The HMG-Co-A reductase inhibitor, atorvastatin, promotes a
... CIITA has multiple promoter regions, with pIV being predominant in epithelial cells and pI predominant in bone marrow derived cells. A previous study reported that statins suppressed IFN-gamma inducible CIITA transcription. ...
... CIITA has multiple promoter regions, with pIV being predominant in epithelial cells and pI predominant in bone marrow derived cells. A previous study reported that statins suppressed IFN-gamma inducible CIITA transcription. ...
T cell vaccination: An insight into T cell regulation
... We have observed (F. J. Quintana and I. R. Cohen; in preparation) that each of the two C region variants in the rat TCR includes ergotopes that are presented in the context of MHC II by rat T cells that have been activated by specific antigen – the same clones of T cells in a resting state do not pr ...
... We have observed (F. J. Quintana and I. R. Cohen; in preparation) that each of the two C region variants in the rat TCR includes ergotopes that are presented in the context of MHC II by rat T cells that have been activated by specific antigen – the same clones of T cells in a resting state do not pr ...
Use of a Lethally Irradiated Major Histocompatibility
... very high proliferative and replating potential, which are abundant in CD34' human umbilical cord blood samples." Cytotoxic assays. Direct TALL-104 cell killing of "Cr-labeled targets was measured in an 18-hour assay, as previously described." The effectors were stimulated overnight with rhIL-2 (100 ...
... very high proliferative and replating potential, which are abundant in CD34' human umbilical cord blood samples." Cytotoxic assays. Direct TALL-104 cell killing of "Cr-labeled targets was measured in an 18-hour assay, as previously described." The effectors were stimulated overnight with rhIL-2 (100 ...
Yukon Immunization Manual: Section 14
... of cells and molecules that make up the immune system. Immunity is the ability of the human body to tolerate the presence of material indigenous to the body (self), and to eliminate foreign (non-self) material. Foreign substances such as viruses, bacteria, toxins, and parasites are surrounded by ant ...
... of cells and molecules that make up the immune system. Immunity is the ability of the human body to tolerate the presence of material indigenous to the body (self), and to eliminate foreign (non-self) material. Foreign substances such as viruses, bacteria, toxins, and parasites are surrounded by ant ...
Lymphatic
... Tonsils are lymphoid nodules in the wall of the pharynx. They fight infections of the nose, ear, and throat region. Lymph nodes are encapsulated masses of lymphoid tissue that contain lymphocytes. Lymph nodes monitor the lymph before it drains into the veins. They remove antigens and initiate approp ...
... Tonsils are lymphoid nodules in the wall of the pharynx. They fight infections of the nose, ear, and throat region. Lymph nodes are encapsulated masses of lymphoid tissue that contain lymphocytes. Lymph nodes monitor the lymph before it drains into the veins. They remove antigens and initiate approp ...
Micro 532 Exam 1995
... You have been asked to consult in a clinical diagnostic laboratory. The lab is trying to determine why its new antibody assay system is not accurately detecting protective antibodies in the sera of persons recently exposed to Bonga-Bonga fever virus. This is very frustrating to the laboratory since ...
... You have been asked to consult in a clinical diagnostic laboratory. The lab is trying to determine why its new antibody assay system is not accurately detecting protective antibodies in the sera of persons recently exposed to Bonga-Bonga fever virus. This is very frustrating to the laboratory since ...
王青青_Tumor Immunology
... • M are important in tumor immunity as APCs to stimulate the immune response and as potential effector cells to mediate tumor lysis. • Activated M may produce cytotoxic factors (such as reactive oxygen intermediates, TNF-, etc.) that mediate killing of tumor cells. • Studies in knockout mice have ...
... • M are important in tumor immunity as APCs to stimulate the immune response and as potential effector cells to mediate tumor lysis. • Activated M may produce cytotoxic factors (such as reactive oxygen intermediates, TNF-, etc.) that mediate killing of tumor cells. • Studies in knockout mice have ...
Brain-Resident Immune Cells Responses As an Endogenous
... Sulfatide, a major lipid component of myelin sheath, participates in diverse cellular events of the CNS, and its cellular level has recently been implicated in many inflammation-associated neuronal diseases. Herein, we report that sulfatide alone can trigger pathological inflammatory responses in gl ...
... Sulfatide, a major lipid component of myelin sheath, participates in diverse cellular events of the CNS, and its cellular level has recently been implicated in many inflammation-associated neuronal diseases. Herein, we report that sulfatide alone can trigger pathological inflammatory responses in gl ...
PD-L1 checkpoint blockade prevents immune dysfunction and
... P 5 .0315) of aPD-L1–treated mice compared with isotype controls (Figure 1D and supplemental Figure 1), indicating effective tumor control. Lymph nodes, the primary site of disease in humans, are barely affected in the Em-TCL1 AT mouse model when the transplantation regimen routinely applied by our ...
... P 5 .0315) of aPD-L1–treated mice compared with isotype controls (Figure 1D and supplemental Figure 1), indicating effective tumor control. Lymph nodes, the primary site of disease in humans, are barely affected in the Em-TCL1 AT mouse model when the transplantation regimen routinely applied by our ...
Animal Models to Study Adult Stem Cell-derived, In Vitro
... somatostatin, glucose transporter-2, GAD-67, and insulinlike growth factors I and II. In addition, genes related to development and differentiation are also detected, including those encoding Reg-1, Pdx-1, Ngn-3, Isl-1, and beta2/ neuroD. Despite detectable expression of these mRNA transcripts for i ...
... somatostatin, glucose transporter-2, GAD-67, and insulinlike growth factors I and II. In addition, genes related to development and differentiation are also detected, including those encoding Reg-1, Pdx-1, Ngn-3, Isl-1, and beta2/ neuroD. Despite detectable expression of these mRNA transcripts for i ...
presentation
... 1980’s-1990’s – Microglia come from bone marrow. ▪ Microglia express common markers with cells of myeloid lineage. ▪ After bone marrow transplant, cells from graft enter the brain and look like microglia. ...
... 1980’s-1990’s – Microglia come from bone marrow. ▪ Microglia express common markers with cells of myeloid lineage. ▪ After bone marrow transplant, cells from graft enter the brain and look like microglia. ...
CD4 and CD8 T Cells Are - The Journal of Immunology
... cells in bulk culture secrete substantial amounts of IFN-␥ (11), a hallmark cytokine of the Th1 response. Surprisingly, our results show that only a small fraction (⬍7%) of CD4 T cells that were recruited into division produced IFN-␥ (Fig. 2B), indicating that most responding CD4 T cells did not ful ...
... cells in bulk culture secrete substantial amounts of IFN-␥ (11), a hallmark cytokine of the Th1 response. Surprisingly, our results show that only a small fraction (⬍7%) of CD4 T cells that were recruited into division produced IFN-␥ (Fig. 2B), indicating that most responding CD4 T cells did not ful ...
- St George`s, University of London
... 2. Part I: Thinking Kinetically—How Long Is a Memory? 2.1. The Longevity of Immune Responses The key desirable property of a vaccine response (or the desirable consequence of naturalimmunity) is longevity. Duration of protection varies widely from one vaccine to another, and from one pathogen to ano ...
... 2. Part I: Thinking Kinetically—How Long Is a Memory? 2.1. The Longevity of Immune Responses The key desirable property of a vaccine response (or the desirable consequence of naturalimmunity) is longevity. Duration of protection varies widely from one vaccine to another, and from one pathogen to ano ...
The Immune System - e-Publications@Marquette
... of capillary dilatation, exudation of fluid and plasma protein into the tissues, and accumulation of neutrophils at the site of infection. These responses are manifested clinica11y as the five cardinal signs of inflammation: heat, redness, swelling, pain, and loss of function. The invading organism ...
... of capillary dilatation, exudation of fluid and plasma protein into the tissues, and accumulation of neutrophils at the site of infection. These responses are manifested clinica11y as the five cardinal signs of inflammation: heat, redness, swelling, pain, and loss of function. The invading organism ...
short Novo Protein Synthesis of c-FLIP De CD95
... nant role. Prominent caspase activation occurs in type II cells only after the loss of ⌬M (4), indicating that mitochondria amplify the executionary apoptosis caspase cascade in these cells. Activation of mitochondria by death receptors is mediated by the Bcl-2 family member Bid. Bid is cleaved by ...
... nant role. Prominent caspase activation occurs in type II cells only after the loss of ⌬M (4), indicating that mitochondria amplify the executionary apoptosis caspase cascade in these cells. Activation of mitochondria by death receptors is mediated by the Bcl-2 family member Bid. Bid is cleaved by ...
Cochlear labyrinth (pars auditiva labyrinthi)
... duct and follows the spirals throughout the cochlea (Fig. 1728). Towards the interior of the duct it is covered by a gel-like membrane (membrana tectoria). The organ of Corti includes two different types of cells: Sensory cells, Supporting cells: Columnar and phalangeal cells. ...
... duct and follows the spirals throughout the cochlea (Fig. 1728). Towards the interior of the duct it is covered by a gel-like membrane (membrana tectoria). The organ of Corti includes two different types of cells: Sensory cells, Supporting cells: Columnar and phalangeal cells. ...
B Cells and Antibodies
... Indeed, the requirement for cross-linking is one way B cells focus on common enemies. Finally, B cell receptors can also be brought together by binding to epitopes on antigens that are clumped together (e.g., a clump of proteins). Regardless of how it is accomplished, cross-linking of B cell recepto ...
... Indeed, the requirement for cross-linking is one way B cells focus on common enemies. Finally, B cell receptors can also be brought together by binding to epitopes on antigens that are clumped together (e.g., a clump of proteins). Regardless of how it is accomplished, cross-linking of B cell recepto ...
Immune attacks - Manchester Immunology Group
... reads out a category and its number, from their first card. • All of the players then in turn read out the number that they have for this category. • The player with the highest number wins and takes each of the top cards from all players. • The winner then places these cards at the bottom of their ...
... reads out a category and its number, from their first card. • All of the players then in turn read out the number that they have for this category. • The player with the highest number wins and takes each of the top cards from all players. • The winner then places these cards at the bottom of their ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.