Modeling and Simulation of the Innate Immune System
... not act directly on extracellular bacterial invaders. They can act on host cells that have been invaded by intracellular bacteria. They also act on cancer cells and host cells that harbor various types of viruses. The signal which activates NK cells to attack is a deficiency of MHC on the surface of ...
... not act directly on extracellular bacterial invaders. They can act on host cells that have been invaded by intracellular bacteria. They also act on cancer cells and host cells that harbor various types of viruses. The signal which activates NK cells to attack is a deficiency of MHC on the surface of ...
Tumor Immunology and Immunotherapy
... • M are important in tumor immunity as APCs to stimulate the immune response and as potential effector cells to mediate tumor lysis. • Activated M may produce cytotoxic factors (such as reactive oxygen intermediates, TNF-, etc.) that mediate killing of tumor cells. • Studies in knockout mice have ...
... • M are important in tumor immunity as APCs to stimulate the immune response and as potential effector cells to mediate tumor lysis. • Activated M may produce cytotoxic factors (such as reactive oxygen intermediates, TNF-, etc.) that mediate killing of tumor cells. • Studies in knockout mice have ...
About Non-Hodgkin Lymphoma in Children What Are the
... Spleen: The spleen is an organ under the lower part of the rib cage on the left side of the body. The spleen makes lymphocytes and other immune system cells to help fight infection. It also stores healthy blood cells and filters out damaged blood cells, bacteria, and cell waste. Thymus: The thymus i ...
... Spleen: The spleen is an organ under the lower part of the rib cage on the left side of the body. The spleen makes lymphocytes and other immune system cells to help fight infection. It also stores healthy blood cells and filters out damaged blood cells, bacteria, and cell waste. Thymus: The thymus i ...
Immunological Studies on the Aerial Roots of the Indian Banyan
... 100 mg/kg resulted in a decrease in the immune stimulation response. The activation and proliferation of T-lymphocytes and cytokine production post stimulation with antigens play important roles against bacterial and viral infection. Immune stimulation is important in many disease conditions where t ...
... 100 mg/kg resulted in a decrease in the immune stimulation response. The activation and proliferation of T-lymphocytes and cytokine production post stimulation with antigens play important roles against bacterial and viral infection. Immune stimulation is important in many disease conditions where t ...
The role of nitric oxide in the regulation of adaptive immune responses
... Apoptotic-inducing mechanisms are activated in mitochondria through the intrinsic pathway or are triggered by death receptors such as CD95/Fas, a member of the tumor necrosis factor receptor family. Fas ligand (CD95L/FasL) interacts with the Fas-associated death domain (FADD) and recruits pro-caspas ...
... Apoptotic-inducing mechanisms are activated in mitochondria through the intrinsic pathway or are triggered by death receptors such as CD95/Fas, a member of the tumor necrosis factor receptor family. Fas ligand (CD95L/FasL) interacts with the Fas-associated death domain (FADD) and recruits pro-caspas ...
B7-1, B7-2 and class II MHC molecules in idiopathic pulmonary
... T-cells after activation and may also regulate T-cell function [4]. Blocking of the B7/CD28 pathway in vitro results in T-cell anergy [5, 6], whereas in vivo blocking of the B7/CD28 pathway results in immunosuppression in animal models [7, 8]. Antigen-presenting cells (APCs) play an important role i ...
... T-cells after activation and may also regulate T-cell function [4]. Blocking of the B7/CD28 pathway in vitro results in T-cell anergy [5, 6], whereas in vivo blocking of the B7/CD28 pathway results in immunosuppression in animal models [7, 8]. Antigen-presenting cells (APCs) play an important role i ...
100500 T-Cell Function and Migration
... material. In inflamed tissues, dendritic cells are mobilized to carry antigen to lymph nodes, where they stimulate antigen-specific T cells. On stimulation, T cells proliferate by clonal expansion and differentiate into effector cells, which express receptors that enable them to migrate to sites of ...
... material. In inflamed tissues, dendritic cells are mobilized to carry antigen to lymph nodes, where they stimulate antigen-specific T cells. On stimulation, T cells proliferate by clonal expansion and differentiate into effector cells, which express receptors that enable them to migrate to sites of ...
Document
... leads to the development of robust and durable adaptive immune responses. The mechanism behind this potentiation of immune responses was not well understood as long as some of the pattern-recognition receptors (PRRs) involved in the innate immune responses to PAMPs were not identified. PRRs are diff ...
... leads to the development of robust and durable adaptive immune responses. The mechanism behind this potentiation of immune responses was not well understood as long as some of the pattern-recognition receptors (PRRs) involved in the innate immune responses to PAMPs were not identified. PRRs are diff ...
Dendritic Cells: A Basic Review
... cells, also called myeloid DCs, express different Toll-like receptors (TLR)-2, -3, -4, and -7. After encountering different natural ligands or pathogens for these TLRs in the blood, DC1 cells become activated and mature into antigen-presenting cells (APC) that can secrete Th-1 or Th-2 cytokines and ...
... cells, also called myeloid DCs, express different Toll-like receptors (TLR)-2, -3, -4, and -7. After encountering different natural ligands or pathogens for these TLRs in the blood, DC1 cells become activated and mature into antigen-presenting cells (APC) that can secrete Th-1 or Th-2 cytokines and ...
antibodies - immunology.unideb.hu
... • She was treated with melphalan (methylphenylalanine mustard), corticosteroids, and irradiation. Her symptoms improved. • In April 1993, further chemotherapy was given because of the persisting elevation of her serum IgG. The treatment reduced her serum IgG level from 8200 mg / dl to 6000 mg / dl. ...
... • She was treated with melphalan (methylphenylalanine mustard), corticosteroids, and irradiation. Her symptoms improved. • In April 1993, further chemotherapy was given because of the persisting elevation of her serum IgG. The treatment reduced her serum IgG level from 8200 mg / dl to 6000 mg / dl. ...
MDS Glossary - MDS Foundation
... Synonyms: Flow, Immunophenotyping Fluorescence-activated cell sorting (FACS) Fluorescence In Situ Hybridization (FISH) An important laboratory test used to help doctors look for chromosomal abnormalities and other genetic mutations. Fluorescence in situ hybridization, also called FISH, directs color ...
... Synonyms: Flow, Immunophenotyping Fluorescence-activated cell sorting (FACS) Fluorescence In Situ Hybridization (FISH) An important laboratory test used to help doctors look for chromosomal abnormalities and other genetic mutations. Fluorescence in situ hybridization, also called FISH, directs color ...
Immune Response
... immunity destroys pathogen-infected body cells (and cancer cells). Humoral immunity destroys free pathogens in the body fluids. The two systems are completely dependent on macrophages and helper T-cells to initiate their responses. Both systems need to be activated for an effective response to the i ...
... immunity destroys pathogen-infected body cells (and cancer cells). Humoral immunity destroys free pathogens in the body fluids. The two systems are completely dependent on macrophages and helper T-cells to initiate their responses. Both systems need to be activated for an effective response to the i ...
The role of B lymphocytes in the progression of autoimmunity to
... (27,28). However, not only autoimmunity but also overt autoimmune disease can be triggered by epitope spreading. SJL/J mice immunized with protelipid (PLP) protein develop T cell responses specific for different epitopes in the molecule. These distinct T cell responses contribute to the relapse phas ...
... (27,28). However, not only autoimmunity but also overt autoimmune disease can be triggered by epitope spreading. SJL/J mice immunized with protelipid (PLP) protein develop T cell responses specific for different epitopes in the molecule. These distinct T cell responses contribute to the relapse phas ...
Diefenbach, A., and D.H. Raulet. 2003. Innate immune recognition by stimulatory immunoreceptors. Curr Opin Immunol 15:37-44.
... cells and virus-infected cells. How NK cells selectively recognize these cells is largely unknown. NK cells express various families of inhibitory receptors, all of which interact with class I MHC molecules. These receptors prevent NK cells from attacking normal self cells, while allowing them to at ...
... cells and virus-infected cells. How NK cells selectively recognize these cells is largely unknown. NK cells express various families of inhibitory receptors, all of which interact with class I MHC molecules. These receptors prevent NK cells from attacking normal self cells, while allowing them to at ...
Hematopoietic cell–derived interferon controls viral replication and
... dependent on BM-derived cells during systemic viral infections. Therefore, we continued to analyze the influence of hematopoietic cell–derived IFN-I on the control of viral replication and disease outcome. Irf7⫺/⫺ mice, WT mice, and BM chimeric mice were infected with the cytopathic MHV A59. Althoug ...
... dependent on BM-derived cells during systemic viral infections. Therefore, we continued to analyze the influence of hematopoietic cell–derived IFN-I on the control of viral replication and disease outcome. Irf7⫺/⫺ mice, WT mice, and BM chimeric mice were infected with the cytopathic MHV A59. Althoug ...
The integration of T cell migration, differentiation and function
... The imperative for migration. Proliferation signals that induce clonal expansion are coupled with differentiation and migration cues that coordinate function with localization. Some T cells may remain within the SLO; for example, CD4+ T follicular helper (TFH) cells upregulate CXCR5 and migrate to l ...
... The imperative for migration. Proliferation signals that induce clonal expansion are coupled with differentiation and migration cues that coordinate function with localization. Some T cells may remain within the SLO; for example, CD4+ T follicular helper (TFH) cells upregulate CXCR5 and migrate to l ...
Dynamics of Lymphocytic Subpopulations in
... to FLY (1 1), but the role of the host immune response to FLY is still uncertain. In the responses of mice to leukemia and sarcoma virus induced tumors, several different cell-mediated immune mech anisms have been demonstrated in vitro (17—19),but the in vivo roles and relative importances of thes ...
... to FLY (1 1), but the role of the host immune response to FLY is still uncertain. In the responses of mice to leukemia and sarcoma virus induced tumors, several different cell-mediated immune mech anisms have been demonstrated in vitro (17—19),but the in vivo roles and relative importances of thes ...
Vasodilation to PTH 1-84 in bone resistance arteries of rats occurs
... femoral principal nutrient artery (PNA; the primary conduit for blood flow to long bones). Further, vasodilation was nearly obliterated with blockade of NO production with the endothelial nitric oxide synthase inhibitor L-NAME, suggesting that vasodilation in the bone vasculature occurs exclusively ...
... femoral principal nutrient artery (PNA; the primary conduit for blood flow to long bones). Further, vasodilation was nearly obliterated with blockade of NO production with the endothelial nitric oxide synthase inhibitor L-NAME, suggesting that vasodilation in the bone vasculature occurs exclusively ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.