cells, immersed in a network of connective tissue, vascularized by fenestrated capillaries and lymphatic vessels. Near milky spots, the mesothelium is practically devoid of basement membrane so that macrophages and lymphocyte ...
... ‘‘Milky spot’’: They consist of macrophages, B and T lymphocytes and mast cells, immersed in a network of connective tissue, vascularized by fenestrated capillaries and lymphatic vessels. Near milky spots, the mesothelium is practically devoid of basement membrane so that macrophages and lymphocyte ...
infected cells expressing H2-D k and CMV - JEM
... to secrete INF-␥ in the absence of infection (Fig. 1 C). However, when infected with MCMV, cells expressing H2-Dk stimulated NKL-Ly49P cells to produce IFN-␥ (Fig. 1 C). Ly49H-expressing NKL (NKL-Ly49H) cells secreted INF-␥ when co-cultured with MCMV-infected cells, irrespective of H2 expression (Fi ...
... to secrete INF-␥ in the absence of infection (Fig. 1 C). However, when infected with MCMV, cells expressing H2-Dk stimulated NKL-Ly49P cells to produce IFN-␥ (Fig. 1 C). Ly49H-expressing NKL (NKL-Ly49H) cells secreted INF-␥ when co-cultured with MCMV-infected cells, irrespective of H2 expression (Fi ...
Ectopic lymphoid-like structures in infection, cancer and autoimmunity
... In the T cell zones of lymphoid tissues, dendritic cells (DCs) present peptide antigens on MHC class II molecules to naive CD4+ T cells. The recognition of the peptide–MHC class II complexes by defined T cell receptors (TCRs) promotes the activation and proliferation of CD4+ T cells, and their diffe ...
... In the T cell zones of lymphoid tissues, dendritic cells (DCs) present peptide antigens on MHC class II molecules to naive CD4+ T cells. The recognition of the peptide–MHC class II complexes by defined T cell receptors (TCRs) promotes the activation and proliferation of CD4+ T cells, and their diffe ...
Biological Activity of Marine Polysaccharides and Animal Health
... Lymphocytes and dendritic cells recruitment and antimicrobial activity ...
... Lymphocytes and dendritic cells recruitment and antimicrobial activity ...
Facts and Concepts
... Functions of the major parts of the eye: Sclera or Scleroid Layer – (white of eye) a tough protective layer of connective tissue that helps maintain the shape of the eye and provides an attachment for the muscles that move the eye Cornea - the clear, dome-shaped part of the sclera covering the front ...
... Functions of the major parts of the eye: Sclera or Scleroid Layer – (white of eye) a tough protective layer of connective tissue that helps maintain the shape of the eye and provides an attachment for the muscles that move the eye Cornea - the clear, dome-shaped part of the sclera covering the front ...
hybridoma technology for production of monoclonal antibodies
... Hybridomas are cells that have been engineered to produce a desired antibody in large amounts. To produce monoclonal antibodies, Bcells are removed from the spleen of an animal that has been challenged with the relevant antigen. These B-cells are then fused with myeloma tumor cells that can grow ind ...
... Hybridomas are cells that have been engineered to produce a desired antibody in large amounts. To produce monoclonal antibodies, Bcells are removed from the spleen of an animal that has been challenged with the relevant antigen. These B-cells are then fused with myeloma tumor cells that can grow ind ...
The Interplay between the Immune System and Cancer
... While cancer immunosurveillance mechanisms are powerful and can eliminate a significant percentage of transformed cells, some can escape immune control and survive. In the equilibrium phase, the surviving cancer cells are held in a state of immune-mediated dormancy, in which cancer cells are elimina ...
... While cancer immunosurveillance mechanisms are powerful and can eliminate a significant percentage of transformed cells, some can escape immune control and survive. In the equilibrium phase, the surviving cancer cells are held in a state of immune-mediated dormancy, in which cancer cells are elimina ...
Basic Concepts of Immune Response and Defense Development
... parts of the immune system involves the role played by antigen-presenting cells (APCs1), which include monocytes, M⌽s, endothelial cells, fibroblasts, fibrocytes, and DCs (Guermonprez et al. 2002; Knight and Stagg 1993). From the specific immune part, B lymphocytes can also function as APCs, but not ...
... parts of the immune system involves the role played by antigen-presenting cells (APCs1), which include monocytes, M⌽s, endothelial cells, fibroblasts, fibrocytes, and DCs (Guermonprez et al. 2002; Knight and Stagg 1993). From the specific immune part, B lymphocytes can also function as APCs, but not ...
Basic Concepts of Immune Response and Defense Development
... The induction of immune responses requires critical interaction between innate parts of the immune system, which respond rapidly and in a relatively nonspecific manner, and other specific parts, which recognize particular epitopes on an antigen. A critical element in this interaction is the role pla ...
... The induction of immune responses requires critical interaction between innate parts of the immune system, which respond rapidly and in a relatively nonspecific manner, and other specific parts, which recognize particular epitopes on an antigen. A critical element in this interaction is the role pla ...
Regulatory B Cells Limit CNS Inflammation and Neurologic Deficits
... IL-10 ⫺/⫺ mice had no effect on infarct volume when transferred into MT ⫺/⫺ mice. These findings strongly support a previously unrecognized activity of IL-10-secreting WT B cells to limit infarct volume, mortality rate, recruitment of inflammatory cells, and functional neurological deficits 48 h af ...
... IL-10 ⫺/⫺ mice had no effect on infarct volume when transferred into MT ⫺/⫺ mice. These findings strongly support a previously unrecognized activity of IL-10-secreting WT B cells to limit infarct volume, mortality rate, recruitment of inflammatory cells, and functional neurological deficits 48 h af ...
In vitro Induction of Myeloid Leukemia ^ Specific - Bio
... molecules, thus making possible combined CD4 and CD8 T-cell responses to the same protein; this situation enables maintenance of the CD8 T-cell response through the provision of cognate CD4 T-cell help (14). Whereas advantageous, it is more difficult to produce protein antigens at purity levels comp ...
... molecules, thus making possible combined CD4 and CD8 T-cell responses to the same protein; this situation enables maintenance of the CD8 T-cell response through the provision of cognate CD4 T-cell help (14). Whereas advantageous, it is more difficult to produce protein antigens at purity levels comp ...
Immunomodulatory Functions Of Extracts From The Chinese
... Extracts of A. membranaccus suppress the growth of renal cell carcinoma.9 (5) A. membranaccus extracts are able to enhance antibody production in mice.10 (6) A. membranaceus is an effectvie immune modulator, capable of potentiating in vitro the antitumor activity of lymphokine activated killer cells ...
... Extracts of A. membranaccus suppress the growth of renal cell carcinoma.9 (5) A. membranaccus extracts are able to enhance antibody production in mice.10 (6) A. membranaceus is an effectvie immune modulator, capable of potentiating in vitro the antitumor activity of lymphokine activated killer cells ...
cell biology of cancer
... The IRE-1/XBP-1 pathway is the most conserved endoplasmic reticulum (ER) stress response. We discovered that genetic deletion of XBP-1 significantly decelerates the progression of chronic lymphocytic leukemia (CLL) in Eµ-TCL1 mice. We set up a high throughput in vitro screening platform to look for ...
... The IRE-1/XBP-1 pathway is the most conserved endoplasmic reticulum (ER) stress response. We discovered that genetic deletion of XBP-1 significantly decelerates the progression of chronic lymphocytic leukemia (CLL) in Eµ-TCL1 mice. We set up a high throughput in vitro screening platform to look for ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.