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A newborn mammal has no opportunity to develop protective
A newborn mammal has no opportunity to develop protective

... Although the fetus possesses the components of innate immunity, it has few or none of its mother's lymphocytes. The placenta generally prevents the maternal lymphocytes from crossing into the uterus, where they would recognize the fetal tissues as foreign antigens and cause a reaction similar to the ...
Immune System
Immune System

... Complement-help to kill pathogens ...
OTHER DISEASE CAUSING FACTORS
OTHER DISEASE CAUSING FACTORS

... Immune Response • T-Cells and B-Cells are “White Blood Cells” • Antibodies are “Antigen Specific” • Measles antibody will only bind with measles antigen ...
Oncoimmunology
Oncoimmunology

...  Combination of A and B antigens make up the ABO Blood Groups (A,B,AB,O)  “naturally” occurring antibody will be made against antigens that the individual does not have  Usually IgM ...
Immune System
Immune System

... Foreign antigens bind to antibodies on B-cells Antigen-antibody complex stimulation Stimulated B-cell will produce/release this specific antibody as free floating antibody 5. Free floating antibodies will bind to all other antigens of the same type 6. Macrophages recognize antibodies and phagocytosi ...
ch 40.2 notes - 4J Blog Server
ch 40.2 notes - 4J Blog Server

... Reaction to tissue damage due to injury/infection White blood cells go to affected tissues  Phagocytes – “eat” bacteria ...
ASAHL antibody - middle region (ARP44939_P050)
ASAHL antibody - middle region (ARP44939_P050)

... Protein Size (# AA) 359 amino acids Molecular Weight ...
Immunoglobulin Structure
Immunoglobulin Structure

... The serum IgG from her was assumed to be monoclonal because it migrated as a tight band on electrophoresis in an agarose gel, and because it reacted with antibodies to lambda but not to kappa chains. What other evidence could be brought to bear to prove the monoclonality of this IgG? The IgG could a ...
The Immune System
The Immune System

... The Immune System: war in your body Mission: ID the enemy, then kill it. Method: make antibodies that recognize the enemy’s flag (the antigen) ...
Section Assignment 1.3 Part C: Defence Systems
Section Assignment 1.3 Part C: Defence Systems

... Antibodies Immune response Immunity Inflammation ...
The humoral immune response defends against pathogens that are
The humoral immune response defends against pathogens that are

... The helper T cell binds to the antigen-MHC class II complex and is induced to ...
Immune system II
Immune system II

... the cell(s) that make antibodies that react with that antigen to produce a clone of antibody producing cells. ! Once stimulated, there are more of the clone ready to be re-stimulated—thus the memory response. ...
topic 11 notes
topic 11 notes

... Procedure for Monoclonal Antibody Production • Inject a specific antigen into a mouse. • Wait while mouse has primary response. • Remove spleen (ouch) to get blood cells including the b-cells that are producing the antibodies. • Keep the b-cells alive by fusing them with cancerous myeloma cells, wh ...
Antibody response
Antibody response

... Key words: antibodies, antigen, pathogen, antibody, B Cells, Memory T Cells ...
Immune System Review Worksheet
Immune System Review Worksheet

... white blood cells ...
Evolutionary Genetics
Evolutionary Genetics

... Each chain has variable (V) and constant (C) region joined by a J region. Variable regions bind to antigen. Constant regions bind to cells or other antibodies. ...
Immunoanalysis - Part 1 : What are antibodies?
Immunoanalysis - Part 1 : What are antibodies?

... immunoassays, for detecting antigens. These techniques are popular as they are cost-effective methods for quickly detecting protein analytes. For immunoassays, the production and purification of antibodies is necessary. Purification may be achieved using: gel filtration to isolate the molecules of a ...
a. active site is covered (toxin)
a. active site is covered (toxin)

... e. Macrophages – “scavengers” – pick up antigens and present them to the B or T cells. They also “eat” tagged bacteria ...
Immunogens and Antigens
Immunogens and Antigens

... Immunogen-Agent capable of inducing an immune response Antigen-Agent that binds specifically to preformed antibodies or T cells ...
The Immune System Learning Module | Vaccine Education Center
The Immune System Learning Module | Vaccine Education Center

... White Blood Cells Courtesy CDC, PHIL ...
The Immune System Learning Module | Vaccine Education Center
The Immune System Learning Module | Vaccine Education Center

... White Blood Cells Courtesy CDC, PHIL ...
The Immune System - Children`s Hospital of Philadelphia
The Immune System - Children`s Hospital of Philadelphia

... White Blood Cells Courtesy CDC, PHIL ...
PowerPoint Presentation - I. Introduction to class
PowerPoint Presentation - I. Introduction to class

... ACTIVITY OF OTHER CELLS OF THE IMMUNE SYSTEM. • DEFENSE AGAINST: • BACTERIA AND VIRUSES THAT ARE INSIDE HOST CELLS AND ARE INACCESSIBLE TO ANTIBODIES. • FUNGI, PROTOZOA, AND WORMS ...
Adaptive or Acquired Immunity
Adaptive or Acquired Immunity

... Note – Precipitation and agglutination reactions are less beneficial because they can cause the formation of complexes that block tiny blood and lymphatic vessels as well as kidney tubules. T-cells do not produce antibodies, but are able to recognize and bind with specific antigens. They have recep ...
Immune System Flow Chart
Immune System Flow Chart

... The killer T cells serve to then prevent the replication of the virus. The helper T cells activate an infected cell of the immune system so that it is able to cure itself. The basic function of a helper T cell is to stimulate the macrophages and focus other immune cells onto the infection. Another i ...
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Monoclonal antibody



Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.
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